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  • damage
  • FT011 is an anti-inflammatory and anti-fibrotic agent that has been reported to attenuate organ damage in diabetic rats with cardiomyopathy and nephropathy. (nih.gov)
  • epigenetic
  • The role of epigenetics in diabetic retinopathy is now an emerging area, and recent work has shown that genes encoding mitochondrial superoxide dismutase ( Sod2 ) and matrix metalloproteinase-9 ( MMP-9 ) are epigenetically modified, activates of epigenetic modification enzymes, histone lysine demethylase 1 (LSD1), and DNA methyltransferase are increased, and the micro RNAs responsible for regulating nuclear transcriptional factor and VEGF are upregulated. (hindawi.com)
  • With the growing evidence of epigenetic modifications in diabetic retinopathy, better understanding of these modifications has potential to identify novel targets to inhibit this devastating disease. (hindawi.com)
  • Diabetic retinopathy is known to be associated with a number of epigenetic markers, including methylation of the Sod2 and MMP-9 genes, an increase in transcription of LSD1, a H3K4 and H3K9 demethylase, and various DNA Methyl-Transferases (DNMTs), and increased presence of miRNAs for transcription factors and VEGF. (wikipedia.org)
  • Several avenues to epigenetic treatment of diabetic retinopathy have been studied. (wikipedia.org)
  • modalities
  • EDITOR,-In his editorial on screening for diabetic retinopathy Bob Ryder asserts that single screening modalities are inadequate and that combined ophthalmoscopy and photography conducted by specialist optometrists or technicians is satisfactory. (bmj.com)
  • vitreous
  • Based on weak evidence, it appears that laser coagulation may be effective in preventing visual loss and vitreous haemorrhage in this condition but that it does not have an effect on regression of proliferative sickle retinopathy or preventing the development of new vessel growth. (wikipedia.org)
  • vascular
  • Diabetic retinopathy is characterized by increased vascular permeability, haemostatic abnormalities, endothelial dysfunction, increased tissue ischemia, and neoangiogenesis [ 2 ]. (hindawi.com)
  • severe
  • An endothelium-specific PDGF-β knockout displays a variety of phenotypes with variable degrees of pericyte loss, with areas of pericyte-covered vessels and areas lacking pericytes and with severe retinopathy localized to the areas lacking pericytes. (diabetesjournals.org)
  • disease
  • What is diabetic eye disease? (nih.gov)
  • Fortunately, the inhibitors and mimics targeted towards histone modification, DNA methylation, and miRNAs are now being tried for cancer and other chronic diseases, and better understanding of the role of epigenetics in diabetic retinopathy will open the door for their possible use in combating this blinding disease. (hindawi.com)
  • damage
  • Precisely what causes it is not fully known, but diabetics have increased risk of both heart attack and stroke, so some of the tissue damage diabetes produces may be involved. (wikipedia.org)
  • Researchers
  • However, a new study from researchers at Children's Hospital of Boston has shown that omega-3 fatty acids may be a useful tool in the fight against retinopathy. (endocrineweb.com)
  • patients
  • The effect of diabetic control on the width of skeletal-muscle capillary basement membrane in patients with Type I diabetes mellitus. (springer.com)
  • Ten percent (10%) of diabetic patients will have vision loss related to macular edema. (wikipedia.org)
  • However, it has been shown that the widely accepted WHO and American Diabetes Association diagnostic cutoff for diabetes of a fasting plasma glucose ≥ 7.0 mmol/l (126 mg/dl) does not accurately identify diabetic retinopathy among patients. (wikipedia.org)
  • Apart from being a major healthcare hub for the local population, the hospital and Institute also receives a large number of international patients The hospital and Institute conducts annual diabetic retinopathy camps It also works in association with its One Vision Trust to regularly perform free eye surgeries for the lesser privileged members of society. (wikipedia.org)
  • high
  • Produced in high levels during periods of stress, infection, etc possibly leading to diabetic ketoacidosis, a very serious condition. (wikipedia.org)
  • damage
  • FT011 is an anti-inflammatory and anti-fibrotic agent that has been reported to attenuate organ damage in diabetic rats with cardiomyopathy and nephropathy. (nih.gov)
  • diseases
  • Napoleone Ferrara (born 26 July 1956, Catania), is an Italian-American molecular biologist who joined University of California, San Diego Moores Cancer Center in 2013 after a career in Northern California at the biotechnology giant Genentech, where he pioneered the development of new treatments for angiogenic diseases such as cancer, age-related macular degeneration (AMD), and diabetic retinopathy. (wikipedia.org)
  • outcomes
  • Purpose:This study was designed to evaluate the visual and anatomical outcomes after cataract surgery in diabetic patients with different intraoperative therapeutic strategies.Methods:The research design comprised of a multicentric, retrospective, interventional study conducted at 6 centers in Argentina, Brazil, Costa Rica, Puerto Rico, Spain, and Venezuela. (unifesp.br)
  • results
  • Despite excellent in vitro and in vivo pharmacology results obtained in preclinical pharmacological models of fibrosis and IPF, and promising phase 1 data showing low toxicity of GKT-831, the company Genkyotex decided to initiate a phase 2 Proof-of-concept in the complex indication of diabetic nephropathy in 2014. (wikipedia.org)