• rats
  • Methods and Results- Twelve weeks after induction of diabetes with streptozotocin, motor and sensory nerve conduction velocities (MCV and SCV) of the sciatic nerves were significantly reduced in diabetic rats. (ahajournals.org)
  • 0.05 versus diabetic saline-treated rats) to levels similar to those achieved with vascular endothelial growth factor-2 (VEGF-2) gene therapy. (ahajournals.org)
  • Interestingly, the SHh-induced vasculature was characterized by larger diameter and more smooth muscle cell-containing vessels, compared with VEGF-2 gene-treated diabetic rats. (ahajournals.org)
  • The anticonvulsant valproate, an effective treatment for diabetic neuropathy, appeared to offer some protection against cisplatin-induced neuropathy in rats. (wikipedia.org)
  • patients
  • 1 Diabetic neuropathy (DN) is a frequent complication of diabetes, affecting 1 to 7 million people, including 7% within 1 year of diagnosis and 50% of patients after 25 years. (ahajournals.org)
  • It has also been reported that up to 90% of patients have subclinical levels of neuropathy. (ahajournals.org)
  • Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, enduring, and often irreversible condition featuring pain, numbness, tingling and sensitivity to cold in the hands and feet (sometimes progressing to the arms and legs) that afflicts between 30% and 40% of patients undergoing chemotherapy. (wikipedia.org)
  • After three months, 38.5 percent of the venlafaxine-treated patients had no neuropathy, vs. 5.6 percent of those on placebo, and while 33.3 percent of the placebo-treated patients had grade 3 neuropathy after 3 months, none of the venlafaxine-treated patients did. (wikipedia.org)