AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth Care
AcromegalyHuman Growth HormoneGrowth Hormone-Secreting Pituitary AdenomaDiabetes Mellitus, Type 1Diabetes MellitusDiabetes Mellitus, Type 2Pituitary NeoplasmsOctreotideDiabetes ComplicationsSomatostatinInsulin-Like Growth Factor IGigantismGrowth HormoneAdenomaDiabetes Mellitus, ExperimentalBromocriptineBlood GlucoseGlucose Tolerance TestAdenoma, AcidophilDiabetes, GestationalGrowth Hormone-Releasing HormoneThyrotropin-Releasing HormoneHemoglobin A, GlycosylatedReceptors, SomatotropinInsulinErgolinesPeptides, CyclicHypoglycemic AgentsAdenoma, ChromophobeProlactinomaPituitary GlandMacroglossiaHyperprolactinemiaRisk FactorsSphenoid BoneHormonesDiabetes InsipidusHypercementosisFibrous Dysplasia, PolyostoticHormone AntagonistsInsulin ResistanceHypophysectomyEndocrine Surgical ProceduresEndocrinologyDisabled PersonsElectronic MailInternet
HyperthyroidismMetabolismEndocrinologyPeople with acromegalyDiagnosis of acromegalyCushing'sCauses AcromegalyComplicationsGigantism rather than acromegalySymptomsHypothyroidismEffects of acromegalyTreat acromegalyDevelop acromegalyDisordersHypopituitarismGrowing duringExcessive secretion of growth hormoneSecretionPituitary glandExcessComorbiditiesMellitus associatedChronicObesityHypertensionChildren and adolescentsOccursEndocrineOctreotideType 2 diabetInsulin resistanceSystemicLife expectancyHormonesTreatmentInsipidusPatients with type 2 diabetSurgeryHigher prevalenceColon2020PrognosisEtiologyBenignArisesHormone
Hyperthyroidism2
Metabolism4
  • Due to the reversal of insulin resistance and the diminution of gluconeogenesis, acromegaly treatment should improve glucose metabolism abnormalities. (mydiabetesday.com)
  • Dr. Fleseriu is Chief Editor of Pituitary Endocrinology for Frontiers in Endocrinology, Section Head for Pituitary and Neuroendocrine F 1000, Associate Editor for European Journal of Endocrinology, Reviews in Endocrinology and Metabolism, Senior Editor for Endocrinology, Diabetes and Metabolism CR and a member of the editorial board of Pituitary. (biospace.com)
  • Type 2/Adult-Onset Diabetes, and Bone and Mineral Metabolism. (ynhh.org)
  • Whole blood-based transcriptional risk score for nonobese type 2 diabetes predicts dynamic changes in glucose metabolism. (medscape.com)
Endocrinology1
  • Endocrinology services focus on the diagnosis, treatment and long-term care needs of people living with diabetes and hormonal disorders. (ynhh.org)
People with acromegaly3
  • Compared with controls, people with acromegaly showed a significantly higher prevalence of vertebral fractures -- with many experiencing multiple and severe fractures. (medpagetoday.com)
  • People with acromegaly also have an increased risk for colon polyps , which may develop into colon cancer if not removed. (nih.gov)
  • Some people with acromegaly may have a genetic condition that can lead tumors to develop in different parts of their bodies. (nih.gov)
Diagnosis of acromegaly1
  • Even someone as drastically affected as André the Giant didn't receive a diagnosis of acromegaly until well into his pro-wrestling career, and after much damage had already been done. (damninteresting.com)
Cushing's4
  • There are disorders such as acromegaly and Cushing's disease that are blatantly linked to diabetes. (mydiabetesday.com)
  • She is a frequent plenary guest speaker at national and international meetings on treatment of Cushing's, acromegaly and growth hormone deficiency, is global principal investigator in clinical trials, and has authored over 170 manuscripts in prestigious journals, including guidelines, consensus papers and book chapters. (biospace.com)
  • She has served on multiple scientific advisory boards for biotechnology and pharmaceutical companies and participated in study design and has been global principal investigator for several Cushing's and acromegaly studies. (biospace.com)
  • The RVC team was the first in the UK to treat cats with acromegaly (hypersomatotropism) and is now also routinely performing hypophysectomy in dogs (and the occasional cat) with pituitary-dependent Cushing's syndrome (hyperadrenocorticism). (rvc.ac.uk)
Causes Acromegaly1
Complications8
  • Caused by a tumor at the base of the brain, it's associated with many complications like diabetes and high blood pressure. (uvahealth.com)
  • The rheumatic manifestations may result from a direct effect of the hormones, the occurrence of several autoimmune phenomena in the same person (due to genetic or environmental influences), secondary to endocrine disease complications or effects of advanced glycation end products in the case of diabetes. (springer.com)
  • The majority of concerns likely come from a physician's familiarity with the complications of acromegaly. (bio.net)
  • What are the complications of acromegaly? (nih.gov)
  • Serum MicroRNA-191-5p Levels in Vascular Complications of Type 1 Diabetes: the EURODIAB Prospective Complications Study. (medscape.com)
  • Our main outcome measures were the prevalence of major metabolic complications of acromegaly (diabetes, hypertension, low-density lipoprotein cholesterol, triglycerides) at diagnosis and last follow-up in comparison with French epidemiological data. (medscape.com)
  • Results As expected, controlling hypersecretion significantly improved the metabolic complications of acromegaly. (medscape.com)
  • [ 1 ] Of note, patients with acromegaly also frequently develop respiratory disorders such as sleep apnea, which may worsen the metabolic and cardiovascular complications. (medscape.com)
Gigantism rather than acromegaly2
Symptoms3
  • Many acromegaly symptoms improve, and you can eventually sleep better and discontinue taking medications for diabetes and high blood pressure. (uvahealth.com)
  • Acromegaly is most often diagnosed in middle-aged adults, but symptoms can appear at any age. (nih.gov)
  • Symptoms of acromegaly can vary from person to person. (nih.gov)
Hypothyroidism2
  • There is also concern with HGH enhancements effect on those already on hormone therapy for metabolic disorders such as diabetes, hypothyroidism, and Addison's syndrome. (bio.net)
  • These hormonal disorders include diabetes, hypothyroidism, and Addison's disease. (bio.net)
Effects of acromegaly3
Treat acromegaly2
Develop acromegaly2
Disorders2
  • In acromegaly, a severe disease that is often diagnosed late, morbidity and mortality rates are high, particularly as a result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. (medscape.com)
  • Conclusions The follow-up of glucose disorders needs to be maintained on a long-term basis in patients controlled for acromegaly. (medscape.com)
Hypopituitarism1
Growing during1
  • Acromegaly occurs in adults after the bones have finished growing during puberty. (barrowneuro.org)
Excessive secretion of growth hormone2
Secretion5
  • Acromegaly is a chronic rare disease associated with excess growth hormone secretion. (pfizer.com)
  • 4 Acromegaly develops gradually and typically is not diagnosed until several years-often, as many as seven-after excess growth hormone secretion has begun. (pfizer.com)
  • Central diabetes insipidus is caused by reduced secretion of antidiuretic hormone (ADH). (merckvetmanual.com)
  • When target cells in the kidney lack the biochemical machinery necessary to respond to the secretion of normal or increased circulating levels of ADH, nephrogenic diabetes insipidus results. (merckvetmanual.com)
  • The lesions responsible for the disruption of ADH synthesis or secretion in hypophyseal diabetes insipidus include large pituitary neoplasms (endocrinologically active or inactive), a dorsally expanding cyst or inflammatory granuloma, and traumatic injury to the skull, with hemorrhage and glial proliferation in the neurohypophyseal system. (merckvetmanual.com)
Pituitary gland9
Excess3
Comorbidities4
  • Patients with RA have an increased risk of insulin resistance (IR) and diabetes (DM) secondary to genetic, inflammatory components or to comorbidities and treatment. (springer.com)
  • Monitoring and treatment of the comorbidities associated with acromegaly are essential for improving patient quality of life. (bmj.com)
  • Our objective was to determine the rate of acromegaly comorbidities once hypersecretion of growth hormone is controlled. (medscape.com)
  • The comorbidities associated with acromegaly are known to lead to an impaired quality of life and an average 10-year reduction in life expectancy in untreated patients compared with the general population, mainly due to cardiovascular disease. (medscape.com)
Mellitus associated1
  • The presence of contrast media induced endothelial swelling with the result of hypoperfusion and diabetes mellitus associated vasculopathy might be a precipitating factor in this patient. (nel.edu)
Chronic4
Obesity2
  • Roughly six in 10 adults with overweight or obesity and either prediabetes or type 2 diabetes treated with GS200 achieved at least 5% body weight loss -- losing on average 11% of their body weight (23 lb) -- plus an average reduction of 5.5 inches off their waist circumference in the LIGHT-UP clinical trial, Gelesis announced. (medpagetoday.com)
  • New Horizons: Epidemiology of Obesity, Diabetes Mellitus, and Cancer Prognosis. (medscape.com)
Hypertension2
  • 1 They may also experience headaches and can often suffer from diabetes, hypertension, arthritis and heart failure. (pfizer.com)
  • However, the proportion of patients having at least one metabolic complication of acromegaly at last follow-up (mean, 72 months after remission) was 27% for altered glucose tolerance or diabetes, 39% for hypertension, 34.3% for hypercholesterolemia, and 13.3% for hypertriglyceridemia. (medscape.com)
Children and adolescents1
Occurs3
  • In addition, when diabetes occurs with lipodystrophy, it has many features of type 2. (ccjm.org)
  • Acromegaly is a disorder that occurs when your body makes too much growth hormone (GH). (nih.gov)
  • Octreotide is also used to treat a certain condition (acromegaly) that occurs when the body makes too much of a certain natural substance called growth hormone. (kaiserpermanente.org)
Endocrine1
  • Diabetes mellitus is among the most common and serious endocrine diseases of cats. (vin.com)
Octreotide3
  • MPOWERED (Maintenance of acromegaly Patients with Octreotide capsules compared with injections - Evaluation of REsponse Durability), was a global, randomized, non-inferiority, open-label, and active-controlled 15-month trial that was designed to support a potential marketing application of MYCAPSSA ® in the European Union. (biospace.com)
  • NEWTON, Mass., Jan. 08, 2016 (GLOBE NEWSWIRE) -- Chiasma, Inc. (NASDAQ:CHMA), a late-stage biopharmaceutical company developing Mycapssa™ (octreotide) capsules, an investigational oral drug for the maintenance therapy of adult patients with the orphan disease acromegaly, today reviewed its key accomplishments for 2015 and provided an update on its core objectives and expected milestones for 2016. (biospace.com)
  • Primary treatment with the somatostatin analogues depot octreotide and lanreotide has been found to induce tumor shrinkage in newly diagnosed acromegaly. (medscape.com)
Type 2 diabet2
  • Patients with type 2 diabetes mellitus (DM) are at increased risk for colorectal adenomas and cancer because of endogenous hyperinsulinemia. (aacrjournals.org)
  • This article summarizes information on type 1 and type 2 diabetes mellitus, their less common subtypes, approaches to diagnosis, and implications for selecting glucose-lowering therapy. (ccjm.org)
Insulin resistance5
  • In acromegaly, insulin resistance, hyperinsulinaemia, and increased gluconeogenesis produce a metabolic environment that leads to the development of diabetes. (mydiabetesday.com)
  • Acromegaly is a unique disease characterized by contemporaneous increases in GH, IGF-I, and insulin concentrations, in which the paradoxical rise in insulin resistance is linked with decreased total body fat and even decreased fat deposition in metabolic organs such as the liver (13, 14). (mydiabetesday.com)
  • Physicians, nurses and staff provide diabetes care for thousands of adult patients with type 1 or type 2 diabetes including those with prediabetes, metabolic syndrome, insulin resistance and polycystic ovary syndrome. (ynhh.org)
  • Insulin resistance is associated with the capillary permeability of thigh muscles in patients with type 2 diabetes. (medscape.com)
  • For instance, the increase of GH levels is responsible for insulin resistance in the liver and other peripheral tissues, leading to impaired glucose tolerance or overt diabetes mellitus. (medscape.com)
Systemic1
  • Over time it leads to a host of systemic problems including arthritis, diabetes, and heart disease. (damninteresting.com)
Life expectancy1
Hormones2
  • In reality, the body's natural growth hormone is part of a group of counter-regulatory hormones that are produced in reaction to low blood sugar, and many children treated with GH develop diabetes. (mydiabetesday.com)
  • Also keep in mind the pituitary tumor in acromegaly not only increases GH production, but also destroys pituitary hormones which stimulate thyroxin, DHEA, thymus hormones, which may well account for the increase in tumor growth as well. (bio.net)
Treatment10
  • The FDA placed a clinical hold on Vertex's investigational diabetes cell therapy VX-880 , saying the company didn't have enough evidence to support a treatment dose increase. (medpagetoday.com)
  • The call will feature presentations by Key Opinion Leader (KOL) Maria Fleseriu, MD, FACE, lead investigator of the MPOWERED study, who will discuss the topline data from Chiasma's Phase 3 MPOWERED study as well as the unmet medical need in acromegaly and the treatment burden that patients experience with monthly somatostatin analog injections. (biospace.com)
  • The Yale Diabetes Center is a regional resource for diabetes diagnosis, education and treatment. (ynhh.org)
  • In 1979, Yale Medicine physicians developed the world's first insulin pump, a milestone for diabetes treatment. (ynhh.org)
  • Obtain U.S. Approval and Successfully Launch Mycapssa ™ - Chiasma is focused on obtaining FDA approval of Mycapssa™ for the potential maintenance treatment of adults with acromegaly, with a PDUFA date of April 15, 2016. (biospace.com)
  • Further work is needed prior to the commercialization of such a product, which may be revolutionary in the treatment of feline diabetes. (vin.com)
  • Lanreotide, an octapeptide analogue of natural somatostatin, is indicated for long-term treatment of acromegaly in patients who experience inadequate response to other therapies. (medscape.com)
  • It is indicated for the treatment of patients with acromegaly who have had an inadequate response to surgery and/or for whom surgery is not an option. (medscape.com)
  • We consider surgical hypophysectomy to be the optimal treatment option for acromegaly. (rvc.ac.uk)
  • Alternative treatment options are limited, since medical treatment is currently cost prohibitive and medical management of the diabetes mellitus alone is often extremely challenging and unrewarding. (rvc.ac.uk)
Insipidus3
Patients with type 2 diabet3
  • Glucagon, which enhances sugar release, and insulin, which stimulates sugar absorption, are frequently out of balance in patients with type 2 diabetes. (mydiabetesday.com)
  • We conducted a cross-sectional study of patients with type 2 diabetes between the ages of 50 and 80 years who completed full colonoscopies. (aacrjournals.org)
  • Metabolites as Risk Factors for Diabetic Retinopathy in Patients with Type 2 Diabetes: a 12-year Follow-up Study. (medscape.com)
Surgery3
  • The prognosis for acromegaly depends on whether surgery can completely remove the tumor and whether medications can induce remission if surgery is not completely successful in removing all the tumor. (barrowneuro.org)
  • Effects of bariatric surgery on blood and vascular large extracellular vesicles according to type 2 diabetes status. (medscape.com)
  • Methods Our retrospective monocentric study was based on 130 patients followed on a regular basis, with acromegaly controlled by medical treatments or cured by surgery or radiation technique. (medscape.com)
Higher prevalence1
  • Interestingly, our data showed that diabetes was the only comorbidity different with a higher prevalence in patients in remission versus a general population of a similar median age (21.6% vs 6.9%, respectively). (medscape.com)
Colon1
20202
  • The classification of diabetes mellitus in 2020 still starts with 2 major types, ie, type 1 and type 2, but each of these now includes a few uncommon variants. (ccjm.org)
  • 2 In 2020, diabetes mellitus is still likely a syndrome with many genetic, epigenetic, and pathophysiologic abnormalities, different complication profiles, and multiple environmental influences such as infections, nutrients, exercise regimens, and the gut microbiome. (ccjm.org)
Prognosis1
Etiology1
  • The specific etiology of the vast majority of diabetes types remains unclear. (mydiabetesday.com)
Benign1
  • Common developments are frequent benign and malignant tumor formations and diabetes. (bio.net)
Arises2
  • The concerns over HGH enhancements cancer inducing potential arises out of 1), the aforementioned incidence in acromegaly, 2) the fact that certain cancers are IGF-1 sensitive, and 3) one study showing IGF-1 of greater than 275 ng/ml had significantly increased incidences of prostate cancer. (bio.net)
  • When such a tumor spills excessive growth hormone into the body, a condition called acromegaly arises. (damninteresting.com)
Hormone9