• NMDA
  • Neurotoxic changes, including vacuolation, have been observed in posterior cingulate and retrosplenial cortices of rats administered other NMDA receptor antagonists such as PCP, but not with dextromethorphan. (wikipedia.org)
  • Bupropion/dextromethorphan (developmental code name AXS-05) is a combination formulation of bupropion (Wellbutrin), a norepinephrine reuptake inhibitor (NRI) and nicotinic acetylcholine receptor (nAChR) antagonist, and dextromethorphan (DXM), a sigma-1 receptor agonist, NMDA receptor antagonist, and serotonin-norepinephrine reuptake inhibitor (SNRI), which is under development by Axsome Therapeutics for the treatment of treatment-resistant major depressive disorder (MDD) and agitation in Alzheimer's disease. (wikipedia.org)
  • Also like those drugs, dextromethorphan is an NMDA receptor antagonist. (wikipedia.org)
  • Dextrorphan, a metabolite of dextromethorphan (one of the most commonly used cough suppressants in the world), is known to be an NMDA receptor antagonist. (wikipedia.org)
  • phencyclidine
  • Dextromethorphan has not been shown to cause vacuolization in animals, also known as Olney's lesions, despite early speculation that it might, due to similarities with phencyclidine (PCP). (wikipedia.org)
  • symptoms
  • Since dextromethorphan also acts as a serotonin reuptake inhibitor (SRI) users describe that regular recreational use over a longer period of time can cause withdrawal symptoms that are similar to those of antidepressant discontinuation syndrome. (wikipedia.org)
  • Dextromethorphan generally does not produce withdrawal symptoms characteristic of physical dependence-inducing substances, but there have been cases of psychological dependence. (wikipedia.org)
  • citation needed
  • Owing to its recreational use and theft concerns,[citation needed] many retailers in the US have moved dextromethorphan-containing products behind the counter so that one must ask a pharmacist to receive them or be 18 years (19 in New York, Virginia, California, and Alabama, 21 in Mississippi) or older to purchase them. (wikipedia.org)
  • citation needed] Some retailers also give out printed recommendations about the potential for abuse with the purchase of products containing dextromethorphan. (wikipedia.org)
  • cause
  • Although there is no specific information comparing use of dextromethorphan in children with use in other age groups, dextromethorphan is not expected to cause different side effects or problems in children 4 years of age and older than it does in adults. (drugs.com)
  • treatment
  • Dextromethorphan has also found numerous other uses in medicine, ranging from pain relief (as either the primary analgesic, or an opioid potentiator) over psychological applications to the treatment of addiction. (wikipedia.org)