• Establishing sensitive biomarkers across the in vitro systems for studying the underlying mechanism of action of chemicals, such as azoles, is valuable for comparing alternative in vitro models and for improving insight in the mechanism of developmental toxicity of chemicals. (uu.nl)
  • These include chemicals classified as mutagens, teratogens, embryotoxins, or those with known developmental and reproductive toxicity. (harvard.edu)
  • Some animal research studies have revealed evidence of embryolethality, embryo/fetal toxicity, and postnatal developmental toxicity. (iytmed.com)
  • Incomplete ocular development during embryogenesis as a result of a variety of faulty processes of ocular growth, most often involving mutations in developmental genes acting as transcription factors for other downstream genes. (entokey.com)
  • We find that mutations and teratogens interact in predictable ways to cause birth defects by changing target cell sensitivity to Hedgehog (Hh) ligands. (stanford.edu)
  • AINTEROL® Cosmetics are all FREE of known or suspected (evidence based) carcinogens (cancer causing chemicals),mutagens (causing cell mutations - cancer), teratogens (causing birth defects), reproductive toxins (male & female infertility), developmental toxins (hazardous to an unborn child) and skin/sense organ toxicants. (ainterol.eu)
  • Today, the term DGS is generally reserved for those rare instances when the etiology is not caused by a 22q11.2 deletion, eg, in association with CHARGE syndrome (due to CHD7 mutations on chromosome 8) and teratogens, such as retinoic acid or diabetic embryopathy. (chop.edu)
  • Birth Defects Research Part B: Developmental and Reproductive Toxicology 83(1):40-7. (nih.gov)
  • Developmental toxicology evaluation of 1-pentanol, 1-hexanol, and 2-ethyl-1-hexanol administered by inhalation to rats. (cdc.gov)
  • A series of aliphatic alcohols was examined for possible developmental toxicology effects due to their widespread use as industrial solvent s. (cdc.gov)
  • His photography was the first to capture early human development and the developmental stages of embryos and fetuses. (asu.edu)
  • In utero exposure to a teratogen that directly inhibits SMO reduces the penetrance and expressivity of birth defects in Mosmo-/- embryos. (stanford.edu)
  • Additionally, tissues that develop normally in Mosmo-/- embryos are refractory to the teratogen. (stanford.edu)
  • Beginning with Aristotle, quickening divided the developmental stages of embryo and fetus. (asu.edu)
  • In fact, this toxin was added to the California Proposition 65 list of suspected teratogens, which are agents that cause malformations of an embryo. (addictivecosmetics.co)
  • The study examined whether prenatal teratogen exposure (i.e., parent-reported alcohol and/or tobacco use) was associated with negative effects on adolescents' performance on various executive function tasks from the NIH Toolbox-Cognition Battery and/or their average grades in school. (claremont.edu)
  • By deconstructing executive function, this study offers a novel approach to exploring the cognitive abilities measured in the ABCD Study and has provided new insights into the connection between working memory, executive function, academic performance, and prenatal teratogen exposure. (claremont.edu)
  • The certificate course in Developmental Psychology will assist students in adeptly discussing developmental theories, milestones, and historical influences, analyzing prenatal and infancy development, evaluating childhood and adolescent cognitive and social aspects, appraising adult cognitive and moral development, and examining aging's effects on physical and cognitive changes across the lifespan. (cognizavest.com)
  • Additionally, the study used a longitudinal approach to explore the role of timing in any associations between teratogen exposure and cognitive outcomes, analyzing data from two separate collection periods: baseline and 2-year follow-up. (claremont.edu)
  • Toluene is a toxin that may also cause birth defects and developmental problems in children of pregnant women who have had extended exposure. (addictivecosmetics.co)
  • 9 This perturbation can be a direct effect of a genetic mutation or can indirectly involve a genetic disturbance, such as in the case of gestational exposure to a teratogen. (aafp.org)
  • For children prenatally exposed to teratogenic substances (i.e., certain prescription medications, maternal infections or conditions, alcohol, tobacco, etc.), higher-order cognitive skills may be compromised, resulting in an increased risk of delayed developmental functioning, deficits in cognitive and executive functioning, and poorer academic outcomes. (claremont.edu)
  • Thus, changes in the abundance of the protein target of a teratogen can change birth defect outcomes by quantitative shifts in Hh signaling. (stanford.edu)
  • As risk factors accumulate, developmental outcomes are usually less positive. (safoceanindien.org)
  • In The SAGE Encyclopedia of Intellectual and Developmental Disorders , edited by Davlantis, Katherine S., and Geraldine Dawson, 487-89. (sagepub.com)
  • An important aspect of this study explored executive function from two theoretical perspectives (i.e., developmental versus cognitive psychology). (claremont.edu)
  • Gross motor developmental delays: Infrequently accompany the cognitive, language, and fine motor/adaptive delays associated with ID unless the underlying condition results in both ID and cerebral palsy. (medscape.com)
  • The goals of ESDM are to reduce the severity of ASD symptoms in very young children and to accelerate children's developmental rates in a multitude of domains, including cognitive, social-emotional, and language domains. (sagepub.com)
  • But can you take a serious teratogen like DES or thalidomide, which were given in therapeutic quantities to pregnant women, and claim any relevance to trace chemicals found in everyday life? (acsh.org)
  • Thalidomide, used for morning sickness more than 50 years ago was found to be a potent teratogen-- a chemical that can cause severe developmental problems. (acsh.org)
  • Some popular teratogens are thalidomide, alkylating agents, intoxicant, drugs, virus ( German measles ) and any uterine infections from the female parent. (graduateway.com)
  • developmental mechanisms of kin recognition. (qub.ac.uk)
  • Except for language and social skills, he has reached most important developmental milestones. (cdc.gov)
  • Developmental milestones were delayed, particularly speech. (chop.edu)
  • 14. Who is the father of developmental psychology? (achievingthedream.org)
  • 6. One of the three major concerns of developmental psychology involves a focus on. (hycoma.de)
  • Pollutants as developmental toxicants in aquatic organisms. (nih.gov)
  • Congenital facial paralysis is classified as traumatic or developmental, unilateral or bilateral, and complete or incomplete (paresis). (medscape.com)
  • The Developmental Biology and Congenital Anomalies Branch (DBCAB) supports basic research that contributes to our understanding of how the nervous system develops under both typical and atypical conditions. (nih.gov)
  • Known genes with syndrome associations include CHD7 (CHARGE syndrome), DPD (developmental delay), HESX1 (septo-optic dysplasia), SOX2 (multiple anomalies), BMP4 (multiple anomalies), STRA6 (multiple anomalies, Matthew Wood syndrome), HCCS (microphthalmia with linear skin defects syndrome), ANOP1 (Lenz microphthalmia), BCOR (oculofacialcardiodental). (entokey.com)
  • Medi-Cal eligible youth, ages 0-18, may receive developmental assessment services and behavior modification therapy through the CHDP program. (211la.org)
  • In the assessment of developmental delay and/or neurocognitive impairment, neuroimaging is warranted when a structural, degenerative, or metabolic process is suspected. (aafp.org)
  • The center provides services for people of all ages with developmental disabilities and their families who live in Riverside and San Bernardino Counties. (211la.org)
  • The Intellectual and Developmental Disabilities Branch (IDDB) supports research on topics related to the genomic, cellular, circuit, behavioral, and clinical aspects of intellectual and developmental disabilities (IDDs). (nih.gov)
  • Animal and human research has clearly shown that anticonvulsants are teratogens and pose a risk for fetal malformations. (nih.gov)
  • The clinician must work with a mother who has seizures prior to conception to achieve the best control of seizures with a single anticonvulsant at the lowest effective dose to minimize the teratogenic potential, but even if this is done there is still a risk of fetal malformations and developmental delays. (nih.gov)
  • In addition, the authors examine congenital heart disease, genetic variants and environmental risk factors (e.g., teratogens and nutritional deficiencies) that disrupt normal heart development and cause various malformations, and the use of cell and animal model systems to study disease pathogenesis and test therapeutic interventions. (cshlpress.com)
  • Growth problems such as low birth weight and developmental delays. (womensframe.com)
  • It is an inconvenient fact of life that alcohol is a « teratogen, » that is, a chemical that can cause physical or functional birth defects. (safoceanindien.org)
  • A professional review of published information of omeprazole use during pregnancy by the Teratogen Information System concluded that therapeutic doses during pregnancy will not likely posture a substantial teratogenic risk. (iytmed.com)
  • If you have a child who has a chronic illness or a developmental disorder you probably already know that environmental toxins can further compromise their fragile immune system and exacerbate already challenging behaviors. (autismfile.com)
  • This volume is therefore a valuable reference for all cell and developmental biologists, geneticists, and cardiologists who are interested in the early development and abnormalities of this complex, vital organ. (cshlpress.com)
  • The model uses knowledge of how typical infants, toddlers, and preschoolers develop, in addition to knowledge of how ASD affects early development, to facilitate an appropriate developmental trajectory in this at-risk population. (sagepub.com)
  • A teratogen is any substance that interferes with normal antenatal development, doing the formation of one or more developmental abnormalcies in the foetus? (graduateway.com)
  • Based on your understanding of the timing of developmental stages, what would be your best advice? (takemyclasshelp.com)
  • The medical literature contains many varied references that appear to indicate that human adverse reproductive/developmental effects are produced by caffeine. (nih.gov)
  • When effects of other developmental processes such as growth are analyzed, quantitation is readily achieved. (nih.gov)
  • Mutants should not be confused with organisms born with developmental abnormalities, which are caused by errors during morphogenesis. (wikipedia.org)
  • The Early Start Denver Model (ESDM), developed by Sally Rogers and Geraldine Dawson, is a developmental behavioral early intervention approach designed for children ages 1 to 5 years who are diagnosed with, or at risk for, autism spectrum disorder (ASD). (sagepub.com)
  • The cause of congenital facial paralysis is associated with either a traumatic injury or developmental deformities of the brain or facial nerve (cranial nerve VII). (medscape.com)
  • Evidence suggests that premature babies exposed to cocaine before birth may be at hazard for ulterior developmental troubles. (graduateway.com)
  • Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength. (stanford.edu)
  • 2001). Some reproductive or developmental changes are observed at high doses in standard experimental animal studies (e.g., delayed vaginal opening and preputial separation) (Ema et al. (cdc.gov)
  • Conversely, no procedures are available that can enable an infant to develop normal function of the facial nerve when the palsy is developmental in origin. (medscape.com)