Developmental bone morphogenetic protein 2. Medical search. Frequent questions

As an adjuvant to allograft bone or as a replacement for harvested autograft, bone morphogenetic proteins (BMPs) appear to improve fusion rates after spinal arthrodesis in both animal models and humans, while reducing the donor-site morbidity previously associated with such procedures. (wikipedia.org)
[ 5 ] BMPs are members of the transforming growth factor-beta superfamily and play a role in the development of bone and other tissues. (medscape.com)
and bone morphogenetic proteins, BMPs) that stimulate tumor growth and bone destruction [ 1 ]. (biomedcentral.com)
Three non-collagenous proteins, osteonectin, transforming growth factor β-1 (TGF-β1) and bone morphogenetic proteins (BMPs), have drawn much attention in the literature lately. (bvsalud.org)
Bone morphogenetic proteins (BMPs) form a unique group of proteins within the transforming growth factor beta (TGF-β) superfamily. (bvsalud.org)
BMPs were first identified by Urist (1984) 6 and there is extensive evidence in support of their role as regulators of bone formation, especially BMP2 and BMP4, which exert potent prodifferentiation effects on early osteoblasts formation. (bvsalud.org)

The use of dual tapered threaded fusion cages and recombinant human bone morphogenetic protein-2 on an absorbable collagen sponge obtained and maintained intervertebral spinal fusion, improved clinical outcomes, and reduced pain after anterior lumbar interbody arthrodesis in patients with degenerative lumbar disc disease. (wikipedia.org)
An odontogenic medium modified by the addition of recombinant human bone morphogenetic protein 2 was used in the experimental groups to induce differentiation. (scielo.br)

Findings suggest that fibrodysplasia ossificans progressiva maps to band 4q27-31, a region that contains at least 1 gene involved in the bone morphogenic protein (BMP) signaling pathway. (medscape.com)

The vast majority (~80%) of DMRs were hypermethylated between P1 and P14, and these hypermethylated regions were associated with transcriptional shut down of important developmental signaling pathways, including Hedgehog, bone morphogenetic protein, TGF-β, fibroblast growth factor, and Wnt/β-catenin signaling. (nih.gov)

Engineering living bone tissue of defined shape on-demand has remained a challenge. (bvsalud.org)
In the body, vascularization is important for the efficient delivery of oxygen and nutrients to support tissue healing and bone formation. (naturalnews.com)
Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. (mdpi.com)
This review critically focuses on opportunities to employ protein-graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. (mdpi.com)
Hard tissue formation in a porous HA/TCP ceramic scaffold loaded with stromal cells derived from dental pulp and bone marrow. (scielo.br)
Tissue Eng Part A. 2008;14(2):285-94. (scielo.br)
These cells could be induced to differentiate Flurazepam dihydrochloride toward trophectoderm also to germ cell precursors in response to bone tissue morphogenetic proteins 4 (BMP-4). (techuniq.com)
Background: Benign fibro-osseous lesions (BFOL) comprise a diverse group of pathologies characterized by the replacement of normal bone by fibrous tissue and a mineralized product. (bvsalud.org)
A complex extracellular matrix with collagenous and non-collagenous proteins composes mineralized tissue. (bvsalud.org)
Surface modifications and the use of various coatings, as well as the development of the controlled release of antibiotics or proteins, have improved the osseointegration and soft-tissue integration of dental implants, as well as their antibacterial and immunomodulatory functions. (encyclopedia.pub)
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
Since the introduction of the mouse small intestinal organoid model in 2009, 1 there has been an avalanche of developments in this field, including development of culture conditions for human organoids derived from primary colonic tissue, 2 as well as from human pluripotent stem cells (hPSCs). (stemcell.com)

Join us and publish in a specialized journal in Developmental Biology, university-based, with a long and prestigious history. (ehu.eus)
Lochab, A.K. and Extavour, C.G. Developmental Biology , 427(2): 258-269 (2017). (extavourlab.com)
Schmitt JM, Hwang K, Winn SR, Hollinger JO: Bone morphogenetic proteins: an update on basic biology and clinical relevance. (medigraphic.com)
Current Topics in Developmental Biology. (wustl.edu)

Mutations in bone morphogenetic protein receptor 2 ( BMPR2 ) are the cause of most heritable cases but the vast majority of other cases are genetically undefined. (biomedcentral.com)
For example, bone morphogenetic protein receptor type 2 ( BMPR2 ) mutations are observed in 60-80% of familial (FPAH) cases, but data from population registries indicate that penetrance of the disease phenotype ranges from 14 to 42% [ 6 ]. (biomedcentral.com)
A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)
We sought genotype-phenotype correlations and undertook a comparative analysis with patients with PAH with BMPR2 (Bone Morphogenetic Protein Receptor type 2) causal variants (n = 162) or no identified variants in PAH-associated genes (n = 741) genotyped via the National Institute for Health Research BioResource-Rare Diseases. (stanford.edu)
Selective modulation of the androgen receptor activation function-2 domain rescues degeneration in spinal bulbar muscular atrophy. (umn.edu)

Both the genes were derived from horses, resulting in the biosynthesis of natural horse proteins in the treated animals. (frontiersin.org)
Examination of late gestation developmental genes in vivo may be limited by early embryonic lethality and compensatory mechanisms. (biomedcentral.com)
Genetic investigation of ocular developmental genes in 52 patients with anophthalmia/microphthalmia. (cdc.gov)
The candidate genes exhibit expression patterns in lung and heart similar to that of known PAH risk genes, and most variants occur in conserved protein domains. (biomedcentral.com)
A total of 1,800 genes were responsive to BMP-2 and expression was modulated from 3- to 14-fold for less than 100 genes during the time course. (umassmed.edu)
BMP-2 immediately responsive genes (1-4 h), which exhibited either transient or sustained expression, reflect activation and repression of non-osseous BMP-2 developmental systems. (umassmed.edu)
A sequential profile of genes mediating changes in cell morphology, cell growth, and basement membrane formation is observed as a secondary transient early response (2-8 h). (umassmed.edu)
Commitment to the osteogenic phenotype is recognized by 8 h, reflected by downregulation of most myogenic-related genes and induction of a spectrum of signaling proteins and enzymes facilitating synthesis and assembly of an extracellular skeletal environment. (umassmed.edu)
With extracellular matrix development, the bone phenotype was further established from 16 to 24 h by induction of genes for cell adhesion and communication and enzymes that organize the bone ECM. (umassmed.edu)
suggesting novel roles for these genes in the bone microenvironment. (umassmed.edu)
The higher expression of gremlin 1 and HIF1a genes after exposure to dragonfly larvae indicated an in vivo hypoxic reaction, while down-regulation of syndecan-2 may indicate impairment of angiogenesis. (biomedcentral.com)
the tadpoles showed reduced expression of cα(E)-catenin , small muscle protein, dystrophin , and myosin light chain genes. (biomedcentral.com)

Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. (wikipedia.org)
The bone morphogenetic protein, BMP-2, a member of the TGFbeta superfamily, induces osteoblast differentiation and functions through the Smad signal transduction pathway during in vivo bone formation. (umassmed.edu)
Two related members of the TGFB superfamily are involved in the function and development of the ovary: Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) (7). (balkanmedicaljournal.org)

The goal of this study was to determine whether DNA methylation plays an important role in guiding transcriptional changes during the first 2 wk of mouse heart development, which is an important period for cardiomyocyte maturation, loss of proliferative capacity and loss of regenerative potential. (nih.gov)
The Drosophila split ends ( spen ) gene encodes a large nuclear protein containing three RNP-type RNA binding motifs, and a conserved transcriptional co-repressor-interacting domain at the C-terminus. (biomedcentral.com)
Genetic variation in the MITF promoter affects skin colour and transcriptional activity in black-boned chickens. (cdc.gov)

Bone morphogenetic protein 2 has been shown to interact with BMPR1A. (wikipedia.org)
Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. (crick.ac.uk)

The goal of this study was to examine whether mice carrying a mutation in a gene encoding the bone morphogenetic protein (BMP) antagonist twisted gastrulation (Twsg1 ), which is associated with a low penetrance of HPE, are sensitized to retinoic acid (RA) teratogenesis. (umn.edu)

The p.Asn173His mutation affects a residue in the forkhead domain that is 100% conserved among vertebrate orthologs and is predicted to participate in protein-protein interactions. (molvis.org)

The ground-breaking, international study, published in the academic journal Frontiers in Veterinary Science , demonstrated gene therapy using a combination of the Vascular Endothelial Growth Factor gene VEGF164, to enhance the growth of blood vessels and bone morphogenetic protein 2 (BMP2), which plays an important role in the development of bone and cartilage. (frontiersin.org)
Since the researchers already knew that vasculogenesis plays a pivotal role in bone formation, they used a bone morphogenetic protein 2 (BMP2)-induced ectopic bone formation model and mice 4T1 breast cancer cells co-implanted with luciferase-labeled C3H/10T1/2 cells (4T1 + C3H/10T1/2-Luc) model for their study. (naturalnews.com)
BMP2 also induces the formation of cartilage and bones. (naturalnews.com)
The researchers found that epimedin C treatment significantly increased the bone weight and blood perfusion of mice in the BMP2-induced ectopic osteogenesis model. (naturalnews.com)
Supplementation with epimedin C also produced a more mature bone than the addition of BMP2 alone. (naturalnews.com)
Based on these results, the researchers concluded that epimedin C effectively promotes vascularization both in the BMP2-dependent bone formation model and in the 4T1 mammary tumor-bearing model by inducing the endothelial-like differentiation of C3H/10T1/2 in vivo. (naturalnews.com)
We have analyzed the immunohistochemical expression of three molecules involved in bone metabolism, namely osteonectin, TGF-1, and BMP2/4. (bvsalud.org)

In the second half of her undergraduate program, Amaneet continued to explore her research interests in Helene Wagner 's landscape genetics group and in Tim Westwood 's research group, where she completed my undergraduate thesis project studying the role of the transcription factor Heat Shock Factor (HSF) during Drosophila embryogenesis using chromatin immunoprecipitation (ChIP), and becoming fascinated with how early developmental processes are controlled. (extavourlab.com)
The Drosophila lymph gland as a developmental model of hematopoiesis. (stemcells-live.fr)
Size control of the Drosophila hematopoietic niche by bone morphogenetic protein signaling reveals parallels with mammals. (stemcells-live.fr)

The in vivo and in vitro effects of bone morphogenetic protein-2 on the development of the chick mandible. (ehu.eus)
In vivo models that mimic the breast cancer-specific osteolytic bone microenvironment are limited. (biomedcentral.com)
Whether the maturation happens in vivo or in vitro, the environment to which the oocyte and its surrounding cells are exposed, affects the developmental competence of the oocyte and subsequent embryonic development [ 5 ]. (juniperpublishers.com)

Like many other proteins from the BMP family, BMP-2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types. (wikipedia.org)
In their previous study, the researchers found that epimedin C could induce endothelial-like (but not osteogenic) differentiation of C3H/10T1/2 cells in vitro. (naturalnews.com)

C3H/10T1/2 is a clonal mouse embryo line used in the developmental determination of vertebrate stem cell lineages and their subsequent differentiation. (naturalnews.com)
Bone morphogenetic proteins (BMP), known as active components of odontogenic differentiation and tooth development, have been used as a growth factor in an appropriate medium. (scielo.br)
Understanding physiological control of osteoblast differentiation necessitates characterization of the regulatory signals that initiate the events directing a cell to lineage commitment and establishing competency for bone formation. (umassmed.edu)
In the present study, BMP-2 responsive factors involved in the early stages of commitment and differentiation to the osteoblast phenotype were analyzed by microarray gene expression profiling in samples ranging from 1 to 24 h following BMP-2 dependent differentiation of C2C12 premyoblasts into the osteogenic lineage. (umassmed.edu)
This global analysis identified a multistage molecular and cellular cascade that supports BMP-2-mediated osteoblast differentiation. (umassmed.edu)
2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
An error during these developmental steps in females may lead to defective gonads, affecting the differentiation and/or function of the gonads and the development, differentiation, and maturity of the germ cells. (lidsen.com)
To investigate the efficiency of growth differentiation factor 9 and bone morphogenetic protein 15 during folliculogenesis in a dehydroepiandrosterone-induced mouse Polycystic ovary syndrome model. (balkanmedicaljournal.org)
Ovarian tissues were examined for growth differentiation factor 9 and bone morphogenetic protein 15 using immunofluorescent labelling and electron microscopic examinations. (balkanmedicaljournal.org)
These results suggest that the decrease in the growth differentiation factor 9 and bone morphogenetic protein 15 expression initiated at the primary follicle stage effect the follicle development and zona pellucida structure and may cause subfertility or infertility in Polycystic ovary syndrome. (balkanmedicaljournal.org)
Aim 2: Examine the effect of PAHs during in vitro differentiation of hESCs to primordial germ cells. (yes4yes.com)

Sequential synthesis of cartilage and bone marker proteins during transdifferentiation of mouse Meckel's cartilage chondrocytes in vitro. (ehu.eus)
Vertebrate bone morphogenic protein 1 (BMP-1), a protein which induces cartilage and bone formation and expresses metalloendopeptidase activity. (embl.de)

Evaluating the association of bone morphogenetic protein 4-V152A and SIX homeobox 6-H141N polymorphisms with congenital cataract and microphthalmia in Western Indian population. (cdc.gov)
This initial response was followed by waves of expression of nuclear proteins and developmental regulatory factors including inhibitors of DNA binding, Runx2, C/EBP, Zn finger binding proteins, forkhead, and numerous homeobox proteins (e.g. (umassmed.edu)

Morone MA, Boden SD, Hair G: Gene expression during autograft lumbar spine fusion and the effect of bone morphogenetic protein 2. (medigraphic.com)

Dr Catrin Rutland , Assistant Professor of Anatomy and Developmental Genetics, led the work at Nottingham. (frontiersin.org)
Ophthalmic genetics 2018 2 39 (3): 314-320. (cdc.gov)

While cooperating mutations can cause transformation, it is unclear whether distinct bone marrow (BM) HSC-niches can influence the growth and therapy response of HSCs carrying the same oncogenic driver. (bvsalud.org)
Identification of PITX3 mutations in individuals with various ocular developmental defects. (cdc.gov)
[ 2 , 3 , 4 ] A full list of the described mutations is available at the TBX5 Gene Mutation Database , an online locus-specific database that contains germline and somatic mutations of the TBX5 gene. (medscape.com)
Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)
The pleiotropic effects of TBX4 in lung disease may be in part explained by the differential effect of pathogenic mutations located in critical protein domains. (stanford.edu)

Here we show that these opposing regulators of myelination are functionally linked by the Olig1/2 common target Smad-interacting protein-1 (Sip1). (elsevierpure.com)
ClueGO, a Cytoscape plug-in, is also used to compare groups of proteins and to visualize the functionally organized Gene Ontology (GO) terms and pathways in the form of dynamical network structures. (biomedcentral.com)
Sequence analysis has revealed the presence of 31 copies of an extracellular domain, here called CUB, in 16 functionally diverse proteins such as the dorso-ventral patterning protein tolloid, bone morphogenetic protein 1, a family of spermadhesins, complement subcomponents Cls/Clr and the neuronal recognition molecule A5. (embl.de)

Using functional annotation, we found that proteins belonging to pathways associated with regulation of the actin cytoskeleton, EGF/EGFR, TGF-β, MAPK signaling, integrin-mediated cell adhesion, and lipid metabolism were significantly enriched in the OA samples (p ≤10 −5 ). (biomedcentral.com)
We identified several pathways and proteins to be associated with OA chondrocytes. (biomedcentral.com)

Postnatal inhibition of DNA methylation with 5-aza-2'-deoxycytidine induced a marked increase (~3-fold) in cardiomyocyte proliferation and ~50% reduction in the percentage of binucleated cardiomyocytes compared with saline-treated controls. (nih.gov)
Vertebrate neurogenesis requires inhibition of endogenous bone morphogenetic protein (BMP) signals in the ectoderm. (molcells.org)

This system promises to provide an excellent opportunity to study environmental and genetic factors in human germ cell development, especially the early developmental stage from embryonic stem cells to primordial germ cells. (yes4yes.com)

Visit our exhibition on genome editing until 2 December 2023. (crick.ac.uk)
2023 Feb;25(2):203-206. (caltech.edu)

Here, in the context of bone regeneration, we aimed at enhancing the osteoinductivity of such ECMs by enriching their immunomodulatory factors repertoire. (bvsalud.org)
They found that this bioactive plant component is a good promoter of vascularization and may have potential applications in bone regeneration. (naturalnews.com)
Nakashima M. Bone morphogenetic proteins in dentin regeneration for potential use in endodontic therapy. (scielo.br)

Asian-Australasian journal of animal sciences 2017 8 31 (2): 180-188. (cdc.gov)

An additional review by Agrawal and Sinha of BMP-2 and its common delivery systems in early 2016 showed how "problems like ectopic growth, lesser protein delivery, [and] inactivation of the protein" reveal a further need "to modify the available carrier systems as well as explore other biomaterials with desired properties. (wikipedia.org)

BMP-2 may be involved in white adipogenesis and may have metabolic effects. (wikipedia.org)
Obesity and its metabolic complications (e.g. type 2 diabetes, cardiometabolic disorders) contributing to the metabolic syndrome represent one of the most important public health problems, with societal and economic implications urging for new therapeutic strategies and effective social policies. (springer.com)

Within the osteolytic lesions of bone metastases, tumor cells interact with osteoclasts (bone resorbing cells) and osteoblasts (bone forming cells), thereby inhibiting normal bone development and ultimately leading to bone destruction [ 1 - 4 ]. (biomedcentral.com)
Osteonectin has been demonstrated immunocytochemically in active, bone-matrix-producing cells (osteoblasts and young osteocytes) 5 . (bvsalud.org)

PLoS Biol 2 , E196. (stemcells-live.fr)

Differential effects of transforming growth factors beta 1, beta 2, beta 3 and beta 5 on chondrogenesis in mouse limb bud mesenchymal cells. (ehu.eus)
C3H/10T1/2 cells can be induced to differentiate into multiple stem cell lineages. (naturalnews.com)
Odontogenic capability: bone marrow stromal stem cells versus dental pulp stem cells. (scielo.br)
These metastases are predominantly osteolytic and develop when tumor cells interact with bone. (biomedcentral.com)
Furthermore, these treatment methods have limited efficacy due in part to the fact that they do not effectively target the interaction between tumor cells and bone [ 5 ]. (biomedcentral.com)
The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model. (sciendo.com)
Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
A key step for this is to understands the interactions between somatic granulosa cells and the oocyte that are required for maturation and developmental competence. (juniperpublishers.com)
Oocytes within the ovarian follicle are surrounded by mural and cumulus granulosa cells, which perform both endocrine and developmental functions, respectively. (juniperpublishers.com)

However, the current view holds that osteoarthritis involves not only the articular cartilage but the entire joint organ, including the subchondral bone and synovium. (medscape.com)

This study provides evidence for further testing on the molecular mechanism of the disease and also propose proteins as candidate markers of OA chondrocyte phenotype. (biomedcentral.com)

Rho GTPases and their downstream effector proteins regulate a diverse array of cellular processes during embryonic development, including reorganization of cytoskeletal architecture, cell adhesion, and transcr. (biomedcentral.com)

Priming with IL1ß a cell line overexpressing BMP-2 enabled engineering of ECMs preserving osteoinductive signals and containing larger amounts of angiogenic (VEGF) and pro-inflammatory molecules (IL6, IL8 and MCP1). (bvsalud.org)
The intestinal niche has been well-characterized, and shown to consist of spatial gradients of high WNT and Epithelial Growth Factor (EGF), while Bone Morphogenetic Protein (BMP) signals are inhibited. (stemcell.com)

BMP-2 like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. (wikipedia.org)
Bone Morphogenetic Protein (BMP) signaling in animal reproductive system development and function. (extavourlab.com)
Mechanisms of Development, 108 (1-2). (edu.au)
Particular syndromes of hamartomatous polyposis are often characterized by the manifestation of similar symptoms, especially at the initial stage of the development of the disease the clinical pictures in many cases do not make it possible to differentiate them (2). (czytelniamedyczna.pl)
Review - TGF-β Family Signaling in Early Vertebrate Development [2] "TGF-β family ligands function in inducing and patterning many tissues of the early vertebrate embryonic body plan. (edu.au)
This study confirmed the developmental origin of OA, and clarified the congenital and the living environment impact on the occurrence and development of OA. (edu.au)
Ovarian hyperandrogenism, paracrine dysregulation of the follicle, menstrual dysfunction and insulin resistance development in ovaries are typical characteristics of PCOS (2,3). (balkanmedicaljournal.org)
Xenopus laevis embryonic protein UVS.2, which is expressed during dorsoanterior development. (embl.de)

Bone morphogenetic protein 2 is shown to stimulate the production of bone. (wikipedia.org)

A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw [4] "Multiple mammalian lineages independently evolved a definitive mammalian middle ear (DMME) through breakdown of Meckel's cartilage (MC). (edu.au)
Mammalian hyaluronate-binding protein TSG-6 (or PS4), a serum and growth factor induced protein. (embl.de)

While hypertrophy of chondrocytes is a physiological process implicated in the longitudinal growth of long bones, hypertrophy-like alterations in chondrocytes play a major role in OA. (biomedcentral.com)
These markers include a variety of proteins usually including growth factors, and hormones among others. (bvsalud.org)
Anti-Müllerian hormone ( AMH ) is also a member of the Transforming Growth Factor-β family of secreted signaling proteins. (edu.au)

In this study, we identified and used a TB microenvironment-specific gene expression signature from this model to extend our understanding of the metastatic bone microenvironment in human disease and to predict potential therapeutic targets. (biomedcentral.com)
By comparing the TB signature with gene expression profiles from human breast metastases and an in vitro osteoclast model, we demonstrate that our model mimics both the human breast cancer bone microenvironment and osteoclastogenesis. (biomedcentral.com)
Our mouse breast cancer model morphologically and genetically resembles the osteoclastic bone microenvironment observed in human disease. (biomedcentral.com)

Int Endod J 1996 Mar;29(2):118-124. (thejcdp.com)

Maintaining and restore the full developmental competence of either mature or immature oocytes after cryopreservation processes to preserve women fertility is a goal in assisted reproductive technologies (ART). (juniperpublishers.com)
Most of them are known to be involved in developmental processes. (embl.de)

We screened 310 probands with developmental ocular conditions for variations in FOXD3 . (molvis.org)

The sympathetic nervous system regulates this function through β-adrenergic stimulation of brown mature adipocytes' dissipation of energy in the form of heat mediated by mitochondrial uncoupling protein-1 (UCP-1) activation. (springer.com)

Even though the bisphosphonate class of drugs (which target the tumor-bone interface) have been shown to improve the quality of life and disease-free survival in some patients, more therapeutic targets and agents are desirable [ 6 ]. (biomedcentral.com)

While a number of strategies exist to treat breast cancer bone metastases (e.g., surgery, radiation and/or chemotherapy), none are curative. (biomedcentral.com)
Bone scans also can help to differentiate osteoarthritis from osteomyelitis and bone metastases. (medscape.com)

Since histological findings alone may be similar for lesions with diverse behavioral characteristics and prognosis, in the absence of good clinical and radiological information, the pathologist can only state that a given biopsy is consistent with a BFOL 1,2,3,4 . (bvsalud.org)
In the 1960s, the first preclinical and clinical studies revealed that implants made of commercially pure titanium (Ti) could achieve anchorage in bone, which shifted the paradigm in implant dentistry [ 1 ] . (encyclopedia.pub)
clinical nutrition as a specialty goes here HN - 2008 BX - Nutrition FX - Diet FX - Food DH - Child Nutrition DI - 052504 MN - SP6.021.062 MS - Nutrition of children aged 2-10 years. (bvsalud.org)

Developmental Cell. (wikipedia.org)
3D bioprinting (3DBP), a biofabrication process capable of yielding cell constructs of defined shape, when combined with developmental engineering can provide a possible path forward. (bvsalud.org)
Previously, we developed a mouse model of tumor-bone interaction in which three mouse breast cancer cell lines were implanted onto the calvaria. (biomedcentral.com)
Bone morphogenetic protein ( BMP ) signaling patterns tissues along the dorsal-ventral axis and simultaneously directs the cell movements of convergence and extension. (edu.au)

Anatomy57

Organisms11

Diseases17

Chemicals and Drugs101

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes49

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

BMPs6

Recombinant human bone2

Signaling pathway1

Fibroblast growth1

Tissue13

Biology4

Receptor5

Genes12

Superfamily3

Transcriptional3

BMPR1A2

Gastrulation1

Vertebrate Orthologs1

BMP27

Drosophila3

Vivo3

Induce2

Differentiation11

Cartilage and bone2

Homeobox2

Autograft1

Genetics2

Mutations5

Functionally3

Pathways2

Inhibition2

Early developmental1

20232

Regeneration3

20171

Ectopic1

Metabolic2

Osteoblasts2

Biol1

Cells9

Subchondral bone1

Phenotype1

Downstream1

Signals2

Development8

Stimulate1

Mammalian2

Growth3

Microenvironment3

19961

Processes2

Ocular1

Mitochondrial1

Targets1

Metastases2

Clinical3

Cell4