Development normal mice mice knockout. Medical search. Frequent questions

To address this question, we created Treg-specific Cd28 conditional knockout mice. (jci.org)
To explore VHL as a regulator defining nephron progenitor self-renewal versus differentiation, we bred Six2-TGC tg mice with VHL lox/lox mice to generate mice with a conditional deletion of VHL from Six2 + nephron progenitors. (lww.com)
The authors used a conditional TET2 knockout model to demonstrate that loss of TET2 in either the HSC or early B-cell stage led to enrichment of GC B cells. (aacrjournals.org)
To understand the broader biological role of Hat1, we have generated a conditional mouse knockout model of this enzyme. (nih.gov)
We show that the conditional depletion of the m 6 A reader protein Ythdf2 in mice causes lethality at late embryonic developmental stages, with embryos characterized by compromised neural development. (biomedcentral.com)
Conditional Nrf1 knockout from embryonic germ cells leads to impaired PGC proliferation and survival. (bvsalud.org)

In this study, we investigated the effects of N-butyldeoxygalacto-nojirimycin (N B-DGJ), an imino sugar that inhibits ganglioside biosynthesis, in normal C57BL/6J mice and in beta-gal knockout (beta-gal-/-) mice from postnatal day 9 (p-9) to p-15. (wikigenes.org)
This phenomenon has been modeled in C57BL/6 mice depleted of CD4 T cells prior to infection with DelNSs RVFV (RVFV containing a deletion of NSs), resulting in late-onset encephalitis accompanied by high levels of viral RNA in the brain in 30% of animals. (cdc.gov)
The viral epitopes targeted by CD4 and CD8 T cells were defined in C57BL/6 mice, and tetramers for both CD4 and CD8 T cells were generated. (cdc.gov)

We used histologic, immunofluorescence, RNA sequencing, and metabolic assays to characterize kidneys from these mice and controls during development and up to postnatal day 21. (lww.com)
Compared with controls, VHL knockout kidneys are smaller and developmentally delayed by postnatal day 1, and have about half the number of glomeruli at postnatal day 21. (lww.com)

A paper published electronically this week by Nature Genetics offers important new insights into the development and differentiation of rod and cone photoreceptors, the light-sensitive cells in the eye's retina that initiate vision and are essential for clear sight. (sciencedaily.com)
As development progresses, nephron progenitors switch from glycolysis to mitochondrial respiration for energy-mediated by an unknown mechanism-and undergo differentiation. (lww.com)
In addition to identifying VHL as a critical regulator of nephron progenitors' metabolic switching, the authors' findings demonstrate that this switch also plays a large role in the differentiation process, and suggest that VHL is required for normal kidney development. (lww.com)
Our findings identify a novel role for VHL in mediating nephron progenitor differentiation through metabolic regulation, and suggest that VHL is required for normal kidney development. (lww.com)
Loss of TET2 has been shown to lead to aberrant gene expression that can disrupt normal differentiation processes. (aacrjournals.org)
However, murine models, including knockout and transgenic mice, have been useful in understanding the mechanisms of B lymphopoiesis, B-cell differentiation, and antibody formation. (medscape.com)

Knockout of the orthologous mouse gene indicates that the protein is necessary for normal cartilage development and aggrecan metabolism. (nih.gov)
This study demonstrates that NRF1, a known regulator for mitochondrial metabolism, plays critical roles in post-migrating PGC development. (bvsalud.org)

We conclude that the neurodegenerative deficits in HMSN/ACC are primarily caused by an axonopathy superimposed upon abnormal development, affecting peripheral but also central nervous system axons, all ultimately because of a genetic defect in the axonal cotransporter KCC3. (nature.com)
An enlarged HSC pool increases the potential for successive genetic events that drive development of diverse hematopoietic malignancies. (aacrjournals.org)
She produced fusions of embryos homozygous for t 12 with control mice from the same genetic line. (asu.edu)
3, 5- 8 Animal models of inflammatory bowel disease (IBD), using knockout or transgenic mice, only acquire characteristic lesions when their colon is populated with normal commensal bacteria, 9- 15 while germ free mice with genetic susceptibility do not develop disease. (bmj.com)
As a result, researchers have been able to develop thousands of mouse strains with mutations that mirror those seen in human genetic disease . (yourgenome.org)
Now, there are over 100 different inbred strains of mice, each with a different genetic background. (yourgenome.org)
Transgenic mice are mice that contain additional, artificially introduced genetic material in every cell. (yourgenome.org)
the other consisted of so-called IL-6 knockout mice (mice whose genetic makeup prevents them from synthesizing IL-6). (foundmyfitness.com)

Our research includes the use of knockout mice and zebrafish as laboratory models. (ncl.ac.uk)
The generation of mutant and transgenic animal models, involving such species as the mouse, Drosophila, zebrafish and Caenorhabditis elegans (C. elegans), provides powerful tools for elucidation of these functions. (nih.gov)
By illustration, a large number of zebrafish and mouse mutants with vestibular system involvement have been developed. (nih.gov)

We report here that the Fgf2 null mutant mice show an ∼40% decrease in cortical glutamatergic pyramidal neurons. (jneurosci.org)
Because Fgf2 −/− mice lacked 45% of cortical neurons at birth, the progenitor loss is compensated only in part during neurogenesis. (jneurosci.org)
The decreased progenitor cell pool indicates that Fgf2 is required for the development of a subset of cortical progenitors within the dorsal PVE, which in turn may differentiate into cortical projection neurons. (jneurosci.org)
Because the dorsal PVE was depleted of progenitors but the ganglionic eminences were not affected in Fgf2 −/− mice, we predicted that these mice should lack a population of pyramidal neurons, but their cortical GABA interneurons should have remained unchanged. (jneurosci.org)
Increase in c-Fos, phosphorylated extracellular signal-regulated kinase, and hyperexcitability of PVA neurons were detected in hyperalgesic mice. (iasp-pain.org)
We further confirmed and extended this result to demonstrate that the entire degeneration process is delayed in neurons from the Kif2a knockout mice. (nih.gov)
To better understand these imbalances, He and his team will study three lineages of mice in which ASH1L has been deleted in particular neuron types: cortical excitatory neurons, cortical inhibitory neurons, and astrocytes. (msu.edu)
In paper №2, I describe how mesDA neurons transplanted in the adult SN of a PD mouse model, extended axons across millimetres into the striatum, functionally reforming the nigrostriatal pathway. (lu.se)

Beatrice Mintz conducted a previous study that examined a reproductive disorder characterized by two distinct populations of germ cells in heterozygous mice. (asu.edu)
One population was a group of normal, functioning germ cells, the other group did not divide and they did not migrate to the correct parts of the embryo. (asu.edu)

Within the Adams Group, I am currently working with Dr Chi Wong to identify the consequences of combinatorial gene knockouts on normal and malignant haematopoiesis in in vivo mouse models. (sanger.ac.uk)
Here, making use of a newly generated Pdgfd knockout mouse, we reveal a functionally important malignant cell heterogeneity modulated by PDGF-DD signaling in pancreatic neuroendocrine tumors (PanNET). (lu.se)

Clarence Little observed that many mouse tumours acted in the same way as human ones. (yourgenome.org)
During his work, Clarence also carried out investigations into cancer and observed that many mouse tumours acted in the same way as human ones. (yourgenome.org)

In addition, the soma of the pyramidal cells in the frontal and parietal cortices are smaller in Fgf2 knock-out mice. (jneurosci.org)
Removing alpha-synuclein in mice (the knock-out mice) also resulted in increased DSBs, following bleomycin treatment. (parkinson.org)
Giving healthy human alpha-synuclein to the alpha-synuclein knock-out mice, restored the mice cells' DNA damage response to normal levels. (parkinson.org)
Using HSL knock out mice, we were able to demonstrate that the lipase controls insulin secretion. (lu.se)
Knock-out mice lacking various aspects of pathways important in Th1 and Tfh development and function were used to demonstrate that T-bet, CD40, CD40L, and MHCII mediated protection from RVFV encephalitis, while IFN- and IL-12 were dispensable. (cdc.gov)

To understand the role of TLR2 during the development of murine experimental deep dermatophytosis, we employed TLR2 knockout mice. (frontiersin.org)
Murine gene mutations in human counterparts may be associated with a clinical illness different from the illness seen in mice. (medscape.com)

Although the role of abnormal prion protein (PrP) conformation in generating infectious brain diseases (transmissible spongiform encephalopathy) has been recognized, the function of PrP in the normal brain remains mostly unknown. (amrita.edu)
A team led by Anand Swaroop, Ph.D., professor of ophthalmology and vision research scientist at the University of Michigan Health System's Kellogg Eye Center, has demonstrated that the retinal protein Nrl is required for rod development and, in fact, acts as a "molecular switch," signaling the cells to develop into rods rather than cones. (sciencedaily.com)
To study the potential role in this metabolic shift of von Hippel-Lindau (VHL), a protein component of a ubiquitin ligase complex, the authors generated nephron progenitor cell-specific VHL knockout mice. (lww.com)
PURA encodes Pur-α, a highly conserved multifunctional protein that has an important role in normal postnatal brain development in animal models. (bmj.com)
T, p.*238Lext57, which is predicted to add an extra 57 amino acids to the normal protein chain. (molvis.org)
In addition, the expression of Hat1 is linked to the normal aging process as Hat1 mRNA and protein becomes undetectable in many tissues in old mice. (nih.gov)
On the other hand, mechanisms that impair the circadian clock genes, such as circadian locomotor output cycles kaput ( CLOCK ), brain and muscle Arnt-like protein 1 ( BMAL1 ), and period genes ( PER1 , PER2 , and PER3 ), contribute to defective beta-cell function and development of type 2 diabetes [ 7 - 12 ]. (hindawi.com)
For example, this may mean the mouse starts to produce a new protein . (yourgenome.org)
ASH1L typically plays a role in gene expression by encoding a protein known as histone methyltransferase and is crucial in regulating gene expression in normal development. (msu.edu)
We show that the m 6 A reader protein Ythdf2 modulates neural development by promoting m 6 A-dependent degradation of neural development-related mRNA targets. (biomedcentral.com)
Currently, we are examining the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, in transgenic mice bearing antimyelin basic protein (MBP) T-lymphocytes. (nyu.edu)
We show that NRF1 protein level gradually increases in post-migrating PGCs during embryonic development. (bvsalud.org)
We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)

By embryonic day 15.5, kidneys of nephron progenitor cell-specific VHL knockout mice begin to exhibit reduced maturation of nephron progenitors. (lww.com)

The mouse is closely related to humans with a striking similarity to us in terms of anatomy, physiology and genetics. (yourgenome.org)
Over time, the mouse has become the preferred organism for research into mammalian genetics because of its rapid generation time, small size and the ease with which it can be bred. (yourgenome.org)
In 1902, French biologist Lucien Cuénot was the first to demonstrate Mendel's theories of inheritance by highlighting the genetics of coat colour characteristics in mice. (yourgenome.org)
Together with his student Clarence Little, Castle produced a series of important papers on the genetics of coat colour in mice. (yourgenome.org)

Some of these genes such as HOXA10 also appear to be involved in haematopoiesis, tumour invasion and normal uterine function. (endocrine-abstracts.org)

Nephron progenitors, the self-renewing cells that give rise to nephrons, are particularly metabolically active, relying primarily on glycolysis for energy generation early in development. (lww.com)
VHL knockout nephron progenitors also exhibit persistent Six2 and Wt1 expression, as well as decreased mitochondrial respiration and prolonged reliance on glycolysis. (lww.com)

Virus-specific antibody responses correlated with protection from encephalitis in all mouse strains, suggesting that Tfh-B cell interactions modulate clinical outcome in this model. (cdc.gov)

These data demonstrate clear postmaturational roles for CD28 in FOXP3 + Tregs and provide mechanisms which we believe to be novel to explain how interruption of CD28-ligand interactions may enhance immune responses independent of effects on thymic development or on other cell types. (jci.org)
In conclusion, we demonstrate that TLR2 diminishes the development of adaptive immune responses during experimental deep dermatophytosis and, in a diabetic scenario, acts to intensify a non-protective inflammatory response. (frontiersin.org)

Although the existence of additional anomalies of the nervous system or other organ systems is difficult to exclude, the existing animal models are a valuable resource for understanding molecular bases for normal inner ear development. (nih.gov)
Here, we showed that anterior nucleus of paraventricular thalamus (PVA) plays an essential role in the development of mechanical hyperalgesia in neuropathic and inflammatory pain models in mice. (iasp-pain.org)
these mice permit the role of specific individual genes in development, in immune response studies and also provide animal models for evaluation of various therapeutic regiments. (assignmenthelp.net)
My lab uses a multi-faceted approach combining biochemistry, cell and molecular biology and various high-end microscopy techniques along with mouse knockout and tumor models to determine the molecular organization of the proteins that are involved in cell adhesion and thereby understand how they each contribute to cell behavior in vivo. (upstate.edu)
Work in knockout mouse models has shown that TET2 loss enhances hematopoietic stem cell (HSC) self-renewal, expanding the HSC pool (reviewed in refs. (aacrjournals.org)
1- 4 Evidence from animal models suggests that an altered immune response to the commensal microflora of the host plays a central role in the development of the condition. (bmj.com)
Molecular analysis of melanocytes and melanoma cells from mouse models: transcriptomics, bioinformatics, proteomics. (ubc.ca)
To date, He and his team have made significant discoveries by using innovative models that "knock out" the ASH1L gene in the brains of mice. (msu.edu)
Neuroscience focusing on human development and disease has long been hampered due to ethical rea¬sons, low tissue availability, and low translatability from animal models. (lu.se)
Animal models of human BTK mutations are confined to mice at this time. (medscape.com)
Mouse models have milder disease than humans. (medscape.com)

In both human cells in a dish (in vitro) and living mouse brains (in vivo) alpha-synuclein was present in the exact same location as the DNA repair proteins, suggesting alpha-synuclein binds directly to DSBs, and helps repair those breaks. (parkinson.org)
We also focus on a transgenic mouse model for asthma to determine in vivo the factors controlling the synthesis of important interleukins involved in the asthmatic process such as IL-4 and IL-5 and the increased production of immunoglobulin E. (nyu.edu)

We found group-housed Grb10 +/p mice do not show evidence of enhanced social dominance, but cages containing Grb10 +/p and wild-type mice lacked the normal correlation between three different measures of social rank. (bath.ac.uk)

however, its role in Treg function has been difficult to dissect, as CD28 is required for thymic Treg development, and blockade of CD28-ligand interactions has confounding effects in trans on nonregulatory cells. (jci.org)
On June 21 and 22, 1999, the National Institute on Deafness and Other Communication Disorders (NIDCD) and the Life Sciences Division of the National Aeronautics and Space Administration (NASA) co-sponsored a program planning workshop, "Role of Transgenic and Knockout Studies in Understanding Sensory-Motor Performance in Altered Gravitational Performance. (nih.gov)
The scientific presentations emphasized developmental processes, encompassing such areas as: 1) the role of homeobox genes and growth factors in inner ear development and plasticity, 2) effects of altered gravitational loading on the development of the inner ear gravity receptor, 3) effects of altered gravitational loading on developing and mature neuromuscular systems and 4) molecular mechanisms that determine muscle fiber diversity and hypertrophic responses. (nih.gov)
In the present study, we investigated the role of TLR2 during the development of experimental deep dermatophytosis in normal mice and mice with alloxan-induced diabetes mellitus, an experimental model of diabetes that exhibits a delay in the clearance of the dermatophyte, Trichophyton mentagrophytes (Tm). (frontiersin.org)
While these investigations were in progress, Mears started to develop the Nrl-knockout mouse to study the role of Nrl in a living animal. (sciencedaily.com)
TET2 is a well-established tumor suppressor in the context of myeloid malignancies, but its role in lymphoma development has been less clear. (aacrjournals.org)
In addition, knockout mouse studies have suggested a role for HOXA10 in implantation but its precise mechanism of action remains unclear. (endocrine-abstracts.org)
It is also found in fish where it plays a role in development of the heart. (scienceblogs.com)
To confirm the role of IL-6, Steve Smith, the lead researcher, gave fake colds (poly(I:C)) to two groups of pregnant, IL-6-free mice . (foundmyfitness.com)
Taken together, our results suggest that post-transcriptional mechanisms play an important role in the brain both during development and in the adult brain. (lu.se)

Our results demonstrated that inoculation of Tm into the footpads of normal mice increases the expression of TLR2 in CD115 + Ly6C high blood monocytes and, in hypoinsulinemic-hyperglycemic (HH) mice infected with Tm, the increased expression of TLR2 was exacerbated. (frontiersin.org)
Hat1 +/- mouse embryonic fibroblasts (MEFs) display modest increases in endogenous DNA damage but have significantly higher levels of reactive oxygen species (ROS). (nih.gov)
Infection-induced interleukin-6 secretion in mice increases the risk for schizophrenia- and autism-like behaviors in offspring. (foundmyfitness.com)
In this classification, parents of affected children were assessed as having either normal (type I), moderate (type III), or significant (type II) increases in cystine excretion. (msdmanuals.com)

We found that the regulation of TE transcription during brain development is essential for the establishment of long-term transcriptional repression carried to adulthood (Paper I and IV). (lu.se)

1991. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius on chick embryos in ovo and in mouse thymus anlagen in vitro . (cdc.gov)

Although defects may occur in many steps in B-cell development and maturation, resulting in agammaglobulinemia, the most common and well-described defect is the impaired maturation of the pro-B cells to pre-B cells. (medscape.com)

The paper "Formation of Genetically Mosaic Mouse Embryos and Early Development of Lethal (t 12 /t 12 )-Normal Mosaics," by Beatrice Mintz, describes a technique to fuse two mouse embryos into a single embryo. (asu.edu)
This was accomplished by introducing the embryos to each other at mouse body temperature. (asu.edu)
The embryos easily adhered to each other and continued to develop as a single mouse. (asu.edu)
Mintz performed these fusions at different intervals in development and discovered that the embryos could form chimeras if they were fused at any point until the morula stage. (asu.edu)
Some embryos did not efficiently fuse and the embryo segregated itself between mutant and normal cells. (asu.edu)
The development of a method for fusing two embryos has proved useful in many ways besides the direct study of the embryos. (asu.edu)

A transgenic mouse is usually created in one of two ways. (yourgenome.org)

Swaroop believes that the Nrl knockout mouse - that is, the mouse bred to have only cone cells - can be used to investigate this behavior. (sciencedaily.com)
Moreover, the original study examined tube-test behavior in isolated mice 10 months of age. (bath.ac.uk)
Without ASH1L, mice displayed telltale signs of ASD including behavior and memory deficits. (msu.edu)
In both groups, offspring grew up normal , showing that IL-6 is necessary for the maternal poly(I:C) treatment to alter fetal brain development and subsequent behavior in the offspring. (foundmyfitness.com)

Each mosaic embryo produced a different pattern of growth, but all the mutant cells began to grow larger in relation to the normal cells due to a reduction in the rate of cell division. (asu.edu)
It monitors this dance between darkness and light, and the seasonal cold and hot temperatures in our environment to help control and monitor our own growth and development. (jackkruse.com)
Aberrant platelet-derived growth factor receptor beta (PDGFRβ) signaling in cancer has motivated the development of several antagonists currently in clinical use, including imatinib, sunitinib, and sorafenib. (lu.se)
The discovery of a novel ligand for PDGFRβ, platelet-derived growth factor (PDGF)-DD, opened the possibility of a previously unidentified signaling pathway involved in tumor development. (lu.se)

We research gene expression control during development and misregulated in diseases. (ncl.ac.uk)

Even though the mice do not have a well-defined macula (a region of the retina that is richer in cones than other parts of the retina), Kellogg researchers hope that this mouse model will allow them to identify the molecules needed for cone function and survival. (sciencedaily.com)
We have obtained preliminary data consistent with this hypothesis in mouse model of asthma where chronic treatment with ß2AR inverse agonists significantly reduces the effects of a bronchoconstrictor. (americanasthmafoundation.org)
According to a quote from lead study author Dr. Bruno Reversade published in The Scientist, "We are able to rescue all these clinical symptoms by administering synthetic Ela[bela] in the knockout mice, so it's not just that we have a new model [of preeclampsia], we have a potential therapeutic. (scienceblogs.com)
This makes the mouse an extremely useful model organism. (yourgenome.org)
We showed how insulin deficiency in Friedreich's ataxia is likely to evolve, and that a mouse model for Huntington's disease develops diabetes due to loss of beta-cells. (lu.se)
In paper №1, I detail the neurodegenerative and behavioural outcomes in a mouse lesion model of PD, which can be used as a platform for the development of novel therapeutic strategies. (lu.se)

Unlike the normal mucosa, the UC mucosa contains large numbers of IgG plasma cells, reminiscent of a typical peripheral immune response towards an invading pathogen, leading to local deposition of IgG on epithelial cells. (bmj.com)
To prove this, they triggered an artificial immune response in pregnant mice-giving them a faux case of the flu. (foundmyfitness.com)
A single, mid-gestation injection of poly(I:C) creates a strong immune response in a pregnant mouse. (foundmyfitness.com)
Although most normal immune responses against pathogens require the action of T-lymphocytes, their improper control lies at the heart of two types of disease: autoimmunity and allergy. (nyu.edu)

She thought a fusion of a mutant embryo with a normal embryo might rescue function long enough to study the mechanism of the mutation similar to the way she studied the blood disorder. (asu.edu)
A second method involves introducing the transgenic DNA into embryonic stem cells (ES cells) derived from a mouse embryo at the very early stages of development. (yourgenome.org)
The embryonic stem cells need a host embryo in which to develop and this is isolated usually from a mouse with different colour fur. (yourgenome.org)

TET2-knockout mice predominantly develop chronic myelomonocytic leukemia (CMML), but they can also develop other myeloproliferative as well as lymphoproliferative diseases, reflecting the prevalence of TET2 mutations in these varied hematologic malignancies. (aacrjournals.org)

SGK1 knockout mice show seemingly normal development. (wikipedia.org)
In this investigation, we considered the effect of PrP gene knock-out (PrP0/0) on cerebellar neural circuits and in particular on granule cells, which show intense PrP expression during development and selective affinity for PrP. (amrita.edu)
Although he reported a novel approach to embryonic fusions, his technique was inefficient and the sole mouse that survived long enough to observe the coat color did not show evidence of chimerism. (asu.edu)
Finally, we show that the Kif2a-null mice exhibit normal sensory axon patterning early during development, but abnormal target hyperinnervation later on, as they compete for limited skin-derived trophic support. (nih.gov)
mice with a mPER2 knockout show a significant increase in tumor development and a significant decrease in apoptosis . (jackkruse.com)

Our laboratory uses transgenic and knockout mice to study the molecular mechanisms responsible for the normal control of T-lymphocyte reactivity and the changes that occur when T-lymphocytes become either aggressive against self antigens or inappropriately reactive against substances (allergens) normally present in the environment. (nyu.edu)

The researchers conducted a series of sophisticated tests in both living mouse brains and human cells to see if this chain of events was taking place. (parkinson.org)
In both healthy human cells and living mouse brains, the laser-induced DSBs, triggered alpha-synuclein to move to the site of DNA damage. (parkinson.org)

As part of the study, researchers also examined the effect of age on cone function in the absence of rods, recording electrical activity in the retina of Nrl knockout mice at different times after birth. (sciencedaily.com)
However, there has been no detailed study of social dominance in Grb10 +/p mice. (bath.ac.uk)
This technique was developed to study the t 12 mutation, which arrests development at the morula stage. (asu.edu)
The identification of undifferentiated pre-GEPCOT and GEPCOT cells will make it possible to directly study the properties of these cells inside the mouse brain, and to isolate live cells to test how they function. (elifesciences.org)
A recent study published in Science showed that mice that do not have this peptide develop preeclampsia. (scienceblogs.com)

Homeobox (HOX) genes encode proteins that are important in normal foetal development. (endocrine-abstracts.org)
These genes encode proteins that are required for the development and maintenance of photoreceptor structure and its matrix membranes, visual transduction, ciliary trafficking and photoreceptor outer segment shedding. (molvis.org)
When researchers administered Elabela to mice with preeclampsia, they discovered that the micropeptide reversed hypertension and the presence of proteins in the urine. (scienceblogs.com)

Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice. (lu.se)

Disease occurrence was not due to subversion of Cd28 -deficient Tregs into pathogenic cells, as complementation with normal Tregs prevented disease occurrence. (jci.org)
It should be clear because of these links that just a simple mismatch in circadian cycles can lead to the development of cancer and neolithic disease. (jackkruse.com)
This schematic view of the morpho-functional unit of the lung (alveolus) depicts the main differences in cellular composition in idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD) compared with normal physiological cellular components. (ersjournals.com)
Overall, our findings highlight the importance of TEs as regulatory agents and their dynamic activity during development, adult life, and disease in the human brain. (lu.se)
Insufficient secretion of insulin is required for the development of Type 2 Diabetes, a disease with a soaring incidence. (lu.se)
This has implications both for normal control of insulin release as well as disease processes in islets, also known as lipotoxicity. (lu.se)

The targeted gene transfer can be used to replace the normal endogenous gene with a specific mutant form of the same gene or the whole gene may be replaced by a DNA sequence desired. (assignmenthelp.net)

He discovered the indenoisoquinolines as novel Top1 inhibitors, which are in clinical development, and the mitochondrial topoisomerase gene, TOP1mt. (cancer.gov)
Three of his indenoisoquinoline TOP1 inhibitors are in Phase 1/2 clinical development (Thomas & Pommier, Clin Cancer Res 2019): LMP400 (Indotecan), LMP776 (Indimitecan) and LMP744. (cancer.gov)
This was critical for the clinical development of Yondelis. (cancer.gov)
Any assay development effort requires testing, evaluation, and validation of the assays with live or inactivated spiking materials in appropriate matrices relevant to the environments in which the assays are intended to be used (e.g., aerosol collection filters, soils, or clinical matrices). (cdc.gov)

We previously reported that Hat1 is required for viability and important for mammalian development and genome stability. (nih.gov)

We conduct studies of early human brain development. (ncl.ac.uk)
While recent studies have identified ASH1L as one of the highest risk genes associated with ASD, little is known about the exact mechanisms underlying ASH1L's function in the development of autistic-like symptoms. (msu.edu)
In previous mice studies, a loss of ASH1L was seen to spur neural hyperactivity, and an excitation/inhibition imbalance in the brain. (msu.edu)

When compared with the human genome it was found that the two genomes were of similar size and almost every gene in the human genome has a counterpart in the mouse. (yourgenome.org)
Almost every gene in the human genome has a counterpart in the mouse. (yourgenome.org)

During development, retinal stem cells differentiate into photoreceptors in response to external and internal cues. (sciencedaily.com)
The adult cows with similar antigens were found to have two different populations of red blood cells suggesting that the precursors of the red blood cells, hematopoietic stem cells, were transferred from one twin to the other during development. (asu.edu)

Overall, these findings reveal a central regulatory mechanism of axonal pruning during development. (nih.gov)

Hypoplasia or absence of the major telencephalic commissures and a hypoplasia of corticospinal tracts to half the normal size, were the major neurodevelopmental defects we observed. (nature.com)
Defects observed in Hat1 +/- mice are consistent with an early-onset aging phenotype. (nih.gov)

Neural crest cell development. (ubc.ca)
Consistently, expression of genes enriched in neural development pathways is significantly disturbed. (biomedcentral.com)

Notable exceptions are the tilted and tilted head mouse mutants, having only one identified phenotypic defect, the absence of otoconia, and 100% penetrance. (nih.gov)

Their mutagenic potential and gene regulatory effect have shaped the evolution of transcriptional networks involved in development, pluripotency, and inflammation. (lu.se)

We prospectively identified, and isolated by flow cytometry, adult mouse lateral ventricle subventricular zone (SVZ) NICs as Glast mid EGFR high PlexinB2 high CD24 −/low O4/PSA-NCAM −/low Ter119/CD45 − (GEPCOT) cells. (elifesciences.org)
Fam13a-mutant mice are viable and healthy, indicating that Fam13a is dispensable for embryonic development and physiological functions in adult animals. (illinois.edu)

In some cases, normal ovarian function may even return for a period of time. (medscape.com)
Transgenic mice are extremely useful for scientists studying gene function. (yourgenome.org)

Anatomy3

Organisms8

Diseases1

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes1

Conditional6

C57BL3

Postnatal day2

Differentiation6

Metabolism2

Genetic8

Zebrafish3

Neurons8

Germ2

Malignant2

Tumours2

Knock-out5

Murine2

Protein13

Progenitor1

Genetics4

Haematopoiesis1

Progenitors2

Antibody1

Demonstrate2

Models11

Vivo2

Wild-type mice1

Role10

Increases4

Adulthood1

Vitro1

Maturation1

Embryos6

Transgenic mouse1

Behavior4

Growth4

Gene expression1

Model6

Immune4

Embryo3

Mutations1

Show5

Molecular mechanisms1

Brains2

Study5

Proteins3

Kidney1

Disease6

Sequence1

Clinical4

Mammalian1

Studies3

Genome2

Stem2

Reveal1

Defects2

Neural2

Phenotypic1

Pluripotency1

Adult2

Function2