IFN-γR-/- mice infected for 4 months and receiving whole body irradiation 2 months after infection developed pathology characterized by extensive adventitial and medial infiltrate and significant neointima, suggesting that infection and immunosuppression were co-requisites of neointima formation. (biomedcentral.com)
Here we report that MCMV infections of gene-targeted mice lacking IFN-γR and subjected to whole body irradiation develop vascular lesions that over 4 months progress to severe vasculopathy characterized by significant neointima formation, a prominent feature of autoimmune vasculopathies in humans. (biomedcentral.com)
and receiving whole body irradiation 2 weeks after infection developed pathology characterized by considerable adventitial and medial infiltrate and significant neointima, suggesting that illness and immunosuppression were co-requisites of neointima formation. (irjs.info)
Right here we survey that MCMV attacks of gene-targeted mice missing IFN-R and put through entire body irradiation develop vascular lesions that over XLKD1 4 a few months progress to serious vasculopathy seen as a significant neointima development, a prominent feature of autoimmune vasculopathies in human beings. (irjs.info)
Autoimmune vasculopathies2
These results indicate that CMV infections may lead to intimal injury that results in the formation of neointima characteristic of autoimmune vasculopathies. (biomedcentral.com)
Conclusion These results indicate that CMV attacks can lead to intimal damage that leads to the forming of neointima quality of autoimmune vasculopathies. (irjs.info)
Carotid8
After exposure for 10 ± 1 weeks, arterial thrombosis and neointima formation at the carotid artery were induced using 10% ferric chloride. (pmiscience.com)
In addition, inhibition of thrombin by dabigatran in serpina3c −/− mice reduced neointima lesion formation due to partial carotid artery ligation. (silverchair.com)
The in vivo neointimal hyperplasia model was established 2 weeks after the carotid artery balloon injury in SHR rats. (hindawi.com)
Administration of fisetin (ip 3 mg/kg daily for 2 weeks) right after the injury significantly increased PON2 expression in the artery, inhibiting ROS production, and efficiently reduced carotid neointimal hyperplasia. (hindawi.com)
Endothelium-targeted transgenic GTP-cyclohydrolase I overexpression inhibits neointima formation in mouse carotid artery. (ox.ac.uk)
Morphological analysis was performed 2 and 4 weeks after carotid injury to assess neointimal formation. (ox.ac.uk)
Endothelium-dependent relaxation was impaired 10 days and 4 weeks after carotid injury, whereas endothelium-independent relaxation remained unaffected. (ox.ac.uk)
Morphological analysis revealed that the endothelial-specific overexpression of GTPCH reduced neointimal formation and medial hypertrophy 2 and 4 weeks after carotid injury. (ox.ac.uk)
Vascular9
CMV infects vascular endothelium with intermittent shedding of the virus and the development of latency. (biomedcentral.com)
von Willebrand Factor Is Produced Exclusively by Endothelium, Not Neointima, in Occlusive Vascular Lesions in Both Pulmonary Hypertension and Atherosclerosis. (stanford.edu)
Abnormal vascular smooth muscle cell (VSMC) proliferation is a critical step in the development of atherosclerosis. (silverchair.com)
China, needing to vascular numerous headline to see in stronger, more high weeks in all traditional directives( Dumbaugh 1992: 17). (zukunftswerkstatt-arbeitspferde.de)
The first grant, a $200.000 Technology Development Award from the UC Center for Accelerated Innovation, is funded through a combination of grants and matching funds from a group comprised of National Heart, Lung and Blood Institute (UC CAI), UCSF School of Medicine, UCSF Department of Surgery, Division of Vascular and Endovascular Surgery, Boston Biomedical Innovation Center ( B - BIC ) and Brigham and Women's Hospital. (ucsf.edu)
The second grant, a $1.8M grant from the NHLBI Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program , is for the development of a d rug -d evice combination for prevention of restenosis. (ucsf.edu)
Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. (kactusbio.com)
Finally, we provide evidence that these observations are applicable in vivo by demonstrating that HDAC inhibition decreased neointima formation and expression of cyclin D1 in a murine model of vascular injury. (cret-signal.com)
n\nConclusion-These findings identify HDAC as a critical component of a transcriptional cascade regulating SMC proliferation and suggest that HDAC might play a pivotal role in the development of proliferative vascular diseases, including atherosclerosis and in-stent restenosis. (cret-signal.com)
What is lacking in computational modelling literature is the representation of the active response of the arterial tissue in the weeks and months following stent implantation, i.e., neointimal remodelling. (nuigalway.ie)
Angiotensin II (AngII) stimulates oxidative stress in VSMC, inducing VSMC proliferation and migration, which is a critical factor in both developments of hypertension and angioplasty-induced arterial restenosis. (hindawi.com)
Lesion2
The cell dynamics and molecular signals driving neointimal lesion formation have been difficult to elucidate as classic mouse models of PH do not develop neointima. (stanfordchildrens.org)
No regression of initial atherosclerotic lesion was achieved and neointima formation and elastin degradation prevailed in all transplanted specimens. (degruyter.com)
Intimal2
Neointima stained positive for both -smooth muscle actin and PCNA indicating proliferation of smooth muscle cells possibly mediated by growth factors TGF-β 1 , PDGF-A and PDGF-B, while TUNEL indicated apoptosis in the intimal layer in affected arteries. (biomedcentral.com)
However, outward redesigning does not happens always, leading to situations where neointima formation results in inward remodeling due to pathological intimal 1-NA-PP1 manufacture hyperplasia and lumen reduction, Figure ?Physique33 (21, 22). (bio-cavagnou.info)
The framework is used to evaluate the effects of the neointima on the mechanics of the stent, when the stent is undergoing uniform or pitting corrosion, and to assess the effects of the neointimal formation rate relative to the overall stent degradation rate (for both uniform and pitting conditions). (nuigalway.ie)
Mice5
Methods: Apolipoprotein E-deficient mice were exposed to filtered air (sham) or to cigarette mainstream smoke at a total particulate matter (TPM) concentration of 600 µg/l for 1, 2, 3, or 4 h, for 5 days/week. (pmiscience.com)
For this, 5-week-old male C57BL6J mice were fed a standard (Chow) or a high-fat (HF) diet for 8 weeks. (met-vasc.com)
The HF diet was replaced by the chow diet for the last 2 weeks in half of HF mice, generating 3 groups: Chow, HF and HF-Chow. (met-vasc.com)
Five-week-old male C57BL/6J mice were fed a standard or a high-fat (HF) diet for 6 weeks. (met-vasc.com)
Moreover, after a 16-week duration of diabetes, Pggt1b Δ / Δ mice exhibited lower α -smooth muscle actin ( α -SMA) and nitrotyrosine level, Rac1 activity, p47phox and NOXO1 expression, and phospho-ERK1/2 and phosphor-JNK content than wild-type mice. (hindawi.com)
Atherosclerotic1
Macrophage apoptosis resulting in necrotic core development and intraplaque hemorrhage additional accelerates the procedure of VGD by development of atherosclerotic lesions with an unpredictable phenotype (1). (bio-cavagnou.info)
Endothelial3
TGF-1 proteins appearance localized predominantly towards the developing neointima and coincided with proclaimed suppression of endothelial TM appearance (162% of vein handles, P .03), a decrease in situ APC-generating capability (539% of vein handles, P=.001) and increased neighborhood thrombus development (3.70.8-fold increase more than vein controls, P .01). (aplarcongress.org)
This study aimed to elucidate if a short-term dietary intervention consisting in replacing the high-fat diet with a standard diet for 2 weeks could reverse obesity-induced endothelial dysfunction via AMPK-CREB activation. (met-vasc.com)
PDGF R plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (kactusbio.com)
Proliferation1
Our results highlight a protective role for serpina3c as a novel thrombin inhibitor in the development of atherosclerosis, with serpina3c conferring protection through the thrombin/PAR-1 system to negatively regulate VSMC proliferation through ERK1/2 and JNK signaling. (silverchair.com)
Pandemic1
The high genetic variability of influenza A viruses poses a continual challenge to seasonal and pandemic vaccine development, leaving antiviral drugs as the first line of defense against antigenically different strains or new subtypes. (frontiersin.org)
Atherosclerosis1
An Apoe −/− /serpina3c −/− -double-knockout mouse model was used to determine the role of serpina3c in atherosclerosis after HFD for 12 weeks. (silverchair.com)
Cardiovascular2
Background: Cigarette smoking is a major risk factor for the development of cardiovascular disease. (pmiscience.com)
For the first time, The Society of Thoracic Surgeons joined the Korean Society for Thoracic and Cardiovascular Surgery (KSTCVS) in their presentation of the Heart Valve Disease Forum (HVDF), an annual conference that delivers the latest developments on the basis, cause, diagnosis, treatment, and future of valve disease. (sts.org)
Injury1
Cold ischemia and subsequent reperfusion injury are non-immunologic cornerstones in the development of graft injury after heart transplantation. (frontierspartnerships.org)
Implantation1
Systemic administration of 1D11 also avoided TM downregulation, preserved activated proteins C-generating capability and decreased regional thrombus in rabbit VGs without observable influence on neointima development and various other morphometric variables 6 weeks after implantation. (aplarcongress.org)
Gene1
The cause of the bottleneck remains unsolved, with proposed answers ranging from gene mutations to cultural developments like language to climate-altering events, among them a massive volcanic eruption. (clinicalnews.org)
Rats1
RAGE and its ligand, S100b, were discovered about islet tissues within 28-week-old diabetic OLETF rats. (mdmsignaling.com)
Inflammation2
Infected immunocompetent animals exhibited widespread perivascular inflammation, which subsided by 8 weeks. (biomedcentral.com)
This altered glucose metabolism state is associated with an increased risk of developing T2DM (Figure 1), although other parameters including excess adiposity, inflammation and dyslipidemia are risk factors associated with the development of insulin resistance, loss of pancreatic function, worsening of hyperglycemia and progression to diabetes (1). (ddw-online.com)
Analysis3
Immunohistochemical analysis revealed myofibroblasts as a major component of neointima. (biomedcentral.com)
Computational modelling such as finite-element analysis has proven to be an extremely useful tool in the continued design and development of these medical devices. (nuigalway.ie)
Immunohistochemical analysis exposed myofibroblasts PF-4136309 biological activity as a major component of neointima. (irjs.info)
Methods1
Methods: Successive people starting uncomplicated LC were accompanied by a once a week cell phone customer survey questionnaire for six months. (hsp90-inhibitors.com)
Diabetes1
Affect of dietary curcumin and ldl cholesterol on the development of experimentally induced diabetes in albino rat. (fairpeel.com)
Leads1
Inside the initial times to weeks this leads to influx of inflammatory cells within the vein graft vessel. (bio-cavagnou.info)
Research1
This specific proof-of-concept research improves the chance that will development of catalase is really a treatment for treating your retinal oxidative anxiety linked to diabetic person retinopathy.Plantar fascia mechanical attributes are believed for you to break down through growing older but improve along with workout. (hsp90-inhibitors.com)
Design1
During the Renaissance, the equivalent English term was "sackbut" the word first appears in court records in as "shakbusshe" at about the time King Henry VII married a Portuguese princess who brought musicians with warzone 2 no recoil script its vast experience working with all businesses from SMEs to large multi-national operations, it offers a wide range of services including web design, eCommerce platforms, marketing, print, development and retail consultation. (kfz-gschaider.at)
High1
The most high computer of movement follows the development, included on the Past login. (cdmw.de)
Heart1
Heart is the first organ to mature during the development. (amegroups.org)
Production1
Synthetic approaches to paclitaxel production led to the development of docetaxel. (wikipedia.org)