AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
OrganogenesisGene Expression Regulation, DevelopmentalMorphogenesisEmbryonic and Fetal DevelopmentIn Situ HybridizationEmbryo, MammalianMesodermHomeodomain ProteinsPlant ShootsMeristemOrganogenesis, PlantLotusBody PatterningCell DifferentiationLymphotoxin beta ReceptorEmbryonic DevelopmentEmbryo, NonmammalianTranscription FactorsSignal TransductionPlant Root NodulationZebrafishToothDigestive SystemIndoleacetic AcidsEndodermLymphotoxin-betaAbnormalities, Drug-InducedRoot Nodules, PlantVulvaCannabaceaeEmbryonic InductionUreterCytokininsZebrafish ProteinsPlant RootsUrogenital SystemTeratogensGene Expression Regulation, PlantKidneyCell LineagePregnancyMolecular Sequence DataEpitheliumBone Morphogenetic Protein 4MutationPancreasOdontogenesisGastrulaWnt4 ProteinBone Morphogenetic ProteinsOrgan Culture TechniquesLymphotoxin-alphaHedgehog ProteinsPhenotypeYolk SacNervous SystemGenes, DevelopmentalMice, KnockoutArabidopsisMice, TransgenicArabidopsis ProteinsWnt ProteinsModels, BiologicalGenes, HomeoboxWolffian DuctsExtremitiesOryziasGestational AgeStem CellsSymbiosisImmunohistochemistryKinetinRNA, MessengerPAX2 Transcription FactorAnimals, Genetically ModifiedChemokine CXCL13FetusBase SequenceLymphotoxin alpha1, beta2 HeterotrimerGonadsChimeraPlant ProteinsFibroblast Growth Factor 10Abnormalities, Radiation-InducedMice, Inbred ICRMice, Mutant StrainsLymphoid TissueEctodermDNA-Binding ProteinsDrosophila ProteinsAmino Acid SequenceTooth GermBranchial RegionGenes, PlantEyePlant LeavesLungMice, Inbred C57BLSomitesChick Embryo
EmbryonicRegenerationFetal developmentEpithelialVitroTissueGestationPituitaryMorphogenesisEmbryogenesisThymus developmentGeneticMolecularKidneyRolesLineageInductionMammalian developmentMechanismsDifferentiationImportanceCellsOrgan developmentStagesSecondary metabolitesResultsEarlyEndogenousPatternsConcentrationsMorphologicalDiseaseOrgansFunctionalShoots2002Child'sCell developmentFunctionApproachesGenesComputationalPrecursorsCritical
Embryonic15
Regeneration2
  • An efficient protocol of plant regeneration through direct and indirect organogenesis in Swertia chirayita was developed. (degruyter.com)
  • A better understanding of the processes that regulate lung development, particularly alveologenesis, will have a significant impact on survival rates for premature infants born with incomplete lung development and will facilitate lung injury repair and regeneration in adults. (nih.gov)
Fetal development1
Epithelial5
  • Extensive research on thymic epithelial cells (TEC) within the cortex and medulla has defined their essential roles during T-cell development. (frontiersin.org)
  • While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
  • Broadly separated into mesenchymal and endothelial cells, NES have been implicated in thymus organogenesis, thymocyte development, tolerance induction and development/maintenance of epithelial stroma. (frontiersin.org)
  • During organ development, tubular organs often form from flat epithelial primordia. (elifesciences.org)
  • Here, we review current understanding of cellular and molecular regulation of thymus organogenesis, focusing on the epithelial component of the thymic stroma which provides many of the specialist functions required to mediate T cell differentiation and T cell repertoire selection. (ed.ac.uk)
Vitro4
  • This chapter highlights the process of in vivo inner ear development, the rationale and process behind inner ear organoid formation, and potential applications and limitations of this in vitro model system. (springer.com)
  • Compared with conventional mice model, this model can recapitulate the human brain development in vitro ( 20 ). (frontiersin.org)
  • The cerebral organoids, which can mimic the endogenous development of human brain, have been applied to different studies as in vitro models for a wide range of brain diseases ( 16 , 21 , 22 ). (frontiersin.org)
  • Since models are limited to study the mechanism of the neurotoxicity of tranylcypromine, here we utilized an in vitro brain organoid culture system which mimics neurogenesis experimentally to investigate the mechanisms by studying the effect of brain development of tranylcypromine and monitoring the brain damage of different concentrations. (frontiersin.org)
Tissue5
  • To complement the forward genetic approaches for identifying genes underlying craniofacial birth defects, we are using the Cre / loxP-mediated tissue specific gene inactivation strategy in combination with microarray / RNAseq, ChIP-seq and molecular marker analyses approaches to unravel the molecular network regulating palate development. (cincinnatichildrens.org)
  • Auxin is a hormone that plays a central role in plant growth, tissue patterning, organogenesis, and responses to light. (cshlpress.com)
  • In this review, we provide an up-to-date overview of the current knowledge of how A. rhizogenes induces root formation, on the new uses for A. rhizogenes in tissue culture and composite plant production (wild-type shoots with transgenic roots), and the recent development of a disarmed version of A. rhizogenes for stable transgenic plant production. (bioone.org)
  • Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
  • Alternative splicing of gene can generate multiple transcripts and proteins to regulate tissue and organ development [ 17 ]. (hindawi.com)
Gestation1
  • Caffeine intake in late gestation affects fetal cardiovascular function, but its effects in early gestation on organogenesis in general and neural tube development in particular are not known [ 18 ]. (cdc.gov)
Pituitary4
  • Sheng HZ, Westphal H. Early steps in pituitary organogenesis. (thejcdp.com)
  • The pituitary gland is entirely ectodermal in origin but is composed of 2 functionally distinct structures that differ in embryologic development and anatomy: the adenohypophysis (anterior pituitary) and the neurohypophysis (posterior pituitary). (medscape.com)
  • The oral ectoderm and neural ectoderm that form the pituitary anlagen are in close contact during early embryogenesis, and this connection is critical for pituitary development. (medscape.com)
  • Development of pituitary gland. (medscape.com)
Morphogenesis2
  • Involvement of Par-1b in Myoepithelial Cell Morphogenesis and Differentiation During Salivary Gland Development. (albany.edu)
  • The lung is a complex organ with lengthy development time driven by interactive gene networks and dynamic cross talk among multiple cell types to control and coordinate lineage specification, cell proliferation, differentiation, migration, morphogenesis, and injury repair. (nih.gov)
Embryogenesis2
  • Within the backdrop of embryogenesis, inner ear development follows an intricate pathway of signaling cues and morphological changes, leading to its complex final three-dimensional (3D) structure. (springer.com)
  • organogenesis happens same time as embryogenesis? (khanacademy.org)
Thymus development1
  • The success of such strategies is likely to depend on a detailed knowledge of the mechanisms regulating thymus development and homeostasis. (ed.ac.uk)
Genetic1
  • Child development is permeated by innumerable performance and mental health, ranging from reduced constraints, including genetic and organic factors related ability to perform routine daily activities in a satisfactory to individual characteristics of the unborn human being, and proper manner of each stage of development, up to broader factors such as environmental, cultural and to cases of bullying, violence, prejudice, among others. (bvsalud.org)
Molecular4
  • It lacks the necessary throughput and resolution to provide a global overview of the dynamic molecular processes that take place in the different and rapidly growing populations and subpopulations of cells during organogenesis. (mpg.de)
  • Understanding the molecular basis of AS is critical for the development of specific therapies. (springer.com)
  • Organogenesis occurs at specific locations and involves complex inductive and inhibitory interactions at the cellular and molecular levels to ensure proper structure and function. (cincinnatichildrens.org)
  • Although with little evidence at the molecular and cellular levels, high-dose tranylcypromine may cause brain damage and inhibit brain development ( 25 - 27 ). (frontiersin.org)
Kidney1
Roles1
Lineage2
  • While adult lymphoid progenitor cells are produced by the bone marrow, their lineage commitment and development into mature T-cells is dependent on their migration into the thymus, where essential interactions with heterogeneous thymic stromal cells take place ( 1 ). (frontiersin.org)
  • The proper methylation status of histones is essential for appropriate cell lineage and organogenesis. (hindawi.com)
Induction1
  • Increased transcript accumulation is associated with two events, the first is nodule organogenesis, while the second is induction of nitrogenase activity. (usda.gov)
Mammalian development1
  • Students and postdoctoral candidates interested in mammalian development and birth defect research are encouraged to contact Rulang Jiang, PhD, ( [email protected] ) to discuss opportunities. (cincinnatichildrens.org)
Mechanisms1
  • Data derived from cephalopod studies can be used to compare and contrast known mechanisms underlying the development of analogous vertebrate structures. (europa.eu)
Differentiation1
  • 2013). Quantitative Single Cell Analysis of Cell Population Dynamics during Submandibular Salivary Gland Development and Differentiation. (albany.edu)
Importance1
  • The thymus is the principal site of T cell development and therefore is of central importance within the immune system: congenital athymia results in profound immunodeficiency, while perturbed thymic function can lead to autoimmunity. (ed.ac.uk)
Cells1
  • However, experimental evidence suggests these cells are important for thymus function by either directly influencing T-cell development, or by indirectly regulating TEC development and/or function. (frontiersin.org)
Organ development2
  • In addition, they described 56 developmental trajectories in organ development for different cell types. (mpg.de)
  • Organ development of mammals is an amazing process. (mpg.de)
Stages2
  • 5-HT interacts with its receptors, which alters cell metabolism and influences several stages of organogenesis 7 . (bvsalud.org)
  • 5-HT also has a stimulatory role in tooth germ development by inducing the formation of enamel and dental papilla to form the bell and crown stages. (bvsalud.org)
Secondary metabolites1
  • Researchers have utilized this tool to study root development and root-biotic interactions, to overexpress proteins and secondary metabolites, to detoxify environmental pollutants, and to increase drought tolerance. (bioone.org)
Results1
  • Results: the final sample totaled 11 articles on: neonatal effects of drug use by pregnant women and consequences of drug use on the cognitive, motor and psychosocial development of children. (bvsalud.org)
Early2
  • Kjaer I, Fischer-Hansen B. The adenohypophysis and the cranial base in early human development. (thejcdp.com)
  • Although highly active in early life, the thymus undergoes premature involution, such that de novo T cell development diminishes significantly with age. (ed.ac.uk)
Endogenous1
Patterns2
  • Global Wound Care Biologics Market Report 2022 comes with the extensive industry analysis by Introspective Market Research with development components, patterns, flows and sizes. (bharatbook.com)
  • Relative levels of gene expression throughout development were determined by quantitative polymerase chain reaction (PCR) analysis and in cases where sufficient specific gene sequence was acquired, ribonucleic acid (RNA) probes were generated to evaluate the spatial expression patterns during the period of organogenesis. (europa.eu)
Concentrations1
  • In summary, BCA affected development of Xenopus embryos only at high concentrations, while DBA did not affect Xenopus development at the concentrations tested. (cdc.gov)
Morphological1
  • Fluoxetine, at the doses administered during pregnancy in this study, did not alter the morphological development of the coronal dentin-pulp complex in their offspring. (bvsalud.org)
Disease2
  • The potential applications of this system include investigation of inner ear development, disease modeling, drug screening, and therapy development. (springer.com)
  • Chi N, Epstein JA (2002) Getting your Pax straight: PAX proteins in development and disease. (springer.com)
Organs1
  • This mechanism is likely to be more generally important for the development of complex tubular organs. (elifesciences.org)
Functional1
  • The thymus supports T-cell development via specialized microenvironments that ensure a diverse, functional and self-tolerant T-cell population. (frontiersin.org)
Shoots2
  • A maximum number of (7.14 ± 0.99) shoots were developed per leaf explants through direct organogenesis. (degruyter.com)
  • Well-rooted shoots transferred to plastic pots containing a soilrite: sand mix and then moved to the greenhouse for further growth and development. (degruyter.com)
20021
  • From 2002, the development of WHO specifications follows the New Procedure , described in the 'Manual for development and use of FAO and WHO specifications for pesticides. (who.int)
Child's1
  • Conclusion: drug use by parents jeopardizes the child's growth and development and can lead to behavioral and mental health problems, either because of direct consequences or because of indirect effects of the child's consumption of these substances. (bvsalud.org)
Cell development2
  • In addition to providing biomechanical support to the islets, ECM components are required for β-cell development, proliferation, survival, and proper insulin secretion. (nature.com)
  • STING gain-of-function disrupts lymph node organogenesis and innate lymphoid cell development in mice. (upenn.edu)
Function2
  • WUS function and impact on maize development and yield remain largely unexplored. (nature.com)
  • Elucidating the function of the mutated gene, ALMS1 , is critical for the development of specific treatments and may uncover pathways relevant to a range of other disorders including common forms of obesity and type 2 diabetes. (springer.com)
Approaches1
  • Protection factors are those that promote conditions of children from different approaches, such as intrinsic that allow the strengthening, coping, growth and full factors present in children(2), influence of parental development of a developing human being. (bvsalud.org)
Genes2
  • In order to find out which genes of a cell were active at a certain point of development, the scientists examined the transcriptome. (mpg.de)
  • The expression of genes encoded within the T-DNA promotes the development and production of roots at the site of infection on most dicotyledonous plants. (bioone.org)
Computational1
  • Other topics include the development of computational models for root and shoot growth, as well as chemical tools and synthetic systems to understand auxin biology. (cshlpress.com)
Precursors2
  • A single cell of the somatic gonad, the anchor cell, organizes the development of the vulva from epidermal precursors as well as the physical connection of the epidermis with the uterus. (wormbook.org)
  • The C. elegans hermaphrodite vulva develops during postembryonic (larval) development from ventral epidermal precursors, and connects the developing uterus to the external environment. (wormbook.org)
Critical1
  • During critical periods of organogenesis (i.e., the 6-week period that follows the establishment of the placental circulation). (cdc.gov)