Development drug resistance microbial. Medical search. Frequent questions

Articles address antimicrobial resistance in pathogens from the community, healthcare settings, and agriculture, among children and adults, and in several countries. (cdc.gov)
It stated that infectious diseases were a leading cause of death, accounting for a quarter to a third of the estimated 54 million deaths worldwide in 1998, and that the spread of infectious diseases results as much from changes in human behavior-including lifestyles and land use patterns, increased trade and travel, and inappropriate use of antibiotic drugs-as from mutations in pathogens. (wikipedia.org)
One very important application of this work is investigating how pathogens like Mycobacterium tuberculosis (Mtb) respond to antibiotics, as this helps inform how Mtb develops antimicrobial resistance or drug resistance. (seattlechildrens.org)
However, with continued use of antibiotics, pathogens have developed antibiotic resistance that has rendered some antibiotics ineffective. (seattlechildrens.org)
As antibiotic resistance in microbial pathogens embodies a global threat to public health, it demands the development of novel strategies for managing microbial infections. (nature.com)
Over the last decade, research on antimicrobials has shifted towards an alternative approach to combat pathogens using anti-infective drugs that selectively interrupt virulence pathways to help prevent or cure bacterial infections. (nature.com)
Anti-infective drugs that do not perturb survival or viability of bacterial pathogens should be less likely to promote resistance than conventional antibiotics 1 , 2 . (nature.com)
Natural bioactive compounds derived from plant species show promising therapeutic properties to combat the emerging resistance in microbial pathogens, which can be exploited as next generation anti-infective drugs. (nature.com)
Third, is the increasing development of resistance in pathogens to antimicrobial drugs. (ilri.org)
Vaccination, access to clean water, and antimicrobial drugs have all changed the relationship between humans and pathogens, resulting in a marked increase in life expectancy. (biomedcentral.com)
A more insidious but pervasive threat to human health is the emergence and dissemination of antimicrobial resistance among numerous pathogens, paralleled by a decline in antimicrobial drug discovery. (biomedcentral.com)
Due to the development of this resistance in human pathogens against commonly used antibiotics, it has become necessary to search for new antimicrobial substances from other sources including plants [ 6 ]. (biomedcentral.com)
Molecular typing of pathogens---a mainstay of infectious disease surveillance, prevention, and control---already is used to trace epidemics ( 2 ), provide information for vaccine development ( 3 ), and monitor drug resistance ( 4 ). (cdc.gov)
The emergence of drug-resistant pathogens knows no discrimination, impacting not only human health but also animal health, agriculture, and the environment. (who.int)
Thus, the future of management of arthroplasty-associated infections lies in devising ways to prevent infections, developing investigations that allow early detection, and minimizing both the emergence of new pathogens and the spread of antibiotic resistance among existing pathogens. (medscape.com)

Antibiotics are required to treat a wide variety of microbial infections. (seattlechildrens.org)
Following development of ODELAM and previously ODELAY, we are integrating these technologies into investigating mechanisms of cellular responses to antibiotics. (seattlechildrens.org)
Microbial biofilms contribute to virulence and resistance to antibiotics by shielding microbial cells from host defenses and antimicrobial drugs, respectively. (who.int)
The long-term goal of this program is to contribute to increase awareness among national policy makers about improving bacterial diagnosis, and controlling antibiotic resistance, by guiding healthcare policy, especially regarding the use and supply of antibiotics and establishing programs to combat resistance in healthcare systems. (hku.hk)
This is a huge concern for the health community, which worries that increases in antimicrobial resistance will deplete the antibiotics we use to treat common infections. (ilri.org)
Broad spectrum antibiotics damage the bacteria in our gut and can generate resistance in non-target species with significant implications for human health. (sfi.ie)
Each year more than 700,000 people across the world die from infections that are resistant to current antibiotics, and by 2050 drug-resistant infections will take an estimated 10 million lives per year. (sfi.ie)
Ireland has a relatively high rate of antimicrobial resistance in human health compared to most European countries, and ranks above the EU average for consumption of antibiotics in the community. (sfi.ie)
Broad spectrum antibiotics, which target a broad range of bacterial species, cause collateral damage to the gut microbiome, which is so important to health, and also generate resistance in non-target species with implications for human health" said Colin Hill , SFI Research Centre APC Microbiome Ireland, UCC . (sfi.ie)
Its theme "Antibiotics: handle with care" became a global, multi-year campaign to increase awareness of antibiotic resistance. (who.int)
These cells are embedded in extracellular polymeric substances, a matrix which is generally composed of eDNA, proteins and polysaccharides, showed high resistance to antibiotics. (biomedcentral.com)
Therefore, biofilm matrix gives the additional resistance power to bacteria which makes them to not only tolerate harsh conditions but also resistant to antibiotics which lead to the emergence of bad bugs infections like multi drug resistant, extensively drug resistant and totally drug resistant bacteria. (biomedcentral.com)
Mycolic acids, a potential permeability barrier could be associated to the higher resistance to antibiotics [ 149 ]. (biomedcentral.com)
did not show any significant change in resistance to any of the tested antibiotics. (who.int)
Additionally, appearance of undesirable side effects of certain antibiotics and increasing resistance to antibiotics in current clinical use is also a cause for concern. (biomedcentral.com)
The human-mediated use and abuse of classical antibiotics has created a strong selective pressure for the rapid evolution of antibiotic resistance. (biomedcentral.com)
As resistance levels rise, the efficacy of classical antibiotics wanes. (biomedcentral.com)
But some bacterial infections have since developed resistance to antibiotics. (healthline.com)
Resistance happens when bacteria come in contact with antibiotics and survive. (healthline.com)
Biofilms: Microbial Shelters Against Antibiotics. (matters-of-activity.de)
Frequent exposure to antibiotics accelerates the spread of antibiotic resistance. (infectioncontroltoday.com)
The scientists identified the new resistance genes by testing intestinal microbial DNA from the children against 18 antibiotics. (infectioncontroltoday.com)
Candida albicans is an opportunistic fungus, which requires some predisposing factors for the disease development, such as immunosuppressive agents, use of broad-spectrum antibiotics, xerostomia, prosthetic use and poor oral hygiene. (bvsalud.org)

These findings provide insights into the underlying mechanisms of action of a cerPAC to restrict the virulence of P. aeruginosa and can have implications in the development of alternative approaches to control infections. (nature.com)
ICAP at Columbia University is being funded to develop a network of four hospitals in Kenya to improve their ability to detect bacterial infections, determine antibiotic resistance in the infections, assess antibiotic use and the prevalence of healthcare-acquired infections, and develop an antibiotic stewardship collaborative to improve the use of antimicrobials at the hospitals. (cdc.gov)
Findings will inform the development of a toolkit that other countries or facilities facing similar challenges can use to improve their IPC efforts and reduce the spread of infections. (cdc.gov)
The World Health Organization observes high resistance rates have been observed against antimicrobials used for treating urinary tract infections and certain types of diarrhea. (pharmiweb.com)
JimO'Neil, Chairman of the review on Antimicrobial Resistance has said that drug-resistant infections already kill hundreds of thousands a year globally, and warned that by 2050 that figure could be more than 10 million. (hku.hk)
Antimicrobial resistance in intra-abdominal infections -- 19. (nshealth.ca)
The two public health crises - cancer and drug resistant infections - are deeply intertwined. (arrepath.com)
There is about one new case of carbapenemase-producing enterobacteriaceae (CPE) found in Ireland everyday " said Martin Cormican , National Clinical Lead for Health Care Acquired Infections and Anti-Microbial Resistance and keynote speaker at the conference. (sfi.ie)
In 2019, an estimated 1.27 million deaths globally were directly attributed to drug-resistant infections. (un.org)
There are many approaches being used to control infections by suppressing its formation but CRISPR-CAS (gene editing technique) and photo dynamic therapy (PDT) are proposed to be used as therapeutic approaches to subside bacterial biofim infections, especially caused by deadly drug resistant bad bugs. (biomedcentral.com)
Efflux pump-mediated resistance to single or multiple antimicrobial agents has not only raised serious concerns but also has constricted the treatment options against bacterial infections. (biomedcentral.com)
ContraFect is a biotechnology company focused on the discovery and development of DLAs, including lysins and amurin peptides, as new medical modalities for the treatment of life-threatening, antibiotic-resistant infections. (itbusinessnet.com)
Antimicrobial resistance (AMR) threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi. (who.int)
A growing number of microbial organisms are becoming resistant to available drugs with increasingly diverse risks for a rapid global spreading of infections. (lu.se)
A multidisciplinary guideline development group covering clinical infectious diseases, clinical microbiology, clinical pharmacology, infection control, and guideline methodology experts jointly developed the present clinical practice guidelines based on best available scientific evidence to address the clinical issues regarding laboratory testing, antimicrobial therapy, and prevention of CRGNB infections. (bvsalud.org)

Some strains of pathogenic bacteria are now resistant to essentially all available antimicrobial drugs, and some remain susceptible to only one. (cdc.gov)
For many bacteria, biofilm formation is a key part of their pathogenic behaviour, and is especially important in the development of medical device-associated infection. (qub.ac.uk)
The development of antibiotic resistance in gram negative bacteria becomes the key challenge in treating disease and lowering patient mortality and morbidity [ 7 ]. (biomedcentral.com)
Antimicrobial drug resistance and tolerance occurs when bacteria, viruses, fungi or parasites no longer respond, or have less sensitivity, to treatments. (ddw-online.com)
They can be found very early in Earth's fossil records (about 3.25 billion years ago) as both Archaea and Bacteria, and commonly protect prokaryotic cells by providing them with homeostasis, encouraging the development of complex interactions between the cells in the biofilm. (wikipedia.org)
Dr. Castanheira completed her Masters in Science and Doctoral (Ph.D.) degrees for evaluating molecular epidemiology and resistance mechanisms of gram-positive and -negative bacteria at Universidade Federal de Sao Paulo (UNIFESP). (element.com)
A medical illustration depicts the drug-resistant, Mycobacterium tuberculosis bacteria. (un.org)
Bacterial cell membranes are a possible target for developing new antibacterial drugs since membrane-based efflux pump systems play an important role in bacterial pathogenicity and antimicrobial resistance in bacteria. (biomedcentral.com)
But some studies have shown that bacteria can begin to develop antibiotic resistance as early as 11 days. (healthline.com)
Although antibiotic resistance refers to bacteria and to your body, there are still steps you can take to avoid contributing to it. (healthline.com)
Abby has worked on comparative genomics projects of many different bacteria, including analyses of whole genome sequences of M. tuberculosis , Enterococcus , Fusobacterium , E. coli , and other microbes, with particular emphasis on the evolution of drug resistance and virulence factors. (broadinstitute.org)
She is doing her PhD thesis at Delft University of Technology in Thomas Abeel's group, exploring antimicrobial resistance in pathogenic bacteria. (broadinstitute.org)

However, C. neoformans biofilms were significantly more resistant to amphotericin B and caspofungin than planktonic cells, and their susceptibilities to these drugs were further reduced if cryptococcal cells contained melanin. (who.int)
Unraveling the resistance of microbial biofilms: has proteomics been helpful? (pasteur.fr)
Biofilms are surface-attached, matrix-encased, structured microbial communities which display phenotypic features that are dramatically different from those of their free-floating, or planktonic, counterparts. (pasteur.fr)
The most notable and clinically relevant property of biofilms is their greater resistance to antimicrobials compared with their planktonic counterparts. (pasteur.fr)
Although both bacterial and fungal biofilms display this phenotypic feature, the exact mechanisms underlying their increased drug resistance are yet to be determined. (pasteur.fr)
Advances in proteomics techniques during the past decade have facilitated in-depth analysis of the possible mechanisms underpinning increased drug resistance in biofilms. (pasteur.fr)
These studies have demonstrated the ability of proteomics techniques to unravel new targets for combating microbial biofilms. (pasteur.fr)
In this review, we discuss the putative drug resistance mechanisms of microbial biofilms that have been uncovered by proteomics and critically evaluate the possible contribution of the new knowledge to future development in the field. (pasteur.fr)
We also summarize strategic uses of novel proteomics technologies in studies related to drug resistance mechanisms of microbial biofilms. (pasteur.fr)
Actinobacillus pleuropneumoniae biofilms: Role in pathogenicity and potential impact for vaccination development. (matters-of-activity.de)

Ensuring adherence to multidrug regimens to prevent emergence of resistance requires uninterrupted drug supplies and is vulnerable to human inconstancy. (cdc.gov)
These data will help experts understand the emergence and spread of antibiotic-resistant gonorrhea domestically and internationally and will be valuable in the development of treatment regimens, therapeutics, diagnostics, and prevention activities needed to combat this threat. (cdc.gov)
The discovery of novel antimicrobial drugs is sparked by the emergence of various antibiotic resistance strains. (biomedcentral.com)
The emergence of microbial resistance, the improper use of antimicrobial drugs, and the need for fewer toxic antifungal treatments in immunocompromised patients have sparked substantial interest in antifungal research. (bepress.com)
Passive surveillance using sequence data generated for clinical use would provide an overview of the emergence and spread of antimicrobial resistance. (biomedcentral.com)
This is an issue of great international significance as it leads to a multitude of problems including the emergence of multi-drug resistant organisms. (biomedcentral.com)
10,11 Other factors that contribute to emergence are microbial mutation and selection and genetic re-assortment that can lead to the development of new genotypes of known diseases, as we see most frequently with influenza A and also in new patterns of antibiotic resistance. (who.int)

In their study, published in Nature Microbiology , the scientists analysed data from 12,000 microbial communities from all over the world, provided by the Earth Microbiome Project. (ddw-online.com)
She is a member of the Editorial Board for Antimicrobial Agents and Chemotherapy, Journal of Clinical Microbiology, Microbial Drug Resistance, and Drug Resistance Updates, as well as serves as an ad hoc reviewer for many other microbiology journals. (element.com)
More recently Dr. Castanheira became involved in the program committees for important international conference in Microbiology and Drug Development and is an active advisor in the Clinical and Laboratory Standards Institute Subcommittees for Antimicrobial and Antifungal Susceptibility Testing. (element.com)
Dr Brantuo noted the challenges by many countries for AMR surveillance capabilities and laboratory infrastructures and underscored the need for capacity development to generate, collect, report, and use quality AMR data using GLASS guidelines and WHONET tool, a free desktop Windows application developed by a WHO Collaborating Center for the management and analysis of microbiology laboratory data with a particular focus on antimicrobial resistance surveillance. (who.int)

Resistance is now an important problem in virtually all areas of infectious diseases, including viral, bacterial, fungal, and parasitic diseases. (cdc.gov)
J. Todd Weber Dr. Weber is the director of the Office of Antimicrobial Resistance, National Center for Infectious Diseases, Centers for Disease Control and Prevention. (cdc.gov)
For that reason, this issue of Emerging Infectious Diseases is devoted to antimicrobial resistance and highlights both burgeoning and neglected areas. (cdc.gov)
Subsequently, he gained expertise in the areas of proteomics, chemical biology and mechanobiology to pioneer a multi-disciplinary research program to unravel avenues for novel diagnostics, therapeutic, and vaccine development for infectious diseases. (rgcb.res.in)
But even where therapies against infectious diseases had been available, an additional threat has gained world-wide attention: antimicrobial resistance (AMR). (lu.se)

Twenty well-known diseases-including tuberculosis (TB), malaria, and cholera-have reemerged or spread geographically since 1973, often in more virulent and drug-resistant forms. (wikipedia.org)
We now know that the burden of food-borne diseases due to microbial contamination of perishables is very high in these countries-comparable to that of malaria, HIV and TB. (ilri.org)
Herbal plants are a promising source of drug targets for various acute and chronic diseases. (biomedcentral.com)
Chandramohanadas Laboratory studies blood cell pathologies arising from systemic diseases, oxidative/chemical damage and microbial infectious agents such as Plasmodium spp , causative agent of Malaria. (rgcb.res.in)
Due to difficulties in diagnosis and the limited availability of effective antifungal drugs, diseases caused by fungi represent a growing threat to human health, and can result in highly attributable mortality 1 . (bvsalud.org)
7-9 The development of new, more sensitive technologies can also provide improved detection and diagnostic procedures allowing a new dimension to pathogen discovery, thus detecting new or cryptic agents for known diseases. (who.int)

Sherkow, Jacob S., "Patent Protection for Microbial Technologies" (2017). (nyls.edu)

In a 2003 Institute of Medicine report, Microbial Threats to Health, antimicrobial resistance was noted as a paramount microbial threat of the twenty-first century ( 2 ). (cdc.gov)
N. gonorrhoeae has quickly developed resistance to each recommended treatment over time and gonorrhea is classified as an Urgent Threat in CDC's 2019 Antibiotic Resistance Threats Report. (cdc.gov)
Dr Jeremy Farrar, Director of the Wellcome Trust, said: "In our interconnected world drug-resistant infection is a threat to us all, and increasingly driving a global health crisis. (hku.hk)
The 2020 Agenda for Sustainable Development calls for an integrated approach to development challenges, and our efforts to end HIV are connected to other areas, such as malaria, tuberculosis, access to medicines, and the increasing threat of anti-microbial resistance. (drugtruth.net)

Schematic representation of mechanisms of resistance to antimicrobial agents. (cdc.gov)
Sixty years later, our understanding of resistance has grown vastly more sophisticated and the proliferation of new antimicrobial drugs has engendered an equally varied collection of resistance mechanisms ( Figure 1 ). (cdc.gov)
CDC supports innovative research to slow antimicrobial resistance through various funding mechanisms . (cdc.gov)
Understanding the mechanisms which increase or decrease the chance of a drug working is crucial to aid the developments of new treatments," explained Jason Yu, co-first author and postdoctoral training fellow in the Molecular Biology of Metabolism Laboratory at the Crick. (ddw-online.com)
Dr. Mariana Castanheira is responsible for designing and overseeing antimicrobial and antifungal drug development projects, surveillance studies, and molecular projects that characterize resistance mechanisms. (element.com)
Dr. Castanheira built on the knowledge she gained at Bristol by dedicating the past 15 years working on discovering and characterizing genes encoding beta-lactamases and other resistance mechanisms. (element.com)

The scope of public health genomics is even broader, encompassing genetic variation in populations, both human and microbial. (cdc.gov)

Poster presentation at Keystone Symposia conference on Antimicrobials and Resistance: Opportunities and Challenges. (tamu.edu)
Unfortunately, the traditional IP based innovation system and regulatory frameworks do not provide sufficient incentives to invest in the development of new antimicrobials. (lu.se)

Friendly microbes in the intestinal tracts of healthy American children have numerous antibiotic resistance genes, according to results of a pilot study by scientists at Washington University School of Medicine in St. Louis. (infectioncontroltoday.com)
Despite the small sample size, the analysis identified 2,500 new antibiotic resistance genes, expanding the list of known antibiotic resistance genes by more than 30 percent. (infectioncontroltoday.com)
Microbes have been battling each other for millennia, regularly inventing new antibiotic synthesis genes to kill off rivals and new antibiotic resistance genes to defend themselves,' Dantas says. (infectioncontroltoday.com)
Scientists use the term resistome to refer to the collective antibiotic resistance genes of a microbial community. (infectioncontroltoday.com)
This study gives us a snapshot of antibiotic resistance genes at single points in different children's lives,' he says. (infectioncontroltoday.com)
Evidence for wastewaters as environments where mobile antibiotic resistance genes emerge. (janusinfo.se)

Biofilm development by C. neoformans followed a standard sequence of events: fungal surface attachment, microcolony formation, and matrix production. (who.int)
A spot enzyme-linked immunosorbent assay and light and confocal microscopy were used to investigate how antifungal drugs affected C. neoformans biofilm formation. (who.int)
Our results suggest that biofilm formation may diminish the efficacies of some antifungal drugs during cryptococcal infection. (who.int)
Poster presentation at International Technical Workshop on Biofilm Biology to Drug Development, SASTRA University. (tamu.edu)
The microbial cells growing in a biofilm are physiologically distinct from planktonic cells of the same organism, which, by contrast, are single cells that may float or swim in a liquid medium. (wikipedia.org)
Skander Hathroubi is a scientist, microbiologist and microbial biofilm researcher. (matters-of-activity.de)

Barring the arrival in the near future of new antimicrobial drugs that are effective against disparate organisms, we are left with imperfect tools to control drug resistance. (cdc.gov)
This so-called antibiotic-induced population heterogeneity is key to how organisms like Mtb develop antibiotic resistance. (seattlechildrens.org)
Instead of focusing either only on individual cultured organisms or computationally predicting functions from DNA sequences, researchers experimentally screen the DNA for specific functions, such as antibiotic resistance. (infectioncontroltoday.com)

Dantas' primary research interest is the ecology and evolution of antibiotic resistance. (infectioncontroltoday.com)

The development of hospital-acquired pneumonia (HAP) represents an imbalance between normal host defenses and the ability of microorganisms to colonize and then invade the lower respiratory tract. (medscape.com)

Sequencing is being used to identify reservoirs of antimicrobial-resistance genes in hospitals, other healthcare facilities, the community, and livestock farming, as well as common transmission pathways between them. (biomedcentral.com)
The genes they identified impaired the effectiveness of all but four of the drugs. (infectioncontroltoday.com)
Many of the resistance genes were found clustered on sections of DNA that can easily jump from one microbe to another. (infectioncontroltoday.com)
There were quite a few resistance genes in microbes from every child we looked at,' Dantas says. (infectioncontroltoday.com)
systematic review of epidemiologic data on birth defects in relation to folic acid intake and variation in the methylenetetrahydrofolate reductase ( MTHFR ) gene illustrates 'Mendelian randomization' ( 14 ), in which the effects of specific environmental exposures, such as dietary elements, drugs or toxins, are either accentuated or mitigated in persons with different variants of genes involved in physiologic response. (cdc.gov)

Microbial Therapeutic Products Market reach a valuation o. (pharmiweb.com)
Future Market Insights' (FMI) global microbial therapeutic products report provides an exhaustive yet unbiased analysis of future growth projections, taking into account the aforementioned developments to provide a bird's eye view of the landscape. (pharmiweb.com)
According to the study, demand for microbial therapeutic products is likely to grow at a steady clip, driven chiefly by growing incidence of antimicrobial resistance. (pharmiweb.com)
However, the microbial therapeutic products market has only stood to benefit from the pandemic crisis, as the global healthcare community accelerates efforts to find a potential cure for this deadly virus. (pharmiweb.com)
Prominent players operating in the global microbial therapeutic products market are emphasizing on acquiring regulatory approvals, forging partnerships and collaborations with competent authorities and biosimilars develop to capture substantial revenue shares across key regions. (pharmiweb.com)
Some reputed players operating within the global microbial therapeutic products landscape include Dr. Reddy's Laboratories, Pfizer Inc., Sanofi SA, Merck & Co. Inc., Novartis AG, Novo Nordisk A/S, Abbott Laboratories and Amgen Inc. to name a few. (pharmiweb.com)
Future Market Insights, in its new report, offers an unbiased analysis of the global microbial therapeutic products market, analyzing historical demand from 2015-2019 and forecast statistics for 2020-2030. (pharmiweb.com)
The book presents an introduction to iatrogenesis which is followed by chapter-wise descriptions of iatrogenic lesions (lesions due to adverse drug reactions, lesions occurring during diagnosis and consequences of various therapeutic interventions) of the organs and systems of the body. (benthamscience.com)
Research areas Through programs spanning genetics, biology, and therapeutic development, Broad researchers are making discoveries that drive biomedical science forward. (broadinstitute.org)

The CDC International Antibiotic-Resistant Gonorrhea Isolate Bank will provide complementary data to CDC's domestic specimens available through the Antibiotic Resistance Laboratory Network. (cdc.gov)
In response to the initial recommendations of the O'Neill review " Tackling a global health crisis: Initial steps " , the UK Government has launched the Fleming Fund to tackle the growing problem of drug-resistant infection. (hku.hk)
Thus, the plant may act as a potent antimicrobial drug against resistant strains. (biomedcentral.com)
Identifying novel antimicrobial agents from plant-based compounds may result in anti-microbial drugs effective against the resistant strains. (biomedcentral.com)
This will bring the greatest benefit to patients with multidrug-resistant and extensively drug-resistant TB (against which first- and second-line drugs are not effective), because conventional testing of second-line drugs is lengthy. (biomedcentral.com)
Background: The aim of this study was to assess the drivers of multidrug-resistant (MDR) bacterial infection development in coronavirus disease 2019 (COVID-19) and its impact on patient outcome. (c19hcq.org)
The choice of agent and dosing may vary based on local resistance rates (high rates of intermediate or resistant pneumococcus may require higher dosing of ampicillin to surmount the altered penicillin-binding protein that is the cause of resistant pneumococcus). (medscape.com)
Josh is a microbiologist interested in the ecological and evolutionary processes that drive the development and spread of antimicrobial-resistant superbugs. (broadinstitute.org)
Nanopore-only assemblies for genomic surveillance of the global priority drug-resistant pathogen, Klebsiella pneumoniae. (cdc.gov)
CRGNB isolates are usually extensively drug-resistant or pandrug-resistant, resulting in limited antimicrobial treatment options and high mortality. (bvsalud.org)

Hence, efforts are underway to accelerate research for discovering breakthroughs in microbial therapeutics. (pharmiweb.com)
Linder E, Wettermark B, Ovesjö ML, Sporrong SK, Ramström H. Knowledge support for environmental information on pharmaceuticals: experiences among Swedish Drug and Therapeutics Committees. (janusinfo.se)

Over the years, the burden of antimicrobial resistance (AMR) has been escalating tremendously, besides prevalence of chronic conditions. (pharmiweb.com)

As a first step, we strongly encourage aquaculture new animal drug sponsors to review CVM GFI #61: Special Considerations, Incentives, and Programs to Support the Approval of New Animal Drugs for Minor Uses and for Minor Species . (fda.gov)
CVM GFI #61: Special Considerations, Incentives, and Programs to Support the Approval of New Animal Drugs for Minor Uses and for Minor Species provides additional information for developing the Target Animal Safety and Effectiveness technical sections for aquaculture sponsors. (fda.gov)
These will limit resistance in non-target species and the resulting damage to human health. (sfi.ie)
Dantas' results, which must be confirmed through additional testing, suggest the resistome in the gut may become fixed more quickly than the distribution of species in the microbial community. (infectioncontroltoday.com)

Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. (cdc.gov)

The sensitivity of ODELAM allows us to detect different resistance states in individual clinical isolates. (seattlechildrens.org)
At its core, personalized medicine is about combining genetic information with clinical data to optimally tailor drugs and doses to meet the unique needs of an individual patient. (engineeringchallenges.org)
The current "gold standard" for testing a drug's worth and safety is the randomized controlled clinical trial -- a study that randomly assigns people to a new drug or to nothing at all, a placebo, to assess how the drug performs. (engineeringchallenges.org)
There are currently only three classes of antifungal drugs in clinical use and in an increasing number of cases, these antifungals fail. (ddw-online.com)
Sequencing also has a role in drug discovery pathways, the laboratory evaluation of lead compounds, and the clinical phases of drug evaluation. (biomedcentral.com)
Exploratory clinical studies have revealed shared patterns of gut microbiome dysregulation in this disease, with mechanistic animal studies providing evidence for active involvement of the gut microbiome in development and pathophysiology of HF. (stanford.edu)

The lack of new drug classes is a consequence of difficulties in discovery of new compounds that has persisted for many years. (cdc.gov)

Cyclic peptides, classified as antifungal peptides, have been in development as potential antifungal agents since 1948. (bepress.com)

A novel approach for combining the metagenome, metaresistome, metareplicome and causal inference to determine the microbes and their antibiotic resistance gene repertoire that contribute to dysbiosis. (cdc.gov)

In fiscal years 2016 through 2021, more than $52 million was awarded through the BAA to fight antimicrobial resistance. (cdc.gov)

La sensibilité de Staphylococcus aureus à l'oxacilline a diminué significativement, passant de 95,0 % entre 1999 et 2002 à 84,4 % en 2008. (who.int)

Atta-ur- Rahman, M. Iqbal Choudhary , " Frontiers in Anti-Infective Drug Discovery ", Bentham Science Publishers (2018). (benthamscience.com)

The economic cost of lost global production caused by antimicrobial resistance will amount to approximately $100 trillion between now and 2050 if it is not tackled. (sfi.ie)
Up to 10 million people could die annually by 2050 due to anti-microbial resistance (AMR), the UN Environment Programme (UNEP) said in a report launched in Bridgetown, Barbados, on Tuesday, highlighting the need to curtail pollution created by the pharmaceuticals, agricultural and healthcare sectors. (un.org)

The findings could help the development of more effective antifungal treatments. (ddw-online.com)

The development of specific chemotherapeutic agents has revolutionized the prognosis of tuberculosis and tuberculous infection, making tuberculosis truly curable and preventable. (cdc.gov)

It calls on the public, policy-makers, and health and agriculture professionals to act to reduce the spread and impact of antibiotic resistance. (who.int)
He is currently exploring the impact of antibiotic use on the human gut resistome and the acquisition of antibiotic resistance elements during international travel. (broadinstitute.org)

An exciting new direction of our lab aims to understand molecular determinants of red blood cell tropism exhibited by Plasmodium spp , with over-arching implications in parasitic adaptations, zoonosis and progressive drug resistance. (rgcb.res.in)
Studies on resistance to chloroquine by Plasmodium falciparum with potential application to the development of a modified in vitro susceptibility test / by Michael Davis Rogers. (who.int)

During the same period, almost half of Escherichia coli isolates developed resistance to cefotoxime. (who.int)

This trend is reflected in the absence of any novel class of antibacterial drug approved for use in the United States between 1968 and 2000. (cdc.gov)

The long-term effectiveness of most antibiotic treatments is restricted by both pathogen drug resistance and non-target effects on the host's commensal microbial community. (nature.com)
Hence, there are few new treatments in the pipeline to replace a growing number of ineffective drugs or problematic drug combinations. (lu.se)

Therefore, governments are lending unconditional support to the global healthcare fraternity in terms of policy relaxation and disbursement of financial grants to aid in the research and development process, catapulting growth prospects. (pharmiweb.com)
Dr. Helio Sader has primarily worked on national and global antimicrobial surveillance programs and new drug development. (element.com)
The environmental crisis of our time is also one of human rights and geopolitics - the antimicrobial resistance report published by UNEP today is yet another example of inequity, in that the AMR crisis is disproportionately affecting countries in the Global South ," said Prime Minister Mia Mottley of Barbados, who chairs a UN-backed initiative of world leaders and experts examining the issue. (un.org)
Health Assembly in resolution WHA68.7 in May 2015.1 This report summarizes progress to date in implementing the global action plan and all requests in the resolution except options for a global development and stewardship framework related to antimicrobial medicines, a report on which is submitted separately in document A69/24 Add.1. (who.int)
External guidance is provided by a Strategic Technical Advisory Group on antimicrobial resistance, and a high-level Steering Group and the Secretariat's Global Technical Coordinating Group provide further support for coordinating organizational actions. (who.int)
A public awareness survey was commissioned covering almost 10 000 people in 12 countries (two per WHO region).1 The findings confirmed the need to improve global public awareness and understanding of antibiotic resistance (for example, almost two thirds of those surveyed know antibiotic resistance is an issue that could affect them and their families but not how and not what they can do). (who.int)
The Regional Office for Africa (AFRO), WHO Geneva in collaboration with WHO Namibia and the Ministry of Health and Social Services conducted a training on Global Antimicrobial Resistance (AMR) and Use surveillance system (GLASS) and WHONET tool in Windhoek, for 12 selected member states. (who.int)

International researchers are gathering in Cork today to discuss the latest developments, particularly those focusing on mobilising the microbiome. (sfi.ie)

Microbial technologies often serve as the basis of fundamental research tools in molecular biology. (nyls.edu)

These numbers continue to increase due to development of resistance in microorganisms against the existing first line drugs. (biomedcentral.com)

Despite this availability, healthcare providers will have a long road ahead with respect to discovering an orally administered drug formulation. (pharmiweb.com)
The pharmaceutical, agricultural and healthcare sectors are key drivers of AMR development and spread in the environment, together with pollutants from poor sanitation, sewage and municipal waste systems. (un.org)
Major healthcare organizations in the United States and around the world are taking steps to overcome antibiotic resistance. (healthline.com)

The Fleming Fund will manage a total of£195 million (1.5 million HKD) of overseas development aid over the next five years to build laboratory capacity and surveillance networks inlow-and middle incomecountries, working with the Wellcome Trust, the Institut Pasteur International Network , the Bill and Melinda Gates Foundation and other organizations. (hku.hk)
For more than two decades, we've been performing surveillance studies for new drug development and post-marketing monitoring of approved drugs, and we continue to provide these critical services through the SENTRY Antimicrobial Surveillance Program . (element.com)
For more than two decades, we've been performing surveillance studies for new drug development and post-marketing monitoring of approved drugs. (element.com)

For new animal drugs used in food-producing animals, the human food safety evaluation ensures that the food derived from treated animals is safe for human consumption. (fda.gov)
CVM assesses the human food safety from the perspectives of microbial food safety, toxicology, and residue chemistry. (fda.gov)
The general principles for evaluating human food safety are described in GFI #3: General Principles for Evaluating the Human Food Safety of New Animal Drugs Used in Food Producing Animals . (fda.gov)
The latest insight and developments in plant and microbial science can have major impact on human health. (jic.ac.uk)
The impact of John Innes Centre science on the human health sector ranges from new drug and vaccine discovery, to fighting antimicrobial resistance and mitigating nutrition-related illnesses. (jic.ac.uk)
and changes in human behaviour such as intravenous drug use. (who.int)

Research from the Francis Crick Institute has revealed a key mechanism that increases tolerance to drugs amongst microbial communities. (ddw-online.com)

Anatomy8

Organisms22

Diseases14

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes76

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science5

Health Care6

Geographicals4

Pathogens15

Antibiotics23

Infections15

Bacteria12

Biofilms10

Emergence7

MICROBIOLOGY4

Infectious Diseases5

Diseases6

20171

Threat4

Mechanisms6

Genomics1

Antimicrobials2

Antibiotic resistance genes6

Biofilm6

Organisms3

Ecology1

Host defenses1

Genes5

Therapeutic9

Resistant10

Therapeutics2

Escalating tremend1

Species4

Genomic surveillance1

Clinical6

Compounds1

Peptides1

Microbes1

20211

Staphylococcus1

Anti-infective1

20502

Effective antifungal1

Infection1

Impact of antibiotic2

Plasmodium2

Isolates1

Novel class1

Treatments2

Global7

Microbiome1

Molecular Biology1

MICROORGANISMS1

Healthcare3

Surveillance3

Human6

Mechanism1