Development cell. Medical search. Frequent questions

The goal of the Initiative to Maximize Student Development (IMSD) program, 'Advancing the Culture of PhD Learning and Scholarship in Biology and Health Science', is to double the number of URM pre-doctoral students within the Division of Biology and Medicine over the next four years. (brown.edu)
Project ARISE is an NIH-funded professional development program for Rhode Island high school biology teachers. (brown.edu)
This Special Issue, "Plant Cell Wall Proteins and Development", will cover a selection of recent research topics in the field of cell wall biology focused on cell wall proteins and their roles during development. (mdpi.com)
The results, appearing in the latest issue of the Journal of Cell Biology , promise to open the door to new possibilities for drug development. (scienceblog.com)
The article, "Full characterization of GPCR monomer - dimer dynamic equilibrium by single molecule imaging" by Rinshi S. Kasai, Kenichi G. N. Suzuki, Eric R. Prossnitz, Ikuko Koyama-Honda, Chieko Nakada, Takahiro K. Fujiwara, and Akihiro Kusumi, was published online in the February 7, 2011 issue of the Journal of Cell Biology . (scienceblog.com)
Single-cell level characterization of embryonic development is a major benchmark of human developmental biology. (newswise.com)
Research areas Through programs spanning genetics, biology, and therapeutic development, Broad researchers are making discoveries that drive biomedical science forward. (broadinstitute.org)
Sarah Teichmann , co-chair of the HCA Organizing Committee and head of cellular genetics at the Wellcome Sanger Institute, said, "Our understanding of human development will be transformed by the HDCA project and could lead to significant advances in biology and medicine. (broadinstitute.org)
In the study, published recently in the journal ACS Chemical Biology , the scientists showed they could disrupt a specific interaction of a critical enzyme that would prevent cell death without harming other important enzyme functions. (medicalnewstoday.com)
Arguably, the most recognized and well-studied stromal populations in thymus biology are thymic epithelial cells (TEC) within the cortical and medullary areas, which are defined by their anatomical separation and function. (frontiersin.org)
The mission of the Molecular Cell Biology, Genetics and Development Track is to educate and train students to make paradigm-shifting discoveries in a diverse range of disciplines, including molecular biology, cell biology, genomics and quantitative biology, stem cells and developmental biology, cancer biology, and human disease modeling. (yale.edu)
In addition to MCGD having phenomenal administrative staff, the faculty are determined to provide a strong foundation in molecular cell biology and genetics by introducing us to the latest research and techniques in our core courses. (yale.edu)
Belong to the Research School in Stem Cell Biology at Lund Stem Cell Center, Lund University. (lu.se)
These findings have relevance for neurotoxicology, pediatrics, public health, risk assessment and retinal cell biology since they occurred at clinically relevant blood [Pb] and correspond with the ERG phenotype. (cdc.gov)

FDA is interested in obtaining patients' perspectives on the impact of sickle cell disease on daily life as well as the available therapies for sickle cell disease. (fda.gov)
MONT-SAINT-GUIBERT, Belgium--( BUSINESS WIRE )--Cellistic, a cell therapy platform provider that partners with therapeutic developers to ensure cell therapies can achieve their full potential, has announced today the world's first off-the-shelf, pre-built cell line and manufacturing platforms aimed at more economically accelerating the development and manufacturing of allogeneic cell therapies. (businesswire.com)
Our platforms enable cell therapies to be developed faster and in a much more affordable way. (businesswire.com)
We've made significant investments to build technology platforms with the mission of significantly reducing the time and providing high quality and reproduceable off-the shelf cell therapies to the market. (businesswire.com)
Cellistic's Pulse™ Cell Line and Echo™ Cell Therapy Manufacturing platforms are built on induced pluripotent stem cell (iPSC) technology which is the most robust and cost-effective way to build off-the-shelf allogeneic cell therapies. (businesswire.com)
This conference brought together leading regenerative medicine and advanced cellular therapy companies to share plans for and results from clinical trials that mainly use stem cell-based therapies to treat numerous diseases, ranging from oncology and cardiovascular to neurologic. (cryo-cell.com)
Gene and cell therapies have the potential to revolutionize the treatment of incurable diseases that are often debilitating, if not fatal. (labmanager.com)
Cell and gene therapies (CGT) have seen expansive clinical development and revenue growth over the past 5 years across various therapeutic areas. (pharmaceutical-technology.com)
In the decade since the first clinical trial, many CAR-T cell therapies have been approved for various subtypes of leukemia, lymphoma, and myeloma and autoimmune diseases such as lupus. (thedp.com)

The Core offers antibody development services for preclinical antibody research and investigation, using the same process involved in therapeutic mAb development. (labmanager.com)
Once they are considered a therapeutic lead, these mouse antibodies must be humanized (by genetic engineering) unless they are made in a humanized mouse, which allows more rapid progress to a potential drug stage," explains Dr. Thomas Moran, a professor of microbiology at the Icahn School of Medicine at Mount Sinai and the director of the Center for Therapeutic Antibody Development. (labmanager.com)
Scientists from the Florida campus of The Scripps Research Institute have uncovered a potentially important new therapeutic target that could prevent stress-related cell death, a characteristic of neurodegenerative diseases such as Parkinson's, as well as heart attack and stroke . (medicalnewstoday.com)
Notably, oncology is the leading therapeutic area, with the highest percentage of new clinical development year-on year compared to other CGT therapy areas, indicating a high level of unmet needs and increased industry investment in the space. (pharmaceutical-technology.com)
In the commercial setting, hiPSCs start as single cells and are expanded into a Master Cell Bank (MCB) to create a therapeutic cell population. (aicompanies.com)
When the therapeutic you're developing is cell-based, constant monitoring to optimize growth and ensure consistent culture conditions throughout multiple stages is critical for success. (aicompanies.com)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)

Here, we show that Cul3 is required during brain development to regulate neuronal migration and thus precisely assemble the cerebral cortex. (nature.com)
Altogether, our analysis highlights a pivotal role for Cul3 in brain development, identifies a new player of neuronal migration, and provides a proof of concept of CRISPR-mediated rescue of an ASD-linked genetic defect. (nature.com)
That migration, coupled with JNK activation, is associated with a number of serious health issues, including apoptosis or programmed cell death, liver damage, neuronal cell death, stroke and heart attack. (medicalnewstoday.com)
Richard Smith will discuss the importance of ionic flux in in utero neuronal development. (the-scientist.com)
2 We have also delivered molecules from nm-sized pipettes to the surface of neuronal cells to locally stimulate and study heat- and pain-sensitive receptors, 3 and delivered small molecular drugs to study receptors on heart cells 4,5 . (lu.se)
and increased neuronal, but not glial, cell fate. (cdc.gov)

cSTAR methodology used for separation of proliferation and differentiation signalling patterns in neuroblastoma cells. (ed.ac.uk)
Loss of GPR56 does not affect cell proliferation, migration, or neurite outgrowth. (jneurosci.org)
Consistent with this hypothesis, developing granule cells from the rostral region of Gpr56 −/− cerebella at birth exhibit a specific defect in cell adhesion to extracellular matrix (ECM) molecules of the pial basement membrane (BM) but no defects in migration, proliferation, or process outgrowth. (jneurosci.org)
Once a tissue sample is received, it is enzymatically digested, directly embedded into a 3D environment, and fed with growth factor and Wnt ligand-rich media that stimulates cancer cell proliferation and organoid formation. (corning.com)
This transition encompasses programmed shutoff of stem/progenitor genes, upregulation of T cell specification genes, proliferation, and ultimately commitment. (lu.se)
The levels are (1) a core gene regulatory network (GRN) architecture from transcription factor (TF) perturbation data, (2) a stochastically controlled chromatin-state gate, and (3) a single-cell proliferation model validated by experimental clonal growth and commitment kinetic assays. (lu.se)
Using RNA fluorescence in situ hybridization (FISH) measurements of genes encoding key TFs and measured bulk population dynamics, this single-cell model predicts state-switching kinetics validated by measured clonal proliferation and commitment times. (lu.se)
Low-level gestational lead exposure increases retinal progenitor cell proliferation and rod photoreceptor and bipolar cell neurogenesis in mice. (cdc.gov)
In vivo BrdU pulse-labeling and Ki67 labeling of isolated cells from developing mice showed that GLE increased and prolonged retinal progenitor cell proliferation. (cdc.gov)

In particular they looked at the role of two proteins and how these are able to impose rest periods (quiescence) on cells to ensure that developing B cells 'grow up' properly. (sciencedaily.com)
In mice, a 98% reduction of mature B cells was seen when the cells lacked these proteins. (sciencedaily.com)
Dr Alison Galloway, first author on the paper and postdoctoral researcher at the Babraham Institute, explained: "We found that the two proteins, RNA binding proteins ZFP36L1 and ZFP36L2, promote cell quiescence by blocking the RNA messages telling the cells to start dividing again. (sciencedaily.com)
Dr Martin Turner, senior author on the paper and Head of the Lymphocyte Signalling and Development research programme at the Institute, commented: "Although roles for transcription factors in establishing quiescence have been established, the contribution of sequence-specific RNA binding proteins was unknown. (sciencedaily.com)
Our findings shed light on the intricate control and coordination of the cell cycle and show that these binding proteins probably form part of a common mechanism to regulate quiescence, not just one specific to developing B cells. (sciencedaily.com)
They mainly comprise polymers like polysaccharides and lignin in lignified secondary walls and a minute amount of cell wall proteins (CWPs). (mdpi.com)
Cell wall proteomics, as well as numerous genetic or biochemical studies, have revealed the high diversity of CWPs, among which proteins acting on polysaccharides, proteases, oxido-reductases, lipid-related proteins and structural proteins. (mdpi.com)
It is estimated that a simple cell can contain as many as 42 million individual protein molecules belonging to more than 10,000 different kinds of proteins. (ed.ac.uk)
Despite the well-understood process of CUL3-mediated protein ubiquitination and degradation 12 , its target proteins in the developing central nervous system and its role in brain development remain utterly understudied. (nature.com)
Monoclonals can be used directly to bind to surface proteins on cancer cells to kill or inhibit their growth," explains Dr. Moran. (labmanager.com)
In this webinar brought to you by 10x Genomics, Richard Smith discusses how his team used single cell approaches to identify the contributions of ion-conducting proteins to human cerebral cortex development. (the-scientist.com)
KBI's approach is the best fit when selecting E. coli as the preferred host for expression of non-glycosylated proteins, including both soluble and insoluble product accumulation including downstream capture, host-cell impurity clearance, and, where necessary, controlled and scalable refolding. (kbibiopharma.com)
Exosomes are extracellular vesicles that carry cell-free cargo such as DNA, RNA, bioactive lipids, and proteins, thereby making them an attractive tool for diagnostic and drug development. (atcc.org)
It has been suggested that this process relies on Notch's ability to inhibit E proteins, which are crucial for early B-cell development. (lu.se)
We are currently developing these pipette-based techniques with the aim to use them to obtain fundamental knowledge about real biological problems such as how proteins interact and organize on the surface of cells and how different molecules interact locally with the cell membrane 6 . (lu.se)

Through a process known as directed differentiation, embryonic stem cells are turned into pancreatic cells in the laboratory. (ca.gov)
One of these is fate determination of the common lymphoid progenitor, promoting T-cell development at the expense of B-cell differentiation. (lu.se)
Early stages of B-cell differentiation can be identified by the status of the immunoglobulin genes and by the cell surface markers CD34, CD19, and surface immunoglobulin (sIg). (medscape.com)

Cryo-Cell was recently invited to attend a conference held in New York City sponsored by the Alliance for Regenerative Medicine. (cryo-cell.com)

June previously won the Dan David Prize for his work on the first United States Food and Drug Administration-approved personalized cellular therapy for cancer treatment and the $1 million Sanford Lorraine Cross Award for his work in cancer cell therapy in 2021. (thedp.com)

We are now accepting applications for a tenure-track Assistant Professor position in the division of Genetics, Genomics & Development. (berkeley.edu)

In addition, we identified a microRNA pathway that is modulated by Notch, and that is required for stabilizing muscle stem cells in their niche by regulating the migration capacity of the muscle stem cell. (kcl.ac.uk)
During embryonic development, the extracellular matrix (ECM) promotes the production of differentiated products by epithelial cells and the migration of mesenchymal cells, and probably also plays a role in epithelial-mesenchymal transformation. (nih.gov)
Here we examine the role of the cell skeleton (actin, microtubules, intermediate filaments) in mediating matrix effects on mesenchymal cell morphology, migration, and formation. (nih.gov)
Since the cortex seems to be anchored to the matrix, it is unlikely that it moves during cell migration. (nih.gov)
Furthermore, we found that Pls3 cell-autonomously regulates cell migration by regulating actin cytoskeleton organization, and its levels are inversely proportional to neural migration speed. (nature.com)
In particular, we found that Cul3 controls the abundance of Plastin 3 (Pls3), a novel player of neural cell migration, whose amount is inversely proportional to neural cell migration speed. (nature.com)
Finally, we found that CRISPR-mediated activation of Cul3 transcription fully rescues neural cell migration defects. (nature.com)
Cell-cell communication network analysis demonstrated that trophoblast-like tissues supplied WNT signaling in neural crest cells to facilitate maturation and migration. (newswise.com)
We developed a small peptide that intervenes in JNK migration and blocks those harmful effects - specifically cell death. (medicalnewstoday.com)
While adult lymphoid progenitor cells are produced by the bone marrow, their lineage commitment and development into mature T-cells is dependent on their migration into the thymus, where essential interactions with heterogeneous thymic stromal cells take place ( 1 ). (frontiersin.org)

During prenatal brain development, ion channels are ubiquitous across several cell types, including progenitor cells and migrating neurons, but their function has been unclear. (the-scientist.com)

Dec. 17, 2019 Gut cells that normally tell the brain and the rest of the body what's going on after a meal shut down completely for a few hours after a high-fat meal, a team of researchers discovered in zebrafish. (sciencedaily.com)

On February 7, 2014, FDA conducted a public meeting on Patient-Focused Drug Development for sickle cell disease. (fda.gov)

Today, microorganisms are considered as microbial cell factories or bioreﬁneries for the production of a wide range of valuable metabolites and products such as pharmaceuticals, nutraceuticals, cosmetics, agrochemicals, biofuels/bioenergy, fine and bulk biochemicals. (elsevier.com)
The book series Developments in Microbial Cell Factories: From Design to Commercial Production publishes the latest research findings and technological developments in the area of isolation and characterization of microbial strains, strain development and improvement, optimization bioprocesses and large-scale production of valuable products by prokaryotic and eukaryotic microorganisms such as archaea, bacteria, yeasts, fungi, microalgae, and protozoa. (elsevier.com)
Books in this series cover recent advances and future trends in microbial cell factories and provide an overview from design and improvement of microbial strains to commercial production of valuable products and allowing us to move towards a bio-based economy. (elsevier.com)
Ahead of upstream process development, KBI focuses on microfermentation screening for microbial cell line development (CLD) to yield consistent, high titers across strains and molecules. (kbibiopharma.com)

Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)
Further experiments revealed that bone marrow stromal cells produced TGF-β in response to dihydrotestosterone (DHT), and neutralization of TGF-β in the DHT-treated stromal cells reversed the suppressive effects. (jci.org)
Androgens only affected B cell development in chimeric mice with androgen-sensitive stromal cells. (jci.org)
These experiments suggest that effects of androgens on developing B cells are mediated through androgen receptors in bone marrow stromal cells. (jci.org)
These microenvironments are classically defined as distinct cortex and medulla regions that each contain specialized subsets of stromal cells. (frontiersin.org)
Significantly, there are additional non-epithelial stromal cells (NES) that exist alongside TEC within thymic microenvironments, including multiple subsets of mesenchymal and endothelial cells. (frontiersin.org)

The interaction of both epithelial cells and mesenchymal cells with ECM seems to involve the actin cortex, which is best developed in the base of the epithelial cell, where it attaches to underlying matrix via membrane-intercalated receptors. (nih.gov)
To interact with the matrix, the fibroblast has appropriate ECM receptors and an actin cortex around the whole cell. (nih.gov)
The work focuses on G protein-coupled receptors (GPCRs), a class of molecules in cell membranes that comprise the largest superfamily in the human genome. (scienceblog.com)

Master Cell Bank (MCB) generation, testing, and characterization are outsourced to established, qualified, and quality-audited third-party vendors. (kbibiopharma.com)

Notably, we found that Notch/RBPJ-bound regulatory elements are located adjacent to specific collagen genes in adult muscle stem cells, and investigated how extrinsic cues assure stem cell quiescence. (kcl.ac.uk)
This data will show which genes are switched on in each individual cell, and help explain vital processes in development. (broadinstitute.org)
Identifying key genes involved in human brain development provides novel insights into biological processes underlying the evolution of the human neocortex and the treatment of brain diseases. (the-scientist.com)
Genes required for B cell development. (medscape.com)

Indeed, granule cells from the rostral region of perinatal Gpr56 −/− cerebella show loss of adhesion to extracellular matrix molecules of the pial basement membrane. (jneurosci.org)
ATCC announced the first launch from a portfolio of exosomes ( i.e. , extracellular vesicles) derived from human cells to serve as reference materials or standards for a variety of research applications. (atcc.org)

We believe that Cellistic's iPSC platform-based approach unlocks the ability to significantly reduce development time and provides a reliable manufacture process at a scale in very cost effective terms. (businesswire.com)
We are already working with autologous and allogeneic cell therapy partners to build their next generation off-the-shelf iPSC-based product leveraging our platforms. (businesswire.com)
Under the alliance, the companies will develop and market up to four induced pluripotent stem cell (iPSC)-derived, engineered natural killer cell (iNK) and/or T cell (iT) programmes. (pharmaceutical-technology.com)
iPSC matrices to increase cell survival and outgrowth without coating plates. (aicompanies.com)

Researchers at the Institute took a deeper look into how B cells, the immune cells that make antibodies, progress through important developmental stages. (sciencedaily.com)
In an early study, they fused mouse myeloma and spleen cells from an immunized donor to produce cell lines that secreted anti-sheep red blood cell antibodies. (labmanager.com)
They] can work by recruiting immune elements, delivering toxins, producing CAR-T cells, or as bispecific antibodies that recruit T or NK cells to kill the cancer cells. (labmanager.com)

In addition, further understanding of the processes during human development will shed light on the processes of aging and how tissues repair themselves, which could lead to advances in regenerative medicine. (broadinstitute.org)

However, there are numerous uses for testing throughout any bioproduction workflow, and cell and gene therapy development will certainly benefit from additional exciting applications. (labmanager.com)
Achieving high transfection efficiency is critical for high viral titer yield, but it is common to see subpar transfection efficiencies in gene therapy development. (labmanager.com)
Access GlobalData's new whitepaper, Cell and Gene Therapy: Oncology Clinical Trial Trends in the United States to gain a better understanding of the developments, challenges and opportunities in CGT including exclusive insights on promising future oncology CGT assets in development. (pharmaceutical-technology.com)

In spite of being the focus of roughly half of modern drug development due to their key role in signaling across the membrane, until now it has not been well understood how GPCRs relay signals from the outside world into cells' interiors. (scienceblog.com)
The research team, funded in part by the Japan Science and Technology Agency (JST) and the Japanese education ministry MEXT, anticipates that their findings will have a broad impact on the further study of signal transduction in the cell membrane and conceptual and methodological development for drug discovery. (scienceblog.com)
The pancreatic cells are loaded into a delivery device, which is essentially a small envelope made with a semi-permeable membrane, not unlike a flat tea bag. (ca.gov)
Widespread commercialization of proton exchange membrane fuel cells remains curbed by various manufacturing and infrastructure challenges. (nist.gov)
One such technical barrier identified by the U. S. Department of Energy is the need for high-speed, in-line process control of platinum-based catalyst layers in the membrane electrode assembly of the fuel cell. (nist.gov)
Osmolality directly affects the movement of solutes across a membrane [5], making it a necessity during cell processing and any subsequent testing of injectable products. (labmanager.com)

In a series of studies, we investigated Notch as a key mediator of muscle stem cell stability and fate. (kcl.ac.uk)
To this end, researchers from University College Dublin, Yale University School of Medicine and the University of Edinburgh, teamed together to develop approaches integrating "omics"-type cell signalling and cell phenotype data for mapping cell states, modelling transitions between them and predicting targeted interventions to convert cell fate decisions. (ed.ac.uk)
The researchers, led by Boris Kholodenko from University College Dublin, presented cell state transition assessment and regulation (cSTAR) approach that uses "omics" data as input, classifies cell states, and develops a workflow that transforms the input data into mechanistic models that identify a core signalling network, which controls cell fate transitions by influencing cellular biochemical environment. (ed.ac.uk)
It offers a cell-specific, mechanistic approach to describe, understand and purposefully manipulate cell fate decisions. (ed.ac.uk)
Cortical epithelial cells (cTEC) support the earliest thymocyte progenitor populations, guiding them through the cortex, directing them to a T-cell lineage fate and ensuring their functional qualities as self-MHC restricted cells through the process of positive selection ( 2 ). (frontiersin.org)

Castration of normal male mice induces expansion of the bone marrow B cell population, an effect that can be reversed by androgen replacement. (jci.org)
The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
Several lines of evidence support the hypothesis that gonadal steroids exert effects on the development of B cells in bone marrow. (jci.org)
Androgens also exert effects on B cell development in bone marrow. (jci.org)

Trastuzumab (Herceptin), for example, targets the HER2 protein on the surface of breast and stomach cells. (labmanager.com)
Recently, they published an article in Science Translational Medicine about how CAR-T cells can target a protein on the surface of nearly all blood cancer cells named CD45. (thedp.com)

In this way, CIRM Accelerated Development Pathway designation of the project will substantially increase the probability that, and pace at which, this product concept becomes a real treatment available to the millions of patients in need. (ca.gov)

A finer detailed understanding of the genetic and molecular mechanisms underlying T-ALL is required identify patients at increased risk for treatment failure and the development of precision medicine strategies. (nih.gov)
We expect this fundamental research to deliver a wide range of important insights - from a better understanding of why miscarriages and genetic developmental disorders happen, through to understanding childhood cancers that have their root in development and the developmental pathways that cancer cells take advantage of in adults. (broadinstitute.org)
For example, exosomes from cancer cells may carry genetic biomarkers that could potentially be used to develop tests for the early detection of cancer. (atcc.org)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)

We develop students to be independent, imaginative and careful scientists, preparing our graduates to be the next generation of molecular cell biologists, geneticists, and developmental biologists in a broad array of science-related careers. (yale.edu)
Intrathymic development of committed progenitor (pro)-T cells from multipotent hematopoietic precursors offers an opportunity to dissect the molecular circuitry establishing cell identity in response to environmental signals. (lu.se)
Altogether our survey underlines the Hox dosage as a key mechanism for shaping Hox molecular function during development and evolution. (bvsalud.org)

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic neoplasm resulting from the malignant transformation of T-cell progenitors, and comprises ~15% and 25% of pediatric and adult ALL cases, respectively. (nih.gov)

cancer cell growth and spreading, it has also been proposed that GPR56 regulates cell adhesion, but this has remained untested in the nervous system. (jneurosci.org)

Cell media osmolality must be controlled to optimize and maintain cell growth and vector production. (labmanager.com)

The economic viability and the environmental impact of both the inert anode and its manufacturing process and the fuel cell application along their whole life cycle, will be monitored. (europa.eu)
Multiple sources have established the importance of osmolality when establishing cultivation conditions for stem cells to preserve optimal critical quality attributes (CQAs) like cell viability and productivity. (labmanager.com)
Ensure stem cells are at the highest viability and product quality levels throughout the entire cell therapy workflow from culture and processing all the way to fill and finish. (aicompanies.com)

Whether it is later used in flasks or bioreactors, media must meet pre-determined osmolality specifications to ensure optimal cell growth and expansion [6]. (labmanager.com)
Adding a simple osmolality measurement to the in-process parameters you measure is a quick and easy way to ensure optimal cell growth, during process development and manufacturing as well as during feed and media preparation. (aicompanies.com)

BMS will be in charge of the clinical development and marketing based on Century's co-promotion rights on specific programmes. (pharmaceutical-technology.com)
Century will oversee the discovery and preclinical works of the development candidate while BMS will handle clinical development and marketing based on co-promotion rights of Century on specific programmes. (pharmaceutical-technology.com)
Century Therapeutics CEO Lalo Flores said: "Bristol Myers Squibb is an ideal partner for us because they bring extensive clinical development and scientific expertise in cell therapy that will increase the probability of technical success of these programmes. (pharmaceutical-technology.com)

Like when we take a holiday, the cell can also pause and take a break after a cell division and this is what researchers call quiescence -- a reversible sedentary state. (sciencedaily.com)
The researchers showed that without these rest periods, B cells didn't survive to become functional immune cells. (sciencedaily.com)
This complexity likely represents the biggest challenge biomedical researchers face in trying to understand how our cells and bodies function. (ed.ac.uk)
Researchers from the global Human Cell Atlas (HCA) Consortium are taking the first steps toward using powerful single-cell genome analysis tools to understand early human development and how this can affect health or lead to disease. (broadinstitute.org)
Researchers at the Wellcome Sanger Institute and Newcastle University have collected genomic data from over 250,000 cells from a range of donated developing human tissues including liver, skin, kidney, and placenta. (broadinstitute.org)
Outside the UK, other HDCA projects are underway and researchers in Sweden are focusing on the development of the brain, lung, and heart, and on first trimester development. (broadinstitute.org)
The first two exosomes available to researchers are derived from the A549 non-small cell lung cancer (NSCLC) cell line and hTERT-immortalized mesenchymal stem cells. (atcc.org)
Since CD45 is not only found in blood cancer cells but also in healthy blood cells, the researchers had to use a method called "epitope editing" to overcome the healthy blood cells. (thedp.com)

Regulation of skeletal muscle stem cells during homeostasis and regeneration involves the interplay of extrinsic and intrinsic cues. (kcl.ac.uk)
Transient transfection of intracellular Notch1 (Notch1-IC) into a pre-B cell line resulted in the down-regulation of EBF-regulated promoters and diminished the capacity of EBF to activate these promoters in an epithelial cell line. (lu.se)

June, the Richard W. Vague Professor in Immunotherapy in the Perelman School of Medicine and director of the Center for Cellular Immunotherapies at Penn Medicine's Abramson Cancer Center, was awarded the prize for his work in creating and pioneering chimeric antigen receptor T cell immunotherapy, according to Penn Today. (thedp.com)

Optimal cell line development is crucial for successfully navigating clinical trials and diverse, challenging regulatory approval processes. (pharmaceuticalonline.com)

The mechanisms by which niche molecules and intrinsic factors regulate muscle stem cell quiescence and properties remain largely unknown. (kcl.ac.uk)
Many of the most important interactions in the human body take place between molecules on the surface of cells. (lu.se)
We are, for this purpose, developing different methods using nm- to µm-sized pipettes to locally manipulate and stimulate molecules on the surface of cells (see Fig. 1). (lu.se)
Combined with advanced fluorescence microscopy (single molecule, FRAP, TIRF) makes this a powerful method to study the properties and function of different molecules in cell membranes. (lu.se)

Furthermore this AGRAL cermet will be tested for two applications: aluminium electrolysis (for the manufacturing of an inert anode up to industrial scale) and for protection of interconnect plates in hydrogen and fuel cell application (up to pre-prototype scale). (europa.eu)
Then, the transfer to the fuel and hydrogen cell applications will be studied. (europa.eu)
A hydrogen fuel cell prototype undergoing testing as part of a joint GM - Army program. (thedetroitbureau.com)
The U.S. Army and General Motors Co. have teamed up on the development of hydrogen-powered fuel cell vehicles. (thedetroitbureau.com)
We believe hydrogen fuel cell technology holds tremendous potential to one day help reduce our dependence on petroleum and we are committed to building on our leadership through the continued development," said Charlie Freese, executive director of GM's global fuel cell engineering activities. (thedetroitbureau.com)
Toyota plans 300-mile range with new hydrogen fuel cell vehicle. (thedetroitbureau.com)
to expand their collaboration in the development of hydrogen fuel cell technology. (thedetroitbureau.com)
Through a new Cooperative Research and Development Agreement, GM and TARDEC will jointly test new hydrogen fuel cell-related materials and designs to evaluate their performance and durability before assembling them into full scale fuel cell propulsion systems. (thedetroitbureau.com)

While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
In this review, we cover how the non-epithelial compartment of thymic stroma represent essential cell populations in regulating thymus function. (frontiersin.org)
Remarkable progress in science and technology has led to the development of powerful tools for genome sequencing and editing increasing ability to study gene expression and function at multiple levels from cells to populations. (cdc.gov)

Even within a single tumour there are cells in different states, which often results in various degrees of aggressiveness and different sensitivity to therapeutics. (ed.ac.uk)
Bristol Myers Squibb (BMS) has signed a research partnership and licence agreement with Century Therapeutics for hematologic malignancies and solid tumour therapy development. (pharmaceutical-technology.com)

Once there, it amplifies the effects of reactive oxygen species that cause significant damage to the cell. (medicalnewstoday.com)
In addition, mTEC screen thymocytes for their expression of high affinity αβ-TCRs, with negative selection limiting the release of these reactive T-cells into the peripheral pool ( 4 ). (frontiersin.org)

Moreover, conditional inactivation of Dnmt3a in mouse hematopoietic cells leads to an accumulation of immature progenitors in the thymus, which are less apoptotic. (nih.gov)

The HDCA is one part of the ambitious Human Cell Atlas, a global consortium that aims to transform biological research and medicine by mapping every cell in the human body. (broadinstitute.org)
ATCC is a premier global biological materials and information resource and standards organization and the leading developer and supplier of authenticated cell lines, microorganisms, and associated data for academia, industry, and government. (atcc.org)

Once there is sufficient antibody titer in the serum, the spleen is removed to create hybridomas by fusing spleen cells with a cell line. (labmanager.com)

BTK is critical to the maturation of pre-B cells to differentiating mature B cells. (medscape.com)

Cell therapy development workflows are time consuming and often present challenges to auditing and quality control. (aicompanies.com)

Moreover, the delivery device has been shown to protect cells from a recipient's immune system. (ca.gov)
Other primary areas of focus for the HDCA include an improved understanding of how blood cells form and how the immune system functions. (broadinstitute.org)
The production of a diverse αβ-T-cell pool is vital to establishing and maintaining a functional adaptive immune system. (frontiersin.org)
The other current release, exosomes from hTERT-immortalized mesenchymal stem cells, could potentially be used in several different applications, including research in drug delivery, wound healing, and immune stimulation. (atcc.org)

We established the human embryonic organoid (HEMO) from expanded potential stem cells and achieved both embryonic and extraembryonic tissues in the same organoid. (newswise.com)
It is made of cells or tissues that perform a specific function. (cdc.gov)

In addition to intrathymic selection, and during this medullary residency period, CD4 + and CD8 + single positive (CD4SP, CD8SP) thymocytes acquire the ability to proliferate in response to TCR stimulation, and undergo licensing for cytokine production, prior to exiting the thymus to join the peripheral T-cell pool as Recent Thymus Emigrants (RTE) ( 5 , 6 ). (frontiersin.org)

The Cell Project at IBM Research Optimizing Compiler for a CELL Processor Using advanced compiler technology to exploit the performance of the Cell Broadband Engine architecture Compiler Technology for Scalable Architectures "An Open Source Environment for Cell Broadband Engine System Software" (PDF). (wikipedia.org)
IBM Research Project - Compiler Technology for Scalable Architectures IBM Systems Journal - Using advanced compiler technology to exploit the performance of the Cell Broadband Engine architecture, 2017-10-23, archived from the original on 2006-04-11 IBM's Octopiler, or, why the PS3 is running late, ArsTechnica, 2006-02-26 "Synergistic Processing in Cell's Multicore Architecture" (PDF). (wikipedia.org)
New research describes a new mechanism through which B cells ensure that they rest up between intensive developmental events. (sciencedaily.com)
Kyoto, Japan - Unprecedented single molecule imaging movies of living cell membranes, taken by a research team based at Kyoto University and the University of New Mexico, have clarified a decades-old enigma surrounding receptor molecule behaviors. (scienceblog.com)
The Institute for Integrated Cell-Material Sciences (iCeMS) at Kyoto University in Japan aims to advance the integration of cell and material sciences - both of which are traditionally strong fields for the university - by creating a uniquely innovative global research environment. (scienceblog.com)
Funded by Wellcome and the MRC, this well-established tissue bank provides vital materials to enable research into understanding human development to help improve health. (broadinstitute.org)
Extensive research on thymic epithelial cells (TEC) within the cortex and medulla has defined their essential roles during T-cell development. (frontiersin.org)
Selected cell line(s) generate Research Cell Banks (RCBs) that are the foundation for further development and scale-up. (kbibiopharma.com)
The research and development phase of cell therapy is critical. (aicompanies.com)
The U.S. Department of Defense has been a major source of financing for research and development in alternative powertrains over the past two decades because military planners believe electric vehicles offer more flexibility and utility in a hostile environment. (thedetroitbureau.com)
GM, Honda form new fuel cell research alliance. (thedetroitbureau.com)
Under the new program GM will team up with the U.S. Army Tank and Automotive Research and Development Center, or TARDEC, in Warren, Mi. (thedetroitbureau.com)
The Research School's Professional Development Program is a one-year complementary educational program that brings together PhD students from diverse laboratories at Lund Stem Cell Center. (lu.se)
The program aims tie into the Research School's overall mission to shape an excellent, inclusive, and collaborative training and research environment at Lund Stem Cell Center. (lu.se)
Build a research community to support connection with your fellow PhD students at Lund Stem Cell Center. (lu.se)
related research and developments should therefore be carefully monitored and assessed, and the rights and dignity of patients respected. (who.int)

Here, we defined the single-cell spatiotemporal gene expression landscape of human embryonic development with stem-cell-derived organoids. (newswise.com)
Overall, our study advances the spatiotemporal analysis of human embryonic development in stem-cell-derived organoids. (newswise.com)
Organoids are cultured from stem cells within a 3D medium to provide a more physiologically relevant and realistic view of cellular interactions than can be seen with traditional 2D models. (corning.com)
Organoids are promising tools for use in precision medicine, particularly for the development of individualized treatments. (corning.com)

When epithelial cells transform into mesenchyme in the embryo, or when they are induced to do this in vitro, they switch from the keratin intermediate filament profile to one rich in vimentin, and the effect of cell matrix interaction on cell shape is profoundly altered. (nih.gov)
In early experiments, physical separation of mesenchymal and epithelial stroma from embryonic murine thymus resulted in defective thymus development when epithelium was cultured in vitro in the absence of mesenchyme ( 7 ). (frontiersin.org)

Given the market need and the clear feasibility, the product could become the most significant stem cell-based medical treatment of the coming decade, and that will be a tremendous achievement for California, its taxpayers, and CIRM. (ca.gov)

Biology14

Therapies9

Therapeutic7

Neuronal6

Proliferation9

Proteins15

Differentiation3

Cryo-Cell1

20211

Genomics1

Migration10

Progenitor cells1

20191

Sickle cell di1

Microbial cell4

Stromal cells6

Receptors3

Characterization1

Genes4

Extracellular2

IPSC4

Antibodies3

Regenerative Medicine1

Gene Therapy3

Membrane6

Fate5

Bone marrow4

Protein2

Pathway1

Genetic4

Molecular3

Acute lymphobl1

Regulates cell1

Controlled to optimize1

Viability3

Ensure optimal cell growth2

Clinical Development3

Researchers8

Regulation2

Chimeric1

Optimal1

Molecules4

Hydrogen8

Populations3

Tumour2

Reactive2

Hematopoietic1

Biological2

Spleen1

Maturation1

Therapy Development1

Immune4

Tissues2

Intrathymic1

Research16

Organoids4

Mesenchyme2

Stem cell-based1