Detect biological toxicity biological assay. Medical search. Frequent questions

The composition of volatile oil of safflower dried flowers was analyzed by gas chromatography-mass spectrophotometry with flame ionization detector (GC-FID) and in vitro sensitivity assays were performed to assess biological activity. (techscience.com)
With current in vitro screening assays now representing a $1.4B market with a predicted 12% annual growth rate, we believe we possess a product capable of significantly impacting the chemical/drug screening market and, here in particular, advancing our understanding of cytotoxic chemical biotransformations as they pertain to public health and consumer safety. (inknowvation.com)
This review focuses on the differential responses of cell types to ATZ toxicity, testicular effects of ATZ in both in vitro and in vivo models and chemopreventive strategies, so as to highlight the current state of the art on the toxicological outcomes of ATZ exposure in several experimental model systems. (frontiersin.org)
The integrative approach of the ToxTracker assay provides a powerful tool for in vitro carcinogenic hazard identification of chemicals by unveiling activation of specific cellular signalling pathways upon exposure and deliver insight into the underlying mechanism of toxicity. (toxys.com)
We evaluated the improved in vitro toxicity screening by combining the mechanistic ToxTracker and MiToxView platforms. (toxys.com)
Toxys is a Dutch biotech company that provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases of product and drug development. (toxys.com)

Then the Safflower ointment was manufactured and its acute toxicity study on rats was tested. (techscience.com)
The prepared ointment had an excellent acute toxicity safety profile. (techscience.com)
Greater understanding of biological disease factors in acute myeloid leukemia (AML) has led to more effective and personalized treatment options. (ascopost.com)
In a retrospective study reported in the Journal of Clinical Oncology, Hodder et al found that blinatumomab was effective as a toxicity-sparing alternative to first-line intensive chemotherapy in children and young persons with B-cell acute lymphoblastic leukemia (ALL) who were. (ascopost.com)
A novel assay may be effective at detecting a unique molecular marker in patients with acute myeloid leukemia (AML), according to a recent study published by Young et al in The Journal of Molecular Diagnostics. (ascopost.com)
1960). TOXICOLOGICAL STUDIES Special studies on the metabolites A summary of the results of acute toxicity studies on vamidothion sulfoxide is shown in Table 1. (inchem.org)

However, most existing technologies for assay of cellular lipids possess poor sensitivity and require large sample volumes making them unsuitable for the assay of mammalian cells which are 1 pL in volume and may possess as little as 10-20 moles of key regulatory lipids. (selectbiosciences.com)
PAPG is commonly used as a substrate for beta-galactosidase activity assays in bacterial and mammalian cell cultures. (chemsynlab.com)
The ToxTracker assay is a mammalian stem cell-based assay that detects activation of specific cellular signalling pathways as the result of biological reactivity of the tested compounds. (toxys.com)
ToxTracker is a mammalian stem cell-based GFP reporter assay that discriminates between induction of DNA damage, oxidative stress, protein damage and general cytotoxicity. (toxys.com)
With some notable and important exceptions, the biological factors affecting the capacity of chemical substances to cause toxicity are broadly similar across mammalian species. (nationalacademies.org)

This results in differing cytotoxic responses that are influenced by the nature of target cells, assay types and concentrations of ATZ. (frontiersin.org)
SPS was added to the culture medium at various concentrations in time-of-addition assay. (molvis.org)
Thus far, this biosensor has shown success in detecting relatively low concentrations of cisplatin-altered DNA. (willamette.edu)

Biomarkers were examined at different levels of biological organization: biochemical markers of defense and damage, biomarkers of genotoxicity (comet assay), and behavioral biomarkers (feeding and burrowing). (inrae.fr)
Mechanistic toxicity profiling of chemicals and nanomaterials by combining the ToxTracker genotoxicity assay and MiToxView mitochondrial toxicity platform. (toxys.com)
كازينو كبار الشخصيات The primary uses of transgenic mouse models in toxicology have mainly been to screen for genotoxicity and carcinogenicity and to understand the mechanisms of toxicity. (tigertox.com)

Yet, it is critical for the mechanisms of toxicity to be understood to accurately assess MST as a therapeutic agent. (uw.edu)

The Mouse Lymphoma Assay was considered to be valid and to reflect the real potential of the test material to cause mutations in the cultured mouse cells used in this study. (europa.eu)

Supplement to documentation of the threshold limit values and biological exposure indices. (cdc.gov)
Biological monitoring can be used to confirm heavy exposure, to follow the progress of recovery, or to assist in return to work decisions. (cdc.gov)
The limitations of biological monitoring were discussed, including problems in establishing baseline levels of enzyme activity, AChE activities not having decreased to steady state values before symptoms of organophosphate poisoning develop, and the inability of AChE monitoring to effectively detect exposure to some ChE inhibiting agents such as carbamates. (cdc.gov)
The DR-CALUX assay uses genetically modified animal cells to detect, specifically and quantitatively, toxicity caused by exposure to dioxin and dioxin-like PCBs in a wide range of matrices, including food. (safefood.net)
The present findings show that Monocrotophos pesticide on exposure to epigeic earthworm species causes significant reproductive toxicity and histopathological abnormalities and these changes could be used as a tool in environmental risk assessment of pesticides. (gmsl.lk)
Exposure to a potential fetal health hazard can be estimated through ecological assessment (e.g., testing the community water supply), questionnaires (e.g., classifying residents accord- ing to whether they drink bottled or tap water), or biological markers (e.g., testing for exposures to chemicals or solvents found in tap water). (cdc.gov)
In this example, a biological exposure marker (blood lead-level) was available for classifying mothers according to their exposure to lead. (cdc.gov)
This indication assumes greatest importance when the route of exposure is oral, the formulation tested is identical or highly similar to that consumed by humans, and more than one species show the same or similar toxicity. (nationalacademies.org)
Information about animal exposure to dietary supplement ingredients may be in the form of formal studies such as traditional toxicity studies, safety pharmacology data, or observations from clinical veterinary medicine. (nationalacademies.org)
In addition, an overproduction of H 2 O 2 by the bivalves was detected following exposure to CBZ but nitrite levels remained unchanged. (scielo.br)

However, oxidative stress could play salient role in the observed cellular and genetic toxicity and apoptosis-like effects which could be abrogated by antioxidant vitamins and flavonoids, including vitamin E, quercetin, kolaviron, myricetin and bioactive extractives with antioxidant effects. (frontiersin.org)
Comprehensive molecular, cellular and systemic-level assays all support a high level of selectivity. (nature.com)
We do so by demonstrating selectivity across comprehensive molecular, cellular, and systemic assays. (nature.com)
Together, our data suggest that integration of a cellular signalling reporter assay with a functional mitochondrial toxicity system could be a valuable platform for reliable identification of the hazardous properties and the mechanism of action of new compounds and nanomaterials. (toxys.com)
Conclusion: Prion protein 106-126 peptide can induce apoptosis in differentiated PC12 cells and present cellular toxicity definitely. (researchgate.net)
It might be a perfect model to study the cellular toxicity of prion protein. (researchgate.net)

Through a combination of structure-based virtual and high-throughput screening, we assayed more than 10,000 compounds-including approved drugs, drug candidates in clinical trials and other pharmacologically active compounds-as inhibitors of M pro . (nature.com)
To characterize the enzymatic activity of SARS-CoV-2 M pro and to carry out high-throughput screening of inhibitors, we developed a fluorescence resonance energy transfer assay. (nature.com)

Pesticides can be classified based upon their biological mechanism function or application method. (wikipedia.org)
The mechanism of organophosphate toxicity in humans was summarized. (cdc.gov)
The mechanism(s) of DUX4 toxicity in muscle is incompletely understood. (elifesciences.org)
Toxicity may also be either mechanism-related, or not mechanism related , which provides a very different context - eg early anti-cancer drugs with unspecific cytotoxicity could easily assumed to have mechanism-related toxic effects. (drugdiscovery.net)
However, the non-mechanism related toxicities are more difficult to anticipate, since one doesn't initially know what to look for. (drugdiscovery.net)
Experiments including photography of fluorescence in HSV-1g or plaque formation by HSV-1f, western blot assays, real-time RT-PCR assays, cytopathic effect inhibition assays, cytotoxicity assays, and viral absorption and penetration assays were performed to explore the antiviral effect and mechanism of the compounds. (molvis.org)

Iron levels were detected by immunofluorescence staining and colorimetric assays. (stanfordchildrens.org)
Attempts were made to characterize its substrate specificity using an indirect colorimetric assay. (willamette.edu)

8 known and 3 unknown compounds were detected in the extract (Fig. 1). (techscience.com)
Competitive labeling/enrichment assays combined with MS have identified several serine or cysteine enzymes in lipid and cell wall metabolism as putative targets of these CyC compounds. (inrae.fr)
These compounds were not detected in sample R because of poor water solubility. (scirp.org)
One of these compounds (ebselen) also exhibited promising antiviral activity in cell-based assays. (nature.com)
Various tested DILI compounds that induced mitochondrial toxicity in MiToxView activated the oxidative stress or unfolded protein response in the ToxTracker platform. (toxys.com)
Interest has grown in natural compounds for the development of anticancer drugs, due to their low toxicity and higher tolerance in patients ( 6 ). (spandidos-publications.com)

In the present study, the reproductive toxicity and histopathological effects of Monocrotophos pesticide on an exotic epigeic Eudrilus eugeniae and an indigenous epigeic Perionyx barotensis earthworm were studied. (gmsl.lk)
Introduction The research of Hatch (1) has greatly increased our understand- ing of the use and potential limitations of biological markers for adverse reproductive effects. (cdc.gov)
Animal studies are especially useful in detecting effects of chronic exposures and effects on reproductive and developmental processes because epidemiological methods of studying humans are especially problematic in these areas. (nationalacademies.org)

Statistical differences were not supported by any results above the GEF with the exception of one concentration in Assay 2 without metabolic activation, however in this case excessive cytotoxicity was observed, thus the result would not be considered positive. (europa.eu)
The ethanolic extracts of the plant were examined for the presence of bioactive components and their total flavonoid content, with focusing on quercetin detection using thin layer bioautography (TLB) and brine shrimp lethality assay (BSLA) for cytotoxicity. (who.int)

Both of those aspects seem superficially mirror images of each other, but far from it - efficacy is the presence of one desirable property , of which there may be one or more which are leading to the desired effect, such as up- or downregulating a particular biological pathway (or many other things). (drugdiscovery.net)
The 'target' of a drug may be also related to efficacy at the same time (' on-target related toxicity '), or it may be an ' off'-target related toxicity , but in any case there is some link assumed to be present between ligand activity against a protein, and a toxic effect of the compound. (drugdiscovery.net)
The WHO Expert Committee on Biological Standardization reviews developments in the field of biological substances, which include vaccines, blood products and biological therapeutics, and recommends procedures to assure their quality, safety and efficacy, including the establishment of international reference materials. (who.int)
In particular, the biological assay of potency recommended in 1991 had been shown not to correlate with the efficacy of the vaccine in infants, nor to provide a sensitive indicator of vaccine quality. (who.int)

These findings suggest quantitative considerations for building scientific confidence in NAM-based systemic toxicity predictions. (nih.gov)

Immunohistochemical, ELISA, and qRT-PCR assays were performed to detect the expressions of targets associated with SS. (hindawi.com)

Besides to the direct effects of the CO 2 -associated pH decrease, the possible effects on marine sediment toxicity were studied by exposing the urchin larvae to elutriate of sediments with different metals concentration, which were subjected to various pH treatments. (news-oceanacidification-icc.org)

Confirmation of Phenotypes of Tester Strains: The phenotypes of the tester strains used in the bacterial reverse mutation assays with regard to membrane permeability (rfa), UV sensitivity (uvrA and uvrB), ampicillin resistance (amp), as well as spontaneous mutation frequencies are checked regularly according to Ames et al. (europa.eu)

When cells were loaded with a fluorescent sphingosine, the conversion of sphingosine to S1P was also detected and the reaction blocked by sphingosine kinase inhibitors. (selectbiosciences.com)
KBU2046 binds chaperone heterocomplexes, selectively alters binding of client proteins that regulate motility, and lacks all the hallmarks of classical chaperone inhibitors, including toxicity. (nature.com)

How do you predict an unknown mode of toxicity that you haven't seen before? (drugdiscovery.net)
Animal studies are powerful because controlled studies can be conducted to predict effects that might not be detected from customary use by humans until they result in overt harmful effects. (nationalacademies.org)

Importantly, viral absorption and penetration assays showed that the relative fluorescence intensity of HSV-1g was significantly reduced by SPS in a dose-dependent manner in the absorption test, but no change was observed in the penetration test. (molvis.org)

Studies have indicated that the toxicity of organophosphates is due primarily to inhibition of AChE at nerve synapses as a result of a reaction with a serine residue at the AChE catalytic center. (cdc.gov)

الرهانات Use of a short-term transgenic mouse assay in combination with a two-year rat chronic study could eliminate the occurrence of false negatives and increase the overall accuracy of detecting carcinogens and non-carcinogens. (tigertox.com)
الكازينو Additional bonuses for use of transgenic assays include reduced duration, conservative use of animals, and decreased cost relative to a traditional two-year rodent chronic toxicity study. (tigertox.com)
If omics-based assays were applied with appropriate study designs, thorough validation of the markers, and careful interpretation of study results then a bioinformatics database could be built of the human response to different chemical exposures and associated chronic diseases. (who.int)

Concerning other biomarkers of defense (superoxide dismutase, lactate dehydrogenase, laccase) and damage (thiobarbituric acid reactive substances, acetylcholinesterase, acid phosphatase), no significant effects were detected. (inrae.fr)
Our research aims to determine whether exosomes provides a vehicle for brain biomarkers to travel through the BBB where they can be detected in the blood. (edu.au)

Nerve agents were formally banned by the Chemical Weapons Convention in 1997, but their illicit use has been detected as recently as 2018. (llnl.gov)

Along with these benefits, pesticides also have drawbacks, such as potential toxicity to humans and other species. (wikipedia.org)
Unless there is scientific evidence that raises significant doubt regarding the relevance of specific toxicity findings to humans, it is prudent and scientifically appropriate to consider animal studies relevant in evaluating potential human toxicity, especially in the many cases of dietary supplement ingredients where sufficient human data are not available. (nationalacademies.org)

Endometrium-derived epithelial cells (Ishikawa) showed no response to the natural compound by using a cell viability assay (MTT). (nutrimedical.com)
Cell viability was determined by using the MTT assay and the morphological changes were observed. (researchgate.net)

A trial on the quantitative risk assessment of man-made mineral fibers by the rat intraperitoneal administration assay using the JFM standard fibrous samples. (cdc.gov)
With the increasing production of new chemicals for a wide range of applications in health care, food and as cosmetics, the demand for rapid and reliable toxicity assessment is growing. (toxys.com)

There was also no detected association with variability for any of the 10 physicochemical properties examined. (nih.gov)
New assays and biotechnologies, including physicochemical techniques, are also evaluated by the Expert Committee, as appropriate, through collaborative laboratory studies. (who.int)

The primary reasons for the preferment of the LLNA are the animal welfare benefits it provides compared with traditional guinea-pig methods (refinement and reduction of animal usage) and the general performance characteristics of the assay with regard to overall reliability, accuracy, and interpretation. (cdc.gov)

Procedure for Growing Cultures: The frozen bacterial cultures were thawed at room temperature and 200 μL inoculum were used to inoculate each 50 mL of Nutrient Broth No.2 for the overnight cultures in the assay. (europa.eu)

The new findings may revolutionize the way AML is detected and treated. (ascopost.com)

For many regulatory authorities, the local lymph node assay (LLNA) is the preferred assay for the predictive identification of skin-sensitizing chemicals. (cdc.gov)
We did so by considering that small chemicals have potent biological properties, that single atom changes in their structure can affect those properties, that chemical structure can be modulated, and that as such they constitute highly refined biological probes. (nature.com)

In general, a pesticide is a chemical (such as carbamate) or biological agent (such as a virus, bacterium, or fungus) that deters, incapacitates, kills, or otherwise discourages pests. (wikipedia.org)
The U.S. national civilian vulnerability to the deliberate use of biological and chemical agents has been highlighted by recognition of substantial biological weapons development programs and arsenals in foreign countries, attempts to acquire or possess biological agents by militants, and high-profile terrorist attacks. (cdc.gov)
NICEATM and NC3Rs are partnering with the National Institute of Allergy and Infectious Diseases, the U.S. Army Combat Capabilities Development Command Chemical Biological Center, and NCATS to direct the MPS for COVID Research (MPSCoRe) working group. (nih.gov)
The chemical character of the CB particle surface mediates its biological reactivity [ 857 ]. (nanomedicine.com)
4-Aminophenyl β-D-galactopyranoside is a chemical compound that is used in biological research to study inflammatory diseases. (chemsynlab.com)

It is commonly used as a substrate for beta-galactosidase activity assays and as a model compound for studying carbohydrate-protein interactions. (chemsynlab.com)
PAPG is commonly used as a substrate for beta-galactosidase activity assays, which are essential for many applications in biochemistry research. (chemsynlab.com)

It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. (cdc.gov)
Also, comprehensive pharmacokinetic and toxicity studies further support therapeutic potential. (nature.com)
Whether such staining actually correlates with organ toxicity is still regularly debated, but TCR studies remain a requirement in the data package for an IND/CTA submission for most biotherapeutics. (genengnews.com)
Selection of suitable positive control material is crucially important for TCR protocol development, as well as for use in GLP studies, to validate the test item in all of the assay runs-which are likely to be numerous. (genengnews.com)
Earthworms are an ideal biological model in toxicity assays and environmental monitoring studies. (gmsl.lk)
However, with an adeq battery of necf expsre blmarkers, prospective studies of en- vironmental effects on pregnancy outcomes might be possible. (cdc.gov)
Because dietary supplements are not required to undergo formal animal toxicity testing before marketing, extensive toxicity studies common to drugs and other substances are not likely to exist, but limited amounts of animal data are available in the scientific literature for a number of dietary supplement ingredients. (nationalacademies.org)
Further studies are needed now for more exploration of the toxicity of CBZ since it could be bioaccumulable throughout the food web and may affect non-target organisms. (scielo.br)

It mainly acts on biological processes such as inflammatory response, chemokine metabolic process, and immune response as well as pathways such as FoxO signaling pathway, Yersinia infection, HIF-1 signaling pathway, and TNF signaling pathway. (hindawi.com)
Use of these models enhances understanding of the role that specific genes play in biological pathways. (tigertox.com)

A membrane receptor reagent and assay is disclosed in which liposomes are bound to an evanescent wave emitting surface. (google.com)

Since a favorable dataset for a TCR study is a negative result, it is very important to know that the assay is specific and robust before the test tissues are examined. (genengnews.com)
While biotinylation is a well-established and relatively straightforward technique for labeling biological molecules, FITC may be preferable in a TCR study as it avoids the need for additional avidin-biotin blocking steps in the assay protocol, without which background staining of tissue is likely to prove problematic. (genengnews.com)
Under the conditions of the study, treatment with the test material did result in a statistically significant and biologically relevant, dose dependent increase in the mutation frequency in the presence of a rat metabolic activation system (S9 fraction) in Assay 1, the observed effect was repeatable within or between assays. (europa.eu)
In the biological sciences the suffix -omics is used to refer to the study of large sets of biological molecules. (who.int)
The blood-based test for ctDNA "can detect tumor DNA in circulation and thus identify even a microscopic cancer that would not be found by other conventional modalities like endoscopy or radiographic imaging," Apaar Dadlani, MBBS, who was an internal medicine resident at the University of Louisville in Kentucky at the time of the study, told Medscape Medical News . (medscape.com)
The study included six patients with stage III colorectal cancer with negative ctDNA and imaging results who had significant postoperative complications or were otherwise considered high risk for severe treatment toxicity. (medscape.com)

Fluorescent probes have detected cell death in pesticide treated earthworms when compared to the control group after 45 days. (gmsl.lk)

This assay detects dioxins based on their specific biological activity towards genetically modified living cells through light generation from the recombinant cells. (safefood.net)
One assay [ 769 ] of ultrafine CB found 19 ppm Fe, 11 ppm Zn, 3.5 ppm Cr, 1.9 ppm Pb, 0.8 ppm Cu, 0.02 ppm Be, and even 0.0039 ppm Tl, all of which may enhance the biological activity of these particles. (nanomedicine.com)
The use of international reference materials for designating the activity of biological substances used in prophylaxis or therapy, or for ensuring the reliability of diagnostic procedures, allows comparability of data globally. (who.int)
this may not have been detected as a metabolite in animals because of the low activity of 32 p incorporated into the vamidothion (Morikawa and Saito, 1969). (inchem.org)
Enzyme activity was assayed using Cl- and SCN- as the substrates. (willamette.edu)
Unfortunately, no activity was detected possibly due to imidazole being a reducer inhibiting the assay reaction. (willamette.edu)
SOR), hydrogen peroxide, and 2, 2-Diphenyl-2-picrylhydrazyl (DPPH) radical activity by a model (most biological y active) of the anticancer plant was also evaluated. (who.int)

It is also used as an immunochemical assay for the diagnosis of inflammatory bowel disease. (chemsynlab.com)

Their toxicities vary greatly, but they have been phased out because of their persistence and potential to bioaccumulate. (wikipedia.org)
Essentially, the presence of therapeutic antibody binding in frozen ex vivo tissues is used to give an indication of potential organ toxicity in vivo . (genengnews.com)
However, the potential use of anthrax as a biological weapon has increased fear of this pathogen. (msdmanuals.com)

Environmental and biological monitoring of organophosphate and carbamate exposures was discussed. (cdc.gov)

Differences in the biological effects of crocidolite asbestos and two glass fibres on epithelial lung cells. (cdc.gov)
the observed effects in invertebrates exposed to CuO NPs were mainly attributed to the toxicity of nanoparticulate rather than dissolved Cu toxicity. (inrae.fr)
To investigate and compare the biological effects of γ-Fe 2 O 3 nanoparticle (NP) and gadolinium dimeglumine (Gd-DTPA) with high and multiple doses on the kidney of healthy mice. (dovepress.com)
The biological effects of γ-Fe 2 O 3 NP and Gd-DTPA on the kidney were obtained using a biochemical automatic analyzer and multiple proinflammatory factor kit on the serum. (dovepress.com)
The effects of the CO 2 -related acidification, associated with unpredictable leaks of CO 2 during the operational phases were studied using the Paracentrotus lividus sea urchin-liquid-phase-assays (fertilisation and embryo-larval development tests). (news-oceanacidification-icc.org)
Correlated effects of acidification, biological response, and the presence of dissolved metals were observed in this work evidencing that the most important factor controlling the reduction of egg fertilisation and larval development success was the combined effects of the reduction of pH and the presence of the contaminants (mainly Zn, Co, and As). (news-oceanacidification-icc.org)

So where do things stand currently - and how good are we at using computational algorithms for predicting the toxicity of small molecules? (drugdiscovery.net)
The technology behind our work involves detecting a disease signature of RNA molecules called microRNA which can be isolated from small biological vesicles called 'exosomes' that travel in the bloodstream. (edu.au)
Through various omic technologies it is now possible to interrogate large sets of biological molecules. (who.int)

Biological monitoring of human serum or erythrocyte AChE served as a quality control measure for primary safety procedures. (cdc.gov)
and this needs to happen at sufficient safety (or tolerable toxicity, which of course is in turn related to effective dose and indication). (drugdiscovery.net)
Target/Protein-based toxicity prediction (analogous to target-based drug discovery), which also forms the basis of eg safety pharmacology , and which is hence regularly employed in practice: You screen a compound against a dozen (or up to a hundred) proteins, and hope that the results will be informative. (drugdiscovery.net)

It produces a long-lasting stain "with relatively low risk of adverse reaction and toxicity" [ 856 ]. (nanomedicine.com)

ATZ at a concentration of 0.2 ppb has been detected in 2-3 million people who use groundwater as their main source of drinking water ( Goldman, 1994 ), as such ATZ has been given a sizeable deal of scientific audit by both governmental and scholarly researchers. (frontiersin.org)

TUNEL staining was used to detect apoptosis. (hindawi.com)
the expression levels of protein associated with apoptosis and endoplasmic reticulum stress (ERS) of SKO-007 cells in various groups were detected by Western blotting method. (researchgate.net)

The carbon immunoassay (CIA) [ 863 ] is a direct serological test relying on a specific reaction between the carbon particles of India ink and rabbit immunoglobulin G. (This assay is also known as the India-ink immuno-reaction (IIR) test [ 864 - 866 ]. (nanomedicine.com)

Then, I will discuss several applications of our modular systems and the assays for selection of rare liquid biopsy targets from clinical samples and molecular analysis of their contents to help guide disease management. (selectbiosciences.com)

Statistical differences were detected using ANOVA and Tukey post-hoc tests (α=0.05). (uw.edu)

Current therapeutic options for SS mainly relies on improving mouth and eye dryness and suppressing immune responses, such as artificial tears and saliva substitutes, nonsteroidal anti-inflammatory drugs, glucocorticoids, hydroxychloroquine, synthetic immunosuppressive agents, and T or B cell-targeting biological therapies [ 12 ]. (hindawi.com)

The increasing complexity and sophistication of biological/biotechnological substances used in human medicine, and the rapid growth in their volume, present a considerable challenge for regulatory authorities, especially in the developing world. (who.int)
Recommendations published by WHO are intended to provide guidance for national regulatory authorities and for manufacturers of biological products. (who.int)

Diagnostic tests for AD and PD need to be greatly improved in order detect the disease early and implement preventative strategies. (edu.au)

1974. Biological handbooks: Biology data book. (cdc.gov)

Furthermore, by leveraging human cells as the sensing platform, our assay provides more accurate and realistic information in regards to bioavailability and a chemical's true effect on individual human health than does the employment of small animal models. (inknowvation.com)
Unlabeled human or humanized antibodies can be detected by precomplexing with an anti-human antibody before applying to the test tissues. (genengnews.com)

Sandy's comment: Do you ever wonder why some scientists, having discovered an important biological fact that connects other things in biology that had hitherto not been connected to it, begin to try to explain everything in terms of that newly discovered connection. (life-enhancement.com)

We are developing unique integrated microfluidic systems that consist of task specific modules interfaced to a fluidic motherboard to carry out multistep assays. (selectbiosciences.com)

WHO has played a key role for over 50 years in establishing international reference materials and in developing recommendations on the production and control of biological substances. (who.int)

The laser welding of biological tissues is a particular use of lasers in surgery.The technique has been proposed since the 1970s for surgical applications, such as repairing blood vessels, nerves, tendons, bronchial fistulae, skin and ocular tissues. (biolifesas.org)
Substantial breakthrough in the laser welding of biological tissues may come from the advent of nanotechnologies. (biolifesas.org)

Anatomy4

Organisms2

Diseases2

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes28

Disciplines and Occupations7

Anthropology, Education, Sociology and Social Phenomena1

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Acute6

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Concentrations3

Genotoxicity3

Mechanisms of toxicity1

Lymphoma Assay1

Exposure10

Cellular6

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Mechanism6

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Compounds6

Reproductive3

Cytotoxicity2

Efficacy4

Systemic1

Immunohistochemical1

Sediment1

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Predict2

Fluorescence1

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Chronic3

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19971

Humans2

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Studies8

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Greatly1

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