• dose
  • With desipramine, it has been noted that up to a 36-fold difference in plasma levels can be observed in patients receiving the same dose. (labcorp.com)
  • However, elderly patients are more likely to have confusion, falling episodes, and age-related kidney problems, which may require an adjustment in the dose for patients receiving desipramine. (mayoclinic.org)
  • It was not possible to combine information from the different studies, but individually they indicated some benefit from desipramine (usually at a dose between 100 mg and 150 mg daily), compared with placebo , at the expense of increased adverse events. (cochrane.org)
  • Do not take a double dose of desipramine. (emedtv.com)
  • For the treatment of depression in adults, the recommended starting dose of desipramine is 75 mg in divided doses, with or without food. (medbroadcast.com)
  • The effect of desipramine on the cumulative dose-response curves of noradrenaline and potassium (K + ) was examined on the isolated rat vas deferens. (springer.com)
  • An exposure of 10 min to 10 −7 M desipramine caused a leftward shift and an increase in the maximum response of cumulative dose-response curves of noradrenaline. (springer.com)
  • TCAs
  • Desipramine tends to be less sedating than other TCAs and tends to produce fewer anticholinergic effects like dry mouth, constipation, urinary retention, blurred vision, and cognitive/memory impairment. (wikipedia.org)
  • Desipramine has the weakest antihistamine and anticholinergic effects of the TCAs. (wikipedia.org)
  • Whereas other TCAs are useful for treating insomnia, desipramine can cause insomnia as a side effect due to its activating properties. (wikipedia.org)
  • usefulness
  • Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of desipramine in the elderly. (mayoclinic.org)
  • ADHD
  • The observed effectiveness of desipramine in the treatment of ADHD was the basis for the development of the selective NRI atomoxetine and its use in ADHD. (wikipedia.org)
  • effect
  • 3. Spina E, Avenoso A, Campo GM, Caputi AP, Perucca E. The effect of carbamazepine on the 2-hydroxylation of desipramine. (labcorp.com)
  • 4.Bonaccorsi A, Garattini S. Effect of desipramine on directly or indirectly elicited catecholamine pressor responses in rats. (webmd.com)
  • drug
  • Desipramine is a prescription drug. (healthline.com)
  • Wash-out of desipramine resulted in a rapid loss of enhanced maximum response to noradrenaline while the maximum response to K + did not show any decrease for up to 120 min after wash-out of drug. (springer.com)
  • responses
  • Desipramine (10 −7 M), in contact with the tissue for 10 min, enhanced responses to cumulative additions of K + without causing a consistent change in threshold concentrations. (springer.com)