• dose
  • With desipramine, it has been noted that up to a 36-fold difference in plasma levels can be observed in patients receiving the same dose. (labcorp.com)
  • However, elderly patients are more likely to have confusion, falling episodes, and age-related kidney problems, which may require an adjustment in the dose for patients receiving desipramine. (mayoclinic.org)
  • It was not possible to combine information from the different studies, but individually they indicated some benefit from desipramine (usually at a dose between 100 mg and 150 mg daily), compared with placebo , at the expense of increased adverse events. (cochrane.org)
  • However, if you usually take your dose at night, you may not want to make up the missed dose, due to the risk of drowsiness that desipramine may cause if it is taken during the day. (emedtv.com)
  • Do not take a double dose of desipramine. (emedtv.com)
  • The effect of desipramine on the cumulative dose-response curves of noradrenaline and potassium (K + ) was examined on the isolated rat vas deferens. (springer.com)
  • An exposure of 10 min to 10 −7 M desipramine caused a leftward shift and an increase in the maximum response of cumulative dose-response curves of noradrenaline. (springer.com)
  • TCAs
  • Desipramine tends to be less sedating than other TCAs and tends to produce fewer anticholinergic effects like dry mouth, constipation, urinary retention, blurred vision, and cognitive/memory impairment. (wikipedia.org)
  • Desipramine has the weakest antihistamine and anticholinergic effects of the TCAs. (wikipedia.org)
  • Whereas other TCAs are useful for treating insomnia, desipramine can cause insomnia as a side effect due to its activating properties. (wikipedia.org)
  • usefulness
  • Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of desipramine in the elderly. (mayoclinic.org)
  • therapy
  • Nurses should assess patients carefully for these risk factors if they're to begin therapy with desipramine and teach patients and their families about possible adverse effects. (nursingcenter.com)
  • ACHONG MR, KEANE PM. Pheochromocytoma Unmasked by Desipramine Therapy. (annals.org)
  • effect
  • 3. Spina E, Avenoso A, Campo GM, Caputi AP, Perucca E. The effect of carbamazepine on the 2-hydroxylation of desipramine. (labcorp.com)
  • 4.Bonaccorsi A, Garattini S. Effect of desipramine on directly or indirectly elicited catecholamine pressor responses in rats. (webmd.com)
  • responses
  • Desipramine (10 −7 M), in contact with the tissue for 10 min, enhanced responses to cumulative additions of K + without causing a consistent change in threshold concentrations. (springer.com)
  • healthcare
  • When desipramine side effects do occur, they are often minor and either require no treatment or can easily be treated by your healthcare provider. (emedtv.com)
  • Click Desipramine Side Effects to learn about specific side effects of the medication, including some of the more serious side effects that you should report to your healthcare provider. (emedtv.com)
  • chemical
  • The chemical name of desipramine is 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine and its free base form has a chemical formula of C18H22N2 with a molecular weight of 266.381 g/mol. (wikipedia.org)