The phenylethylamine derivatives are the broadest hallucinogen group and incorporate many substances. (medscape.com)
Synthesis2
The present review focuses on the synthesis and application of different piperazine derivatives and their metal complexes having diverse applications. (rsc.org)
7 In this article, we present our results on the synthesis, crystal structure and anti-ischaemic activity of new cinnamide derivative of (E)-1-{4-[bis(4-methoxyphenyl)methyl]piperazin-1- yl}-3-(4-chlorophenyl)prop-2- en-1-one (5). (scielo.org.za)
Piperidine derivatives1
Therefore, we first focused on an in-depth analysis of the protonation states of piperazine and piperidine derivatives in the studied compounds. (iasp-pain.org)
Methyl6
The title compound (E)-1-{4-[bis(4-methoxyphenyl)methyl]piperazin-1-yl}-3-(4-chloro- phenyl)prop-2-en-1-one (C 28 H 29 ClN 2 O 3 , Mr = 476.98) (5) was synthesized and studied by the single crystal X-ray diffraction method. (scielo.org.za)
We reported the syntheses of novel cinnamide derivatives containing bis(4-fluorophenyl)methyl moiety starting from commercially available materials. (scielo.org.za)
The reaction of cinnamic acid chloride with 1-[bis(4-methoxyphenyl)methyl]piperazine in the presence of triethylamine in dichloromethane at room temperature afforded the corresponding new cinnamide derivative with a total yield of 73.5 % ( Scheme 1 ), which was expected to be a potent neuroprotective agent. (scielo.org.za)
13 The title compound (E)-1-{4-[bis(4-methoxyphenyl)methyl]piperazin-1-yl}-3-(4-chlorophenyl)prop-2-en-1-one 5 was obtained as follows:thionylchloride (2mL) and piperadine (1 drop) were added to a stirred solution of (E)-3-(4-chlorophenyl)acrylic acid (4,4 mmol) in dichloromethane (15 mL) at room temperature. (scielo.org.za)
The varied speciality and pharmaceutical companies that we deal in consists of Cyanogen Bromide Cyclopropyl Isothiocyanate, Malonate Derivatives, Methyl 4-Chlorobutyrate, Thiophosgene and many more. (moltuslab.net)
Compounds4
The piperazine scaffold is a privileged structure frequently found in biologically active compounds. (rsc.org)
This is one of the reasons why piperazine based compounds are gaining prominence in today's research. (rsc.org)
Piperazine ring-based compounds find their application in biological systems with antihistamine, anticancer, antimicrobial and antioxidant properties. (rsc.org)
However, we kept in mind that within the previous series, a pair of closely related compounds, and , differing only in the piperazine/piperidine moiety in the structural core showed a significantly different affinity at sigma-1 receptors (σRs). (iasp-pain.org)
Analogs1
ecstasy, Molly) is likely the most common of the phenylethylamine derivatives, some others include such newer novel synthetics as cathinones ("bath salts"), the 2C family of drugs, as well as their N-o-methoxybenzyl analogs (NBOMe). (medscape.com)
Substances1
In this review, we survey current trends in the abuse of psychotropic substances and plants in Japan, focusing especially on synthetic cannabinoids, cathinone derivatives and psychotropic plants. (erowid.org)
TFMPP1
The most common piperidines and piperazine are phencyclidine (PCP), ketamine, benzylpiperazine (BZP), and 3-trifluoromethylphenylpiperazine (TFMPP). (medscape.com)
Urea1
The method's derivatizing agent is 1-(9-anthracenylmethyl) piperazine (MAP), which converts the isocyanate into a stable urea derivative. (cdc.gov)
Amphetamine1
BZP(benzyl-piperizine)-derivatives, are currently being used inplace of other amphetamine derivatives like MDMAs, as they are a legal alternative. (bestbets.org)
Moiety1
1-Acylbenzimidazoles undergo 1,3-dipolar cycloaddition with nitrileimine to produce derivatives of the 1 H ,9 H -1,2,4-triazolo[4,3-a]benzimidazole system, followed by a rapid in situ substitution at 9a-position by the benzhydrazidoyl moiety. (heterocycles.jp)
Drugs2
Piperazine nucleus is found in many marketed drugs in the realm of antidepressants (amoxapine), antipsychotics (bifeprunox), antihistamines (cyclizine and oxatomide), antifungals (itraconazole), antibiotics (ciprofloxacin), etc . (rsc.org)
Although the distribution of tryptamine-type designer drugs has decreased since the amendment of the law, the distribution of cathinone derivatives, as well as of phenetylamine-type and piperazine-type designer drugs, has increased. (erowid.org)
Chemical2
Prazosin hydrochloride, USP a quinazoline derivative, is the first of a new chemical class of antihypertensives. (nih.gov)
To produce a new derivative, the manufacturers of research chemicals will often make minor adjustments to the drug's original chemical composition. (healthnewsplus.net)
Stable1
A number of methods used 9-(N-methylaminomethyl)anthracene as a reagent to derivatize the HDI allowing subsequent detection of a stable derivative by UV absorbance or fluorescence detection (Andersson et al. (cdc.gov)
Drug2
In addition to the ring carbons, substitution in the nitrogen atom of piperazine not only creates potential drug molecules but also makes it unique with versatile binding possibilities with metal ions. (rsc.org)
Ranolazine is, like trimetazidine, a piperazine derivative - piperazine itself was introduced in 1953 as an anthelmintic - a drug to expel parasitic worms in the body. (escardio.org)
Potential1
Piperazine-derived small molecules as potential Flaviviridae NS3 protease inhibitors. (us.es)
Group1
With the piperazine group (of which perphenazine (perphenazine) is an example), the extrapyramidal symptoms are more common, and others (e.g., sedative effects, jaundice , and blood dyscrasias) are less frequently seen. (medicinenet.com)
Products1
Hydrophilic high-swell hydrogels are in particular polymers of (co)polymerized hydrophilic monomers, graft (co)polymers of one or more hydrophilic monomers on a suitable grafting base, crosslinked cellulose or starch ethers, crosslinked carboxymethylcellulose, partially crosslinked polyalkylene oxide or natural products which swell in aqueous fluids, for example guar derivatives. (vtex.vn)
Agent2
A piperazine derivative, PHOSPHODIESTERASE 5 INHIBITOR and VASODILATOR AGENT that is used as a UROLOGICAL AGENT in the treatment of ERECTILE DYSFUNCTION . (online-medical-dictionary.org)
Another derivatization agent used was 1-(2-pyridyl)piperazine either in a toluene solution (Ellwood et al. (cdc.gov)
Application1
The invention relates to 1-piperazine- and 1-homopiperazine-carboxylate derivatives, and to the preparation and therapeutic application thereof. (allindianpatents.com)
Effects1
A first generation antihistamine, derivative of piperazine with sedative and antocholinergic effects. (e-lactancia.org)
Include1
Anthelminthic agents include the macrocyclic lactone derivatives ivermectin and moxidectin, piperazine derivatives, and benzimidazole derivatives. (medscape.com)
Significant1
We have synthesized a new quinoline (4,7-dichloroquinoline) derivative which showed significant larvicidal and pupicidal properties against a malarial and a dengue vector and a lethal toxicity ranging from 4.408 µM/mL (first instar larvae) to 7.958 µM/mL (pupal populations) for Anopheles stephensi and 5.016 µM/mL (larva 1) to 10.669 µM/mL (pupae) for Aedes aegypti . (nature.com)
Find1
In her pocket, you find several tablets later identified as party pills (or piperazine derivatives). (bestbets.org)
Form1
I reacted with PCl 5 to give the 11, 11-dichloro derivative (VI) and with hydroxylamine to form its oxine (VII). (go.jp)