Deprivation therapy androgens. Medical search. Frequent questions

Systemic androgen deprivation therapy (ADT), also referred to as hormone therapy, has long been the primary treatment for metastatic prostate cancer. (cochrane.org)
Androgen deprivation therapy (ADT) is a first-line therapy for locally advanced and metastatic prostate cancer (PCa). (oncotarget.com)
The standard treatment for men with metastatic prostate cancer is androgen deprivation therapy (ADT). (peoplebeatingcancer.org)

The advent of safe and reversible forms of androgen deprivation, such as luteinizing hormone-releasing hormone (LHRH) analogues and antiandrogens (AAs), has also contributed to enthusiasm for NADT. (medscape.com)
Many studies have been conducted to determine if androgen deprivation (surgical castration, estrogen, cyproterone, luteinizing hormone-releasing hormone agonists (LHRH), anti-androgens or a combination thereof) combined with radiotherapy is more effective than radiotherapy alone. (oncolink.org)
This includes the use of Gonadotropin-releasing hormone (Luteinizing-hormone releasing hormone) agonists and antagonists suppressing the production of testosterone, and non-steroidal anti-androgens (e.g. (oncotarget.com)

Anti-androgens work by preventing testosterone from getting to and acting on the prostate cancer cells. (movember.com)
Both older and newer types of anti-androgens may be available, depending on where you live. (movember.com)
Some anti-androgens also work by preventing cells (including prostate cancer cells) from making testosterone. (movember.com)

Of these, only two found a significant improvement in survival with the addition of androgen deprivation. (oncolink.org)
In addition, of the four retrospective reviews that analyzed cancer-specific survival, none found that the addition of androgen deprivation to radiotherapy improved this endpoint. (oncolink.org)
An increase in urinary incontinence (16 versus 29%, p=0.002) with the addition of androgen deprivation therapy was reported in one trial. (cancer.org.au)

Prostate cells contain an Androgen Receptor (AR), that when stimulated by androgens like testosterone, promotes growth and maintains prostatic differentiation. (wikipedia.org)
Antiandrogens can enter cells and prevent the binding of testosterone to the receptor proteins, due to their higher affinity for the Androgen Receptor. (wikipedia.org)
Recent randomized controlled trials (RCTs) examined the role of adding androgen receptor signaling inhibitors (ARSIs), including abiraterone acetate (ABI), apalutamide, darolutamide (DAR), and enzalutamide (ENZ), to docetaxel (DOC) and androgen deprivation therapy (ADT) in patients with metastatic hormone-sensitive prostate cancer (mHSPC). (nih.gov)
Synergistic effects of Obatoclax with androgen receptor inactivation can be observed. (oncotarget.com)
Altogether, our results suggest that MCL1 is a key molecule deciding over the fate of PCa cells upon inactivation of androgen receptor signaling. (oncotarget.com)
WHIPPANY, N.J.- The Phase III ARASENS trial investigating the use of the oral androgen receptor inhibitor (ARi) NUBEQA ® (darolutamide) in metastatic hormone-sensitive prostate cancer (mHSPC) has met its primary endpoint. (blstimes.com)
The purpose of this work was to evaluate the effect of androgen receptor (AR) inhibition on prostate-specific membrane antigen (PSMA) uptake imaged using 68 Ga-PSMA-11 PET in a mouse xenograft model and in a patient with castration-sensitive prostate cancer. (snmjournals.org)
In fact, cellular PSMA expression is regulated by the androgen receptor (AR), which is frequently targeted during prostate cancer treatments and can therefore confound interpretation. (snmjournals.org)
Small Indels in the Androgen Receptor Gene: Phenotype Implications and Mechanisms of Mutagenesis. (medscape.com)

Prolia was later approved to treat men with osteoporosis, glucocorticoid induced osteoporosis, bone loss in men receiving androgen deprivation therapy for prostate cancer and in women receiving aromatase inhibitor therapy for breast cancer. (medlineplus.gov)

New antiandrogens that target testosterone synthesis (abiraterone acetate and seviteronel) or AR nuclear translocation (enzalutamide, apalutamide, and darolutamide), as well as combined therapies (galeterone) have been recently developed and may function to better target androgen-responsive cells in combination with ADT. (wikipedia.org)
Androgen deprivation therapy (ADT) combined with docetaxel or antiandrogens (abiraterone, enzalutamide, or apalutamide) improved the outcomes in men with metastatic hormone-sensitive prostate cancer (mHSPC). (thieme-connect.com)
ARCHES: A Randomized, Phase III Study of Androgen Deprivation Therapy With Enzalutamide or Placebo in Men With Metastatic Hormone-Sensitive Prostate Cancer. (uchicago.edu)
Previous treatment with at least 1 Novel androgen axis drug (NAAD) (e.g., enzalutamide, apalutamide, darolutamide and/or abiraterone). (who.int)

Androgen deprivation therapy in the form of GnRH agonists is very costly, making it the second highest Medicare Part B expenditure, at approximately .2 billion in 2003,' they wrote. (patientcareonline.com)
Some retrospective studies have shown that agonists are associated with a greater risk of cardiovascular disease and cardiovascular mortality and morbidity, and a similar risk with agonists and combined androgen blockade. (siuj.org)
The evidence for the increased cardiovascular risk of GnRH agonists over antagonists for androgen deprivation therapy is unclear. (siuj.org)

Several studies have concluded that ADT has demonstrated benefit in patients with metastatic disease, and as an adjunct to radiation therapy in patients with locally advanced disease, as well as those with unfavorable intermediate-risk or high-risk localized disease. (wikipedia.org)
However, the NCCN notes that androgen deprivation therapy before, during, and/or after radiation prolongs survival in selected patients who are receiving radiation therapy only. (medscape.com)
5 years, the NCCN guidelines support the use of external beam radiation therapy (EBRT) and NADT. (medscape.com)
However, a meta-analysis of the sequencing of androgen deprivation therapy with radiation therapy in localized prostate cancer concluded that adjuvant androgen deprivation therapy results in superior outcomes, compared with neoadjuvant or concurrent androgen deprivation therapy. (medscape.com)
In the randomized, controlled trial, the investigators aimed to evaluate the use and duration of androgen-deprivation therapy with postoperative radiation therapy by randomly assigning patients to receive either no, 6 months (short course), or 24 months (long course) of androgen-deprivation therapy. (ascopost.com)
Key eligibility criteria included the indication for radiation therapy after previous radical prostatectomy and no previous postoperative androgen-deprivation therapy. (ascopost.com)
The reason this is important, they said, is that although androgen deprivation combined with radiation therapy has been shown to improve survival in men with locally advanced prostate cancer, the therapy is associated with significant side effects, including sexual dysfunction, osteoporosis, and fractures. (patientcareonline.com)
They can also be used along with radiation therapy in less advanced prostate cancer. (movember.com)
The aim of this study is to evaluate the dosemetric parameters and acute toxicity of dose-escalated whole pelvis (WP) Intensity Modulated Radiation Therapy (IMRT) and volumetric modulated arc therapy (VMAT) prostate boost following neoadjuvant and concomitant with androgen deprivation therapy in high-risk prostate cancer patients. (scirp.org)
Androgen deprivation therapy (ADT) was given for all patients before and during radiation therapy. (scirp.org)
The Proctitis and frequency were the commonest acute toxicity and were maximal during the 5th week of radiation therapy. (scirp.org)
In a Phase III trial, The Radiation Therapy Oncology Group (RTOG) showed improved progression-free survival (PFS) for high-risk prostate cancer patients treated with Whole Pelvis Radiation Therapy (WPRT) compared with prostate-only radiation therapy (PORT) [4]. (scirp.org)
Dose escalation can be achieved with either 3-Dimensional Conformal Radiation Therapy (3-DCRT) or with intensity-modulated Radiation Therapy (IMRT). (scirp.org)
Trial Description: This phase III trial compares less intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in treating patients with high risk prostate cancer and low gene risk score. (dana-farber.org)
Radiation therapy uses high energy rays to kill tumor cells and shrink tumors. (dana-farber.org)

With NADT prior to RP, the intent is to eradicate malignant androgen-dependent cells, in the hope that sufficient tumor regression will permit complete resection of residual prostate cancer, improving pathologic outcome and survival. (medscape.com)
Some preliminary results show that increasing the duration of therapy to 6 or 8 months further reduces tumor volume and PSA nadir levels and decreases the likelihood of positive margins. (medscape.com)
Low DHT levels in the prostate with aggressive PCa are probably sufficient to propagate the growth of the tumor, and the prostate with aggressive PCa can produce androgens from the adrenal precursors more autonomously than that with non-aggressive PCa does under the low testosterone environment with testicular suppression. (urotoday.com)
GALVESTON, Tex. - Whether a man with prostate cancer is treated with androgen deprivation may depend more on his choice of urologist than on the nature of his tumor or his age, researchers here suggested. (patientcareonline.com)
They used multilevel analyses to create estimates of the relative contributions of urologists' choices, tumor characteristics, and patient characteristics to the decision to use androgen deprivation therapy within six months of diagnosis. (patientcareonline.com)
For part 2, patients were randomized 11 to receive either AAPL for 12 months ( arm 2A) or observation ( arm 2B), stratified by neoadjuvant therapy and pathologic tumor classification . (bvsalud.org)
Nevertheless, the cells that remain can eventually regrow a tumor, and when they do, the tumor is usually resistant to further hormone therapy. (mskcc.org)
Apalutamide may help fight prostate cancer by blocking the use of androgen by the tumor cells. (dana-farber.org)
we found no impact of the addition of metformin to [androgen deprivation] therapy on risk of metabolic syndrome associated with castration therapy and no additional anti-tumor effects. (oncotarget.com)

Prostate cancer cells usually require androgen hormones, such as testosterone, to grow. (wikipedia.org)
Prostate cancer cells require androgens, such as testosterone, to survive. (oncolink.org)
What kinds of hormone therapies are used to lower testosterone? (movember.com)
These hormone therapies lower the amount of testosterone made by your testicles. (movember.com)
So, if you're considering an orchiectomy, your doctor may suggest trying other forms of hormone therapy first to see how your body responds to low levels of testosterone. (movember.com)
If PSA levels and testosterone begin to rise, therapy will be started again. (movember.com)
It is driven by the male hormone testosterone, and measures used to block testosterone commonly known as hormonal therapy (Androgen Deprivation Therapy-ADT) forms an important treatment in localised and advanced disease. (mdpi.com)
Effect of Testosterone Replacement Therapy on Sexual Function and Hypogonadal Symptoms in Men with Hypogonadism. (medscape.com)

The study aimed to compare the efficacy and safety of androgen deprivation therapy (ADT) with abiraterone or docetaxel versus ADT alone as neoadjuvant therapy in patients with very-high-risk localized prostate cancer. (frontiersin.org)
Compared with ADT alone, neoadjuvant therapy with ADT plus docetaxel or abiraterone could achieve better pathological outcomes (pCR or MRD) for very-high-risk localized prostate cancer. (frontiersin.org)
In the ARASENS trial, NUBEQA in combination with docetaxel and androgen deprivation therapy (ADT) significantly increased overall survival (OS) compared to docetaxel and ADT. (blstimes.com)

[8] In all trials ADT consisted of an LHRH agonist and a non-steroidal anti-androgen, flutamide. (cancer.org.au)
One RCT, RTOG 92-02, [10] [11] compared short-term with long-term androgen deprivation (four months neoadjuvant plus concurrent LHRH agonist and non-steroidal anti-androgen, flutamide, with or without two years of adjuvant LHRH agonist). (cancer.org.au)

A PubMed search was conducted for papers published in the last 15 years using the following MeSH terms: "prostate neoplasms," "gonadotropin-releasing hormone," "androgen agonist," "androgen antagonists," "cardiovascular disease," "epidemiology. (siuj.org)

Based on these trials the authors conclude that combined modality therapy may improve disease free survival compared to radiotherapy alone, but the impact of androgen deprivation combined with radiotherapy on overall survival remains unclear. (oncolink.org)
The second trial is a comparison of radiotherapy alone versus radiotherapy with two to five years of a non-steroidal anti- androgen, bicalutamide. (cancer.org.au)
A recent update of RTOG 85-31 which compared radiotherapy alone with radiotherapy plus indefinite adjuvant androgen blockade also reported no statistically significantly difference in RTOG grade 3-4 genitourinary or gastrointestinal toxicities. (cancer.org.au)

The aim of this review was to find out what the effect of adding abiraterone was, in men with prostate cancer, who were receiving and still responding to hormone therapy. (cochrane.org)
The studies compared abiraterone acetate and hormone therapy to hormone therapy alone. (cochrane.org)
Adding abiraterone acetate to hormone therapy improves overall survival but probably not quality of life. (cochrane.org)

Neoadjuvant androgen deprivation therapy (NADT) is systemic therapy administered after the diagnosis of prostate cancer but before locoregional therapy such as radical prostatectomy (RP) or radiation. (medscape.com)
The addition of 24 months of androgen-deprivation therapy to postoperative radiotherapy after radical prostatectomy provided a metastasis-free survival benefit and improved the time to salvage therapy in patients with prostate cancer, according to the preliminary results from the RADICALS-HD trial (ISRCTN40814031). (ascopost.com)
Based on the first results of the RADICALS-HD trial, 24 months of androgen-deprivation therapy with radiotherapy after radical prostatectomy improved metastasis-free survival, compared with 6 months of androgen-deprivation therapy, with a 10-year rate of metastasis-free survival of 78% vs 72%, respectively. (ascopost.com)
Current concerns regarding prostate cancer progression have led to a renewed interest in the use of neoadjuvant androgen deprivation (NAD) therapy prior to radical prostatectomy ( RP ). (medscape.com)

Are cumulative treatment toxicities different when androgen blockade (androgen ablation, deprivation) is used as first line therapy in the adjuvant or neoadjuvant setting with radiotherapy for locally advanced prostate cancer in locally advanced disease? (cancer.org.au)
All trials were consistent, with no increase in acute or late urinary or bowel toxicity reported with the addition of androgen blockade. (cancer.org.au)
In an accompanying editorial, Paul F. Schellhammer, M.D., a professor of urology at Eastern Virginia Medical School, in Norfolk, acknowledged the uncertainties surrounding androgen deprivation/blockade for prostate cancer. (patientcareonline.com)

However, the prognostic significance of PLR has not been investigated in the prostate cancer (PCa) patients receiving hormonal therapy. (biomedcentral.com)
Although AAT has some adverse side effects and data from breast cancer patients indicate that such side effects from hormonal therapies may contribute to anxiety and depression and may also hinder AAT treatment compliance, this issue has not been investigated within a sample of PCa patients. (edu.au)
Also, an updated analysis of the same study demonstrated improvement of PSA control and PFS at 10 years with added neoadjuvant hormonal therapy to WPRT [5]. (scirp.org)

The purpose of this research is to determine whether a 16-week culturally tailored, technology-based, aerobic and resistance exercise intervention improves cardiovascular risk factors in Black men diagnosed with prostate cancer and are undergoing androgen deprivation therapy (ADT), and whether it will also improve physical fitness and function, body composition, and outcomes such as quality of life, cancer symptoms, and self-esteem. (dana-farber.org)
Two RCTs assessing long-term androgen deprivation therapy in addition to radiotherapy report radiotherapy toxicity outcomes. (cancer.org.au)
Effects of vasopressin during CPR on cardiac arrest outcomes, duration of obesity and CAC, androgen deprivation therapy and AKI, and more. (ama-assn.org)
and health-related quality of life will be assessed using the Functional Assessment of Cancer Therapy Prostate Module and the Medical Outcomes Study 12-item Short Form Health Survey Version 2. (umanitoba.ca)
However, neoadjuvant therapy may provide an important paradigm for the discovery of active agents for the treatment of prostate carcinoma, in addition to improving clinical outcomes for men with early, high-risk disease. (medscape.com)
Postradical prostatectomy prostate-specific antigen outcomes after 6 versus 18 months of perioperative androgen-deprivation therapy in men with localized, unfavorable intermediate-risk or high-risk prostate cancer: Results of part 2 of a randomized phase 2 trial. (bvsalud.org)
Antiandrogen therapy (AAT) is a common adjunct treatment for prostate cancer (PCa) patients and has shown significant benefits to long-term outcomes from radiation or surgery. (edu.au)

ADT reduces the levels of androgen hormones, with drugs or surgery, to prevent the prostate cancer cells from growing. (wikipedia.org)
Hormone therapy (drugs to reduce the level of male hormones) has been the main treatment for advanced disease, but this does not work forever. (cochrane.org)
RxWiki News) Most prostate cancers are fed by male hormones called androgens. (rxwiki.com)

Androgen deprivation therapy (ADT), also called androgen ablation therapy or androgen suppression therapy, is an antihormone therapy whose main use is in treating prostate cancer. (wikipedia.org)

The control group consisted of patients with prostate cancer with no androgen deprivation therapy use, matched by age, geographic region, insurance plan and index year. (rand.org)

this population of patients has yet to be defined, but its parameters may become clearer as the optimal duration and form of NAD therapy is defined. (medscape.com)
More research is needed to guide the choice, the duration, and the schedule of hormone deprivation therapy and the impact of long-term hormone therapy with regard to toxicity and the patient's quality of life. (medscape.com)

A study looking at the differences of using GnRH-A (and androgen suppressant) or an orchiectomy report differences in sexual interest, the experience of erections, and the prevalence of participating in sexual activity. (wikipedia.org)

Men with history of fracture and comorbidities are at an increased risk of fracture after long-term use of androgen deprivation therapy, and initiating this therapy should be carefully considered in older men with localized prostate cancer. (medicaldaily.com)
Evidence Central , evidence.unboundmedicine.com/evidence/view/infoPOEMs/426308/all/Androgen_deprivation_therapy_associated_with_increased_risk_of_fracture__DM__CVD_death. (unboundmedicine.com)

It is the most radical treatment for ending the production of androgens. (wikipedia.org)
Therefore a complementary treatment was developed that uses antiandrogens to block the body's ability to use any androgens. (wikipedia.org)
To analyze the oncologic benefit of triplet combination therapies using ARSI + DOC + ADT, and comparing them with available treatment regimens in patients with mHSPC. (nih.gov)
The role of medications that suppress androgen production is controversial in the treatment of prostate cancer. (oncolink.org)
When men are getting radiotherapy for prostate cancer as their initial treatment, we know the addition of hormone therapy improves efficacy and survival. (ascopost.com)
With intermittent hormone therapy, hormone treatment will be paused once your prostate specific antigen (PSA) levels drop and stay stable. (movember.com)
If you have localized prostate cancer (early-stage cancer that has not spread outside the prostate gland), hormone therapy can be used to increase the effectiveness of your treatment. (movember.com)
Introduction The use of androgen deprivation therapy (ADT) in the treatment of prostate cancer is associated with changes in body composition including increased fat and decreased lean mass. (elsevierpure.com)
books was performed, concentrating on data from your last 10 yr (January 2000 to July 2011) and using the conditions androgen deprivation, hormone treatment, prostate malignancy and undesireable effects. (cancerhugs.com)
Particularly, the part of ADT was examined in individuals with nonmetastatic disease as the principal and only treatment, in conjunction with rays therapy (RT) or after medical procedures, and in individuals with metastatic disease. (cancerhugs.com)
Treatment with bilateral orchiectomy, luteinizing hormoneCreleasing hormone agonist therapy, with and without antiandrogens continues to be associated with several serious adverse occasions, including coronary disease, diabetes, and skeletal problems that could also have an effect on mortality. (cancerhugs.com)
Androgen deprivation therapy only compared with surgery treatment Androgen deprivation continues to be weighed against RP in node-positive individuals [13C16]. (cancerhugs.com)
An ongoing GETUG-AFU-18 phase III trial is evaluating the impact of dose escalation in combination with 3-year androgen deprivation treatment on 5-year biochemical or clinical control in high-risk prostate cancer patients [8]. (scirp.org)
Additionally, we imaged one patient with castration-sensitive prostate cancer before and 4 wk after treatment with androgen deprivation therapy (ADT). (snmjournals.org)
Two phase 3 trials have compared SRT with and without androgen deprivation therapy (ADT), finding that combined treatment (SRT+ADT) improves both PFS and overall survival. (wjgnet.com)
For treatment recommendations for patients with a life expectancy ≥20 y, see initial therapy for Low Risk of Recurrence, below. (medscape.com)
Therapy should be individualized based on each patient's clinical scenario, with the risks and benefits of treatment discussed between the clinician and patient. (medscape.com)

Three databases and meetings abstracts were queried in April 2022 for RCTs analyzing patients treated with first-line combination systemic therapy for mHSPC. (nih.gov)

The 15-year progression-free survival was 36% with adjuvant therapy versus 29% with neoadjuvant therapy ( P = 0.01). (medscape.com)
However, no randomized or nonrandomized study using 3 months of neoadjuvant therapy has shown any statistically significant benefit in terms of overall and disease-free survival. (medscape.com)
A multidisciplinary approach with a team of oncologists and urologists will be critical to making advances in the arena of neoadjuvant therapy for prostate carcinoma and to aiding in the efficient evaluation of new therapies. (medscape.com)

Orchiectomy (surgical castration) It consists of removing the testicles, the organ where androgens are synthesized, of the cancer patient. (wikipedia.org)
1 ] The upfront management of men with metastatic hormone-sensitive prostate cancer (mHSPC) had been with only androgen deprivation therapy (ADT), for a long time, either with medical or surgical castration. (thieme-connect.com)
Substantial evidence indicates that men with prostate cancer are at an increased risk for cardiovascular disease, and medical and surgical androgen deprivation therapy is associated with further increased cardiovascular risk. (siuj.org)

Lowering androgen levels or stopping them from getting into prostate cancer cells often makes prostate cancer shrink or grow more slowly for a time. (wikipedia.org)
When medications deplete the body's androgen supply or when the testes are removed (the testes supply 97% of a man's androgen), prostate cancer cells die. (oncolink.org)
Unfortunately, androgen deprivation rarely results in cure, as not all prostate cancer cells are androgen-dependent. (oncolink.org)

Adjuvant therapy was also superior with respect to biochemical failure, distant metastasis, and metastasis-free survival. (medscape.com)
It probably also extends disease-specific survival, and delays disease progression compared to androgen deprivation therapy alone. (cochrane.org)
Secondary endpoints included the time to salvage androgen-deprivation therapy and overall survival. (ascopost.com)
However, overall survival was not improved with a long vs short course of androgen-deprivation therapy with radiotherapy after surgery. (ascopost.com)
Should androgen deprivation therapy be withheld because of the paucity of evidence-based trials demonstrating survival benefits, or should it be administered because it could provide, at the minimum, a temporary dramatic biochemical, radiologic, or clinical response? (patientcareonline.com)
However, the NCCN notes that androgen deprivation therapy before, during, and/or after radiation prolongs survival in selected radiation-managed patients. (medscape.com)
Targeting the pro-survival side-effects of androgen-deprivation therapy in prostate cancer. (ox.ac.uk)

An orchiectomy may be offered to men who need long-term hormone therapy. (movember.com)

The BH3-mimetic Obatoclax induces apoptosis and decreases MCL1 expression in androgen-sensitive PCa cells, while castration-resistant PCa cells are less sensitive and react with an upregulation of MCL1 expression. (oncotarget.com)

Hence, there is increased interest in radiation dose escalation combined with androgen deprivation in high risk prostate cancer patients [6] [7]. (scirp.org)

In patients treated with ADT the pituitary-adrenal axis mediated by adrenocorticotropic hormone has a central role in the regulation of androgen synthesis. (urotoday.com)

Do patient-reported androgen-deprivation therapy side effects predict anxiety and depression among prostate cancer patients undergoing radiotherapy? (edu.au)
Dive into the research topics of 'Do patient-reported androgen-deprivation therapy side effects predict anxiety and depression among prostate cancer patients undergoing radiotherapy? (edu.au)

Risk factors were more favorable in the no-androgen-deprivation vs short-course therapy arms, compared with the short- vs long-course therapy arms, according to the study details. (ascopost.com)
A higher proportion of patients who were not randomized to adjuvant therapy had a favorable prostatectomy pathologic response (32.3% in nonrandomized patients compared with 17.1% in randomized patients ). (bvsalud.org)

They are usually not used on their own to treat prostate cancer but combined with other hormone therapies or treatments. (movember.com)
When is hormone therapy used to treat prostate cancer? (movember.com)
The data come from a review of recent studies involving androgen deprivation therapy to treat prostate cancer. (mdedge.com)

A MEDLINE search was used to identify all English language articles published between January 1990 and September 1998 in which prostate cancer patients were treated with a combination of radiotherapy and androgen deprivation. (oncolink.org)

Many male patients being treated for prostate cancer undergo androgen deprivation therapy, which has been shown to have several risky side effects, including osteoporosis. (pharmacytimes.com)
The challenge is that men who undergo this therapy many experience side effects including hot flashes, cardiotoxicity, metabolic and musculoskeletal alterations. (peoplebeatingcancer.org)

Antiandrogen therapy Adrenal glands were discovered as another center of androgen production even after a castration process. (wikipedia.org)

Nonpharmacologic preventive measures include modification of general lifestyle factors, such as increasing weight-bearing and muscle-strengthening exercise, which epidemiologic studies have linked to lower fracture rates, and ensuring optimum calcium and vitamin D intake as adjunct to active antifracture therapy. (medscape.com)

Anatomy13

Organisms3

Diseases21

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Psychiatry and Psychology10

Phenomena and Processes23

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena6

Humanities1

Information Science6

Health Care22

Geographicals3

Metastatic prostate cancer3

Luteinizing hormone3

Anti-androgens3

Addition of androgen deprivation3

Receptor9

Aromatase inhibitor therapy for breast cancer1

Enzalutamide4

Agonists3

Radiation therapy15

Tumor9

Testosterone8

Docetaxel3

LHRH2

Antagonists1

Radiotherapy alone3

Abiraterone3

Radical prostatectomy4

Blockade3

Hormonal3

Outcomes7

Hormones3

Ablation1

Patients with prostate cancer1

Duration2

GnRH1

Risk of fracture2

Treatment17

Systemic therapy1

Neoadjuvant therapy3

Surgical3

Prostate cancer cells3

Survival7

Orchiectomy1

Castration-resistant1

High-risk prostate1

Regulation1

Among prostate cancer patients2

Favorable2

Treat prostate cancer3

Combination1

Undergo2

Adrenal1

Fracture1