- Typically, patients with macrophage activation syndrome become acutely ill with the sudden onset of nonremitting high fever, profound depression in all 3 blood cell lines (ie, leukopenia, anemia, and thrombocytopenia), hepatosplenomegaly, lymphadenopathy, and elevated serum liver enzyme levels. (medscape.com)
- Severe leukopenia, thrombocytopenia, macrocytic anemia, and/or pancytopenia may occur in patients being treated with Azathioprine tablets. (arthritis-unplugged.com)
- Antiproliferative actions on bone marrow and GI tissue: Due to the drug's preference for rapidly proliferating tissues, bone marrow depression ( anemia , leukopenia , pancytopenia , or even rarely agranulocytosis ) may occur. (mdwiki.org)
- The bacteria enter the white blood cells where it reproduces and can go on to infect the lymph nodes, spleen, liver and bone marrow. (homehealth-uk.com)
- After returning to her home in Texas, she was initially diagnosed with West Nile virus (WNV) infection, developed pancytopenia, liver failure, and disseminated intravascular coagulopathy, and died. (cdc.gov)
- Effete red cells are phagocytized and metabolized by the macrophages of spleen, bone marrow, and liver. (ivis.org)
- [ 1 , 2 ] Macrophage activation syndrome is characterized by pancytopenia, liver insufficiency, coagulopathy, and neurologic symptoms and is thought to be caused by the activation and uncontrolled proliferation of T lymphocytes and well-differentiated macrophages, leading to widespread hemophagocytosis and cytokine overproduction. (medscape.com)
- Patients with preexisting bone marrow depression and liver impairment should be treated with caution. (mdwiki.org)
- Parasites infect the tissues of major organs, especially the liver , spleen, and bone marrow. (medicinenet.com)
- Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal hyperinflammatory syndrome that can be familial or acquired, and is characterized by persistent fever, pancytopenia, hepatosplenomegaly, and increased serum ferritin ( 2 ). (cdc.gov)
- Visceral leishmaniasis causes irregular fever, hepatosplenomegaly, pancytopenia, and polyclonal hypergammaglobulinemia with high mortality in untreated patients. (msdmanuals.com)
- Here we are reporting rare case series of capecitabine induced marrow aplasia in patients of colorectal cancer during adjuvant treatment. (jbclinpharm.org)
- It showed severe marrow aplasia (less than 10% cellularity) and all 3 cell lines were suppressed [ Figure 1 ]. (jbclinpharm.org)
- Rare but potentially serious side effects include bone marrow suppression which usually improves on discontinuing the medication. (worldsbest.rehab)
- Treatment of patients with B-cell chronic lymphocytic leukaemia (CLL) with sufficient bone marrow reserves. (medscape.co.uk)
- As pegylated liposomal formulation: In combination with bortezomib for the treatment of progressive cases in patients who have undergone or are unsuitable for a bone marrow transplant and who have received at least 1 prior therapy: 30 mg/m 2 on day 4 of the bortezomib 3 week regimen given via infusion over 60 minutes immediately after bortezomib infusion. (azurewebsites.net)
- Matulane is contraindicated in patients with known hypersensitivity to the drug or inadequate marrow reserve as demonstrated by bone marrow aspiration. (guidelinecentral.com)
- Bone marrow toxicity can be irreversible and may cause death, particularly in immunocompromised patients. (mdwiki.org)
- Apart from the physical symptoms, it is also associated with neurological symptoms like depression and incoordination. (petable.care)
- Bone marrow aspiration & trephine biopsy showed moderate hypo cellular marrow with bicytopenia. (jbclinpharm.org)
- Patient underwent marrow aspiration and biopsy after 5 cycle of CAPOX. (jbclinpharm.org)
- Repeat marrow aspiration and biopsy showed less than 10% cellularity. (jbclinpharm.org)
- DENV-3 was detected in a premortem bone marrow biopsy in which erythrophagocytosis was evident. (cdc.gov)
- It is also known as tropical canine pancytopenia, canine hemorrhagic fever, canine rickettsiosis, canine typhus, and tracker dog disease. (petable.care)
- The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc-shaped anucleate particles for 7-10 days. (medscape.com)
- Chapter 52 Sphingolidosis DIAGNOSIS LAB RESULTS ▪ Enzymatic assay to confirm glucocerebrosidase deficiency ▪ Genetic testing ▫ Prenatal diagnosis available TREATMENT OTHER INTERVENTIONS ▪ Enzyme replacement therapy Figure 52.2 A section of bone marrow demonstrating numerous crinkled paper macrophages, or Gaucher cells, in an individual with Gaucher's disease. (osmosis.org)
- First patient is 51 year old male with locally advanced rectal cancer, developed persistent pancytopenia after 5th cycle of chemotherapy. (jbclinpharm.org)
- She had a history of Crohn's disease treated with mercaptopurine and mesalamine, hysterectomy because of uterine cancer, thyroidectomy, hypertension treated with lisinopril, coronary artery disease, hyperlipidemia, chronic renal disease with microhematuria, obesity, and depression treated with fluoxetine. (cdc.gov)
- Other radioactive strontium isotopes have been employed for medical uses: 89Sr (as MetastronTM) as a cancer therapeutic for the relief of bone pain and 85Sr in the radiologic imaging of bone. (cdc.gov)
- From the above three cases, it is evident that capecitabine causes hypocellular marrow, which we are using as adjuvant or palliative chemotherapy in colorectal cancer. (jbclinpharm.org)
- It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Albendazole. (worldsbest.rehab)
- People treated with drugs compromising bone marrow function (e.g. cytostatics ) should be treated carefully. (mdwiki.org)
- Histopathologic criterion: Evidence of macrophage hemophagocytosis is found in the bone marrow aspirate sample. (medscape.com)
- Prompt reduction in dosage or temporary withdrawal of the drug may be necessary if there is a rapid fall in or persistently low leukocyte count, or other evidence of bone marrow depression. (arthritis-unplugged.com)
- Numbers of circulating RBCs are affected by changes in plasma volume, rate of RBC destruction or loss, splenic contraction, erythropoietin (EPO) secretion, and the rate of bone marrow production. (ivis.org)
- Purulent pericarditis results from depression of myocardial ischemia angina pectoris empiric trial regardless of the eating disorder, examining instead the impact of longitudinal deficiency affecting the cervical vertebrae, are common. (albionfoundation.org)