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ReserpineIproniazidMethyltyrosinesTyraminealpha-MethyltyrosineNorepinephrineAdrenergic Uptake InhibitorsLymphocyte DepletionHydroxydopaminesTetrabenazineChlorpromazinePargylineMephentermineCatecholaminesCatecholamine Plasma Membrane Transport ProteinsSecologanin Tryptamine AlkaloidsBiogenic AminesSerotoninSympathomimeticsNialamideAdrenal MedullaFenclonineVesicular Monoamine Transport ProteinsBretylium CompoundsPituitary IrradiationVesicular Biogenic Amine Transport ProteinsNormetanephrineMonoamine Oxidase InhibitorsChromaffin GranulesDopamine17-HydroxycorticosteroidsPhenoxybenzamineMethyldopaPharmacologyMethysergideSynephrineVas DeferensChromaffin SystemClopamideDesipramineAdrenergic AgentsTranylcypromine5-HydroxytryptophanGuanethidineChlorisondamineDextroamphetamineTranquilizing AgentsEpinephrineMetaraminolSympatholyticsDihydroxyphenylalanineTime FactorsEphedrineEthidiumPhentolamine
NorepinephrineAntagonized reserpine-inducedDopamineAlkaloidRauwolfiaCatecholaminesMonoamine depletionAnti-hypertensiveVesicularCatecholamineRescinnamineDepressionSedationAntidepressantsVMAT2Adverse effectsIproniazidLevelsIncreasesBrainResultsResearchersBoundBrainsMiceTherapyEffectsTreatmentDrugHigh blood prPatientsAnimalsEffectAgentActiveProduceStudiesDays
Norepinephrine7
Antagonized reserpine-induced1
  • The results showed that DSS treatment significantly antagonized reserpine-induced ptosis in mice. (hindawi.com)
Dopamine9
  • In his succeeding experiments, he introduced reserpine, a chemical used to deplete the storage the neurotransmitters including dopamine, to different animals. (assistertselvhjelp.no)
  • He noted that the animals showed inability to perform spontaneous movements, presumably due to the depletion of dopamine. (assistertselvhjelp.no)
  • It is also clear in retrospect that the reserpine-induced state was a state ol dopamine blockade, characterised by sedation and inactivity, rather than a valid model ol depression. (medicalbrandnames.com)
  • In their 1957 and 1958 papers [1.2], (Carlsson et al 1957) (Carlsson et al 1958) Carlsson and co-workers made the intriguing observation that the akinetic effects of reserpine could be reversed by an intravenous injection of the dopamine (and noradrenaline) precursor, 3,4- dihydroxyphenylalanine (DOPA). (lu.se)
  • The functional effect was correlated to a recovery of dopamine, but not noradrenaline, content in the brain, suggesting that depletion of dopamine, rather than noradrenaline or serotonin, was the cause of the akinetic state in reserpine-treated animals. (lu.se)
  • The ability of bromocriptine (BRC), a selective dopamine D-2 receptor agonist, to induce yawning responses was studied in rats pretreated with reserpine and alpha-methyl-p-tyrosine (alpha-MPT). (baillement.com)
  • Current evidence indicates that symptoms of Parkinson's disease are related to depletion of dopamine in the corpus striatum. (mdtodate.com)
  • 6-Pyruvoyl-tetrahydropterin synthase (PTPS) deficiency results in depletion of the brain neuro-transmitters serotonin and dopamine. (rarediseasesjournal.com)
  • PTPS deficiency, therefore, leads to hyperphenylalaninemia and depletion of the brain neurotransmitters serotonin and dopamine 1 . (rarediseasesjournal.com)
Alkaloid3
  • Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. (immunoportal.com)
  • Reserpine, an alkaloid in Rauwolfia reduces BP by decreasing the activity of central and peripheral noradrenergic neurons. (hempstreet.in)
  • The anti-psychotic alkaloid, reserpine, also found in Rauwolfia species is removed from Rovol V during the extraction process. (rifedigital.net)
Rauwolfia4
  • Derived from Rauwolfia serpentina (a plant that for centuries has been used in India for the treatment of mental illness, insomnia, and snake bites), reserpine was introduced in the West as a treatment for schizophrenia. (medscape.com)
  • Reserpine is derived from Rauwolfia serpentina, and was commonly used as an antihypertensive agent in the 1950s 12 . (drugbank.com)
  • Reserpine is in a class of medications called rauwolfia alkaloids. (drugbank.com)
  • The second , reserpine , was isolated from the Rauwolfia root in 1952 by Műller, Schlittler and Bein in the laboratories of CIBA, a Swiss pharmaceutical company(Műller, Schlittler, Bein 1952). (inhn.org)
Catecholamines3
  • The antihypertensive actions of Reserpine are a result of its ability to deplete catecholamines from peripheral sympathetic nerve endings. (drugbank.com)
  • This results in catecholamines and serotonin lingering in the cytoplasm where they are destroyed by intraneuronal monoamine oxidase, thereby causing the depletion of catecholamine and serotonin stores in central and peripheral nerve terminals. (drugbank.com)
  • The depletion of catecholamines and 5-hydroxytryptamine from the brain is thought to be the mechanism of the sedative and tranquilizing properties. (hempstreet.in)
Monoamine depletion2
  • Since these effects are resistant to prior monoamine depletion and/or synthesis inhibition by means of reserpine and alpha-propyldopacetamide (H22/54), respectively, they are most likely to be attributable to direct serotonin receptor agonism by 8-OH-DPAT. (erowid.org)
  • Since reserpine had been found to reduce levels ol serotonin and noradrenalin in the brain, it was suggested that the mechanism ol reserpine-induced depression was monoamine depletion. (medicalbrandnames.com)
Anti-hypertensive1
  • A number of reports of substance-induced mood disorders (SIMDs) have emerged since the 1950s, when psychiatric complications were described in patients treated with the anti-hypertensive reserpine. (medscape.com)
Vesicular3
  • The long-term decrease in 5-HT concentrations and tryptophan hydroxylase activity produced by MDMA was antagonized by depletion of vesicular monoamines with reserpine or interruption of monoamine synthesis with the decarboxylase inhibitor, monofluoro methyl DOPA (dihydroxyphenylalanine). (erowid.org)
  • ii) The turnover quantity of the reserpine-sensitive, proton-driven vesicular monoamine transporter VMAT2 (400 min?1) [8] is greater than that of the plasmalemmal transporters (120C180 min?1) [9,10]. (buyresearchchemicalss.net)
  • that is further backed from the noticed depletion of vesicular monoamine storage space by amphetamines performing in the vesicular monoamine transporters (observe above). (buyresearchchemicalss.net)
Catecholamine2
  • Reserpine is a catecholamine -depleting sympatholytic that is FDA approved for the {{{indicationType}}} of mild essential hypertension . (wikidoc.org)
  • These include models of tryptophan depletion, catecholamine depletion, and alterations in the hypothalamic-pituitary-adrenal axis. (medscape.com)
Rescinnamine1
  • The active ingredients in this drug are alkaloids and about 50 have been identified through various studies, although the primary psychoactive components appear to be reserpine, rescinnamine, and deserpidine 10 . (drugbank.com)
Depression4
  • Elucidation of the mechanismsof action of these first antidepressants, along with those of reserpine and amphetamine, led tothe monoamine theories of depression. (psychiatrist.com)
  • Reserpine may cause mental depression . (wikidoc.org)
  • Reserpine depletes brain (depression) and peripheral (PPH) noradrenaline (NA) storage sites, guanethidine depleted NA storage via blockade of reuptake 14 . (drugbank.com)
  • The neuroleptic drug reserpine was commonly thought to cause a depressive illness in a high proportion ol people who took it and lor this reason its sedative effects in animals were used as an animal model ol human depression. (medicalbrandnames.com)
Sedation9
  • acrivastine and reserpine both increase sedation. (medscape.com)
  • asenapine transdermal and reserpine both increase sedation. (medscape.com)
  • benzhydrocodone/acetaminophen and reserpine both increase sedation. (medscape.com)
  • brivaracetam and reserpine both increase sedation. (medscape.com)
  • buprenorphine subdermal implant and reserpine both increase sedation. (medscape.com)
  • buprenorphine, long-acting injection and reserpine both increase sedation. (medscape.com)
  • reserpine and ganaxolone both increase sedation. (medscape.com)
  • RESERPINE INJECTION produces a prolonged calming effect without sedation, drowsiness, or loss of coordination while vicious or dangerously anxious horses will become relaxed, sociable and co-operative with continued treatment. (kihorsemed.com)
  • However the original research only demonstrated that imipramine reduced the hypothermic effect ol reserpine and not other effects such as sedation. (medicalbrandnames.com)
Antidepressants2
  • Subsequently Italian researchers claimed that imipramine was also able to reduce the effects ol reserpine, which seemed to conlirm that the different types ol antidepressants had some linal common pathway ol action on a coherent underlying disease process. (medicalbrandnames.com)
  • This research is generally presented as demonstrating that tricyclic antidepressants block the depressive state induced by reserpine. (medicalbrandnames.com)
VMAT21
  • Reserpine binds irreversibly to VMAT2 and the duration of its effect is several days. (medscape.com)
Adverse effects1
  • In the same year, Steck reported on the similarities in therapeutic and adverse effects of reserpine and CPZ (Steck1954). (inhn.org)
Iproniazid1
Levels3
  • reserpine increases levels of berotralstat by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
  • Mean maximum plasma levels of plasma concentrations after 0.5 mg of Reserpine, administered as two 0.25 mg tablets or as an aqueous solution, peaked after 2.5 hours. (drugbank.com)
  • In 1955 researchers at the National Institutes of Health reported that reserpine reduces the levels of serotonin in the brains of animals. (rjwhelan.co.nz)
Increases2
  • reserpine increases toxicity of deutetrabenazine by pharmacodynamic synergism. (medscape.com)
  • Since reserpine increases gastrointestinal motility and secretion, it should be used cautiously in patients with a history of peptic ulcer , ulcerative colitis , or gallstones ( biliary colic may be precipitated). (wikidoc.org)
Brain1
  • This loss of NA transporter sites could result from depletion of central NA stores due to a reserpine-like effect of ammonia which is known to accumulate to millimolar concentrations in brain in ischemic liver failure. (hepato-neuro.ca)
Results2
  • Depletion results in a lack of active transmitter discharge from nerve endings upon nerve depolarization, and consequently leads to a decreased heart rate and decreased arterial blood pressure as well as sedative effects 12 . (drugbank.com)
  • Reserpine results in a rapid reduction in cardiac output, heart rate, and peripheral vascular resistance. (hempstreet.in)
Researchers1
  • In contrast, another group ol researchers found that imipramine appeared to potentiate the sedative effects ol reserpine, which would be consistent with it being a neuroleptic-type substance. (medicalbrandnames.com)
Bound1
  • Reserpine is extensively bound (95%) to plasma proteins 15 . (drugbank.com)
Brains1
  • Up-regulation of P-glycoprotein expression by means of glutathione depletion- induced oxidative stress in rat brains microvessel endotelial cells. (fosite.ru)
Mice1
  • To induce fibromyalgia in model mice, reserpine was injected intraperitoneally into wild-type mice once a day for 3 days. (e-jer.org)
Therapy1
  • Among his other discoveries is that fragments of RNA (which he called Beljanski Leucocyte Restorers or BLBs) are capable of rapidly restoring the depletion of (red) blood platelets and (white) leucocytes brought about by radiation therapy and chemotherapy agents. (rifedigital.net)
Effects4
  • The net depletion of these substances creates the calming and relaxing effects of RESERPINE INJECTION. (kihorsemed.com)
  • One was the effects of antidepressant drugs and the other was the effects of reserpine. (medicalbrandnames.com)
  • It is difficult to know how reliable it was and in any case it did not demonstrate any effect ol imipramine on the sedating or depressogenic effects ol reserpine. (medicalbrandnames.com)
  • BRC cannot be considered a directly acting agonist like apomorphine, since reserpine and -MPT inhibit or completely abolish most of the behavioral effects induced by BRC (Johnson et al. (baillement.com)
Treatment1
  • In particular, combined treatment with reserpine (5 mg/kg) and BRC (10 and 20 mg/kg) elicited upright fighting and jumping behaviors which were inhibited by haloperidol (1 mg/kg IP), a non-selective D-1 and D-2 receptor antagonist, SCH23390 (0.05 mg/kg SC). (baillement.com)
Drug3
  • Spoiler alert: Brodie's work showed that a new psychiatric drug known as reserpine was capable of fully depleting the brain's stores of serotonin and ― of greatest significance, as it turned out - mimicking the neuromuscular symptoms typical of Parkinson's disease. (medscape.com)
  • There is limited information regarding Clinical Trial Experience of Reserpine in the drug label. (wikidoc.org)
  • Reserpine is almost completely metabolized in the body, and only about 1% is excreted as unchanged drug in the urine 15 . (drugbank.com)
High blood pr1
  • Reserpine is used to treat high blood pressure. (drugbank.com)
Patients2
  • There is limited information regarding Off-Label Guideline-Supported Use of Reserpine in adult patients. (wikidoc.org)
  • There is limited information regarding Off-Label Non-Guideline-Supported Use of Reserpine in adult patients. (wikidoc.org)
Animals1
Effect1
  • INDICATION: RESERPINE INJECTION is particularly indicated where a prolonged effect to reduce anxiety and/or to calm horses is required, especially in the handling and management of dangerously anxious horses. (kihorsemed.com)
Agent1
  • RESERPINE INJECTION (Compare to the active ingredients of Nature Vet Rakelin®) is a long-acting non-sedating injectable calmative agent. (kihorsemed.com)
Active2
  • Stallions which have been treated with RESERPINE INJECTION (Compare to the active ingredients of Nature Vet Rakelin®) should not be used to service mares for at least fourteen days following injection. (kihorsemed.com)
  • In 1953 chemists at Ciba, a pharmaceutical company, isolated the active compound from this herb and called it reserpine. (rjwhelan.co.nz)
Produce1
Studies1
Days1