PhosphodiesteraseIntracellularAdenosinePhosphorylationProtein Kinase ActivityNucleotide PhosphodiesterasesPhosphodiesterasesAdenylate cyclaseProteinsEndothelial cellsCGMPRegulatesDecreasesAccumulationMeSHCytokineGeneConcentration-dependentSubunitCAMPTranscription factorPDE3CellsParticulateResponsesLevelsActivationDose-dependentStimulationMechanismsBetaEnzymeRoleIncreaseEffectFoundTypeLevelHigher
Phosphodiesterase4
- Using a mouse model of genetic copper misregulation, in combination with pharmacological alterations in copper status and imaging studies in a 3T3-L1 white adipocyte model, we found that copper regulates lipolysis at the level of the second messenger, cyclic AMP (cAMP), by altering the activity of the cAMP-degrading phosphodiesterase PDE3B. (nih.gov)
- Although cGMP activates the cyclic AMP (cAMP)-dependent pathway by suppressing cGMP-inhibited phosphodiesterase 3 (PDE3), the effects of the cAMP-dependent pathway on γ-globin gene expression are unknown. (elsevierpure.com)
- cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase . (wikipedia.org)
- In the oocyte, cyclic GMP prevents the breakdown of cyclic AMP by the phosphodiesterase PDE3, and thus maintains meiotic arrest. (wikipedia.org)
Intracellular8
- The inhibitory effect of cAMP could not be reversed by inhibition of cAMP-dependent protein kinase (PKA) but was blocked by depletion of the alternative intracellular cAMP sensor exchange protein activated by cAMP 1 (Epac1), which is also required to observe SOCS-3 accumulation in response to cAMP. (gla.ac.uk)
- an enzyme that phosphorylates target proteins in response to a rise in intracellular cyclic AMP. (oxfordreference.com)
- cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway . (wikipedia.org)
- With regard to the intracellular cyclic AMP level in normal PEC, it was significantly enhanced by a high concentration of TBX (10(-3) g/ml). (unboundmedicine.com)
- In addition to cleavage of NAD + to Nam and ADP-ribose, NADases found in animals act as ADP-ribosylcyclases, generating cyclic ADP-ribose (cADPR), a potent intracellular Ca 2+ mobilizing agent 7 . (nature.com)
- Thus, our discovery of the role of functional interaction between intracellular signaling pathways mediated by calcium ions (Ca 2+) and cyclic adenosine monophosphate (cAMP) (Ca 2+ /cAMP signaling interaction) in these cellular responses, opened a great avenue for the development of new antitumor therapeutic strategies. (researchgate.net)
- 0.05), neither associated to the uncoupling between the membrane electrical activity and Ca2+ release from intracellular stores nor to the impairment of the mechanisms controlling the Ca2+ homeostasis, nor to altered intracellular cyclic AMP levels. (units.it)
- Liraglutide increases intracellular cyclic AMP (cAMP) leading to insulin release in the presence of elevated glucose concentrations. (empr.com)
Adenosine5
- The objective of this work is to examine the capacity of a mechanical stress to cause changes in cell/substratum and cell/cell interactions via the second messenger cAMP pathway (cyclic Adenosine Monophosphate). (utc.fr)
- Cyclic adenosine monophosphate ( cAMP , cyclic AMP , or 3',5'-cyclic adenosine monophosphate ) is a second messenger , or cellular signal occurring within cells, that is important in many biological processes. (wikipedia.org)
- Earl Sutherland of Vanderbilt University won a Nobel Prize in Physiology or Medicine in 1971 "for his discoveries concerning the mechanisms of the action of hormones", especially epinephrine, via second messengers (such as cyclic adenosine monophosphate, cyclic AMP). (wikipedia.org)
- Erowid.org: Erowid Reference 3068 : Adenosine Cyclic 3',5'-Monophosphate in the Liver Fluke, fasciola hepatica. (erowid.org)
- In the presence of O.i mM 5HT, AC activity in the fluke particles was inhibited by 0.5 mcM LSD, and LSD also antagonized the 5HT stimulated increase in cyclic AMP levels, Adenine, adenosine, histamine (Calbiochem), adrenaline (Mann), tryptophan, dopamine, GTP (Sigma - Chem. (erowid.org)
Phosphorylation6
- A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. (rush.edu)
- The effect of phosphorylation by cyclic GMP-dependent protein kinase (G-kinase) on the activity of the plasmalemmal Ca2+-transport ATPase was studied on isolated plasma membranes and on the ATPase purified from pig erythrocytes and from the smooth muscle of pig stomach and pig aorta. (portlandpress.com)
- The levels of phosphorylation of mitogen-activated protein kinases (MAPKs) were not affected by the cAMP-dependent pathway. (elsevierpure.com)
- cAMP exerts its effects by activating the cAMP-dependent protein kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. (wikipedia.org)
- Disturbances in mitochondrial dynamics may influence many cellular and molecular pathways, as calcium-dependent immune activation, transcription factors phosphorylation, cytokine secretion, organelle transference and even cell death. (frontiersin.org)
- Cyclic AMP increased phosphorylation of fluke protein in both fractions. (erowid.org)
Protein Kinase Activity2
- Protein kinase activity was 2-5 times greater in the 'head' than in the posterior end of the fluke and in both particulate and supernatant fractions half-maximal activation was obtained at 0.1-0.4 mcM cyclic AMP. (erowid.org)
- Incubation of fluke heads for 5 min with 1 mM 5HT increased protein kinase activity of both fractions in the absence of added cyclic AMP, but with 5 mcM cyclic AMP protein kinase activity was increased inthe particulate and decreased in the super-natant fraction. (erowid.org)
Nucleotide Phosphodiesterases1
- Considerably higher resistance against cyclic nucleotide phosphodiesterases compared to dibutyryl- or 8-Br-cAMP (Cat. (biolog.de)
Phosphodiesterases1
- cAMP-dependent phosphodiesterases (PDEs) are essential components of the cAMP signaling cascade and fine-tune cyclic nucleotide signaling. (sdbonline.org)
Adenylate cyclase3
- The cAMP-dependent pathway was activated in K562 cells using the adenylate cyclase activator forskolin. (elsevierpure.com)
- Cyclic AMP is synthesized from ATP by adenylate cyclase located on the inner side of the plasma membrane and anchored at various locations in the interior of the cell. (wikipedia.org)
- Fasciola hepatica were collected from fresh beef livers and particulate fractions of whole flukes, 'tails' or 'heads' (anterior ends) assayed for adenylate cyclase (AC) activity and cyclic AMP concentration using a protein binding assay. (erowid.org)
Proteins3
- In addition, cAMP binds to and regulates the function of ion channels such as the HCN channels and a few other cyclic nucleotide-binding proteins such as Epac1 and RAPGEF2 . (wikipedia.org)
- Cyclic AMP binds to specific locations on the regulatory units of the protein kinase, and causes dissociation between the regulatory and catalytic subunits, thus enabling those catalytic units to phosphorylate substrate proteins. (wikipedia.org)
- However, as the oocyte grows, these proteins are synthesized, and meiotic arrest becomes dependent on cyclic AMP . (wikipedia.org)
Endothelial cells1
- Here we demonstrate that elevation of cyclic AMP (cAMP) levels in human umbilical vein endothelial cells (HUVECs) specifically attenuates ERK1,2 activation in response to either leptin or a soluble interleukin IL-6 receptor-α/IL-6 (sIL-6R-α/IL-6) trans-signalling complex but not protein kinase C activator phorbol 12-myristate 13-acetate. (gla.ac.uk)
CGMP3
- Fetal hemoglobin inducers such as hemin, butyrate, and hydroxyurea stimulate γ-globin gene expression by activating the cyclic GMP (cGMP)-dependent pathway. (elsevierpure.com)
- The cAMP-dependent pathway was found to be activated in K562 cells in which the cGMP-dependent pathway was activated by hemin. (elsevierpure.com)
- two of them play a dual role in cyclic guanosine monophosphate (cGMP) and cAMP signaling, whereas only Dunce (Dnc) is cAMP specific. (sdbonline.org)
Regulates1
- ICA69 regulates activity-dependent synaptic strengthening and learning and memory. (neurotree.org)
Decreases2
- [5] Because the granulosa cells and oocyte are connected by gap junctions, cyclic GMP also decreases in the oocyte, causing meiosis to resume. (wikipedia.org)
- Liraglutide also decreases glucagon secretion in a glucose-dependent manner. (empr.com)
Accumulation2
- 5HT (Calbiochem) caused a marked concentration-dependent accumulation of cyclic AMP especially in 'heads', maximal activation of AC occurring at i mM, and an accompanying increase in motility of the isolated fluke head. (erowid.org)
- Maxi-mum accumulation of cyclic AMP occurred in 5-10 min. (erowid.org)
MeSH1
- Cyclic AMP-Dependent Protein Kinase Type II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
Cytokine2
- Woolson, H. D. , Thomson, V. S. , Rutherford, C. , Yarwood, S. J. and Palmer, T. M. (2009) Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic amp via Epac1-dependent induction of suppressor of cytokine signalling-3. (gla.ac.uk)
- In addition, it reveals a novel Epac-dependent mechanism by which cAMP can specifically inhibit ERK in response to cytokine receptor activation. (gla.ac.uk)
Gene6
- Activation of the cAMP-dependent pathway by forskolin inhibited hemin-induced expression of γ-globin mRNA and decreased transcriptional activity of the γ-globin gene promoter. (elsevierpure.com)
- These results suggested that the cAMP-dependent pathway, which is independent of MAPK pathways, plays a negative role in γ-globin gene expression in K562 cells. (elsevierpure.com)
- cAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene. (wikipedia.org)
- Furthermore, we find that extracellular signal-regulated kinase (ERK)-mediated retrograde signalling is required for PCAF-dependent regenerative gene reprogramming. (nature.com)
- In addition, we observed that extracellular signal-regulated kinase (ERK) axonal retrograde signalling is required for PCAF-dependent acetylation at these promoters and for their enhancement in gene expression. (nature.com)
- Our results propose that a broad pattern of astrocyte responses to dopamine specifically relies on CTCF-dependent gene networks. (jneurosci.org)
Concentration-dependent1
- We found that extracellular dopamine triggered rapid concentration-dependent stellation of astrocytic processes that was not a result of dopamine oxidation but instead relied on both cAMP-dependent and cAMP-independent dopamine receptor signaling. (jneurosci.org)
Subunit1
- Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition. (rush.edu)
CAMP9
- To investigate the role of the cAMP-dependent protein kinase (PKA) in the desensitization and down-regulation of the D 1 dopamine receptor, we stably expressed the rat cDNA for this receptor in mutant Chinese hamster ovary (CHO) cell lines deficient in PKA activity. (aspetjournals.org)
- These cell responses were cAMP‐dependent. (utc.fr)
- In eukaryotes, cyclic AMP works by activating protein kinase A (PKA, or cAMP-dependent protein kinase ). (wikipedia.org)
- Several classes of protein kinases , including protein kinase C, are not cAMP-dependent. (wikipedia.org)
- Further effects mainly depend on cAMP-dependent protein kinase , which vary based on the type of cell. (wikipedia.org)
- We demonstrate here that the kinases Gsk3β and cAMP-dependent protein kinase A (PKA) are novel determinants of IZ formation and cooperate with E(Spl) activity in a dose-dependent manner. (biologists.com)
- Within these neurons, two cyclic AMP (cAMP)-dependent mechanisms balance the degree of tolerance. (sdbonline.org)
- In neuronal cell lines, ethanol exposure reduces cyclic AMP (cAMP) levels, which results in cellular tolerance. (sdbonline.org)
- Over fifty members of this family exist, most of which bind specifically to regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASE TYPE II such as CAMP PROTEIN KINASE RIIALPHA or CAMP PROTEIN KINASE RIIBETA. (bvsalud.org)
Transcription factor1
- Western blot was performed using Anti-ATF2 Recombinant Rabbit Monoclonal Antibody (SZ17-01) (Product # MA5-32022) and 60kDa and 40kDa bands corresponding to Cyclic AMP-dependent transcription factor ATF-2 was observed across all the tested cell lines and tissues, except Mouse Skeletal Muscle. (thermofisher.com)
PDE31
- Biochemical studies of the copper-PDE3B interaction establish copper-dependent inhibition of enzyme activity and identify a key conserved cysteine residue in a PDE3-specific loop that is essential for the observed copper-dependent lipolytic phenotype. (nih.gov)
Cells3
- We further show that the cyclic AMP-dependent protein kinase (protein kinase A [PKA]) pathway maintains the cytoplasmic localization of Sip1 in glucose-grown cells. (elsevierpure.com)
- The granulosa cells produce a small molecule, cyclic GMP , that diffuses into the oocyte through the gap junctions. (wikipedia.org)
- Luteinizing hormone acts on receptors in the outer layers of granulosa cells of the follicle, causing a decrease in cyclic GMP in the granulosa cells. (wikipedia.org)
Particulate1
- A cyclic AMP-dependent protein kinase subtype primarily found in particulate subcellular fractions. (uchicago.edu)
Responses1
- The Snf1/AMP-activated protein kinase family has diverse roles in cellular responses to metabolic stress. (elsevierpure.com)
Levels3
- The enhanced levels of cyclic AMP were preserved by both caffeine and papaverine, and NaF up to 5 mM caused a specific stimulation of AC. (erowid.org)
- both strongly stimulated motility but had no effect on cyclic AMP levels. (erowid.org)
- glucagon (Lilly) and noradrenaline (Winthrop) had no effect on motility or cyclic AMP levels. (erowid.org)
Activation1
- The degree of activation by cyclic AMP was inversely correlated with endogenous cyclic AMP and 5HT concentration. (erowid.org)
Dose-dependent1
- Dose-Dependent Effect of Prenatal Dexamethasone Treatment on beta-Adrenergic Receptor Coupling to Ornithine Decarboxylase and Cyclic AMP. (epa.gov)
Stimulation1
- The stimulation of the (Ca2+ + Mg2+)-dependent ATPase activity of the purified Ca2+ pump reconstituted in liposomes depended on the phospholipid used for reconstitution. (portlandpress.com)
Mechanisms1
- Alteration of synaptic concentrations of catecholamines with either reserpine or tricyclic antidepressants does not alter the actions of dobutamine in animals, which indicates that the actions of dobutamine are not dependent on presynaptic mechanisms. (drugs.com)
Beta2
- Cyclic AMP-dependent pathway, exactly how beta 2- adrenergic tHC Amphetamines Cocaine nice words encouraging me to continue working on myself. (globalgamingfactory.com)
- Esta familia consta de unas cincuenta proteínas, la mayoría de las cuales se unen específicamente a subunidades reguladoras de la PROTEÍNA CINASA DEPENDIENTE DEL AMP-CÍCLICO DE TIPO II, como son las subunidades PROTEÍNA CINASA DEPENDIENTE DEL AMPC RII ALFA o PROTEÍNA CINASA DEPENDIENTE DEL AMPC RII BETA. (bvsalud.org)
Enzyme1
- Aspirin irreversibly inhibits the enzyme COX, resulting in reduced platelet production of TXA 2 (thromboxane - powerful vasoconstrictor which lowers cyclic AMP and initiates the platelet release reaction). (wikidoc.org)
Role1
- The cyclic AMP-dependent protein kinase A signaling pathway plays a major role in regulating plant infection from the rice blast fungus and or are both necessary for development of spores and appressoria by and play roles in cell wall differentiation, regulating melanin pigmentation and cell surface hydrophobicity during spore formation. (bio2009.org)
Increase1
- 5-Methoxytryptamine (1 mM, Calbiochem) caused a 4-fold increase in motility similar to 5HT but had a much diminished effect on cyclic AMP and AC acitivity, while tryptamine (Calbiochem), 5 - hydroxydimethyltryptamine (Sigma-Chem. (erowid.org)
Effect1
- Cyclic AMP-dependent protein kinase (A-kinase) did not exert such an effect. (portlandpress.com)
Found1
- We found that p300/CBP-associated factor (PCAF)-dependent acetylation of histone 3 lysine 9 (H3K9ac), paralleled by a reduction in methylation of H3K9 (H3K9me2), occurred at the promoters of select genes only after PNS axonal injury. (nature.com)
Type2
- This graph shows the total number of publications written about "Cyclic AMP-Dependent Protein Kinase Type II" by people in this website by year, and whether "Cyclic AMP-Dependent Protein Kinase Type II" was a major or minor topic of these publications. (uchicago.edu)
- Below are the most recent publications written about "Cyclic AMP-Dependent Protein Kinase Type II" by people in Profiles. (uchicago.edu)
Level1
- At the neuronal level, Dunce and Hangover are required in the same neuron pair to regulate experience-dependent motor output. (sdbonline.org)
Higher1
- Preductal and postductal oxygen saturation measurements via pulse oximetry will often show a 10% or higher gradient difference, which is dependent on the magnitude of left-to-right shunting at the foramen ovale (with preductual saturations being higher). (medscape.com)