• clinical
  • All of the VCI criteria rely on clinical evidence of a cognitive impairment syndrome (subdivided as MCI or dementia), clinical evidence of cerebrovascular disease (most commonly, history of stroke or neuroimaging evidence of severe clinically unapparent cerebrovascular disease), and a clinical judgment that the cerebrovascular disease is causing the cognitive impairment. (ahajournals.org)
  • This may be a result of the time it took for DLB diagnostic criteria established in 1996 to become part of routine clinical practice when diagnosing dementia. (lbda.org)
  • symptoms
  • Dr. Rodolfo Savica and colleagues identified individuals who had documented two core symptoms of LBD (parkinsonism and dementia) and studied their medical records to further diagnose individuals with LBD. (lbda.org)
  • For example, some cases of undiagnosed DLB have documented dementia but not other DLB symptoms like fluctuating cognition or sensitivity to neuroleptics, to support a DLB diagnosis. (lbda.org)
  • Some DLB symptoms, like fluctuating cognition or REM sleep behavior disorder, would not have been widely screened for in the 1990's and 200's when making a differential dementia diagnosis. (lbda.org)
  • It is hoped that AZT will stabilize or improve the symptoms of the AIDS dementia complex. (clinicaltrials.gov)
  • mild
  • In this article, we review trial design and drug development for vascular cognitive impairment (VCI), focusing on symptomatic patients with vascular mild cognitive impairment (MCI) or dementia. (ahajournals.org)
  • health
  • Dementia is a large and growing health problem in developed and developing countries, with total costs approaching 1% of global gross domestic product, threatening the sustainability of healthcare systems. (ahajournals.org)