• clinical
  • All of the VCI criteria rely on clinical evidence of a cognitive impairment syndrome (subdivided as MCI or dementia), clinical evidence of cerebrovascular disease (most commonly, history of stroke or neuroimaging evidence of severe clinically unapparent cerebrovascular disease), and a clinical judgment that the cerebrovascular disease is causing the cognitive impairment. (ahajournals.org)
  • This may be a result of the time it took for DLB diagnostic criteria established in 1996 to become part of routine clinical practice when diagnosing dementia. (lbda.org)
  • mild
  • In this article, we review trial design and drug development for vascular cognitive impairment (VCI), focusing on symptomatic patients with vascular mild cognitive impairment (MCI) or dementia. (ahajournals.org)
  • symptoms
  • Dr. Rodolfo Savica and colleagues identified individuals who had documented two core symptoms of LBD (parkinsonism and dementia) and studied their medical records to further diagnose individuals with LBD. (lbda.org)
  • For example, some cases of undiagnosed DLB have documented dementia but not other DLB symptoms like fluctuating cognition or sensitivity to neuroleptics, to support a DLB diagnosis. (lbda.org)
  • Some DLB symptoms, like fluctuating cognition or REM sleep behavior disorder, would not have been widely screened for in the 1990's and 200's when making a differential dementia diagnosis. (lbda.org)
  • disorders
  • The terms VCI, vascular contributions to cognitive impairment and dementia, vascular cognitive disorders, and vascular neurocognitive disorders all describe circumstances in which cognitive impairment or dementia is partly or primarily causally related to vascular disease. (ahajournals.org)
  • health
  • Dementia is a large and growing health problem in developed and developing countries, with total costs approaching 1% of global gross domestic product, threatening the sustainability of healthcare systems. (ahajournals.org)