• clinical
  • All of the VCI criteria rely on clinical evidence of a cognitive impairment syndrome (subdivided as MCI or dementia), clinical evidence of cerebrovascular disease (most commonly, history of stroke or neuroimaging evidence of severe clinically unapparent cerebrovascular disease), and a clinical judgment that the cerebrovascular disease is causing the cognitive impairment. (ahajournals.org)
  • disorders
  • The terms VCI, vascular contributions to cognitive impairment and dementia, vascular cognitive disorders, and vascular neurocognitive disorders all describe circumstances in which cognitive impairment or dementia is partly or primarily causally related to vascular disease. (ahajournals.org)
  • health
  • Dementia is a large and growing health problem in developed and developing countries, with total costs approaching 1% of global gross domestic product, threatening the sustainability of healthcare systems. (ahajournals.org)
  • patients
  • In this article, we review trial design and drug development for vascular cognitive impairment (VCI), focusing on symptomatic patients with vascular mild cognitive impairment (MCI) or dementia. (ahajournals.org)