• tissue
  • A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. (google.ca)
  • It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells. (google.ca)
  • however, in traditional formulations, only small amounts of the administered drug penetrate the cornea to reach the desired intraocular tissue due to corneal barriers and dilution caused by lacrimation [ 1 - 3 ]. (omicsonline.org)
  • tumor
  • [ 24 - 26 ] Moreover, by virtue of the unique enhanced permeability and retention (EPR) effect of nanoscaled materials, [ 27 - 29 ] nanopharmaceuticals always exhibit specific tumor targeting ability, which greatly mitigates the side effect of conventional pharmaceuticals on normal tissues. (pubmedcentralcanada.ca)
  • Certain chemotherapeutic agents may enhance the immune effects of genetically modified tumor vaccines. (jove.com)
  • biological
  • In contrast to traditional methods of drug discovery (known as forward pharmacology), which rely on trial-and-error testing of chemical substances on cultured cells or animals, and matching the apparent effects to treatments, rational drug design (also called reverse pharmacology) begins with a hypothesis that modulation of a specific biological target may have therapeutic value. (wikipedia.org)
  • Hence
  • Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. (wikipedia.org)
  • Due to similarities in binding sites, closely related targets identified through sequence homology have the highest chance of cross reactivity and hence highest side effect potential. (wikipedia.org)
  • undergo
  • 10 Patients must be willing to undergo multiple treatment periods and, if important to trial design, to take a blinded medication. (ahrq.gov)
  • cellular
  • Multiple cellular processes related to apoptosis or cell proliferation lead to alterations in signaling pathways that are responsible for resistance to chemotherapy and drug tolerance in a cancer cell. (dovepress.com)
  • drugs
  • Since its introduction by Nicholas Bodor in the late 1970s, the soft drug concept generated considerable research both in academic and in industrial settings and there are several rationally designed soft drugs that have either already reached the market, such as esmolol (Breviblock) landiolol (Onoact) remifentanil (Ultiva) loteprednol etabonate (Lotemax, Alrex, Zylet) clevidipine (Cleviprex) or are in late-stage development (remimazolam, budiodarone, celivarone, AZD3043, tecafarin). (wikipedia.org)
  • however, negative side effects remain a significant problem in the field, hampering our ability to bring safe and effective drugs to market. (researchandmarkets.com)
  • experiments
  • Conceived and designed the experiments: DA CH MT OK MM. Performed the experiments: VP PLM MT CT GJ ES MG. Analyzed the data: CH MT OK MM. Contributed reagents/materials/analysis tools: ES MG MM CT OK. (pubmedcentralcanada.ca)
  • organ
  • Whereas, CDSs are designed to achieve drug targeting at a selected organ or site, SDs are designed to afford a differential distribution that can be regarded as reverse targeting. (wikipedia.org)
  • research
  • SU2C's funding model for the Innovative Research Grants was designed s. (bio-medicine.org)
  • With detailed acquaintance of these subcellular behaviours, we anticipate that the research we discuss in this review can inspire other scientists to develop next generation nanopharmaceuticals that can be guided by fluorescence imaging and thus can realize concisely controllable drug delivery. (pubmedcentralcanada.ca)
  • We report on the process and outcome of our formative research aimed at systematically selecting and adapting an EBI designed to reduce secondary HIV risk and improve adherence to antiretroviral therapy among soon-to-be-released HIV-infected prisoners. (hindawi.com)
  • Our research team has addressed this unmet need by conducting formative research designed to inform the selection, adaptation, and placement of an evidence-based secondary HIV risk reduction and antiretroviral adherence intervention specifically for implementation during the transition period when HIV-infected prisoners are preparing to return to the community. (hindawi.com)
  • treatment
  • Evidence-based interventions (EBIs) have been developed for HIV-infected drug users in prisons [ 3 ] as well as drug users enrolled in community-based drug treatment settings [ 17 , 18 ], though none to date have been successfully tailored to prepare inmates for the extremely high risk period immediately following release during which newly released HIV-infected prisoners are becoming reintegrated into the community. (hindawi.com)
  • high
  • Penile female preoperative bags on outdated of june 2015 at times effects for electronic tumour are recently more similar in active lowest risk or is bijwerkingen kamagra oral jelly high. (wlconstruction.com)
  • sites
  • Assuming an ideal situation, with a CDS the drug is present at the site and nowhere else in the body because enzymatic processes destroy the drug at those sites. (wikipedia.org)
  • particular
  • I am interested in exploring the concept of drug-disease interaction, and studying the effect of inflammation, in particular, on the renin-angiotensin system (RAS) at enzyme, peptide, and receptor levels in order to fully understand the underlying mechanisms. (isu.edu)
  • important
  • To obtain clinically acceptable design is very important as it serves in terms of both patient safety and optimal performance of implants. (einnext.com)
  • process
  • Based on the effect of pH on the fibrillization of human calcitonin, the analysis of conformationally constrained analogues of the hormone, and our suggestion regarding the role of aromatic residues in the process of amyloid fibril formation, we studied the ability of a short aromatic charged peptide fragment of calcitonin (NH(2)-DFNKF-COOH) to form amyloid fibrils. (jove.com)
  • features
  • Most importantly, these features can be designed and tailored using computer assisted design (CAD) for individual patients to optimize therapy. (patents.com)
  • site
  • or ion channel openers or blockers) will be designed that are complementary to the binding site of target. (wikipedia.org)
  • order
  • In order for a biomolecule to be selected as a drug target, two essential pieces of information are required. (wikipedia.org)
  • benefit
  • The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. (wikipedia.org)
  • disease
  • Potential drug targets are not necessarily disease causing but must by definition be disease modifying. (wikipedia.org)
  • Another consume for resolve downfall business has become medical as europe migrates from disease to large side. (wlconstruction.com)
  • significant
  • This information provides significant information that can be used to design further studies aimed at developing less toxic eye drops. (omicsonline.org)
  • help
  • With the help of CFD analysis we identify the locations of excess deposition and the locations devoid of drug that could help in optimizing the design of asthma inhalers. (einnext.com)
  • changes
  • We explore performance of various orthopedic implants and their significance based on design changes through finite element analysis. (einnext.com)
  • 1,2 Many interventions of interest to patients, such as those that facilitate the management of side effects or those addressing lifestyle changes, have never been tested by RCTs, making evidence-based decisions among these alternatives impossible. (ahrq.gov)