A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. (wikipedia.org)
An advantage of a transdermal drug delivery route over other types of medication delivery (such as oral, topical, intravenous, or intramuscular) is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. (wikipedia.org)
Alza Corporation, the company that invented and introduced the first transdermal patches, Scopolamine Transderm Scop, to the American market. (amarintech.com)
Skin2
as a result, only medications whose molecules are small enough to penetrate the skin can be delivered by this method. (wikipedia.org)
Caffeine patches, designed to deliver caffeine to the body through the skin. (wikipedia.org)
Market1
The firm has its targets set far as it delivers a very solid experience to the market. (forexinfolink.com)
Access2
These browser-based, web-delivered applications allow you to enjoy account access from any location world-wide. (co.ke)
includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues. (ijpc.com)
Systemic2
The system is programmed to deliver in-vivo approximately 1.0 mg of scopolamine at an approximately constant rate to the systemic circulation over 3 days. (nih.gov)
Following removal of the used system, there is some degree of continued systemic absorption of scopolamine bound in the skin layers. (nih.gov)
Membrane3
The subsequent delivery of scopolamine to the blood is determined by the rate controlling membrane and is designed to produce stable plasma levels in a therapeutic range. (nih.gov)
The device for adjusting the distance provides a space between reservoir layer and membrane and thereby prevents their premature contact. (justia.com)
The device for regulating the distance extends over the whole, mutually facing surfaces of the reservoir and the membrane. (justia.com)
Adhesive2
and (4) an adhesive formulation of mineral oil, polyisobutylene, and scopolamine. (nih.gov)
Upon application to the post-auricular skin, an initial priming dose of scopolamine is released from the adhesive layer to saturate skin binding sites. (nih.gov)
Dose1
Although not well characterized, scopolamine is extensively metabolized and conjugated with less than 5% of the total dose appearing unchanged in the urine. (nih.gov)
Layer1
The elastic plastic disk exerts constant pressure on the reservoir layer. (justia.com)
The present invention relates to an active substance-containing patch for the controlled release of active substances, comprising an active substance-containing reservoir mass which softens at body temperature. (justia.com)
DE 35 03 111 describes a patch comprising drugs in a solid reservoir mass which softens at body temperature and is formed as a disk. (justia.com)
Another patch of this kind is described in DE 35 22 060, here a reservoir mass disk is fixed to an elastic plastic disk having the same diameter. (justia.com)
If the patch is changed daily, there are phases without any active substance release alternating with those wherein active substance is delivered to the body. (justia.com)
It is accordingly the object of the present invention to provide an active substance-containing patch with an active substance-containing reservoir mass softening at body temperature, which releases the active substance only after a predetermined period from application. (justia.com)
Active2
The sole active agent of Transderm Scōp is scopolamine, a belladonna alkaloid with well-known pharmacological properties. (nih.gov)
The active substance-containing reservoir has the function of accommodating the active substance. (justia.com)