Mice, KnockoutPhenotypeGene DeletionSequence DeletionChromosome DeletionGene Knockout TechniquesMolecular Sequence DataBase SequenceMice, Inbred C57BLMutationAmino Acid SequenceCells, CulturedCell LineSignal TransductionRNA, MessengerPolymerase Chain ReactionDisease Models, AnimalPlasmidsGene TargetingDNA PrimersCloning, MolecularChromosome MappingGene Expression RegulationHomozygotePromoter Regions, GeneticReactive Oxygen SpeciesTranscription, GeneticTranscription FactorsRecombination, GeneticExonsEscherichia coliDNA-Binding ProteinsDNA Mutational AnalysisAllelesGenotypeTime FactorsHeterozygoteMutagenesisMice, TransgenicBacterial ProteinsMembrane ProteinsTransfectionCell Differentiation