• aldolase
  • Utilized in the bacterial degradation of toxic aromatic compounds, the enzyme's crystal structure indicates that intermediates are shuttled directly between active sites through a hydrophobic intermediary channel, providing an unreactive environment in which to move the reactive acetaldehyde intermediate from the aldolase active site to the acetaldehyde dehydrogenase active site. (wikipedia.org)
  • In enzymology, a 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) is an enzyme that catalyzes the chemical reaction 4-hydroxy-2-oxopentanoate ⇌ {\displaystyle \rightleftharpoons } acetaldehyde + pyruvate Hence, this enzyme has one substrate, 4-hydroxy-2-oxopentanoate, and two products, acetaldehyde and pyruvate. (wikipedia.org)
  • Crystallization and preliminary X-ray analysis of dmpFG-encoded 4-hydroxy-2-ketovalerate aldolase--aldehyde dehydrogenase (acylating) from Pseudomonas sp. (wikipedia.org)
  • symptoms
  • Acetaldehyde is more toxic than alcohol and is responsible for many hangover symptoms. (wikipedia.org)
  • As acetaldehyde is one of the major causes of the symptoms of a "hangover", this produces immediate and severe negative reaction to alcohol intake. (wikipedia.org)
  • The result is a patient with a prolonged and deeper level of intoxication for any given dose of ethanol, and reduced "hangover" symptoms (since these adverse symptoms are largely mediated by acetaldehyde build up). (wikipedia.org)
  • exposure
  • The HbAA levels are not only a good biomarker for increased internal exposure levels to acetaldehyde but may also be a predictive biomarker for acetaldehyde-mediated carcinogenesis. (aacrjournals.org)
  • The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. (wikipedia.org)