• enzymology
  • In enzymology, a phosphogluconate dehydrogenase (decarboxylating) (EC 1.1.1.44) is an enzyme that catalyzes the chemical reaction 6-phospho-D-gluconate + NADP+ ⇌ {\displaystyle \rightleftharpoons } D-ribulose 5-phosphate + CO2 + NADPH Thus, the two substrates of this enzyme are 6-phospho-D-gluconate and NADP+, whereas its 3 products are D-ribulose 5-phosphate, CO2, and NADPH. (wikipedia.org)
  • oxidative
  • Several studies have linked oxidative stress to diseases such as Alzheimer's disease, as well as cancer, These studies have found phosphogluconate dehydrogenase activity to be up-regulated, both in tumor cells and in relevant cortical regions of Alzheimer's patient brains, most likely as a compensatory reaction to highly oxidative environments. (wikipedia.org)
  • activity
  • Several deficiencies in the level of activity (not function) of glucose-6-phosphate dehydrogenase have been observed to be associated with resistance to the malarial parasite Plasmodium falciparum among individuals of Mediterranean and African descent. (wikipedia.org)
  • studies
  • These studies have revealed co-localization of 1-deoxy-D-xylulose 5-phosphate synthase ( VvDXS ) with the major QTL positioned on chromosome 5. (biomedcentral.com)