Degree polymorphism genetic. Medical search. Frequent questions

Aim To examine whether intraocular pressure (IOP) reduction by latanoprost correlates with single nucleotide polymorphisms (SNPs) of the prostaglandin F2α (FP) receptor gene in patients with glaucoma and ocular hypertension (OH). (bmj.com)
Four tagged single-nucleotide polymorphisms (SNPs) of HMGB1 were detected by a TaqMan-based real-time polymerase chain reaction (PCR) in patients. (jcancer.org)
Two coding single nucleotide polymorphisms (SNPs) supposedly affect their functions: GSTO1*C419A (rs4925) causing alanine to aspartate substitution (*A140D) and GSTO2*A424G (rs156697) causing asparagine to aspartate substitution (*N142D), and have been associated with several neurodegenerative diseases and cancers. (cancerindex.org)
This study identified SNPs which differentiate samples that are affected by acidification and waterway regulation from those that are unaffected, or affected to a lesser degree. (nofima.no)
OncoVue identifies abnormal single nucleotide polymorphisms, or SNPs, which are known to have age-specific genetic associations with breast cancer risk. (optics.org)
No clinical studies have explored the effect of single nucleotide polymorphisms (SNPs) resulting in reduced activity enzymes (e.g. (aspetjournals.org)
We produced assemblies for the five species ranging in aggregate length from 68 to 79 megabase pairs, identified putative orthologs for more than 12,000 human genes, and predicted more than 32,000 cross-species single nucleotide polymorphisms (SNPs). (biomedcentral.com)
We ing practice, different workload, and the use of personal are monitoring single nucleotide polymorphisms (SNPs) protection devices. (cdc.gov)

Initiation and propagation of tumors reflect underlying genomic alterations such as mutations, polymorphisms, and copy number variations found in genes of multiple cellular pathways. (hindawi.com)
Chromosomal abnormalities, HLA phenotypes, and polymorphisms of various genes have been associated with acne. (springer.com)
All of the genotypes analyzed were in Hardy-Weinberg equilibrium, but different degrees of linkage were observed for polymorphisms in the CYP1A1 and EPHX1 genes. (scielo.br)
Patients were genotyped for a panel of 192 tagging polymorphisms in 34 immune-related genes. (frontiersin.org)
Certain common changes (polymorphisms) in the CYP2C9 and VKORC1 genes account for most of the variation in warfarin metabolism due to genetic factors. (medlineplus.gov)
Polymorphisms in other genes, some of which have not been identified, have a smaller effect on warfarin metabolism. (medlineplus.gov)
Additionally, people who have more than one polymorphism in a gene or polymorphisms in multiple genes associated with warfarin sensitivity have a lower tolerance for the drug's effect or take even longer to clear the drug from their body. (medlineplus.gov)
This effect may occur through polymorphisms in the genes involved in slow-wave sleep generation or sleep depth. (sleepreviewmag.com)
Concomitance of Polymorphisms in Glutathione Transferase Omega Genes Is Associated with Risk of Clear Cell Renal Cell Carcinoma. (cancerindex.org)
The enrichment remained significant after controlling for other known genetic enrichment factors, and for affiliation to genes highly expressed in the brain. (nature.com)
Previous studies have noted a specific association between type 1 diabetes and insufficient levels of vitamin D, as well as polymorphisms within genes related to vitamin D pathways. (diabetesjournals.org)
Sexually antagonistic genes and traits are interesting because they may hold the key to one of the long-standing paradoxes in evolutionary biology: the maintenance of standing genetic variation. (lu.se)

Genome wide association studies, fluorescence in situ hybridization, comparative genomic hybridization, and candidate gene studies have enumerated genetic contributors to cancers in women. (hindawi.com)
Here, we investigated whether genomic regions that underwent positive selection in humans after divergence from Neanderthals are enriched for genetic association with phenotypes related to cognitive functions. (nature.com)
Genomic variation was assessed at 3761 single nucleotide polymorphism (SNP) markers in Atlantic salmon from 25 salmon populations in western and south western Norway. (nofima.no)
The results revealed that genetic variation among Iranian population of the pathogen is very high, and further that RAPD is a vigorous tool for genomic analysis of Ascochyta rabiei . (ac.ir)
ii) quan- genetic factors together can influence genomic stability. (cdc.gov)

There is strong evidence that inherited genetic factors (mutations plus single nucleotide polymorphisms) can play a major role in breast cancer susceptibility [ 1 ]. (hindawi.com)
Genetic loci implicated in hereditary, familial, and sporadic breast cancer susceptibility. (hindawi.com)
Other contributors to genetic susceptibility, for example, polymorphisms, may have a higher relative contribution to risk, but their lower penetrance makes identification more difficult. (hindawi.com)
Furthermore, modification of genetic susceptibility by environmental factors, both endogenous and exogenous, may alter the degree of penetrance. (hindawi.com)
Estimation of the level of genetic susceptibility showed that the individual calculated risk value (iCRV) ranged from 1 to 16, with a higher iCRV indicating a greater genetic susceptibility to lung cancer. (scielo.br)
Furthermore, we found that HMGB1 rs1360485 polymorphisms seemed to be related to susceptibility to developing poorly differentiated cancer linked to tobacco consumption in EGFR mutant patients. (jcancer.org)
CYP2C9 * 3 ) on drug clearance have been well characterized but much less is known about whether these polymorphisms alter susceptibility to drug-drug interactions. (aspetjournals.org)
Clinical Relevance: Identification of genetic RCD susceptibility markers can guide understanding of biological processes in rotator cuff degeneration and help inform disease risk in the clinical setting. (cdc.gov)

Put simply, polymorphism is when there are two or more possibilities of a trait on a gene. (wikipedia.org)
Several CYP2C9 gene polymorphisms decrease the activity of the CYP2C9 enzyme and slow the body's metabolism of warfarin. (medlineplus.gov)
Certain VKORC1 gene polymorphisms decrease the amount of functional VKORC1 enzyme available to help activate clotting proteins. (medlineplus.gov)
Functional relevance of yet another GSTO2 polymorphism, identified at the 5' untranslated (5'UTR) gene region (GSTO2*A183G, rs2297235), has not been clearly discerned so far. (cancerindex.org)
With the recognition that DNA was the genetic material, the word "gene" took on an additional meaning as a physical unit of function. (blogspot.com)
The purpose of this study was to identify the polymorphism of the mitogen-activated protein kinase 5 ( MAP3K5 ) gene and determine whether it was associated with the body size traits (body height, body length, chest circumference, and cannon circumference) in Hu sheep. (copernicus.org)
A new strategic plan from National Institutes of Health's National Human Genome Research Institute envisions scientists being able to identify genetic bases of most single-gene disorders and gaining new insights into multi-gene disorders in the next decade. (massdevice.com)
For example, variants of the ADIPOQ gene (the rs266729 single-nucleotide polymorphism) are associated with obesity and diabetes in various Arab countries. (who.int)
My main interest is in the evolutionary genetics of sex differences, especially sexually antagonistic genetic variation-in other words, when the same gene has opposite effects on the fitness of males and females. (lu.se)

The significance of geographical variation is that it may lead to allopatric speciation, whereas true polymorphism takes place in panmictic populations. (wikipedia.org)
Therefore, the aim of this study was to assess genetic variation in populations of Atlantic salmon in western Norway that have experienced environmental changes due to river acidification and waterway regulation. (nofima.no)
In order to determine the fitness consequences in populations of Atlantic salmon affected by these studied anthropogenic activities, it will be necessary to include more samples from a greater distribution to estimate population size changes and changes in genetic variation over a temporal time scale. (nofima.no)
The conclusion drawn from this comparison is that, although there is evidence that a degree of similarity of frequency exists between populations, the extent of such similarity is extremely difficult to quantify objectively. (dur.ac.uk)
NO compelling evidence has been found to indicate that Chromosomal polymorphisms have an adaptive importance in present-day human populations, nor has any information which would indicate a theoretical basis for such an observation. (dur.ac.uk)
Germana obtained a master degree with honors in Molecular Biology and a PhD in Genetics and Molecular Biology in Rome studying haemoglobin variants of West African populations. (shoklo-unit.com)
Her main interest was the genetic of resistance to malaria in humans and the evolution of advantageous polymorphisms in African populations. (shoklo-unit.com)
We analyzed allele frequencies and other statistical parameters in three selected populations in order to identify groups of specific ethnic origin and establish their genetic relationship. (wayne.edu)
This activity would explain why non-African populations display what appears to be a 1 to 4 percent genetic contribution from Neanderthals while African people groups display no contribution whatsoever. (reasons.org)
Varying degrees of intraspecific ecological divergence were observed across the ten color morph pairs, but most pairs exhibited a consistently parallel ecological and evolutionary trajectory across populations. (biomedcentral.com)
Population genetic studies enabled the detection of population structure with those markers, but a more comprehensive analysis of natural populations was only possible with the development of statistical methods that combined both molecular data and environmental variables. (intechopen.com)
Population genetic studies deal with allele frequencies and processes that shape their variation within and among populations. (intechopen.com)
Importance of Including Non-European Populations in Large Human Genetic Studies to Enhance Precision Medicine. (cdc.gov)
Populations on different continents vary considerably in their predisposition to disease, probably as a result of adaptation to local selective factors such as climate and available nutrients but also as a result of genetic ancestry. (cdc.gov)

The polymorphism of MAP3K5 was identified by using PCR amplification, followed by Sanger sequencing, and KASPar (Kompetitive Allele Specific PCR) technology was used for genotyping subsequently. (copernicus.org)
From 189 healthy volunteers who were genotyped for CYP2C9 polymorphisms, 11 control subjects ( CYP2C9 * 1/ * 1 ), 9 heterozygous and 2 homozygous for the CYP2C9 * 3 allele participated in the pharmacokinetic drug interaction study. (aspetjournals.org)
Sexual antagonism may provide an answer since it means that the fitness of any given allele is context-dependent, preventing rapid depletion of genetic variance. (lu.se)

Genetic polymorphism is a term used somewhat differently by geneticists and molecular biologists to describe certain mutations in the genotype, such as single nucleotide polymorphisms that may not always correspond to a phenotype, but always corresponds to a branch in the genetic tree. (wikipedia.org)
To broaden our understanding on the population structure and genetic diversity of C. albicans strains in birds, we analysed 30 isolates recovered from animal and human hosts and investigated whether the genotype distribution related to their different source. (springer.com)
It is noteworthy that no differences in genotype frequencies of the VDBP polymorphisms were associated with serum VDBP levels or between type 1 diabetic patients and control subjects. (diabetesjournals.org)
Analysis of fractional clearances suggested that the fraction metabolized by CYP2C9, as influenced by genotype, determined the degree of drug interaction observed. (aspetjournals.org)

Rare variations are not classified as polymorphisms, and mutations by themselves do not constitute polymorphisms. (wikipedia.org)
The aim of this study was to explore potential associations between genetic polymorphisms of HMGB1 and EGFR mutations in a cohort that included 280 patients with NSCLC, some of whom were smokers and others who never smoked. (jcancer.org)

Our aim was to integrate our previously reported clinical-genetic prognostic score with new immunogenetic markers of 5-year disease-free survival (DFS) to evaluate the recurrence risk stratification before fluoropyrimidine (FL)-based adjuvant therapy. (frontiersin.org)
The scope of the present study did not allow for accurate testing of selection of these markers due to the lack of historical samples and low sample sizes, however selection cannot be excluded as the cause of genetic differentiation. (nofima.no)
Other genetic markers, detectable from blood samples, have also been studied, with a view to comparing the patterns of variability shown by these in the population, with those of the less well studied chromosome variants. (dur.ac.uk)
Background: While evidence indicates that familial predisposition influences the risk of developing degenerative rotator cuff disease (RCD), knowledge of specific genetic markers is limited. (cdc.gov)
We used logistic regression to test for genetic association of 674,405 typed and >10 million imputed markers, after adjusting for age, sex, population principal components, and follow-up. (cdc.gov)

In biology, polymorphism is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species. (wikipedia.org)
Balanced polymorphism refers to the maintenance of different phenotypes in population. (wikipedia.org)
These findings support the notion that phenotypes related to higher order cognitive skills typical of humans have a recent genetic component that originated after the separation of the human and Neanderthal lineages. (nature.com)

The contributions of any single genetic variation or mutation in a population depend on its frequency and penetrance as well as tissue-specific functionality. (hindawi.com)
Single nucleotide polymorphism (SNP) typing for VDBP polymorphisms (SNP rs4588 and rs7041) was performed on this cohort to determine potential genetic correlations. (diabetesjournals.org)
The analysis, called SNP-array (single-nucleotide polymorphisms), is revealing "large regions of absence of heterozygosity on multiple chromosomes in children referred for intellectual or developmental disabilities or multiple congenital anomalies," the researchers from the Baylor College of Medicine wrote in The Lancet . (massdevice.com)
Recent evidence shows that certain single nucleotide polymorphisms increase the risk of lymphoma. (msdmanuals.com)

Some degrees of diversity were noted among accessions even from the same origins. (airitilibrary.com)
In this study, multilocus sequence typing was used to characterise the genetic diversity and population structure of 24 avian origin C. albicans isolates collected from different birds with candidiasis and compared to human isolates. (springer.com)
C. albicans is predominantly diploid and displays high degree of genetic diversity across isolates, notably variations in the distribution of heterozygous polymorphisms along the genome. (springer.com)
Another complication relates to the population size of Neanderthals estimated from the genetic diversity of mitochondrial DNA sequences. (reasons.org)
Species were chosen to maximize the morphological, behavioral, and genetic diversity among the Malawi species flock. (biomedcentral.com)
Identification of Genetic Diversity in the Ascochyta Blight Pathogen of Chickpea [Ascochyta rabiei (Pass. (ac.ir)
On the basis of this molecular marker, the estimated genetic diversity index was 98% and the pair-wise genetic distance of the isolates varied from 0.16 to 0.61. (ac.ir)

Chromosomal polymorphisms detected with the stain quinacrine dihydrochloride have been examined in a sample of people resident in County Durham. (dur.ac.uk)

However, the molecular genetic factors involved in the evolution are still relatively unexplored. (nature.com)
Information concerning the molecular nature of chromosomes, and their polymorphisms, has been reviewed with the intention of revealing any theoretical basis there may be for an adaptive significance of the variants. (dur.ac.uk)
Results from Genetic Studies in Patients Affected with Craniosynostosis: Clinical and Molecular Aspects. (cdc.gov)

To investigate whether genetic polymorphisms of glutathione S-transferases ( GSTM1 , GSTT1 , and GSTO2 ) in relation to the work place contribute to the development of cataract. (molvis.org)

either through loss of genetic variability or through adaptive responses to altered selective regimes. (nofima.no)
We demonstrate unprecedented ecological and evolutionary consequences of color polymorphism in this adaptive radiation. (biomedcentral.com)

it is related to biodiversity, genetic variation, and adaptation. (wikipedia.org)
Polymorphism does not cover characteristics showing continuous variation (such as weight), though this has a heritable component. (wikipedia.org)
Polymorphism deals with forms in which the variation is discrete (discontinuous) or strongly bimodal or polymodal. (wikipedia.org)
Because adaptation may involve the structure of virulence factors (by antigenic variation) and their regulation, we extended our studies on the evolution of B. pertussis by investigating polymorphism in the promoter of Ptx ( ptxP ), a major virulence factor and component of all pertussis vaccines ( 1 ). (cdc.gov)
For example in complex animal systems, color polymorphisms tend to have unknown inheritance mechanisms, exhibit continuous or intermediate variation, result from assortative mating under natural conditions, and/or be sex-linked [ 3 ] as seen in the African cichlid fishes [ 7 ]. (biomedcentral.com)
In this study, efforts were made to detect genetic variation of the pathogen in Iran. (ac.ir)
I have studied sexually antagonistic genetic variation in fruit flies ( Drosophila melanogaster ) for a number of years, and have added a new study organism to my lab since I started working in Lund: the hermaphroditic flatworm Macrostomum lignano . (lu.se)

However, the understanding of color polymorphisms and their evolutionary implications is frequently impaired by sex-linkage of coloration, unknown inheritance patterns, difficulties in phenotypic characterization, and a lack of evolutionary replicates. (biomedcentral.com)

In summary, the presence of CYP2C9 * 3 alleles (either one or two alleles) can alter the degree of drug interaction observed upon coadministration of inhibitors. (aspetjournals.org)
CYP2C9 * 3 ) and their effect on the degree of inhibition interactions observed. (aspetjournals.org)
in individuals of the CYP2C9 * 1/ * 1, * 1/ * 3 , and * 3/ * 3 genotypes to characterize the magnitude of the drug interaction in subjects with different CYP2C9 polymorphisms. (aspetjournals.org)

According to the theory of evolution, polymorphism results from evolutionary processes, as does any aspect of a species. (wikipedia.org)
Color polymorphisms are a conspicuous feature of many species and a way to address broad ecological and evolutionary questions. (biomedcentral.com)
Three potential major evolutionary fates of color polymorphisms are conceivable over time: maintenance, loss, or speciation. (biomedcentral.com)
Hence, the role of color polymorphisms in promoting ecological and evolutionary diversification remains poorly understood. (biomedcentral.com)
Because Midas cichlids are known to mate color assortatively, the putative genetic correlation of this color polymorphism with an eco-morphological divergence suggests an innate potential to promote ecological and evolutionary divergence across this species complex. (biomedcentral.com)
Given the prevalence of color polymorphisms throughout the tree of life, it is surprising that their significance in promoting ecological and evolutionary diversification has been rarely demonstrated empirically [ 3 , 5 , 6 ]. (biomedcentral.com)

6,000 years old), which revealed sympatric ecological differentiation associated with the conspicuous binary (gold/dark) color polymorphism. (biomedcentral.com)
Roughly 3% to 5% of loci surveyed are statistical outliers for genetic differentiation (F ST ) within species, between species, and between major lineages. (biomedcentral.com)

A large twin study demonstrated that 81 % of the variance of the disease was attributed to additive genetic effects, whereas the remaining 19 % was attributed to unique, unshared environmental factors [10]. (springer.com)
The GCA: SCA ratios for thestudied traits were higher than one indicating the presence of additive genetic effects for most of the characteristicsstudied, except for sympodia branch length. (researchgate.net)

To qualify as a polymorphism, some kind of balance must exist between morphs underpinned by inheritance. (wikipedia.org)

When selection is strong and traits are heritable, it is expected that standing genetic variance for fitness should be rapidly depleted. (lu.se)

The FP receptor genetic polymorphism may influence the degree of IOP reduction by latanoprost in these patients. (bmj.com)

Color polymorphisms, or the occurrence of two or more genetically determined color morphs within an interbreeding population [ 1 ], occur in animals and plants alike. (biomedcentral.com)

This finding suggests that the polymorphisms of GSTM1 and GSTO2 and also work place may act additively for developing cataract. (molvis.org)

The use of state-of-the-art genetic approaches (including transcriptomics, phenomics, epigenomics, whole genome association studies, next generation sequ encing, exome sequencing, & systems biology) to identify and validate (including in vitro models, animal models, & human samples) viral and host genetic factors which influence the pathophysiology of HAND are encouraged. (nih.gov)

Jacques Montplaisir, MD, PhD, of the Hopital du Sacre-Coeur de Montreal, looked at the prevalence of sleepwalking and sleep terrors during childhood, any link between early sleep terrors and sleepwalking later in childhood, and the degree of association between parental history of sleepwalking and the presence of sleepwalking and sleep terrors in children. (sleepreviewmag.com)
However, animal or mainly attributed to the accumulation ing prevalence of uncontrolled weight genetic studies, studies not relevant of intra-abdominal (visceral) fat ( 13 ). (who.int)

Polymorphism usually functions to retain a variety of forms in a population living in a varied environment. (wikipedia.org)
Supporters of the polygenic nature of breast cancer suggest that the contributions from polymorphisms are very important because of their high frequency in the population. (hindawi.com)
The genetic variability of this population was distributed in six clusters that were defined based on their genetic characteristics. (scielo.br)
The integration of IFNG -rs1861494 in our previous clinical genetic multiparametric score of DFS improved the patients' risk stratification (Log-rank P = 0.0026 in the pooled population). (frontiersin.org)
The polymorphisms associated with warfarin sensitivity often differ by population and ethnic background. (medlineplus.gov)
Unweighted pair group method with arithmetic averages (UPGMA) and eBURST analyses showed that the genetic construction of avian origin C. albicans population is fairly diverse. (springer.com)
Slovak Habans are typical founder population with significant social isolation for which high degree of inbreeding is typical. (wayne.edu)
Present study investigated STR polymorphisms as a powerful genetic tool for population genetic studies. (wayne.edu)
The aim was to perform a comparative, population genetic study based on 15 STR loci widely used in forensic genetics, of the Haban population, the Slovak majority population and the population of Tyrol. (wayne.edu)
4 It appears that the ancestral population possessed the genetic signature attributed to Neanderthals. (reasons.org)
Ultimately, color polymorphisms can be maintained in the population, they can disappear from the population, and under particular circumstances may facilitate sympatric diversification. (biomedcentral.com)

Cluster analysts basest on genetic similarity of zymotyps was done. (airitilibrary.com)
The phylogenic tree was constructed by cluster analysis and all the isolates grouped to 22 genetic clusters at the 90% similarity level. (ac.ir)

Remarkably, at age 14 years, facial acne in girls was less influenced by genetic factors than in boys and was significantly influenced by common environmental factors [12]. (springer.com)
The purpose of the study was to identify maternal HLA class Ib genetic factors associated with anti-HLA allo-immunization in pregnancy and the degree of tolerance estimated by IgG4 expression. (frontiersin.org)
Biological and genetic factors have been associated with pregnancy-induced anti-HLA alloimmunization, however, the process remains poorly understood. (frontiersin.org)
The National Institute of Mental Health (NIMH) and The National Institute of Neurological Disorders and Stroke (NINDS) solicit research grant applications to supp ort studies focused on viral and host genetic factors involved in HIV-1 Associated Neurocognitive Disorders (HAND) in the setting of highly active anti-retroviral therapy (HAART). (nih.gov)
ASD are highly genetic and multifactorial, with many risk factors acting together. (eurekaselect.com)
Genetic factors appear to play a role. (msdmanuals.com)
Sex and chronological age, along with other clinical factors and those related to orthodontic treatment, do not seem to influence the degree of EARR, except the prolonged treatment time and heavy forces that are associated with increased amounts of EARR. (bvsalud.org)
Studies evaluating treatment with extractions, intermaxillary elastics, and different genetic polymorphisms showed contradictory results, restricting the determination of whether these factors can contribute to EARR. (bvsalud.org)
although various intrinsic, clinical, orthodontic, and genetic factors were described in the literature, the most common factors associated with increased values of EARR were prolonged treatment time and heavy forces during the orthodontic treatment. (bvsalud.org)
Worldwide, its incidence has increased progressively over the last century, as have the levels of exposure to ultraviolet (UV) radiation, a well-known risk factor, and it has been suggested that certain environmental and genetic factors also increase melanoma risk [3] . (cdc.gov)
This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)

In the past decade, there has been an increase in the number of lung cancer cases in young people, which suggests an important role for genetic background in the etiology of this disease. (scielo.br)

Only ten primers showed polymorphism among isolates. (ac.ir)
The least genetic distance belonged to isolates 20 and 22 from Qazvin and Golestan while the highest distance belonged to isolates 26 and 12 from Mazandaran and Markazi. (ac.ir)

The focus of this initiative is to encourage studies to discover novel genetic paradigms that may account for the interactions between the virus, the host, and the therapeutic drugs in the central nervous system (CNS) that result in the pathogenesis, progression, and clinical manifestations of HAND. (nih.gov)
However, genetic polymorphisms in drug-metabolizing enzymes are not routinely evaluated for their impact on drug interactions during clinical studies. (aspetjournals.org)

The authors found that concentrations of clopidogrel and its active metabolite did not correlate with the degree of platelet function inhibition. (vin.com)
Attempts have been made to correlate the frequencies of these polymorphisms with certain demographic variables, information about which was collected from the participants using questionnaires. (dur.ac.uk)

A common garden experiment suggests there is a genetic correlation of color and eco-morphological traits. (biomedcentral.com)

Enzymes such as diaphorase (DIA), malate dehydrogenase (MDH), phoshporylase (PP) and peroxidase (PX), which indicated polymorphisms, were included. (airitilibrary.com)
The kinetic parameters of enzymes that regulate the formation of neurotoxic metabolites of MDMA differ among species, as does the ability of MDMA to self-inhibit these enzymes and the degree of genetic polymorphisms exhibited by these enzymes. (nih.gov)
The effects of genetic polymorphisms in drug-metabolizing enzymes (e.g. (aspetjournals.org)

In this sample, there was antagonistic multiplicative interaction between MTRR G66A and MTHFR C677T polymorphisms in predicting breast cancer-specific mortality (p for interaction: 0.08). (louisville.edu)

Pharmacogenetic studies have been also performed in order to evaluate the role of host genetic variants in the prediction of recurrence risk and response to adjuvant treatment with FLs and OXA. (frontiersin.org)
Nico holds dual bachelor's degrees in anthropology and Latin American studies from the University of Louisville. (washington.edu)
And for studies that seek to employ a multi-level design by combining hormone measurements with genetic analysis, it is now well documented that saliva is also a convenient source of high-quality DNA. (salimetrics.com)
Replication studies identify several genetic variants in Arabs with obesity- linked diabetes. (who.int)

Genetic investigation of syndromic forms of obesity. (cdc.gov)

The current study is in line with this important scientific theme by investigating a role of maternal HLA class Ib polymorphisms in pregnancy allo-immunization. (frontiersin.org)

Although species-specific lineages were not found, some degree of separation in the evolution of bird and human strains could be observed. (springer.com)

The familial risk of adult acne: a comparison between first-degree relatives of affected and unaffected individuals. (springer.com)
The first is OncoVue , a DNA saliva test that not only indicates the degree of risk of breast cancer but also when that risk is likely to manifest. (optics.org)
Identification of a novel genetic marker for risk of degenerative rotator cuff disease surgery in the UK Biobank. (cdc.gov)
Also, patients with a first-degree relative with Hodgkin or non-Hodgkin lymphoma have an increased risk of non-Hodgkin lymphoma. (msdmanuals.com)
This facilitates the quantification of differences in individual uptake, the degree of work- potential risk of exposure at the level of individuals. (cdc.gov)
Timely cancer genetic counseling and testing for young women with breast cancer: impact on surgical decision-making for contralateral risk-reducing mastectomy. (cdc.gov)

These findings point to a strong genetic influence on sleepwalking and, to a lesser degree, sleep terrors. (sleepreviewmag.com)

Migraine is most common in women and has a strong genetic component. (medscape.com)

but these polymorphisms resulted in expression of inactive proteins that should not be subject to inhibition. (aspetjournals.org)

Genetic control of sebum excretion and acne - a twin study. (springer.com)
The main objective is to develop and validate the methodology to study the genetic polymorphism of Organic cation transporter (OCT1) rs622342. (pharmdinfo.com)

A retrospective, cross-sectional analysis of VDBP levels used samples from 472 individuals of similar age and sex distribution, including 153 control subjects, 203 patients with type 1 diabetes, and 116 first-degree relatives of type 1 diabetic patients. (diabetesjournals.org)
La présente analyse récapitule les facteurs pathologiques majeurs liant l'obésité au diabète, en se concentrant sur les données épidémiologiques actuelles relatives aux patients diabétiques obèses dans le monde arabe, l'étiologie de la maladie et les déterminants génétiques du diabète et de l'obésité. (who.int)

2. HLA system and tissue typing: the genetic organization and polymorphisms of the HLA system, the protein structure of HLA antigens, non-HLA genetics, HLA in health and disease, and the impact of HLA matching on donor selection and transplant outcomes. (ncl.ac.uk)

Genetic and environmental influences on acne in adolescent twins. (springer.com)

Anatomy2

Organisms3

Diseases19

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Psychiatry and Psychology2

Phenomena and Processes77

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena1

Information Science6

Named Groups5

Health Care25

Geographicals19

SNPs8

Genes12

Genomic5

Susceptibility8

Gene9

Populations14

Allele3

Genotype4

Mutations2

Markers5

Phenotypes3

Single4

Diversity7

Chromosomal1

Molecular3

Glutathione1

Adaptive2

Variation7

Linkage1

CYP2C93

Evolutionary6

Differentiation2

Additive genetic effects2

Inheritance1

Heritable1

Receptor1

Genetically1

GSTO21

Biology1

Prevalence2

Population11

Similarity2

Factors11

Lung1

Isolates2

Clinical2

Correlate2

Suggests1

Enzymes3

Antagonistic1

Studies4

Obesity1

Pregnancy1

Found1

Risk6

Lesser degree1

Strong genetic1

Proteins1

Study2

Patients2

Genetics1

Environmental1