Proto-Oncogene Proteins c-vavProteasome Endopeptidase ComplexProteolysisUbiquitinBiodegradation, EnvironmentalUbiquitinationUbiquitin-Protein LigasesMolecular Sequence DataCell Cycle ProteinsCysteine EndopeptidasesCell LineUbiquitinsAmino Acid SequenceSignal TransductionMultienzyme ComplexesProtein BindingEndoplasmic Reticulum-Associated DegradationPhosphorylationProto-Oncogene ProteinsGuanine Nucleotide Exchange FactorsMutationOncogene ProteinsHydrolysisKineticsCells, Culturedrac1 GTP-Binding ProteinProtein Structure, TertiaryProtein Processing, Post-TranslationalRNA, MessengerRNA StabilityPeptide HydrolasesProteinsEndoplasmic ReticulumProteasome InhibitorsModels, BiologicalF-Box ProteinsProtein TransportCysteine Proteinase InhibitorsAutophagyBase SequenceHeLa Cellsrac GTP-Binding ProteinsRecombinant Fusion ProteinsCell Line, TumorProtein StabilityTime FactorsBlotting, WesternEndopeptidasesJurkat CellsHEK293 CellsSubstrate SpecificityAdaptor Proteins, Signal TransducingEnzyme ActivationImmunoprecipitationProtease InhibitorsNuclear ProteinsCarrier ProteinsDown-RegulationRecombinant ProteinsGene Expression Regulationbeta-Transducin Repeat-Containing ProteinsRNA InterferenceDNA-Binding ProteinsCullin ProteinsI-kappa B ProteinsSaccharomyces cerevisiaePolyubiquitinTyrosineElectrophoresis, Polyacrylamide GelSKP Cullin F-Box Protein LigasesMembrane ProteinsFibroblastsRNA, Small InterferingSaccharomyces cerevisiae ProteinsLigasesTranscription FactorsEndocytosisTranscription, GeneticBinding SitesUbiquitin-Protein Ligase ComplexesCOS CellsImmunoblottingUbiquitin-Conjugating EnzymesPlasmidsCell NucleusCalpainApoptosisChromatography, High Pressure LiquidMice, KnockoutEndopeptidase ClpHalf-LifeEscherichia coliNF-kappa BBacterial ProteinsMolecular ChaperonesReceptors, Antigen, T-CellTemperaturePeptide FragmentsSequence Homology, Amino AcidCytoplasm