• pVHL
  • Using green fluorescent protein-tagged end-binding protein 1 to label microtubule plus ends, we found that pVHL does not affect the microtubule growth rate but is needed to orient the growth of microtubules toward the cell periphery, a prerequisite for the formation of cilia. (rupress.org)
  • VHL disease is an autosomal-dominant disorder, and tumor development in VHL disease is linked to somatic inactivation of the remaining wild-type VHL allele, leading to loss of the wild-type VHL gene product, VHL protein (pVHL). (rupress.org)
  • Moreover, pVHL interacts with the Par3-Par6-atypical PKC (aPKC) polarity complex, suggesting that pVHL may connect Par3-Par6-aPKC polarity proteins to microtubule capture and ciliogenesis. (rupress.org)
  • Hydroxylation of HIF creates a binding site for pVHL (the protein transcript of the VHL gene). (wikipedia.org)
  • pVHL directs the polyubiquitylation of HIF1A, ensuring that this protein will be degraded by the proteasome. (wikipedia.org)
  • hypoxia-induci
  • Hypoxia--which occurs when tumors outgrow their blood supply--provides a metastatic trigger through the transcription factor HIF (hypoxia-inducible factor). (sciencemag.org)
  • This complex is involved in the ubiquitination and degradation of a hypoxia-inducible factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. (wikipedia.org)
  • vascular
  • This heterodimer of HIF is a transcription factor that activates genes that encode for proteins such as vascular endothelial growth factor (VEGF) and erythropoietin, proteins that are both involved in angiogenesis. (wikipedia.org)
  • gene
  • Phosphoinositide-3-kinase enhancer (PIKE) proteins encoded by the PIKE/CENTG1 gene are members of the gamma subgroup of the Centaurin superfamily of small GTPases. (readbyqxmd.com)
  • The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. (wikipedia.org)
  • cells
  • Within host cells, L. pneumophila establishes a replicative haven by delivering numerous effector proteins into the host cytosol, many of which target membrane trafficking by manipulating the function of Rab GTPases. (readbyqxmd.com)
  • Bernards provides background information and discusses the implications with regard to when during cancer development tumor cells acquire the capacity to metastasize. (sciencemag.org)