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  • protein
  • In this paper, we study Drosophila melanogaster lacking active TBC1D24/Skywalker (Sky), a protein that in humans causes severe neurodegeneration, epilepsy, and DOOR (deafness, onychdystrophy, osteodystrophy, and mental retardation) syndrome, and identify endosome-to-lysosome trafficking as a mechanism for degradation of synaptic vesicle-associated proteins. (rupress.org)
  • Our findings define a mechanism in which synaptic transmission is facilitated by efficient protein turnover at lysosomes and identify a potential strategy to suppress defects arising from TBC1D24 mutations in humans. (rupress.org)
  • This CMA-targeting motif is recognized by a cytosolic chaperone, heat shock cognate protein of 70 kDa (hsc70) which targets the substrate to the lysosome surface. (wikipedia.org)
  • In mechanically strained cells and tissues, CASA mediates the degradation of the actin-crosslinking protein filamin. (wikipedia.org)
  • complex
  • Cathepsin S participates in the degradation of the invariant or Ii chain that prevents loading the antigen into the complex. (wikipedia.org)
  • Proteolytic degradation of Ii is important since it facilitates dissociation of CLIP from MHC II and then, complex can load the selected antigen. (wikipedia.org)
  • Mechanical tension results in unfolding of filamin, leading to recognition by the CASA chaperone complex and to the autophagic degradation of damaged filamin. (wikipedia.org)
  • When a phagocytic cell engulfs bacteria, a phagosome is formed around it and the entire complex is ultimately trafficked to the lysosome for degradation. (wikipedia.org)
  • Cell
  • Caveolae can be used for entry to the cell by some pathogens and so they avoid degradation in lysosomes. (wikipedia.org)
  • Contrary, inhibition of cathepsin S will lead to a delay in degradation of Ii and loading the antigen into MHC II as well as inappropriate presence of uncleaved Li-fragments in MHC II on the cell surface. (wikipedia.org)
  • eventually
  • Once properly localized, these proteins are then taken into the endosome via vesicles, forming multivesicular bodies, and are eventually delivered to the lysosome where they are degraded. (wikipedia.org)
  • report
  • In this manuscript, we report our recent progresses in identifying two different groups of ABCG2 inhibitors with one inhibiting only ABCG2 function (static) and the other induces ABCG2 degradation in lysosome in addition to inhibiting its function (dynamic). (nih.gov)
  • proteasome
  • Only poly-ubiquitination on defined lysines, mostly on K48 and K29, is related to degradation by the proteasome (referred to as the "molecular kiss of death"), while other polyubiquitinations (e.g. on K63, K11, K6 and M1) and monoubiquitinations may regulate processes such as endocytic trafficking, inflammation, translation and DNA repair. (wikipedia.org)
  • Its main function is to segregate protein molecules from large cellular structures such as protein assemblies, organelle membranes and chromatin, and thus facilitate the degradation of released polypeptides by the multi-subunit protease proteasome. (wikipedia.org)
  • cells
  • LAPTM5 physically interacts with the B cell receptor complex and promotes its degradation in the lysosomal compartment in mouse B cells. (antibodies-online.com)
  • Here, we report that sphingosine 1-phosphate (S1P)-S1PR1 signaling in plasmacytoid dendritic cells (pDCs) directly inhibits IFN-α autoamplification by induced degradation of the interferon alpha receptor 1 (IFNAR1) receptor and suppression of signal transducer and activator of transcription 1 (STAT1) signaling. (pnas.org)