• In particular, the researchers pinpointed differences in something known as lipid peroxidation-the degradation of lipids that produces free radical molecules that can go on to cause cell damage. (eurasiareview.com)
  • RESULTS: Ellagic acid showed high DPPH radical scavenging and lipid peroxidation inhibition activities. (nutrimedical.com)
  • Between the results of lipoxgenase inhibition and the lipid peroxidation a linear correlation was found. (google.com)
  • This inhibition of lipid peroxidation could be explained by the presence of at least two hydroxyl groups in ring B of the flavonoid structure, regardless of their positions. (scirp.org)
  • In vitro exposure of erythrocytes to oxygen radical generating systems (such as H 2 O 2 , ascorbate/Fe 3+ , cumene hydroperoxide, tert-butyl hydroperoxide, etc.) was shown to induce lipid peroxidation, protein degradation, loss of deformability, an increase in osmotic fragility, membrane lipid bilayer perturbation, inhibition of enzymes and hemolysis [5-12]. (scirp.org)
  • Ferrstatin-1, a synthetic antioxidative ferroptosis inhibitor, rescued iron accumulation, lipid peroxidation and ferroptosis caused by inhibition of mitophagy. (ijbs.com)
  • Lipids are susceptible targets of oxidation because of their molecular structure, which is abundant with reactive double bonds. (ac.ir)
  • Readers will find references on methods used to test food quality, food color analysis, the role of Tannins in wine taste as well as NMR studies on lipid oxidation and large protein complexes. (benthambooks.com)
  • Lipid oxidation/peroxidation is a key issue in the storage, and processing of edible oils and oil containing and oil-based food. (benthambooks.com)
  • Their anti-oxidant properties and their protective effect on membranes against lipid oxidation have been discussed. (benthambooks.com)
  • The chain reaction mechanism of lipid peroxidation primarily targets polyunsaturated fatty acids due to their multiple double bonds and the presence of reactive hydrogen atoms in the methylene bridges (-CH2-) between these bonds. (wikipedia.org)
  • Among these signaling lipids, a particular group of oxygenated polyunsaturated fatty acids (PUFA), so called lipid mediators, has been thoroughly investigated over several decades. (cdc.gov)
  • Death of GSCs was apparently due to the iron dependent form of programmed cell death characterized by the accumulation of lipid peroxides called ferroptosis. (nature.com)
  • Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
  • In 2012, Dixon 1 first proposed the concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS). (nature.com)
  • The results showed that cisplatin induced mitochondrial injury, ROS release, intracellular iron accumulation, lipid peroxidation and ferroptosis in the kidney, which were aggravated in Bnip3 knockout , Pink1 knockout or Park2 knockout cisplatin-treated mice. (ijbs.com)
  • Its unique signature that distinguishes it from other forms of cell death is the formation and accumulation of lipid hydroperoxides, particularly oxidized forms of polyunsaturated phosphatidylethanolamines (PEs), which drives cell death. (cdc.gov)
  • Is iron necessary to promote the production of lipid peroxides, or can other substances take the place of iron in ferroptosis? (nature.com)
  • Ferroptosis is a novel type of regulated cell death caused by iron-dependent lipid peroxidation [ 26 ]. (hindawi.com)
  • Ferroptosis, a new modality of programmed cell death, is characterized by iron-dependent phospholipid peroxidation and oxidative membrane damage. (ijbs.com)
  • Ferroptosis is an iron dependent form of cell death, that is triggered by the discoordination of iron, lipids, and thiols. (cdc.gov)
  • The new research, published online in the journal Redox Biology , also revealed that the drug, CMS121, works by changing how brain cells metabolize fatty molecules known as lipids. (eurasiareview.com)
  • They discovered that when it came to levels of lipids-fatty molecules that play key roles in cells throughout the body-mice with the disease had several differences compared to both healthy mice and those treated with CMS121. (eurasiareview.com)
  • Indeed, a number of signaling functions of (phospho)lipid molecules has been discovered. (cdc.gov)
  • The researchers went on to show that CMS121 lowered levels of a lipid-producing molecule called fatty acid synthetase (FASN), which, in turn, lowered levels of lipid peroxidation. (eurasiareview.com)
  • The average nutritional quality values of the fatty acids were: polyunsaturated/saturated (0.85-1.33), omega-6/omega-3 (0.18-0.22), atherogenic index (0.35-0.46), thrombogenic index (0.23-0.33), hypocholesterolemic/hypercholesterolemic ratio (2.21-2.77), nutritive value index (0.87-1.68), health-promoting index (2.19-2.82), and fish lipid quality (24.18-28.88). (eeer.org)
  • The depletion of adenosine triphosphate (ATP) leads to membrane damage and reduces lipid synthesis [ 8 ]. (biomedcentral.com)
  • A chemical reaction involving oxidative attack from free radicals on a lipid molecule, resulting in its degradation. (foodb.ca)
  • ALL-Q Plus prevents collagen degradation by inhibiting MMP-1 expression. (dsm.com)
  • Meanwhile, other ingredients stanch free-radical and singlet-oxygen-induced lipid peroxidation and prevent the fragmentation and degradation of collagen and elastin fibers. (nutritionaloutlook.com)
  • Free radicals in the body exploit the instability of PUFAs to trigger chain reactions that drive LPO and the resulting degradation of these vital PUFAs. (globenewswire.com)
  • Lipid peroxidation is a extensively identified occasion of oxidative hurt in cell membranes, lipoproteins, and totally different lipid-containing buildings. (crn-ccrc.org)
  • The damage was typically characterized by epithelial degeneration and necrosis in the gills, esophagus, and intestines, as well as by lipid loss and palisade pattern degradation in the liver. (go.jp)
  • When CCl 4 gets into the liver, it acts as a xenobiotic and converted into free radicals CCl 3 and CCl 3 O 2 by the P-450 monooxygenase-dependent microsome system and causes liver damage through membrane lipid peroxidation [ 10 ]. (biomedcentral.com)
  • For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)
  • Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. (nutrimedical.com)
  • Chemical stability was evaluated by detection of lipid peroxidation according to the thiobarbituric acid test and changes in pH. (pda.org)
  • Spiking of the samples with the highly efficient photosensitizer 5-hydroxymethyl furfural (5-HMF), a thermal degradation product of glucose commonly present in steam-sterilized glucose infusions, did not reduce physical stability. (pda.org)
  • Hence, the lipid peroxidation and changes in pH and color induced by irradiation of certain preparations did obviously not influence their physical stability. (pda.org)
  • They demonstrate that NMR can be effectively used for determining the oxidative stability of lipids and oils, and their products. (benthambooks.com)
  • Once activated, it resulted in MITF degradation and further down-regulated the expression of tyrosinase, TRP-1, TRP-2, Myosin Va, Rab27a and Cdc42, ultimately inhibited melanin synthesis and melanosome transport. (frontiersin.org)
  • The effects of eleven flavonoids on lipid peroxidation, protein degradation, deformability and osmotic fragility of human erythrocytes exposed in vitro to 10 mM H 2 O 2 for 60 min at 37˚C have been studied. (scirp.org)
  • quercetin, 3,5,7-trihydroxy-4'-methoxy flavone-7-rutinoside and 3-hydroxy flavone significantly protected erythrocytes against protein degradation. (scirp.org)
  • Quercetin and 3,5,7-trihydroxy-4'-methoxy flavone-7-rutinoside significantly protected erythrocytes against loss of deformability and increased osmotic fragility, indicating that the loss of erythrocyte deformability and the increase in osmotic fragility of erythrocytes exposed to H 2 O 2 are related to protein degradation rather than to lipid peroxidation. (scirp.org)
  • Within the phagocytes, iron is recycled through enzymatic degradation of heme and delivered via ferroportin into the circulation, accounting for approximately 90% of the daily iron needs. (haematologica.org)
  • Mucopolysaccharidoses (MPSs) are a group of lysosomal storage diseases, each of which is produced by an inherited deficiency of an enzyme involved in the degradation of acid mucopolysaccharides, now called glycosaminoglycans (GAGs). (medscape.com)
  • This undesirable series of complex reaction leads to the development of off-flavour, odour, and degradation of the overall quality. (benthambooks.com)
  • This major drawback of dietary agents may be due to one or many of the several factors like poor solubility, inefficient permeability, instability due to storage of food, first pass effect and GI degradation. (nutrimedical.com)
  • Effect of factors of favism on the protein and lipid components of rat erythrocyte membrane. (anandpub.com)