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CartilageCartilage, ArticularCartilage DiseasesChondrocytesNasal CartilagesOsteoarthritisEar CartilageLaryngeal CartilagesHyaline CartilageProteoglycansKnee JointCartilage Oligomeric Matrix ProteinAggrecansOsteoarthritis, KneeCollagen Type IIProteasome Endopeptidase ComplexGlycosaminoglycansMatrilin ProteinsExtracellular Matrix ProteinsChondrogenesisCollagenGrowth PlateFractures, CartilageProteolysisStifleTibiaPatellaCattleNasal SeptumFemurUbiquitinMenisci, TibialBiodegradation, EnvironmentalEpiphysesCells, CulturedMatrix Metalloproteinase 13Extracellular MatrixMolecular Sequence DataArytenoid CartilageJointsTissue EngineeringWeight-BearingCricoid CartilageThyroid CartilageOsteochondritisUbiquitinationUbiquitin-Protein LigasesHyaluronic AcidBone and BonesCompressive StrengthSynovial MembraneRNA, MessengerAmino Acid SequenceSynovial FluidChondroitin SulfatesStress, MechanicalFemur HeadCysteine EndopeptidasesMagnetic Resonance ImagingBiomechanical PhenomenaRabbitsKnee InjuriesCollagenasesMatrix Metalloproteinase 3Arthritis, ExperimentalUbiquitinsCell LineUronic AcidsMandibular CondyleLubricationMultienzyme ComplexesTime FactorsSOX9 Transcription FactorMatrix MetalloproteinasesTissue Culture TechniquesEndoplasmic Reticulum-Associated DegradationProcollagen N-EndopeptidaseAnterior Cruciate LigamentModels, BiologicalEndopeptidasesGlycoproteinsMutationChondroitinArthroplasty, SubchondralLectins, C-TypeInjections, Intra-ArticularKineticsMicroscopy, PolarizationSignal TransductionProtein BindingHydrolysisCollagen Type IXTissue ScaffoldsImmunohistochemistryRibsProteinsFrictionBone DevelopmentInterleukin-1Chick Embryo
OsteoarthritisChondrocytesDegenerationExtracellularProgressive degradation of articularIntra-articular administrationLoss of articular cartilageInflammationHyaline cartilageSingle intra articular injectionType II collaProteoglycanTissuesInflammatoryPathologic changesAggrecanEpiphyseal cartilageBone and cartilageChondrocyteVitroCharacterizationMicrofractureJoint deteriorationApoptosisFull-thicknessDamageJointsProgressionCytokineFibrilCompressiveBovineInfiltrationFrictionSynoviumExplantsEnzymesNutrientsThicknessMolecularAbnormalDefectsSynergisticMatrixBreakdownUrinaryMedial
Osteoarthritis18
  • Genetically modified mice in which the catalytic domain of ADAMTS5 was deleted are resistant to cartilage destruction in an experimental model of osteoarthritis. (wikipedia.org)
  • Osteoarthritis (OA) is a degenerative disease that eventually leads to the complete degradation of articular cartilage. (cabi.org)
  • Systematic review and meta-analysis of positive long-term effects after intra-articular administration of orthobiologic therapeutics in horses with naturally occurring osteoarthritis. (cabi.org)
  • All common treatment options aim to reduce the clinical consequences of osteoarthritis (OA) characterized by persistent synovitis and progressive degradation of articular. (cabi.org)
  • Osteoarthritis (OA) is described as a chronic degenerative disease characterized by the loss of articular cartilage. (cabi.org)
  • Evaluating the safety of intra-articular mitotherapy in the equine model: a potential novel treatment for osteoarthritis. (cabi.org)
  • Chronological age is a powerful epidemiologic risk factor for osteoarthritis (OA), a multifactorial disease that is characterized by articular cartilage (AC) degradation. (bepress.com)
  • In Paper III, we developed and validated a robust and specific ELISA assay measuring a MMP-1 and MMP-13 cleaved type II collagen fragment (T2CM) that we identified in the study for Paper I. It was elevated in response to pro-inflammatory cytokine treatment of bovine articular cartilage, and in osteoarthritis patients referred for a total knee joint replacement surgery compared to patients with moderate or severe disease. (lu.se)
  • Either alone or in a biomarker panel T2CM could be useful for assessing cartilage degradation in osteoarthritis. (lu.se)
  • The pathogenesis of osteoarthritis (OA) involves articular cartilage, synovial tissue and subchondral bone and is therefore a disease of the whole joint. (uni-frankfurt.de)
  • The purpose of the present study was to determine relationship between disease activity, systemic markers of cartilage degradation, urinary C-terminal cross-linking telopeptides of type II collagen (uCTX-II), and bone degradation, urinary C-terminal cross-linking telopeptides of type I collagen (uCTX-I), structural progression of osteoarthritis (OA) and potential therapeutic efficacy of type II collagen (COLLII) in combination with glucosamine and chondroitin sulfate (GC). (springer.com)
  • Numerous studies have shown that chondrocytes also have tissue-specific antigens, which induce the introduction of antibodies in patients with cartilage grafts, as well as those with osteoarthritis (OA) [ 1 ]. (springer.com)
  • This study aimed to investigate the anti-osteoarthritic activities of intra-articular administration of SHINBARO and determine its underlying molecular mechanism in a monosodium iodoacetate (MIA)-induced osteoarthritis rat model. (biomedcentral.com)
  • Osteoarthritis (OA) is a degenerative joint disease characterized by abrasion of articular cartilage and trabecular bone loss [ 1 ]. (biomedcentral.com)
  • It is obvious that loss of meniscus tissue leads to focal overload of articular cartilage and finally to a higher incidence of osteoarthritis [ 1 , 3 ]. (biomedcentral.com)
  • OBJECTIVE: A hallmark of osteoarthritis (OA) is degradation of articular cartilage proteoglycans. (nordicbioscience.com)
  • The current view holds that osteoarthritis involves not only the articular cartilage but the entire joint organ, including the subchondral bone and synovium. (medscape.com)
  • The degradation of articular cartilage in osteoarthritis (OA) is the result of an imbalance in the construction (anabolism) and the degradation (catabolism) of the extracellular matrix. (lu.se)
Chondrocytes10
  • Prolonged, repetitive, and heavy loading of joints results in deformation of articular cartilage and chondrocytes and promotes the initiation and progression of OA [ 10 ]. (hindawi.com)
  • HE staining and iron red solid green staining were used to observe the degeneration of articular chondrocytes in rats. (researchsquare.com)
  • Cartilage degeneration seemed to be driven mainly by the increased synovial inflammation accompanied by an increased MMP13 expression in synoviocytes and not in chondrocytes. (uni-frankfurt.de)
  • Monosodium iodoacetate (MIA) is an inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) that results in a reduction of glycolysis and causes articular cartilage changes related to the histological and morphological features of OA by impeding integration of the chondral structure and inducing cell death of chondrocytes [ 15 ]. (biomedcentral.com)
  • In isolated human OA chondrocytes, the anti-inflammatory cytokine Interleukin-37 (IL-37) lowers the expression of the proteolytic MMP and ADAMTS enzymes, which mediate this degradation. (nordicbioscience.com)
  • Methods Chondrocytes were isolated from the joint cartilages of OA patients (grade 3-4) during total knee arthroplasty with the approval of Kecioren Training and Research Hospital, Clinical Research Ethics Committee (B.10.4.İSM.4.06.68.49), as described previously.⁴ The alterations in cell counts, viability (MTT, NRU), proliferation (RTCA-iCELLigence System), reactive oxygen species (ROS) generation, stress-related signalling proteins and inflammatory progenitors ICE/caspase-1 (ELISA) were determined. (metu.edu.tr)
  • 4] Naranda J, Gradišnik L, Gorenjak M, Vogrin M, Maver U. Isolation and characterization of human articular chondrocytes from surgical waste after total knee arthroplasty (TKA). (metu.edu.tr)
  • The chondrocytes are responsible for the synthesis, maintenance, degradation, and repair of articular cartilage. (drlintner.com)
  • Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
  • The articular cartilage consists of cartilage cells (also known as chondrocytes) surrounded by extracellular matrix. (lu.se)
Degeneration16
  • KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
  • Histologically, compromised aortic integrity is the result of ECM remodeling within the aorta, including collagen degradation, elastic fiber fragmentation, and medial layer degeneration ( 4 , 5 ). (frontiersin.org)
  • However, the underlying mechanism of cartilage degeneration in FJOA remains unclear. (researchsquare.com)
  • Immunohistochemistry and Western blot were used to observe the expression of P2Y12, MMP13, COL2 and other cartilage degeneration and apoptosis related indexes. (researchsquare.com)
  • Thus, ibuprofen treatment was effective in attenuating HRHF-induced inflammation and early articular cartilage degeneration. (cdc.gov)
  • Sympathectomy leads to less pronounced cartilage degeneration (OARSI score) after DMM compared to DMM in WT mice. (uni-frankfurt.de)
  • Furthermore, the release of the type II collagen degradation fragment CTX-II was abolished in Syx DMM mice compared to WT DMM mice, suggesting that less SNS activity due to sympathectomy reduced the cartilage degeneration during OA pathogenesis. (uni-frankfurt.de)
  • The pathological changes in synovium and cartilage might also be linked to each other, as indicated by the moderate correlation between the synovial inflammation (synovitis score) and cartilage degeneration (OARSI score). (uni-frankfurt.de)
  • The data on DMM induction in β2-AR deficient mice revealed that the β2-AR signaling is involved in cartilage degeneration and the aggravated subchondral bone changes as these mice had less pronounced cartilage degeneration compared to WT mice. (uni-frankfurt.de)
  • While the cartilage degeneration was similar, the subchondral bone changes were more pronounced in β2-AR deficient mice compared to the Syx mice. (uni-frankfurt.de)
  • A reduced SNS activity by sympathectomy attenuated cartilage degeneration and synovitis but aggravated the OA specific subchondral bone changes. (uni-frankfurt.de)
  • They are the other contiguous tissues that are affected by the degeneration of the articular cartilage . (consciouslifenews.com)
  • Patients may have pain, effusion, or mechanical symptoms and because of the inadequate healing response, joint mechanics can be altered and the adjacent cartilage can undergo degeneration. (drlintner.com)
  • Because true hyaline cartilage is not capable of being formed over the injured area, however, over time, degeneration ensues and further damage can result. (drlintner.com)
  • Though cartilage degradation does the major damage during arthritis, subsequent bone degeneration cannot be neglected. (uni-mysore.ac.in)
  • When the cartilage thickens markedly, in osteochondrosis, diffusion of nutrients in its deeper portion in poor, leading to degeneration and necrosis of cartilage cells. (vin.com)
Extracellular9
Progressive degradation of articular1
Intra-articular administration1
  • Intra-articular administration of SHINBARO (IAS) at 20 mg/kg remarkably restrained the decrease in bone volume/total volume, being 28 % ( P = 0.0001) higher than that in the vehicle-treated MIA group. (biomedcentral.com)
Loss of articular cartilage1
  • Anteroposterior (AP) radiograph of the hip reveals severe superior migration of the femoral head (which reflects loss of articular cartilage), subchondral sclerosis, prominent osteophytes, and a large Egger cyst in the superior acetabulum. (medscape.com)
Inflammation9
  • Intra-articular injection of mitochondria is a novel treatment that has the potential to improve cell metabolism and decrease inflammation, but safety of this treatment has yet to be established in the horse. (cabi.org)
  • The pathologic changes in OA joints include degradation of the articular cartilage, especially at the superficial zones, thickening of the subchondral bone, osteophyte formation, and variable degrees of synovial inflammation 11 . (nature.com)
  • Persistence of aortic inflammation also contributes to the apoptosis of SMCs along with medial degradation and ultimately increases the risk of intimal disruption ( 6 , 9 ). (frontiersin.org)
  • Cytokines, locally produced in the synovial membrane of patients with rheumatoid arthritis (RA), play an important part in regulating the chronic joint inflammation which may lead to serious tissue damage, such as cartilage degradation, bone resorption, and fibrosis. (bmj.com)
  • OA is characterized by progressive degradation of cartilage, synovial inflammation, osteophyte formation and subchondral bone sclerosis. (uni-frankfurt.de)
  • Glucosamine is used as a substrate for certain components of the cartilage matrix, while chondroitin sulfate plays an important role in controlling the enzymes associated with inflammation and tissue destruction. (kppusa.com)
  • However, a well-formulated joint supplement helps protect cartilage against the damage caused by inflammation. (kppusa.com)
  • The reduction in the n-3/n-6 PUFA ratio of the IFP is in concordance with the inflammation and cartilage degradation in early OA and could contribute to disease pathogenesis. (biomedcentral.com)
  • These results suggested that PNE enhanced the susceptibility of OA in male elderly offspring rats by down-regulating TGFβ signaling, which increased articular cartilage local inflammation, matrix degradation, and cell apoptosis. (edu.au)
Hyaline cartilage4
Single intra articular injection1
  • Male Sprague-Dawley rats received a single intra-articular injection of MIA into the infrapatellar ligament of the right knee. (biomedcentral.com)
Type II colla1
  • Based on the size of the degradation products found by Western blot analysis, it is likely that in addition to MMPs, other proteolytic enzymes able to digest type II collagen are also active. (rug.nl)
Proteoglycan7
  • The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. (wikipedia.org)
  • superficial structural changes (e.g., pannus) and reduced proteoglycan staining were observed in wrist articular cartilages. (cdc.gov)
  • Articular cartilage is divided into four zones-superficial, intermediate, deep and calcified-according to morphology, the orientation of collagen fiber, and the proteoglycan content. (springer.com)
  • Significant evidence exists that trauma to a joint produced by a single impact load below that which causes subchondral bone fracture can result in permanent damage to the cartilage matrix, including surface fissures, loss of proteoglycan, and cell death. (lievers.net)
  • This hypothesis was tested by impacting bovine cartilage explants with nominal stresses ranging from 0.5 to 65 MPa and measuring proteoglycan biosynthesis, cell viability, and water content immediately after impaction and 24 hours later. (lievers.net)
  • Parkkinen JJ, Lammi MJ, Helminen HJ, Tammi M. Local stimulation of proteoglycan synthesis in articular cartilage explants by dynamic compression in vitro. (lievers.net)
  • Burton-Wurster N, Vernier-Singer M, Farquhar T, Lust G. Effect of compressive loading and unloading on the synthesis of total protein, proteoglycan, and fibronectin by canine cartilage explants. (lievers.net)
Tissues4
  • Cartilage-surrounding tissues are innervated by tyrosine hydroxylase (TH)-positive sympathetic nerve fibers with the most important sympathetic neurotransmitter norepinephrine (NE) detected in the synovial fluid of OA patients. (uni-frankfurt.de)
  • Stabilize collagen aldimine reducible cross-links to reinforce the strength and elasticity of connective tissues such as cartilage, synovium, ligaments, tendons, fascia, bone, blood vessel walls and the dermis of the skin. (life-enthusiast.com)
  • MRIs low diagnostic validity for intraarticular pathology with hemarthrosis may be attributed to the shifting paramagnetic properties of the blood remains and catabolic processes in meniscal and chondral tissues during the hemoglobin degradation process. (nih.gov)
  • The degradation of the cartilage (and other tissues in the joint) is slow, and therefore it is sometimes said that OA is a degenerative disease. (lu.se)
Inflammatory9
  • ADAMTS5 is the major aggrecanase in mouse cartilage in a mouse model of inflammatory arthritis. (wikipedia.org)
  • In Paper I we investigated the effect of pro-inflammatory cytokine interleukin-17 on articular cartilage in a bovine explant model system. (lu.se)
  • Mechanical disturbances caused by internal derangement or disk displacement have been regarded as a main factor in the development of secondary inflammatory changes and progressive degradation of the articular cartilage. (jcda.ca)
  • Furthermore, MIA causes a repeated progression of synovial hyperplasia and inflammatory cell infiltration, destroys articular cartilage, and induces bone loss and chondral deformation [ 16 ]. (biomedcentral.com)
  • Studies using equine cartilage explants (small pieces of actual living tissue) have shown these ingredients complement each other in inhibiting the production of inflammatory cells. (kppusa.com)
  • The articular cartilage is avascular and aneural and unless subchondral bone has been penetrated with injury, no inflammatory response will occur. (drlintner.com)
  • ACL injury can lead to the production of inflammatory mediators due to abnormal, traumatic cartilage loading contributing to the progression of OA [ 9 ]. (biomedcentral.com)
  • Furthermore, the expression of apoptosis factors (caspase-3 and caspase-8), inflammatory factors [interleukin (IL)-1, IL-6] and matrix degradation enzymes [matrix metalloproteinase (MMP)-3, MMP-13] were also significantly increased. (edu.au)
  • Cartilage fissuring releases degradation products that have a pro-inflammatory effect. (vin.com)
Pathologic changes1
Aggrecan5
  • We observed induction of matrix metalloproteinase (MMP)-mediated collagen and A Disintegrin And Metalloproteinase with Thrombospondin Motifs-mediated aggrecan degradation markers, and the upregulation of proteases was confirmed by gelatin zymography and/or mass spectrometry. (lu.se)
  • Inside this "armour" lies the protein aggrecan, whose role is to bind water and keep the cartilage soft and elastic so that it swells and becomes a "cushion" in the joint. (lu.se)
  • The thickness of the cartilage is mainly dependent on the interaction between collagen and aggrecan. (lu.se)
  • During the first stage of cartilage degradation, the aggrecan content in the cartilage decreases. (lu.se)
  • During the second stage, the collagen network or the cartilage "armour" starts to break down and the amount of aggrecan in the network decreases. (lu.se)
Epiphyseal cartilage2
  • The increase of epiphyseal volume, in growing animals, occurs through endochondral ossification within the epiphyseal cartilage. (vin.com)
  • The epiphyseal cartilage is avascular, so that it only receives its nutrition via osmosis from the synovial fluid. (vin.com)
Bone and cartilage2
Chondrocyte1
  • Matrix damage and chondrocyte viability following a single impact load on articular-cartilage. (lievers.net)
Vitro4
Characterization1
  • Torzilli PA, Grigiene R, Huang C, Friedman SM, Doty SB, Boskey AL, Lust G. Characterization of cartilage metabolic response to static and dynamic stress using a mechanical explant test system. (lievers.net)
Microfracture1
  • This microfracture corresponds to the "osteochondritis" stage and is referred to as "dissecans" ("dissecting") due to the formation of a cartilage flap separating from the subchondral bone. (vin.com)
Joint deterioration1
Apoptosis1
Full-thickness1
  • Indications for Carticel: Patients between the ages of 15-55 who have symptomatic, full-thickness articular surface defects or for osteochondritis dissecans (OCD) of the medial/lateral femoral condyle with an unstable fragment. (drlintner.com)
Damage2
  • Rupture of the medial retinaculum in cases with patellar dislocation or significant damage of articular cartilage were only detected by MRI in a few cases (27% and 20% sensitivity, respectively). (nih.gov)
  • Lameness can result when damage occurs to any joint tissue, whether it involves the bones, articular cartilages, or synovial membranes. (kppusa.com)
Joints3
Progression2
  • These findings suggested that the sympathetic neurotransmitter NE might suppress the chondrogenic capacity of MSC and their dependent cartilage regeneration and may also play a role in OA progression and manifestation. (uni-frankfurt.de)
  • Histological analyses and the Mankin's score showed increased cartilage destruction and accelerated OA progression in adult offspring from the PNE group. (edu.au)
Cytokine1
  • 6-16 However, most previous studies based on immunohistochemical staining of intra-articular cytokine production in RA have been performed on acetone fixed tissue, a procedure which does not readily allow subsequent discrimination of cytokine producing cells and cytokine binding cells. (bmj.com)
Fibril5
  • The interplay between fibril level degradation and the tissue-level aggregate response to biomechanical loading was explored in this work by a computational multiscale cartilaginous model. (elsevierpure.com)
  • The computational model was constructed by incorporating the results from prior molecular dynamics simulations (tensile test) of microfibril degradation into a hyper-elastoplastic fibril-reinforced cartilage model. (elsevierpure.com)
  • Including MMPs-mediated collagen fibril-level degradation in computational models may help understand the ECM pathomechanics at the tissue level. (elsevierpure.com)
  • The mechanics of cartilage tissue and fibril show variations in mechanical integrity depending on the different combinations of MMPs-1 and 9 with a concentration ratio of 1:1, 3:1, and 1:3 in simulated indentation tests. (elsevierpure.com)
  • The biomechanical function of the collagen fibril ultrastructure of articular cartilage. (lievers.net)
Compressive1
  • With a compressive load, the cartilage deforms to increase contact area and spread the load over a greater area of the joint. (drlintner.com)
Bovine1
  • High Frequency Acoustic Parameters of Human and Bovine Articular Cartilage Following Experimentally-Induced Matrix Degradation. (polymtl.ca)
Infiltration1
  • The protocol consisted of an intra articular infiltration of a medical mixture of Oxygen-Ozone (95% -5%) 20ml, at a 20ug / ml concentration, and a total number of 4 sessions (1 per week). (jscimedcentral.com)
Friction1
Synovium1
Explants1
Enzymes1
  • These findings indicate that cartilage's global and local mechanisms of failure largely depend on the relative abundance of the two key enzymes-collagenase (MMP-1) and gelatinase (MMP-9) and the spatial characteristics of diffusion across the layers of the cartilage ECM. (elsevierpure.com)
Nutrients4
  • Joint Armor's complete formula provides your horse with the nutrients necessary to support both healthy joint cartilage and synovial fluid. (kppusa.com)
  • The articular cartilage contains synovial fluid, a thick liquid that serves two primary functions: (1) as a source of nutrients for the articular cartilage and (2) as a lubricant and shock absorber for the bones that form a joint. (kppusa.com)
  • Articular cartilage has a maximum thickness of 3-4 mm because it depends on diffusion of nutrients from the synovial fluid for nutrition. (drlintner.com)
  • 14 , but this strategy seems to be in contrast to the natural environment, as cartilage is not subjected to an external active flow and except for the perichondrium does not receive nutrients from the sides 15 . (nature.com)
Thickness2
  • Subchondral bone volume as well the thickness of the subchondral bone plate (SCBP) and calcified cartilage (CC) were increased in Syx mice compared to WT after DMM. (uni-frankfurt.de)
  • However, since the collagen network is still intact, the thickness of the cartilage is not affected. (lu.se)
Molecular1
  • We found that the OA in STR/Ort mice exhibited a molecular phenotype resembling human OA, and we pinpointed a central role of NF-κB signaling and the emergence of an immune-related signature in OA cartilage over time. (bepress.com)
Abnormal1
  • Dysregulated cartilage homeostasis, articular cartilage degradation and abnormal bone remodeling are common denominators in joint disease and can lead to severe disability for the patients. (lu.se)
Defects1
  • Effective treatment of cartilage defects represents a challenging problem, mainly due to the tissue's limited intrinsic self-repair capacity. (nature.com)
Synergistic1
  • Faisal, TR, Adouni, M & Dhaher, YY 2023, ' Surrogate modeling of articular cartilage degradation to understand the synergistic role of MMP-1 and MMP-9: a case study ', Biomechanics and Modeling in Mechanobiology , vol. 22, no. 1, pp. 43-56. (elsevierpure.com)
Matrix3
  • It supports both the cartilage matrix and synovial fluid. (kppusa.com)
  • Further, reactive oxygen species (ROS) formed at the ruffled border of osteoclasts also causes bone resorption and matrix degradation. (uni-mysore.ac.in)
  • As the cartilage grows, the cells left in the newly formed matrix undergo a maturation, or degenerative process, while the ground substance becomes mineralised. (vin.com)
Breakdown1
  • A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw [4] "Multiple mammalian lineages independently evolved a definitive mammalian middle ear (DMME) through breakdown of Meckel's cartilage (MC). (edu.au)
Urinary1
  • Changes in bone were highly correlated between microcomputed tomography and radiographic analysis and changes in cartilage correlated well between urinary glycosaminoglycan levels and serum aggrecanase analyses. (hindawi.com)
Medial1