Degenerative cartilage articular. Medical search. Frequent questions

Osteoarthritis (OA) is a degenerative disease that eventually leads to the complete degradation of articular cartilage. (cabi.org)
Systematic review and meta-analysis of positive long-term effects after intra-articular administration of orthobiologic therapeutics in horses with naturally occurring osteoarthritis. (cabi.org)
All common treatment options aim to reduce the clinical consequences of osteoarthritis (OA) characterized by persistent synovitis and progressive degradation of articular. (cabi.org)
Osteoarthritis (OA) is described as a chronic degenerative disease characterized by the loss of articular cartilage. (cabi.org)
Evaluating the safety of intra-articular mitotherapy in the equine model: a potential novel treatment for osteoarthritis. (cabi.org)
Osteoarthritis is a degenerative condition that affects a large section of the Indian and world population. (iitk.ac.in)
Lumbar facet osteoarthritis (LFJOA) is one of the most common degenerative diseases of the spine. (researchsquare.com)
Osteoarthritis , also known as degenerative joint disease is the most common type. (hss.edu)
This is a form of early onset osteoarthritis that results from an injury to the ligaments, cartilage and/or bone in or around a joint. (hss.edu)
Going into the study the researchers did speculate that patients with symptomatic degenerative meniscal lesions without osteoarthritis undergoing autologous PRP injections would experience a significant clinical improvement at 12 months. (caringmedical.com)
In this study, a total of 69 patients with symptomatic degenerative meniscal lesions without knee osteoarthritis received 4 autologous (their own blood) PRP injections once a week. (caringmedical.com)
[ 70 ] No single biomarker has proved reliable for diagnosis and monitoring, but combinations of cartilage-derived and bone-derived biomarkers have been used to identify osteoarthritis subtypes, with possible impact on treatment. (medscape.com)
Osteoarthritis (OA) is a non‑inflammatory degenerative joint disease, characterized by joint pain and stiffness. (spandidos-publications.com)
Osteoarthritis (OA) is a chronic and degenerative disease that involves various structured tissues in the joint on the basis of cartilage degeneration and bone hyperplasia ( 1 ). (spandidos-publications.com)
See page 4 to learn about knee osteoarthritis, a degenerative condition of the joints . (healthxchange.sg)
Osteoarthritis (OA) is a degenerative joint disease causing loss of articular cartilage and structural damage in all joint tissues. (kobv.de)
In osteoarthritis, the cartilage in the knee joint gradually wears away. (aaos.org)
KGN/PVA/n-HA scaffolds effectively alleviated cartilage damage and prevented the occurrence of osteoarthritis. (bvsalud.org)
However, the current view holds that osteoarthritis involves not only the articular cartilage but the entire joint organ, including the subchondral bone and synovium. (medscape.com)
In osteoarthritis, the cartilage in the joints breaks down. (medlineplus.gov)

Hemophilic arthropathy is caused by recurrent hemorrhage into joints and results in an arthritis that is characterized by soft tissue changes of proliferation of hemosiderin-laden synovium and osteochondral changes of subchondral erosions, cyst formation, and cartilage loss. (medscape.com)
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder characterised by synovitis and progressive damage to articular cartilage and subchondral bone. (bmj.com)
Pathological changes initially occur in the articular cartilage, and later invade the subchondral bone plate and synovial tissues surrounding the joint. (spandidos-publications.com)
The synovial masses erode the juxta-articular cartilage and the subchondral bone (see the first image below). (medscape.com)
This image shows dark, synovial masses that erode the cartilage and produce subchondral cysts (arrows). (medscape.com)

In addition, there are two specialized types of cartilage within the knee joint called the lateral and medial meniscus. (hss.edu)
PRP injections into the meniscus and around the cartilage. (caringmedical.com)
An MRI may also be ordered to rule out other injuries to the meniscus or cartilage. (healthxchange.sg)
See page 3 for injuries to the meniscus and articular cartilages (symptoms and treatment) . (healthxchange.sg)
3,5 When the tear is too complex, degenerative, or in an avascular portion of the meniscus, surgical treatment will require partial meniscectomy. (hcplive.com)
Two wedge-shaped pieces of cartilage called meniscus act as "shock absorbers" between your thighbone and shinbone. (aaos.org)
MRI scan right knee Oct 2015 - degenerative medial meniscus tear. (roberthowells.com.au)
A torn meniscus can either be caused by an sudden injury to the knee (traumatic meniscus tear) or happen over time with increasing age (degenerative meniscus tear). (lu.se)
When a meniscus tears, the load transmission in the joint is affected, creating an uneven load on the articular cartilage. (lu.se)
Degenerative meniscus tears are often seen in middle-aged people and are a lot more common than traumatic meniscus tears. (lu.se)
We still don't know enough about degenerative meniscus tears, but research is underway to learn more about them. (lu.se)
Degenerative meniscus tears seldom require surgery, and knee pain is usually caused by something else which can be treated just as well with physiotherapy. (lu.se)
As degenerative meniscus tears are relatively often found in conjunction with early-stage OA of the knee, rehabilitation and exercise should always be recommended as first-line treatment for knee symptoms that signalize OA. (lu.se)
I Favor Allograft Replacement for Menisci Torn Beyond Repair Whether a meniscus transplant can prevent arthritis is not yet known, but, says a noted surgeon, the procedure does appear to offer the best hope for cartilage protection in these patients. (medscape.com)

The bones of the knee are covered with a smooth, glistening layer called articular cartilage and connected by strong ligaments and powerful muscles that are attached to the thigh and calf by tendons, and which provide side-to-side stability. (hss.edu)
The immune system damages normal tissue (such as cartilage and ligaments) and softens the bone. (aaos.org)

Recurrent hyperemia of the joint in the growing child causes juxta-articular osteoporosis and overgrowth of the epiphysis. (medscape.com)

Articular cartilage repair treatment involves the repair of the surface of the articular joint's hyaline cartilage. (wikipedia.org)
In addition, some water is displaced from the surface of the articular cartilage, which provides a lubricating film. (trackactive.co)

Her research group is particularly interested in developing biomaterials and cell-based therapeutics to improve regeneration of various musculoskeletal tissues including bone, cartilage, tendon, blood vessels etc. (stanford.edu)

Intra-articular hemarthroses affect approximately 90% of patients with severe hemophilia, with the most frequently involved joints being the ankles, knees, and elbows. (medscape.com)
Plain radiographic classification systems can describe clinical progression of arthropathy, but MRI has advantages over radiography because it can visualize soft tissue and cartilage changes in hemophilic joints. (medscape.com)
They also provide detailed information on the biomechanics of the human body including bone tissue, articular cartilage, soft tissue, blood and fluids, spinal cord and nerve tissue, joints, and extremities. (lawyersandjudges.com)
However, it is being investigated as a tool for monitoring cartilage degeneration, and it can be used for guided injections of joints not easily accessed without imaging. (medscape.com)
The equine cervical articular process joints (APJs) are subject to developmental defects, osteochondrosis, fractures and degenerative joint disease. (ivis.org)
Treatment of various degenerative and inflammatory disorders of hip and knee joints. (ahdubai.com)
So, it is of imminent importance to study the molecular process of chondrocytes differentiation and dedifferentiation in order to discover potential therapies to manipulate the activity to rehabilitate chondrogenic functions and morphology to prevent degeneration of articular joints in various cartilage associated diseases. (researchsquare.com)
As clinicians we often see patients with degenerative joints. (trackactive.co)
Furthermore, despite the progressive breakdown of articular cartilage in osteoarthritic joints, studies have revealed the beneficial effects of cyclical loading. (trackactive.co)
Loose fragments of cartilage and other tissue can interfere with the smooth motion of joints. (aaos.org)
[ 1 ] It can be thought of as a degenerative disorder arising from the biochemical breakdown of articular (hyaline) cartilage in the synovial joints. (medscape.com)

HE staining and iron red solid green staining were used to observe the degeneration of articular chondrocytes in rats. (researchsquare.com)

If the insole with a subtalar strap maintains FTA for more than 2 years, it may restrict the progression of degenerative articular cartilage lesions of knee OA. (nih.gov)
The moral of the story is clear - when dealing with patients with articular damage such as arthritis, it is important that appropriate exercise programmes are prescribed in order to reduce disease progression. (trackactive.co)
Biologic Treatments for OA: A Sports Medicine Perspective Studies show that several biologic treatments can prevent degenerative arthritis or its progression and allow many seniors to remain active late in life. (medscape.com)

Objectives (1) To compare spontaneous and stimuli-induced adipocytokine secretion by articular adipose tissue (AAT) and synovial membrane (SM) explants obtained from patients with rheumatoid arthritis (RA). (bmj.com)
Knee arthritis literally means "inflammation of the knee joint," most often as a result of cartilage in the joint wearing down to a degree where it no longer cushions the surfaces of bone which make up the joint. (hss.edu)
On an X-ray of a knee with arthritis, this space is reduced or, in some places, even absent due to worn cartilage. (hss.edu)
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. (embl.de)
The late sequelae of joint hemorrhage appear in adolescence or adulthood as a joint deformity, contracture, and/or degenerative arthritis. (medscape.com)
and degenerative arthritis. (medscape.com)
It is a degenerative, wear-and-tear type of arthritis that occurs most often in people 50 years of age and older, although it may occur in younger people, too. (aaos.org)
Xray right hip ordered May 2016 - degenerative arthritis with complete joint space loss and femoral head flattening. (roberthowells.com.au)

Chondropathy is the umbrella term for pathological changes in the articular cartilage. (ottobock.com)

Intra-articular bleeding produces a direct chemical effect on the synovium, cartilage, and bone. (medscape.com)
Intra-articular injection of mitochondria is a novel treatment that has the potential to improve cell metabolism and decrease inflammation, but safety of this treatment has yet to be established in the horse. (cabi.org)

According to statistics in Poland, approximately 8 million people suffer from degenerative diseases [ 13 ]. (hindawi.com)
These conditions commonly reported in different cartilage degenerative diseases. (researchsquare.com)
However, in various cartilage degenerative diseases, the chondrocytes transition itself to more flattened fibroblast cells with different morphological, genetical and biochemical characteristics which is characterized as dedifferentiation 4,5 . (researchsquare.com)
These cell models are used to study the molecular mechanism of various cartilage associated degenerative diseases. (researchsquare.com)
Osteochondrosis is a complex of degenerative diseases of articular cartilage. (ostelife-premium-plus.eu)

dubious - discuss] A 2011 study reports histologically confirmed hyaline cartilage regrowth in a 5 patient case-series, 2 with grade IV bipolar or kissing lesions in the knee. (wikipedia.org)
They explain that the significance of this cartilage regeneration protocol is that it is successful in patients with historically difficult-to-treat grade IV bipolar or bone-on-bone osteochondral lesions. (wikipedia.org)
With fully detailed discussions of degenerative, inflammatory, and neoplastic lesions, the book is an authoritative guide to quickly and accurately identifying common and uncommon lesions in small animals and horses. (a3shop.hu)

The main target groups are patients with very small defects of the articular cartilage. (wikipedia.org)
An alternative treatment option for focal cartilage defects could be the usage of monomer solutions, especially the novel generated sulfobetaine-methacrylate-based monomer solution, as bionic for cell-based 3D bioprintable hydrogels. (kobv.de)
Fortunately, recent studies have claimed that RADA-16 peptide is an attractive therapeutic strategy for repairing cartilage defects. (bvsalud.org)

Lavage focuses on removing degenerative articular cartilage flaps and fibrous tissue. (wikipedia.org)
Microfracture techniques show new potential, as animal studies indicate that microfracture-activated skeletal stem-cells form articular cartilage, instead of fibrous tissue, when co-delivered with a combination of BMP2 and VEGF receptor antagonist. (wikipedia.org)
The implant is designed to support the formation of hyaline cartilage through a unique guided tissue mechanism. (wikipedia.org)
It protects the repair site from infiltration of undesired fibrous tissue while providing the appropriate environment for hyaline cartilage matrix formation. (wikipedia.org)
The expression of P2Y12 increased in OA cartilage tissue, and P2Y12 inhibited apoptosis. (researchsquare.com)
Accumulating evidence supports the role of cartilage tissue engineering in cartilage defect repair, but the biological function has yet to be fully explained. (bvsalud.org)
In conclusion, these results suggest that the KGN/PVA/n-HA scaffolds can facilitate tendon-bone healing after ACL reconstruction and might be considered novel hydrogel biomaterials in cartilage tissue engineering. (bvsalud.org)

In the last 25 years, arthroscopy has become a useful tool for diagnosing and treating a variety of articular disorders in horses, and today it can be considered to be one of the most useful techniques in equine joint surgery. (ivis.org)
Underwent right knee arthroscopy 6 months previously (Nov 2015) for treatment of a meniscal tear (degenerative). (roberthowells.com.au)
For Articular Cartilage Injury, a Holistic Approach Is Best Mastery of arthroscopy isn't enough to treat injury to the knee's articular cartilage. (medscape.com)

The study included polymerization and deposition of methacryloyloxyethyl-phosphorylcholine- and a novel sulfobetaine-methacrylate-based monomer solution within ex vivo human OA-cartilage explants and the encapsulation of isolated chondrocytes within hydrogels and the corresponding effects on chondrocyte viability. (kobv.de)
Cartilage is made up of cells called chondrocytes, which are contained in an extracellular matrix consisting of cross-linked type II collagen fibres. (trackactive.co)
The displacement of water in and out of cartilage during loading assists in increasing the rate at which the chondrocytes receive nutrients (Handley, 1995). (trackactive.co)

Knee articular cartilage injuries present a great challenge for musculoskeletal clinicians and scientists, leading to substantial morbidity and significant time lost from work and sport and even permanent disability. (researchgate.net)

This can lead to a loss of cartilage. (ottobock.com)
The knee joint may develop cysts, bone spurs, or loss of cartilage. (hss.edu)

The menisci are crescent-shaped pieces of cartilage that provide the knee with stability and help distribute the load in the knee joint. (lu.se)

Ten patients with degenerative meniscal tears treated with PRP injections. (caringmedical.com)

Studies, however, have shown that marrow stimulation techniques often have insufficiently filled the chondral defect and the repair material is often fibrocartilage (which is not as good mechanically as hyaline cartilage). (wikipedia.org)

osteophytes (bone spurs) at the articular surfaces. (3bscientific.com)
The bones are covered with smooth cartilage surfaces that act as a cushion during weight-bearing activity. (hss.edu)
This causes instability that increases the wearing down of cartilage surfaces. (hss.edu)
The loss of the gliding surfaces of the cartilage may make people feel as though their knee is stiff and their motion is limited. (hss.edu)
As we know, articular cartilage is present on the ends of bones and is responsible for providing resistance to compressive forces, distributing load, and together with synovial fluid, allowing the near frictionless movement of the surfaces of the articulating joint. (trackactive.co)

The differentiated chondrocyte is capable of synthesizing and regulating the extracellular matrix such as collagen type II, proteoglycans which are responsible for cartilage development and repair 1-3 . (researchsquare.com)

Researchers have investigated the use of monoclonal antibodies, synovial fluid markers, and urinary pyridinium cross-links (ie, breakdown products of cartilage) as osteoarthritic indicators. (medscape.com)

Given the limited regenerative capacity of articular cartilage, methods to support the native structural properties of articular cartilage are highly anticipated. (kobv.de)
We focus on joint preservation and regenerative medicine in treating Joint Articular Cartilage damage. (ahdubai.com)

As articular cartilage is avascular, diffusion from the synovial fluid is a major means by which cartilage obtains nutrients. (trackactive.co)

Let's start with a brief rundown on the anatomy and physiology of articular cartilage as this provides the basis for understanding the need for movement. (trackactive.co)

When the necrotic process involves the articular cortex, the fate of the associated articular cartilege becomes crucial. (cdc.gov)

Roosendaal and Lafeber found that the articular cartilage is sensitive to the presence of blood and that damage may occur to the cartilage independent of the synovial changes caused by bleeding. (medscape.com)
Damage to the bone and articular cartilage appears later. (medscape.com)
These treatments have been shown to be especially beneficial for patients who have articular cartilage damage. (wikipedia.org)
Marrow stimulating techniques attempt to solve articular cartilage damage through an arthroscopic procedure. (wikipedia.org)
There was significant damage to the articular cartilage at the superior and posterior edge of the humeral head consistent with the chondral lesion there at the time of the injury. (aapc.com)
This increased risk of developing OA is mainly due to whether the damage was traumatic or degenerative, and if other risk factors are present. (lu.se)

They are disorders of growth and remodeling of bone and cartilage. (medscape.com)

Degenerative joint disease secondary to elbow dysplasia is mainly evaluated on hyperflexed lateral, cranio-caudal and craniolateral / caudomedial 15°oblique views. (vin.com)
Good preservation of medial and lateral articular cartilage. (roberthowells.com.au)

Degenerative tears with mainly a horizontal or cleavage component are not unstable as a general rule and most unlikely to cause pain and mechanical symptoms. (roberthowells.com.au)

The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. (embl.de)

The cartilage softens, often due to overuse or an injury. (ottobock.com)

Though these solutions do not perfectly restore the articular cartilage, some of the latest technologies have started to bring very promising results in repairing cartilages from traumatic injuries or chondropathies. (wikipedia.org)
These changes can in turn be triggered by various underlying causes of a traumatic, degenerative or inflammatory nature. (ottobock.com)

citation needed] Further on, chances are high that after only 1 or 2 years of the surgery symptoms start to return as the fibrocartilage wears away, forcing the patient to reengage in articular cartilage repair. (wikipedia.org)
This is a slow, progressive in which the articular cartilage of the femur, tibia, or patella wears down over time. (hss.edu)
As the cartilage wears away, it becomes frayed and rough, and the protective space between the bones decreases. (aaos.org)

Articular cartilage has limited intrinsic capacity for self-repair and, to date, there is no curative treatment for OA. (cabi.org)

The aim of this study was to infiltrate zwitterionic monomer solutions into human OA-cartilage explants to replace lost proteoglycans. (kobv.de)

Over six to 12 months, the implant resorbs from its surface inward, enabling it to be gradually replaced with new cartilage. (wikipedia.org)

4. Degenerative posterior labral tear. (aapc.com)
The shaver was used to debride the anterior, superior, and posterior labrum as well as the underside of the supraspinatus and the fibrillated articular cartilage on the glenoid and the humeral head. (aapc.com)
The distal radius has a biconcave articular surface with two articular facets that are separated by an anterior and a posterior ridge. (medscape.com)

If left untreated, knee articular cartilage injuries may lead to the development of widespread degenerative joint disease. (researchgate.net)

Many people over the age of fifty experience this sort of wear and tear to their kneecaps and cartilage. (ottobock.com)

Broadly taken, there are five major types of articular cartilage repair:[citation needed] Arthroscopic lavage is a "cleaning up" procedure of the knee joint. (wikipedia.org)
As the cartilage is worn away preferentially on one side of the knee joint, people may find their knee will become more knock-kneed or bowlegged. (hss.edu)
The ends of the three bones that form the knee joint are covered with articular cartilage, a smooth, slippery substance that protects and cushions the bones as you bend and straighten your knee. (aaos.org)

citation needed] During the standard microfracture procedure, the implant is applied to the cartilage defect as a liquid. (wikipedia.org)
It is then exposed to UVA light for 90 seconds, turning it into a solid, soft implant that completely occupies the space of the cartilage defect. (wikipedia.org)

A thicker labral graft could support mechanical stability and protect cartilage better. (researchgate.net)

A hydrogel implant to help the body regrow cartilage in the knee is currently being studied in U.S. and European clinical trials. (wikipedia.org)
The results demonstrated that zwitterionic cartilage-hydrogel networks are formed by infiltration. (kobv.de)

Degenerative disc disease is one of the most prevalent causes of back/neck pain that often leads to disability for individuals of working age. (tue.nl)
Unlike those with achondroplasia or hypochondroplasia, patients with diastrophic dysplasia have epiphyseal involvement and are at risk for degenerative joint disease. (medscape.com)
Elbow dysplasia" (ED) is a syndrome that includes several conditions resulting in an incongruency of the joint, eventually leading to degenerative joint disease (DJD). (vin.com)

Anatomy20

Organisms1

Diseases5

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes2

Technology, Industry, Agriculture1

Osteoarthritis20

Subchondral5

Meniscus14

Ligaments2

Overgrowth of the epiphysis1

Surface of the articular2

Tissues1

Joints11

Degeneration of articular1

Progression3

Arthritis8

Pathological1

Intra-articular2

Diseases5

Lesions3

Defects3

Tissue7

Arthroscopy3

Chondrocytes3

Musculoskeletal1

Loss of cartilage2

Pieces of cartilage1

Patients with degenerative1

Hyaline1

Surfaces5

Extracellular matrix1

Osteoarthritic1

Regenerative2

Avascular1

Anatomy1

Involves1

Damage6

Disorders1

Lateral2

Tears1

Biochemical1

Softens1

Traumatic2

Wears3

Intrinsic1

Explants1

Enabling it to be1

Posterior3

Injuries1

Tear1

Knee joint3

Defect2

Labral1

Hydrogel2

Disease3