AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and Processes
ApomorphineDopamine AgonistsReceptors, DopamineHaloperidolPiribedilEmeticsPenile ErectionStartle ReactionStereotyped BehaviorPimozideDopamine AntagonistsDopamineLevodopaAntiparkinson AgentsReceptors, Dopamine D2CatalepsyTranquilizing AgentsCarbidopaParkinson DiseaseSensory GatingBehavior, AnimalQuinpiroleHydroxydopaminesMotor ActivityYawningDopamine AgentsParkinson Disease, SecondaryOxidopamineAdministration, SublingualAmphetamine2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineDomperidoneReceptors, Dopamine D1ErgolinesBis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfideCorpus StriatumSubstantia NigraHarmineReceptors, Dopamine D3BenzazepinesPenisDyskinesia, Drug-InducedInfusion PumpsRats, Sprague-DawleyDose-Response Relationship, DrugSulpirideAntipsychotic AgentsAttention Deficit Disorder with HyperactivityInjections, SubcutaneousSpiperoneErectile DysfunctionLisurideFlupenthixolScopolamine Hydrobromide
Dopamine deficitBehavioralParkinson'sApokynNeuronsPotentiationAnosognosiaRotarodReceptorCorticalSensoryADHDMiceSignificantlyUnawareDisordersMotorStimulationTreatmentSpecificPatientsAnimalsFactorPrepulse inhibitionSubcutaneous apomorphineAttention deficitLevodopaAgonistLesionsRatsDopaminergicHydrochlorideSchizophreniaDopamine receptorLocomotorCognitiveInhibitoryAmphetamine-inducedPersistentPharmacokineticsAttenuatesEffectsAnimalsAdministration
Dopamine deficit1
  • 2019. Presynaptic dopamine deficit in minimally conscious state patients following traumatic brain injury. . (cornell.edu)
Behavioral7
  • In animals, unlike D2 receptor antagonists like haloperidol, sonepiprazole does not block the behavioral effects of amphetamine or apomorphine, does not alter spontaneous locomotor activity on its own, and lacks extrapyramidal and neuroendocrine effects. (wikipedia.org)
  • Using behavioral tests, grip strength and numbers of apomorphine-induced contralateral rotation were declined in the ceftriaxone-treated group. (edu.hk)
  • 2] The deficit must not be fully attributable to primary sensory deficits (eg, hemianopia) or motor disturbance (eg, hemiparesis).Treatment for spatial neglect focuses on visuomotor, cognitive, and behavioral training, in a rehabilitation program including specific exercises. (medscape.com)
  • Subsequent behavioral testing involved beam walking task, rotarod, visual discrimination task and apomorphine rotation. (johnshopkins.edu)
  • Significant and relatively stable behavioral deficits were observed up to 30 days. (johnshopkins.edu)
  • Other neurobehavioral manifestations include attention-deficit-hyperactivity disorder, obsessive-compulsive disorder, poor impulse control, and other behavioral problems. (medscape.com)
  • In animal models, HL192 showed disease-modifying effects, as demonstrated through improvements in behavioral deficits. (neurologylive.com)
Parkinson's4
  • In the present study, efficacy of ceftriaxone in neuroprotection of dopaminergic neurons and amelioration of motor deficits in a rat model of Parkinson's disease were investigated. (edu.hk)
  • Their meta-analysis of 34 different studies using data from 1,295 participants shows a robust link between Parkinson's and specific deficits in recognizing emotions, especially negative emotions, across different types of stimuli and tasks. (sciencedaily.com)
  • advanced Parkinson's), Nutropin ® (growth hormone) and INCRELEX ® (IGF-1 for the treatment of growth deficits). (pharmaboardroom.com)
  • Dopaminergic dysfunction has been implicated in the pathophysiology of schizophrenia, mood disorders, attention-deficit disorder, Tourette's syndrome, substance dependency, tardive dyskinesia, Parkinson's disease and other disorders. (psychiatrictimes.com)
Apokyn1
  • Dysport ® (Botulinum toxin type A, 500U, for the treatment of dystonias, spasticity and cosmetic uses), Somatuline ® Autogel ® (lanreotide for the treatment of acromegaly and neuroendocrine tumors), Apokyn ® (apomorphine for the treatment of the syndrome. (pharmaboardroom.com)
Neurons2
  • The deficit of these neurons is the factor that gives rise to the illness. (ub.edu)
  • Because LGF partially protects dopamine neurons from 6-OHDA neurotoxicity in the substantia nigra, and reduces engine deficits in these animals, we propose Rabbit polyclonal to ZNF562 LGF like a novel factor that may be useful in the treatment of Parkinsons disease. (antiviralbiologic.com)
Potentiation2
  • The possible involvement of the dopaminergic system in the actions of T. catigua extract was substantiated by data showing the potentiation of apomorphine-induced hypothermia and by the prevention of haloperidol-induced catalepsy. (hindawi.com)
  • Potentiation of Apomorphine-Induced Climbing Behaviour in Mice by d-LS. (erowid.org)
Anosognosia2
  • Spatial neglect also encompasses a cluster of symptoms affecting several areas of vital importance in daily life and is associated with other cognitive dysfunction, such as emotional processing dysfunction and abnormal awareness of deficits (anosognosia for hemiplegia [may occur in the hyperacute phase of right hemispheric stroke in as many as 32% of patients, about 18% after 1 week and 5% after 6 months[6] ] and anosodiaphoria), which may affect independence. (medscape.com)
  • Many patients are often also unaware they have a deficit ( anosognosia ). (scholarpedia.org)
Rotarod1
  • The deficit observed after 21 days in rotarod was responsive to apomorphine, which improved the performance of the animals. (ufc.br)
Receptor2
  • Here, we further characterized the VTA dopamine neuron and sensorimotor gating functions of PCE rats exposed to acute stress or a challenge of the D2 receptor agonist apomorphine, by using in vivo single-unit extracellular recordings and Prepulse Inhibition (PPI) analyses. (nih.gov)
  • Polymorphisms in the gene coding for the adhesion G-protein coupled receptor LPHN3 are a risk factor for attention-deficit/hyperactivity disorder (ADHD). (hal.science)
Cortical1
  • However, it does reverse the prepulse inhibition deficits induced by apomorphine, and has also been shown to enhance cortical activity and inhibit stress-induced cognitive impairment. (wikipedia.org)
Sensory1
  • It has been shown that the symptoms of cognitive disorder and abnormal thoughts of schizophrenics are associated with the deficit of sensory gating. (psych.ac.cn)
ADHD1
  • Restless legs syndrome and attention deficit hyperactivity disorder (ADHD) are associated with decreased dopamine activity. (alchetron.com)
Mice1
  • Iloperidone has also been shown to reduce the effects of apomorphine induced climbing behavior in mice as well as the effects of head twitching induced by 5-HT in rats. (bionity.com)
Significantly2
  • The PPI deficit normally incurred by each psychotic drug was significantly diminished by the co administration of iloperidone. (bionity.com)
  • Despite the fact that speech and language, memory, and other mental abilities may be spared in brain-injured patients with spatial neglect, the prognosis for recovery of independent function in patients with persisting spatial neglect is significantly worse than in those with seemingly more disabling deficits in these other abilities. (medscape.com)
Unaware1
  • The deficit may be so profound that patients are unaware of large objects, even people, towards their neglected or contralesional side - the side of space opposite brain damage. (scholarpedia.org)
Disorders1
  • 2019. Treating Disorders of Consciousness With Apomorphine: Protocol for a Double-Blind Randomized Controlled Trial Using Multimodal Assessments. . (cornell.edu)
Motor1
  • Oral r-(-)-11-o-valeryl-n-n-propylnoraporphine reverses motor deficits in mptp-treated marmosets. (harvard.edu)
Stimulation3
  • Further clarification is provided in a second study that showed that deep-brain stimulation, compared with medication, caused a consistently large deficit in the recognition of fear and sadness - two key facial expressions that, when understood, aid survival. (sciencedaily.com)
  • The research in France, along with previous studies, indicates that deep-brain stimulation produces an even more severe deficit. (sciencedaily.com)
  • For refractory, disabling symptoms in patients without dementia, stereotactic deep brain stimulation or lesional surgery and levodopa and an apomorphine pump may help. (msdmanuals.com)
Treatment1
  • This plant is widely used in folk medicine as a tonic for the treatment of fatigue, stress, impotence and against deficits of memory, being also employed as a digestive and purgative substance. (hindawi.com)
Specific1
  • The study reads: "Although there is considerable empirical support for the asteroid impact hypothesis, the evidence is also consistent with the possibility that dinosaurs went extinct partly as a consequence of a specific behavioural deficit: an inability to form learned food aversions. (express.co.uk)
Patients1
  • Numerous studies have used apomorphine (APO) in the evaluation of dopaminergic (DA) function in schizophrenic patients. (mdpi.com)
Animals1
Factor1
  • Professor Gallup said: "Though the asteroid certainly played a factor, the psychological deficit which rendered dinosaurs incapable of learning to refrain from eating certain plants had already placed severe strain on the species. (express.co.uk)
Prepulse inhibition2
  • The authors tested the hypothesis that the use of an atypical drug, clozapine, for patients with schizophrenia is related to less impairment in information processing deficits (assessed by prepulse inhibition of the startle response) than is the use of typical anti-psychotics. (psychiatryonline.org)
  • Objectives: We have carried out a pharmacological characterization of the Roman high- (RHA-I) and low-avoidance (RLA-I) rat strains with different acutely administered propsychotic (DOI, MK-801) and antipsychotic drugs (haloperidol, clozapine), as well as apomorphine, on prepulse inhibition (PPI) of startle and locomotor activity (activity cages). (uab.cat)
Subcutaneous apomorphine2
  • Levodopa pharmacokinetics were unchanged when subcutaneous apomorphine and levodopa were co-administrated in patients. (nih.gov)
  • Three device-aided treatments are currently available to provide different kinds of continuous stimulation: levodopa/carbidopa intestinal gel infusion, deep brain stimulation (DBS), and subcutaneous apomorphine pump infusion (not approved in US). (pd-thrive.com)
Attention deficit3
  • Abnormal dopaminergic transmission is implicated in schizophrenia, attention deficit hyperactivity disorder, and drug addiction. (nih.gov)
  • In addition, we show that both the indirect dopamine receptor agonist amphetamine and the direct agonists apomorphine and quinpirole inhibit locomotor activity in the DAT knockdown mice, leading to the hypothesis that a shift in the balance between dopamine auto and heteroreceptor function may contribute to the therapeutic effect of psychostimulants in attention deficit hyperactivity disorder. (nih.gov)
  • Abnormal dopamine levels are associated with Parkinson's disease, restless legs syndrome, and attention-deficit hyperactivity disorder (ADHD). (healthnews.com)
Levodopa3
  • The clearance of apomorphine does not appear to be influenced by age, gender, weight, duration of Parkinson's disease, levodopa dose or duration of therapy. (nih.gov)
  • For refractory, disabling symptoms in patients without dementia, stereotactic deep brain stimulation or lesional surgery and levodopa and an apomorphine pump may help. (msdmanuals.com)
  • It is unclear whether acute levodopa or apomorphine challenge has any advantage over clinical diagnostic criteria. (medscape.com)
Agonist8
  • Unlike clozapine however, the effect of which is abolished by the D2 receptor agonist apomorphine, alstonine requires 5-HT2A and 5-HT2C receptors to produce this effect, as it is abolished by antagonists of these receptors. (wikipedia.org)
  • APOKYN ® (apomorphine hydrochloride, USP) is a non-ergoline dopamine agonist. (nih.gov)
  • The aims of this study were to assess the effects of the dopamine agonist apomorphine on experimental pain models in healthy subjects and to explore the possible association between these effects and a common polymorphism within the dopamine transporter gene. (nih.gov)
  • The mixed dopamine D1/D2 agonist, apomorphine, at the dose of 0.05 mg/kg, decreased PPI in RHA-I, but not RLA-I rats. (uab.cat)
  • In this study the authors tested the efficacy of apomorphine (APO), a non-specific dopamine agonist, in the 3xTg mouse model. (nih.gov)
  • We have examined the effects of ageing on the motor behaviours elicited by a range of doses of the classical D1/D2 dopamine agonist apomorphine in the rat. (baillement.com)
  • Finally, in order to better appreciate whether the effects of ageing on the responses to apomorphine reflect alterations in D1 or D2 receptors, the locomotor stimulant effects of 14 days of continuous infusion of the selective D2 agonist (+)-4-propyl-9-hydroxynaphthoxazine (PHNO) were also investigated. (baillement.com)
  • Pharmacological stimulation of dopamine systems demonstrated an age-related decrement in yawning , but an increase in stereotyped sniffing and licking or gnawing induced by the mixed D1/D2 agonist apomorphine. (baillement.com)
Lesions4
  • In particular, apomorphine attenuates the motor deficits induced by lesions in the ascending nigrostriatal dopaminergic pathway with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in primates. (nih.gov)
  • Aged animals with unilateral 6-hydroxydopamine (6-OHDA) lesions have been reported to show decreased rotation following contralateral striatal dopamine infusion or systemic apomorphine. (baillement.com)
  • The increased latency to remove adhesive patches is also consistent with a dopaminergic deficit, but may also be seen with cortical lesions. (baillement.com)
  • Although creating lesions in these structures improves motor function in monkeys with induced parkinsonism and patients with Parkinson's disease, such lesions are associated with neurologic deficits, particularly when they are created bilaterally. (keyopinionleaders.com)
Rats4
  • Eight weeks later, the rats were tested for apomorphine-induced rotational asymmetry and evaluation of explanted grafts infected with the complementary DNA for GDNF containing NPCs and NPCs alone. (medscape.com)
  • Results: RHA-I rats display a consistent deficit of PPI compared with RLA-I rats. (uab.cat)
  • The typical antipsychotic haloperidol (dopamine D2 receptor antagonist) reversed the PPI deficit characteristic of RHA-I rats (in particular at 65 and 70 dB prepulse intensities) and reduced locomotion in both strains. (uab.cat)
  • Deficits in shock-induced freezing and naltrexone enhancement of freezing in fawn hooded rats. (omeka.net)
Dopaminergic1
  • Whilst the loss of the dopaminergic nigrostriatal pathway is the classical biochemical deficit in PD, pathologically it is the formation of Lewy bodies. (hindawi.com)
Hydrochloride3
  • Apomorphine hydrochloride appears as minute, white or grayish-white glistening crystals or as white powder that is soluble in water at 80°C. (nih.gov)
  • Each mL of solution contains 10 mg of apomorphine hydrochloride, USP as apomorphine hydrochloride hemihydrate and 1 mg of sodium metabisulfite, NF in water for injection, USP. (nih.gov)
  • Apomorphine hydrochloride is a lipophilic compound that is rapidly absorbed (time to peak concentration ranges from 10 to 60 minutes) following subcutaneous administration into the abdominal wall. (nih.gov)
Schizophrenia2
  • Structural abnormalities in deficit and non-deficit schizophrenia. (nih.gov)
  • Information processing deficits of schizophrenia patients: Relationship to clinical ratings, gender and medication status. (nih.gov)
Dopamine receptor1
Locomotor1
  • Quantitative assessment of these behavioral deficits using a video movement analysis system demonstrated a significant decrease in locomotor activity and peak tangential velocity in 3NP-treated animals compared to controls. (inra.fr)
Cognitive5
  • In addition, schizophrenic patients are suffering from cognitive deficits, such as impaired attention and memory. (justia.com)
  • 26. Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease. (nih.gov)
  • 29. Long-term naringin consumption reverses a glucose uptake defect and improves cognitive deficits in a mouse model of Alzheimer's disease. (nih.gov)
  • 38. Overexpression of Ubiquilin-1 Alleviates Alzheimer's Disease-Caused Cognitive and Motor Deficits and Reduces Amyloid-β Accumulation in Mice. (nih.gov)
  • PD patients are also affected by a variety of nonmotor deficits such as hyposmia, autonomic dysfunction, sleep disturbances, cognitive impairment, and psychiatric symptoms [ 1 ]. (hindawi.com)
Inhibitory1
  • Finally, PD patients who exhibited deficits in a measure of inhibitory control showed weaker convergent thinking while "on" medication, supporting previous evidence on the importance of inhibitory control in creative problem-solving. (frontiersin.org)
Amphetamine-induced1
  • It also possesses anxiolytic-like effects in preclinical studies, attenuates amphetamine-induced lethality and stereotypy as well as apomorphine-induced stereotypy, and attenuates haloperidol-induced catalepsy. (wikipedia.org)
Persistent2
  • In animals receiving 3NP and the solvent of riluzole, 12 weeks of high-dose 3NP treatment resulted in the appearance of persistent leg dystonia and significant increases in the incidence of three categories of abnormal movements and in the dyskinesia index in the apomorphine test (0.5 mg/kg i.m. (inra.fr)
  • 4 PDD is characterised by the gradual emergence of day-to-day fluctuations in cognition, confusion, attention and alertness, as opposed to the persistent amnestic deficits of Alzheimer's disease. (racgp.org.au)
Pharmacokinetics1
  • In general, an increased duration of stereotyped behaviour following apomorphine bas been noted, possibly reflecting differences in drug pharmacokinetics. (baillement.com)
Attenuates1
  • In preclinical studies alstonine attenuates MK-801-induced hyperlocomotion, working memory deficit and social withdrawal. (wikipedia.org)
Effects1
  • Relatively few studies have examined the effects of ageing on the behavioural responses to apomorphine in otherwise intact animals. (baillement.com)
Animals1
  • The impairments seen on tests of strength and co-ordination are in keeping with deficits previously reported in aged animals. (baillement.com)
Administration4
  • After subcutaneous administration, apomorphine appears to have bioavailability equal to that of an intravenous administration. (nih.gov)
  • In a study comparing subjects with hepatic impairment (moderately impaired as determined by the Child-Pugh classification method) to healthy matched volunteers, the AUC 0-∞ and C max values were increased by approximately 10% and 25%, respectively, following a single subcutaneous administration of apomorphine into the abdominal wall. (nih.gov)
  • Heat pain threshold and intensity, cold pain threshold, and the response to tonic cold pain (latency, intensity, and tolerance) were evaluated before and for up to 120 min after the administration of 1.5 mg apomorphine/placebo. (nih.gov)
  • An association was found between the enhancing effect of apomorphine on pain tolerance (120 min after its administration) and the DAT-1 polymorphism. (nih.gov)