ColobomaDown SyndromeSyndromeCostello SyndromePrurigoAbnormalities, MultipleMicrophthalmosChromosomes, Human, Pair 22AnophthalmosGenetic Diseases, InbornChoanal AtresiaDevelopmental DisabilitiesInfant, NewbornPedigreeHeart Defects, CongenitalFetal DiseasesChromosome DisordersBirth WeightPregnancyMutationEye AbnormalitiesHypertelorismChromosome AberrationsPupil DisordersPremature BirthIrisPAX2 Transcription FactorPosterior Eye SegmentBirth RateInfant, Low Birth WeightMetabolic Syndrome XFundus OculiChoroidCHARGE SyndromeEye