Defects human bone regeneration. Medical search. Frequent questions

Mesenchymal stem cell research has yielded the most promising results for craniofacial regeneration, as MSCs can be found in many types of postnatal tissues, including orofacial tissues. (wikipedia.org)
Such stem cells include bone marrow mesenchymal stem cells (BMMSC), adipose-derived mesenchymal stem cells (AMCs), muscle satellite cells (MuSCs), periodontal ligament stem cells (PDLSCs), and stem cells from human exfoliated deciduous (SHED teeth). (wikipedia.org)
The process of regeneration is initiated by an inflammatory response to injury, followed by angiogenesis, leading to mesenchymal stem cell (MSC) differentiation. (wikipedia.org)
Three-dimensional (3D) spheroid culture can promote the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSC). (biomedcentral.com)
PEI-al nanocomposites carrying BMP-2 gene could efficiently transfect bone marrow mesenchymal stem cells. (dovepress.com)
Our results suggested that PEI-al nanocomposites efficiently deliver the BMP-2 gene to bone marrow mesenchymal stem cells and that BMP-2 gene-engineered cell sheet is an effective way for promoting bone regeneration. (dovepress.com)
We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
Cell seeding and viability tests with human umbilical cord mesenchymal stem cells (HUCMSCs) indicated excellent biocompatibility with these cells. (ku.edu)
Preliminary biological studies were conducted to evaluate adhesion (6 h) of human mesenchymal stem cells (hMSC) to the patterns in terms of cell number and morphology. (ibecbarcelona.eu)
Human orofacial bone-derived mesenchymal stem cells (OMSCs) showed distinct differentiation traits from mesenchymal stem cells (MSCs) derived from long bones, mouse OMSCs have not been isolated due to technical difficulties, which in turn precludes using mouse models to study orofacial diseases. (ca.gov)
The grant entitled "Bone regeneration: mesenchymal stem cells and graphenebiomimetic nanomaterials" has been funded for a three-year period by NIH. (utmck.edu)
Newly developed porous NiTi, produced by Selective Laser Melting (SLM), is currently under investigation as a potential carrier material for human mesenchymal stem cells (hMSC). (icams.de)
To focus their study on bone regeneration, the researchers used bone marrow-derived mesenchymal stem cells (BMSCs) from rats. (lifespan.io)
This study was designed to explore the effects of hydroxy-apatite/tricalcium-phosphate (HA/TCP) and platelet-rich plasma (PRP) on the osteogenesis ability of human adipose-derived mesenchymal stem cells (hAdMSCs) in vitro and in vivo. (virascience.com)
Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
The human bone morphogenet ic protein (rhBMP) developed by genetic engineering, was isolated by Urist, in 1965, and it is considered a substance capable of inducing differentiation of mesenchymal stem cells into osteoblasts, the cells that are responsible for the synthesis of bone matrix. (bvsalud.org)
Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)

Regeneration of large bone defects is a common clinical problem. (dovepress.com)
Currently, the bone autograft is the most frequently used strategy to manage large bone loss. (frontiersin.org)
Large bone loss as a result of trauma, tumor removal, infection, and developmental congenital disorders, often leads to delayed healing or non-union, and remains a critical challenge for orthopedic surgeons. (frontiersin.org)
It has been reported that large bone gaps around immediate dental implants may interfere with the osseointegration process because of migration of the surrounding soft tissues into these gaps. (allenpress.com)
Before this study, large bone defects in patients were difficult to treat with BMP2 or other existing products available to surgeons," Ting said. (uclahealth.org)
3 Combinations of autogenous bone grafts, biodegradable scaffolds with bone morphogenetic protein 2 (BMP‐2), an osteoinductive growth factor, are often used to improve healing in large bone defects. (health.mil)

Reconstruction of advanced maxillofacial bone deficiencies is a clinical challenge. (biomedcentral.com)
This thesis reports PLGA colloidal gels as novel injectable drug-loaded fillers desirable for promoting reconstruction and regeneration of cranial defects. (ku.edu)
Objective(s): Autologous bone transplantation known as the "gold standard" to reconstruction of osseous defects has known disadvantages. (virascience.com)
To review the literature on the use and clinical viability of human morphogenetic protein for the jaws reconstruction. (bvsalud.org)
Despite being a high-cost biomaterial, rhBMP-2 is a viable and very effective alternative for reconstruction of defects of the face. (bvsalud.org)
Here, we report a paper-based bioactive scaffold platform for stem cell culture and transplantation for bone reconstruction. (neoscate.com)
Horstmann P.F., Raina D.B. , Isaksson H., Hettwer W., Lidgren L., PetersenM.M., Tägil M. Composite Biomaterial as a Carrier for Bone-Active Substances for Metaphyseal Tibial Bone Defect Reconstruction in Rats. (lu.se)
Between May 2015 and November 2015, 18 consecutive patients underwent staged reconstruction of complex and/or contaminated soft tissue defects utilizing either conventional NPWT or modified NPWT with instillation and continuous dermatotraction via bridging retention sutures. (medscape.com)
In 2 patients with delayed, recurrent periprosthetic infection (mean, 7.5 weeks), serial debridement/hardware removal mandated free tissue transfer for composite defect reconstruction. (medscape.com)
[ 1 ] This situation is frequently encountered during closure of prior fasciotomies or delayed reconstruction of traumatic/contaminated abdominal wall defects. (medscape.com)

β-tricalcium phosphate scaffolds are characterized by their porous three-dimensional synthetic scaffold structures that stimulate growth, migration, and differentiation in human cells leading to bone reparation. (wikipedia.org)
Tamaddon M, Samizadeh S, Wang L, Blunn G, Liu C. Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering. (scielo.br)
The team previously discovered that when stem cells are placed on a low oxygen form of a carbon-based polymer (graphene) scaffold, the stem cells transform into bone cells and start to make the components of bone matrix without additional stimuli. (utmck.edu)
Through this new study, once the investigators determine the mechanism that changes the stem cells to bone cells, the graphene scaffold can be modified to make the process of bone formation occur faster and more efficiently. (utmck.edu)
This will allow the investigators to evaluate bone healing capacity of the scaffold/stem cells as well as biotoxicity and biodegradation. (utmck.edu)
The long-term goal of this research is to develop an optimal scaffold design that, when combined with stem cells, results in bone healing of a critical sized defect and a return to normal form and function in veterinary or human patients. (utmck.edu)
Background: In this study, we radiologically evaluated the performance of gelatin nano-bioglass scaffold applied in Dog's skull defect. (uitm.edu.my)
It can mimic physiological bone healing processes, in which a biodegradable scaffold is gradually replaced by neo-tissue, and the sustained release of miRNA plays a vital role in creating an optimal osteogenic microenvironment, thus achieving promising bone repair outcomes. (desktopmetal.com)
However, the balance between two key factors - scaffold degradation behavior and miRNA release profile - on osteogenesis and bone formation is still poorly understood. (desktopmetal.com)
Pluripotent cells are implanted in a hydroxyapatite-coated poly- L -lactic acid scaffold that releases bone morphogenic protein 2. (nature.com)
A bioactive paper scaffold significantly enhances in vivo bone regeneration of hADSCs in a critical-sized calvarial bone defect. (neoscate.com)
Our study suggests that paper possesses great potential as a bioactive, functional, and cost-effective scaffold platform for stem cell-mediated bone tissue engineering. (neoscate.com)
This is then fed into a microfabrication device to carve a piece of pig or cattle bone matrix into the same shape, creating a scaffold for the new bone tissue to grow in. (prweb.com)
The scaffold is populated with stem cells from the patient's own abdominal fat and placed inside a bioreactor, which mimics the finely calibrated conditions within the human body, enabling the bone to grow. (prweb.com)
Because bone tissue is constantly renewing itself, the animal scaffold will eventually be replaced with the patient's own bone. (prweb.com)

Furthermore SHED-Cryo-mediated cells engineering induced bone regeneration in essential calvarial bone-defect sites of immunocompromised mice. (bio-cavagnou.info)

Bone tissue engineering (BTE) strategies are increasingly being used to overcome the limitations of autogenous bone grafts and existing bone-substitute materials to reconstruct such defects [ 1 ]. (biomedcentral.com)
1 The obstacles of current bone substitutes include the limited amounts of donor bone, the bone resorption of autografts, the risk of disease transmission and graft rejection of allografts, and the shortage of osteoinductive property for synthetic grafts. (dovepress.com)
However, in cases of large defects, fractures with loss of segment and resection of tumors, the use of grafts (autografts, allografts and xenografts) or bone substitutes may be indicated to contribute to healing [ 1 1. (scielo.br)
Bone grafts and biomaterials substitutes for bone defect repair: A review. (scielo.br)
Inflammation and alveolar bone loss are hallmarks of periodontal disease, and historically, regenerative attempts have involved a myriad of techniques and materials usually consisting of bone grafts and/or barrier membranes to repair bony defects. (allenpress.com)

By way of this review, a deeper understanding of the basic mechanisms of β-TCP for bone repair will be achieved which will aid in the optimization of strategies to promote bone repair and regeneration. (frontiersin.org)
The application of platelet-rich plasma (PRP) has been hypothesized to enhance tissue repair and regeneration in musculoskeletal injuries. (thieme-connect.de)
Our work aims to develop optimal tissue engineered constructs for the repair and regeneration of different types of musculoskeletal tissues, including bone, cartilage and tendon. (edu.au)

Additional related steps include the healing process and nerve regeneration, which is briefly covered. (wikipedia.org)
He was also supervised by Dr. Daniel Chen to bioprint artificial tissue scaffolds for damaged nerve regeneration. (csuohio.edu)

This suggested that eliminating senescent cells may be able to improve bone regeneration. (lifespan.io)
1 While great strides have been made in periodontal research, novel therapies that improve bone regeneration are still needed, and combining treatments that have already demonstrated partial bone restoration may offer greater efficacy than single therapies. (allenpress.com)
In Dentistry, many studies have aimed to improve bone regeneration through the use of BMPs for bone replacement. (bvsalud.org)

Alginate hydrogel, which contains nerve growth factor, has been used to deliver stem cells to tissues during regeneration. (wikipedia.org)
MSCs were initially isolated from bone marrow but are now known to exist in a wide range of tissues in the human adult, including brain, thymus, lung, liver, spleen, kidney, and dental pulp [ 11 , 12 ]. (hindawi.com)
Wnt proteins regulate cell proliferation, at first during the development of embryos, and then in the growth and regeneration of other tissues. (medicalnewstoday.com)
The success of any technology aimed at repairing chondral defects will thus be based on its ability to produce tissues that most closely recapitulate the mechanical and biochemical properties of native cartilage. (nature.com)
After the scientific evidence of osseointegration in the ending of the 1970s, which made viable Implantology, increased the interest of researchers in search by new natural or synthetic substances that could replace tissues bone lost 9 . (bvsalud.org)
Biomaterials can be defined as "any material, natural or synthetic, that acts in tissues/organs in order to replace the bone defect lost and s function" 13 . (bvsalud.org)
The dermis offers low resistance, as do almost all internal tissues except bone, which is a poor conductor of electricity. (medscape.com)
GALNS deficiency induces the accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S) in multiple tissues, particularly bone, cartilage, heart valves, and cornea, whereas β-galactosidase deficiency induces the accumulation of only KS in those tissues. (medscape.com)

Objective: Stem cells from human exfoliated deciduous teeth (SHED) have bone regeneration ability and potential therapeutic applications. (unair.ac.id)
Coupled with reports that allogeneic MSCs have immunoprivileged status and immunomodulatory properties, there has been considerable interest in exploring the use of these cells as a therapeutic option for bone repair. (hindawi.com)
Clinical examination indicated that local implantation of PDLPs may provide therapeutic benefit for the periodontal defects. (ca.gov)
The findings may be a big step toward developing effective therapeutic treatments for bone skeletal defects, bone loss and osteoporosis. (uclahealth.org)
2 Due to the high incidence of VML injury among wounded Service Members and limited treatment options, the Peer Reviewed Orthopaedic Research Program (PRORP) is committed to the development of novel regenerative therapies with solutions that can properly address these challenging musculoskeletal injuries for accelerated healing timelines of complex fractures and therapeutic enhancement of muscle regeneration. (health.mil)
Furthermore we assessed the therapeutic effectiveness of the recovered SHED from your cryopreserved deciduous dental care pulp cells on immune modulation and bone regeneration in SLE model-MRL/and bone defect model-immunocompromised mice. (bio-cavagnou.info)

7 , 8 Several authors 9 - 15 have tried various techniques, such as the use of barrier membranes, autogenous bone, and bone substitutes with or without platelet-rich plasma, to manage this problem. (allenpress.com)
We present a case of a patient with ABC of the calcaneus treated with an endoscopic resection followed by grafting with an autologous-based matrix composed of allograft bone chips and autologous platelet-rich plasma (PRP) in semisolid and liquid states. (thieme-connect.de)
Platelet-rich plasma (PRP) is an autogenous source of growth factors shown to facilitate human bone growth. (allenpress.com)

In 2014, George K. Sándor performed a small size clinical trial (n = 13) on patients with craniomaxillofacial defects where AMCs were transplanted with scaffolds of either bioactive glass or β-tricalcium phosphate in an attempt to reconstruct the defect. (wikipedia.org)
Regeneration of bone remains an important clinical challenge because the regeneration potential of human bone appears to be limited. (dovepress.com)
However, conflicting results indicate the clinical use of β-TCP for bone repair remains questionable in several specific experiment models. (frontiersin.org)
We have successfully established BRONJ minipig and mouse models treated with oncologic doses of zolendronate (Zometa)/Dexamethasone (Dex) developed BRONJ-like pathological lesions with similar clinical, radiographic, and histological features as described in the human disease. (ca.gov)
This study demonstrated clinical and experimental evidences supporting a potential efficacy and safety of utilizing autologous PDL cells in the treatment of human periodontitis. (ca.gov)
A UCLA research team has found a combination of proteins that could significantly improve clinical bone restoration. (uclahealth.org)
There is no definitive clinical standard of care for regeneration of lost muscle tissue in VML injuries. (health.mil)
The aim of this study was to conduct a literature review on the use and clinical viability of human bone morphogenetic protein (rhBMP-2) for grafting bone in Dentistry. (bvsalud.org)
Clinical evidences support the effectiveness of MSC-based skeletal cells regeneration [2] [3]. (bio-cavagnou.info)
Bone defects remain a major threat to human health and bone tissue regeneration has become a prominent clinical demand worldwide. (desktopmetal.com)
However, their low frequency in bone marrow necessitate ex vivo expansion for further clinical application. (biomedcentral.com)

However, autografts are limited by defect size. (health.mil)

The results indicated that the BMP-2-producing cell sheet group was more efficient than other groups in promoting bone formation in the defect area. (dovepress.com)

Common symptoms and features of a craniofacial defect include abnormal cranial morphology, difficulty in cranio-related functions such as breathing, hearing, swallowing, or speech, or facial paralysis. (wikipedia.org)
To further test the osteogenic potential of the cell sheet in vivo, enhanced green fluorescent protein or BMP-2-producing cell sheets were treated on the cranial bone defects. (dovepress.com)
The unique properties of high concentration, cohesive colloidal gels investigated here make it a potential candidate for injectable filler to repair bone, such as cranial defects. (ku.edu)
These materials were also implanted in rats and histological and histochemical analyses confirmed that the PLGA colloidal gels stimulated bone formation in rat cranial bone defects. (ku.edu)

Barrier Membranes for Guided Bone Regeneration" Encyclopedia , https://encyclopedia.pub/entry/38111 (accessed December 07, 2023). (encyclopedia.pub)
Barrier membranes play an important role in this process by preventing soft tissue invasion outgoing from the mucosa and creating an underlying space to support bone growth. (encyclopedia.pub)

We isolated a new population of stem cells from human orofacial tissue gingiva, a tissue source easily accessible from the oral cavity, namely GMSC, which exhibited clonogenicity, self-renewal, and multipotent differentiation capacities. (ca.gov)
We developed techniques to isolate mouse OMSCs derived from mandibles and verified their MSC characteristics by single colony formation, multi-lineage differentiation, and in vivo tissue regeneration. (ca.gov)
Therefore, it is not surprising to find that human OMSCs are distinct from BMMSCs in terms of differentiation traits and immunoregulation. (ca.gov)
An optimal paper type is found to provide structural, physical, and mechanical cues to enhance the osteogenic differentiation of human adipose-derived stem cells (hADSCs). (neoscate.com)
To address this question we first developed human oligonucleotide microarrays with 30.000 elements and then performed large-scale expression profiling of long-term expanded MSC and MSC during differentiation into osteoblasts. (biomedcentral.com)
Despite growing experience and knowledge concerning human MSC and their use in cell-based strategies, the molecular mechanisms that govern MSC self-renewal, expansion and multilineage differentiation are not well understood and remain an active area of investigation. (biomedcentral.com)

Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
Osteoprogenitor MSCs not only differentiate into bone, but they also exert modulatory effects on immune cells via a variety of mechanisms. (hindawi.com)
Insight into this paradigm can provide valuable clues in identifying cellular and noncellular targets that can potentially be modulated to enhance both natural bone healing and bone repair augmented by the exogenous addition of MSCs. (hindawi.com)
Activated T-lymphocytes impaired OMSCs via the Fas/Fas ligand pathway, as occur in long bone MSCs. (ca.gov)
Furthermore, we found that OMSCs are distinct from long bone MSCs with respect to regulating T-lymphocyte survival and proliferation. (ca.gov)
Many experts have investigated to apply MSCs as progenitors of osteoblasts for bone tissue executive. (bio-cavagnou.info)

However, when challenged in vivo, it was reported that only "a little over half" of the mice with the differentiated BMMSCs showed potential to develop bone structure. (wikipedia.org)
Bone regeneration was assessed via in vivo computed tomography (CT), ex vivo micro-CT and histology. (biomedcentral.com)
In vivo CT revealed comparable bone formation after 4, 8 and 12 weeks in all groups. (biomedcentral.com)
To enhance the osteogenic potential of stem cell sheet, we fabricated bone morphogenetic protein 2 ( BMP-2 ) gene-engineered cell sheet using a complex of polyethylenimine-alginate (PEI-al) nanocomposites plus human BMP-2 complementary(c)DNA plasmid, and studied its osteogenesis in vitro and in vivo. (dovepress.com)
The effect of CD146 on SHED-mediated bone regeneration in vivo remains unknown. (unair.ac.id)
Our study suggests that both OMSCs and host cells contribute to bone formation in vivo. (ca.gov)
In this study, elevated levels of MMPs were observed in the in vitro senescent BMSCs and in the bone tissue of aged rats in vivo . (lifespan.io)
Stacking the paper scaffolds with osteogenically differentiated hADSCs and human endothelial cells resulted in vascularized bone formation in vivo. (neoscate.com)
In this study we asked if human MSC are developing in an aberrant or unwanted way during ex vivo long-term cultivation and if cultivation conditions exert any influence on their stem cell maintenance. (biomedcentral.com)
The results of the in vivo experimental study suggested that PDL-derived cell sheets on AM were useful biomaterial for periodontal regeneration. (jarde.jp)

Both forms are resorbed simultaneously with new bone formation when they are used to promote healing of osseous defects. (allenpress.com)
17 Beta-tricalcium phosphate (beta-TCP) is currently used by oral and maxillofacial surgeons to augment the deficient alveolar bone and to fill the osseous defects in the maxillofacial region. (allenpress.com)

Current treatments for bone skeletal defects utilize bone morphogenetic protein-2, or BMP2, an FDA-approved bone-healing protein. (uclahealth.org)

Chen F, Liu X. Advancing biomaterials of human origin for tissue engineering. (scielo.br)
She was awarded with a postdoc fellow from the Ministry of Science at the Technical University of Catalonia in Biomaterials for bone tissue regeneration and since 2010 has been professor at this university. (ibecbarcelona.eu)
Her research is focused on developing biomaterials and harnessing their potential for tissue regeneration. (southampton.ac.uk)
Specifically, he is interested in integrating advanced biomanufacturing techniques, materials/biomaterials, and cell/stem cell techniques to build tissue analogues, and leveraging them to explore the mechanisms underlying diseases and regeneration. (csuohio.edu)
Biomaterials can be defined as any material that acts replacing a lost bone defect and its function. (bvsalud.org)

The autologous graft is still considered the gold standard, as it has the necessary properties for bone regeneration, in terms of combined osteoconduction, osteoinduction and osteogenesis [ 5 5. (scielo.br)
In collaboration with investigators in Taiwan, we implanted one type of autologous OMSCs (periodontal ligament progenitors, PDLPs) to treat an orofacial infectious bone defect disease periodontitis. (ca.gov)
Endoscopic curettage together with allograft bone and autologous PRP is effective in treating ABC patients and could be a good adjuvant treatment to prevent reinjury and enhance consolidation. (thieme-connect.de)
Loading porous SLM-NiTi implants with autologous hMSC may enhance bone growth and healing for critical bone defects. (icams.de)

While some signals are mitogenic and proosteogenic, others function to inhibit osteogenesis and increase bone resorption, and it appears that a well-controlled, delicate balance of inflammatory factors is necessary for proper fracture repair [ 3 - 6 ]. (hindawi.com)

Embryologic development and amalgamations of the complex array of bones and cartilage in the craniofacial region have revealed that the molecular mechanisms controlling skeletogenesis in the orofacial bones are quietly unique and different from in the axial and appendicular bones. (ca.gov)

Repair of skeletal defects resulting from traumatic insult, tumor ablation, or congenital deformities remains a formidable challenge for clinicians. (ku.edu)

Results: Bone regeneration was observed upon transplantation with CD146 + and heterogeneous populations of SHED, with significantly higher bone regeneration observed with CD146 + cells. (unair.ac.id)
Conclusion: Transplantation of CD146 + SHED into bone defects may be useful for bone regeneration. (unair.ac.id)
SHED-Cryo-transplantation was also able to recover osteoporosis bone reduction in long bones of MRL/mice. (bio-cavagnou.info)

She is currently focused on modulating macrophage and stem cell responses to bioactive Nanoclay for bone regeneration in collaboration with Kyoto University, Japan, funded by MRC-AMED Regenerative Medicine and Stem Cell Research Initiative grant. (southampton.ac.uk)

The discrepancy in bone development between orofacial bones and long axial/appendicular bones give rises to specific diseases in the orofacial bone region, such as periodontitis, cherubism, and hyperparathyroid jaw tumor syndrome, which only affect the jaw bones. (ca.gov)

Most bone defects such as fractures have the capacity for spontaneous regeneration, which leads to treatment by conventional therapies. (scielo.br)
An estimated 126.6 million Americans are affected by musculoskeletal conditions such as bone diseases and bone injuries ranging from simple fractures to face/jaw defects, catastrophic bone loss, and bone cancers. (utmck.edu)
1 Of specific concern are type III open fractures involving severe bone and soft-tissue injury that result in segmental bone defects (SBD) and volumetric muscle loss (VML). (health.mil)

Bone substitutes : An update. (scielo.br)
are used to develop new bone substitutes that restore, improve or prevent the deterioration of compromised tissue function [ 8 8. (scielo.br)
The demand for bone graft substitutes is estimated to increase by 30 percent from 2013 to 2020. (edu.au)

Regardless of monolayer or spheroid cell culture, PLATMC-HPLG constructs represent promising scaffolds for bone tissue engineering applications. (biomedcentral.com)

Materials and Methods Ethics Statement Methods using human samples (exfoliated deciduous teeth and peripheral blood) were carried out in Berbamine hydrochloride accordance with the Declaration of Helsinki and authorized by the Kyushu University or college Institutional Review Table for Human being Genome/Gene Study (Protocol Quantity: 393-01). (bio-cavagnou.info)
Therefore, local drug delivery systems play a vital role in bone disorders due to the elimination of disadvantages introduced by conventional methods. (iyte.edu.tr)

Other applications include corrections to birth defects (such as hypertelorism), maxillofacial surgery, craniosynostosis, rare craniofacial clefts, or removal of tumors. (wikipedia.org)
Teeth that are embedded in bone (eg, impacted or wisdom teeth) must be removed by an oral and maxillofacial surgeon who is trained for 4-6 years after obtaining a dental or medical degree. (medscape.com)

An aneurysmal bone cyst (ABC) is a rare bone tumor usually observed in long bones. (thieme-connect.de)
An aneurysmal bone cyst (ABC) is a benign, solitary, and osteolytic bone tumor usually located in the metaphyseal region of long bones. (thieme-connect.de)

Exfoliated deciduous teeth possess advantages of minimal invasiveness and easily accessible tissue source in comparison with other human cells such as bone marrow and adipose cells [10]. (bio-cavagnou.info)

Bone resorption after teeth extraction decreases the height and width of the alveolar bone. (allenpress.com)

The purpose of this study was to analyze whether a combination of PRP and Bio-Oss would enhance bone regeneration better than either material alone. (allenpress.com)

Similar systems can also be utilized with extended applications in other areas, including repairing different tissue defects and providing long-term, local drug delivery. (ku.edu)
To the best of our knowledge, this is the first study reporting the feasibility of a paper material for stem cell application to repair tissue defects. (neoscate.com)

This page covers birth defects and injuries related to the craniofacial region, the mechanisms behind the regeneration, the medical application of these processes, and the scientific research conducted on this specific regeneration. (wikipedia.org)
genetic damage to the fetus, possibly resulting in birth defects. (cdc.gov)

Large segmental bone loss and bone resection due to trauma and/or the presence of tumors and cysts often results in a delay in healing or non-union. (frontiersin.org)
Nonunion and segmental bone loss after fracture, reconstructive surgery, or lesion excision can present complex orthopedic problems, and the multiple surgical procedures often needed are associated with patient morbidity and reduced quality of life. (who.int)

The same research team has conducted other studies on bone growth, including one that utilized a protein called NELL-1, which successfully increased bone formation and stimulated key factors for bone growth in multiple preclinical models. (uclahealth.org)

We evaluated the transplant of cultivated beagle dog periodontal ligament (PDL) cells grown on human amniotic membrane (AM) to promote periodontal regeneration in artificial fenestration defects in jaw bones. (jarde.jp)

Cytotoxicity assessment of polyhydroxybutyrate/chitosan/nano- bioglass nanofiber scaffolds by stem cells from human exfoliated deciduous teeth stem cells from dental pulp of exfoliated deciduous tooth by: Batool Hashemi-Beni, et al. (uitm.edu.my)

Bone loss caused by congenital defects, traumatic injury, cancer, reconstructive surgery, or periodontal disease has aroused widespread concern all over the world. (dovepress.com)

Thus any process or systemic condition that alters this optimal inflammatory milieu, such as bone diseases like osteoporosis or severe trauma, steroid therapy, diabetes, or advanced age, can disrupt the normal fracture healing process, resulting in nonunions or delayed healing, pain, disfigurement, and loss of function. (hindawi.com)
Prof. Elisabeth Engel got her PhD in 2003 in bone metabolism diseases in medical school. (ibecbarcelona.eu)
These bone injuries and diseases result in significant pain, distress, and loss of quality of life, as well as considerable financial hardships for patients and the health care system. (utmck.edu)

However, to the best of our knowledge, no studies have evaluated the efficacy of the application of PRP and bone allograft after endoscopic curettage in reducing recurrence rates or helping with bone consolidation. (thieme-connect.de)
The combination of NELL-1 and BMP2 resulted in improved safety and efficacy of bone regeneration in animal models - and may, one day, offer patients significantly better bone healing. (uclahealth.org)
Previous and present studies demonstrate a strong rationale for combining NELL-1 with BMP2 to significantly improve the safety and efficacy of current bone regeneration options. (uclahealth.org)
Overall, these results are supportive of the efficacy and safety of TPO for bone healing in large animals, though additional optimization of dosing or timing of drug treatment were still needed. (health.mil)
OBJECTIVE: To assess the efficacy of osteogenic protein-1 (OP-1) for long bone nonunion. (who.int)

A critical defect of 8 mm was performed in 36 Wistar male adult rats that were divided into four groups. (scielo.br)
A new study in ACS Applied Materials and Interfaces used a combined geroscience and tissue engineering approach to regenerate bone in aged rats [1]. (lifespan.io)
Most recently, scientists at Sichuan University have used the senolytic quercetin and a TG-18 hydrogel to regenerate a bone defect in aged rats [1]. (lifespan.io)

Biocomplex favored the insertion and permanence of the particulate material in bone defects, creating a favorable microenvironment for accelerate repair process. (scielo.br)

Human being exfoliated deciduous teeth have been considered to be a promising resource for regenerative therapy because they contain unique postnatal stem cells from human being exfoliated deciduous teeth (SHED) with self-renewal capacity multipotency and immunomodulatory function. (bio-cavagnou.info)
Recent discovery has evaluated that fresh dental care pulp cells of human being exfoliated deciduous teeth preserve MSC human population termed SHED [10]. (bio-cavagnou.info)

Anatomy44

Organisms15

Diseases21

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes41

Disciplines and Occupations2

Technology, Industry, Agriculture22

Information Science3

Health Care1

Mesenchymal21

Large bone6

Reconstruction10

Scaffold15

Calvarial bone-defect1

Grafts5

Repair and regeneration3

Nerve regeneration2

Improve bone regeneration3

Tissues8

Therapeutic6

Platelet-rich plasma3

Clinical11

Autografts1

Promoting bone formation1

Cranial4

Barrier membranes2

Differentiation6

MSCs6

Vivo10

Osseous defects2

Morphogenetic protein1

Biomaterials5

Autologous4

Osteogenesis1

Cartilage1

Skeletal defects1

Transplantation3

Bioactive1

Orofacial bone1

Fractures3

Substitutes3

Scaffolds for bone tissue1

Methods2

Maxillofacial2

Tumor2

Marrow and adipose1

Resorption1

Enhance bone1

Tissue defects2

Birth defects2

Segmental bone loss2

Preclinical1

Periodontal ligament1

Stem cells from human exfoliated deciduous1

Traumatic1

Diseases3

Efficacy5

Rats3

Microenvironment1

Deciduous2