• autonomic
  • A key role is played by the autonomic nervous system (ANS), whose modulation regulates cardiovascular functions during sleep onset and different sleep stages. (frontiersin.org)
  • Therefore, an interest on the evaluation of autonomic cardiovascular control in health and disease is growing by means of linear and non-linear heart rate variability (HRV) analyses. (frontiersin.org)
  • More recently, the use of non-linear tools, such as entropy-derived indices, have provided new insight on the cardiac autonomic regulation, revealing for instance changes in the cardiovascular complexity during REM sleep, supporting the hypothesis of a reduced capability of the cardiovascular system to deal with stress challenges. (frontiersin.org)
  • A key role in the physiology of sleep is played by the autonomic nervous system (ANS), whose regulation modulates cardiovascular functions during sleep onset and the transition to different sleep stages. (frontiersin.org)
  • The autonomic nervous system's physiological state (see below) leading to loss of consciousness may persist for several minutes, so If sufferers try to sit or stand when they wake up, they may pass out again The person may be nauseated, pale, and sweaty for several minutes or hours Reflex syncope occurs in response to a trigger due to dysfunction of the heart rate and blood pressure regulating mechanism. (wikipedia.org)
  • contraction
  • The few studies that determined the effect of smooth muscle tone on AWV yielded complex results, showing either higher AWV in muscular arteries 7 11 and increased AWV in response to smooth muscle contraction, 12 13 or no effect under sinusoidal pressure waves of small amplitude. (ahajournals.org)
  • inflammation
  • Finally, vascular inflammation detected by FDG-PET/CT has been shown to predict cardiovascular (CV) events independent of traditional risk factors 21,22 and is also highly associated with overall burden of atherosclerosis 23 . (jove.com)
  • vivo
  • The technique produces a physiologically relevant measure of stiffness compared to ex vivo approaches because physiological influences on aortic stiffness are incorporated in the measurement. (jove.com)
  • responses
  • This results in a spectrum of hemodynamic responses: On one end of the spectrum is the cardioinhibitory response, characterized by a drop in heart rate (negative chronotropic effect) and in contractility (negative inotropic effect) leading to a decrease in cardiac output that is significant enough to result in a loss of consciousness. (wikipedia.org)
  • One account for these physiological responses is the Bezold-Jarisch reflex. (wikipedia.org)
  • activation
  • Left: Activation (opening) of a K + channel (gray) in the cell membrane allows K + to flux out of the cell, causing a decrease in E m (ie, hyperpolarization) and consequent inhibition (closure) of voltage-activated Ca 2+ channels (white) and a decrease in cytosolic Ca 2+ levels, resulting in vascular muscle relaxation (vasodilatation). (ahajournals.org)
  • Recent progress in cardiovascular therapy suggests that stimulation of Angiotensin Converting Enzyme 2 (ACE2), production of Angiotensin-(1-7) Ang-(1-7), and activation of the Ang-(1-7) receptor, Mas, are viable targets for disease prevention and treatment. (ufl.edu)
  • In addition, activation of the ACE2/Ang-(1-7)/Mas axis also attenuates many of the pathophysiological states that involve increased production of Ang II by Angiotensin Converting Enzyme (ACE), and subsequent activation of the AT1R (ACE/Ang II/AT1R axis). (ufl.edu)
  • Therefore, small molecule ACE2 activators are promising compounds for ACE2/Ang-(1-7)/Mas axis activation and treatment of cardiovascular disease. (ufl.edu)
  • Based on previous studies indicating the presence of ACE2 and Mas in the brain as well as a protective role for ACE2/Ang-(1-7)/Mas axis during cardiovascular disease, we have developed the general hypothesis that activation of the brain ACE2/Ang-(1-7)/Mas axis will have cerebroprotective action during ischemic stroke. (ufl.edu)
  • Cocaine-induced platelet activation and thrombus formation is another deleterious effect, caused by alpha-adrenergic- and adenosine diphosphate-mediated increase in platelet aggregation. (wikipedia.org)
  • Under normal physiological conditions, RYR2 mutation has no discernable effect on calcium induced-calcium release from the sarcoplasmic reticulum (SR). Ryr2 is normally activated by increased cytosolic calcium, but under stressful conditions such as increased beta adrenergic activation, RYR2 is activated by luminal calcium in association with increased SR calcium loading. (wikipedia.org)
  • A Ryr2 mutation may increase sensitivity to luminal calcium activation, therefore increasing calcium release from the SR under store-overload conditions and thus triggered arrhythmias. (wikipedia.org)
  • arterial
  • In vitro, arterial segments were submitted first to steady pressure (0 to 200 mm Hg) by increments of 20 mm Hg, then to increasing levels of pulse pressure (20 to 50 mm Hg) at various mean arterial pressures (75 to 150 mm Hg). (ahajournals.org)
  • After both PE and SNP, AWV increased with pulse pressure but was not influenced by mean arterial pressure. (ahajournals.org)
  • The principal actions of cocaine on the cardiovascular system are from alpha- and beta-1-adrenoceptor stimulation resulting in increased heart rate, systemic arterial pressure, and myocardial contractility, which are major determinants of myocardial oxygen demand. (wikipedia.org)
  • The method is to unload the arterial wall in order to linearize this phenomenon with a counter pressure as high as the pressure inside the artery. (wikipedia.org)
  • effects
  • Estrogen, through estrogen receptor-α, increased Nox-derived ROS and redox-sensitive growth in hPASMCs, with greater effects in PAH-hPASMCs versus control hPASMCs. (ahajournals.org)
  • The ACE2/Ang-(1-7)/Mas axis has been shown to counteract many of the physiological effects of the Angiotensin II (Ang II) Type 1 Receptor (AT1R), including vasoconstrictor and proliferative actions. (ufl.edu)
  • citation needed] It should be noted though that these sequelae are very transient effects: The total duration of the cardiovascular effects is no more than one to two minutes, while the facial flush may take around 3-4 minutes to dissipate. (wikipedia.org)
  • citation needed] Because these effects are so transient, there is no reason to administer adjunctive therapy to ameliorate either the cutaneous or the cardiovascular effects. (wikipedia.org)
  • Because atracurium undergoes Hofmann elimination as a primary route of chemodegradation, one of the major metabolites from this process is laudanosine, a tertiary amino alkaloid reported to be a modest CNS stimulant with epileptogenic activity and cardiovascular effects such a hypotension and bradycardia. (wikipedia.org)
  • occur
  • These types of stressors tend to have a more negative effect on health because they are sustained and thus require the body's physiological response to occur daily. (wikipedia.org)
  • sympathetic
  • The application of classical tools for ANS analysis, such as HRV during physiological sleep, showed that the rapid eye movement (REM) stage is characterized by a likely sympathetic predominance associated with a vagal withdrawal, while the opposite trend is observed during non-REM sleep. (frontiersin.org)
  • Emergency treatment of cocaine-associated hyperthermia consists of administering a benzodiazepine sedation agent, such as diazepam (Valium) or lorazepam (Ativan) to enhance muscle relaxation and decrease sympathetic outflow from the central nervous system. (wikipedia.org)
  • Damage
  • In addition, a modest decrease in blood pressure and associated reductions in end organ damage are observed with chronic administration of DIZE to spontaneously hypertensive rats. (ufl.edu)
  • Damage to the left hemisphere in patients results in a marked increase in depression. (wikipedia.org)
  • nervous
  • These are cell atrophy, impaired metabolism (increased catabolism), reduction of the defense capacity of the organism, reducing healing processes and regeneration, degeneration of the nervous system. (erank.tv)
  • It is essential for cardiovascular function, and development and function of skeletal muscle, the retina, and the central nervous system. (wikipedia.org)
  • mortality
  • Although overall life expectancy has improved, people with Down syndrome have even greater mortality at any age, compared with age-matched sample from the general population or compared with individuals with intellectual disabilities due to causes other than Down syndrome. (erank.tv)
  • Pre-spawn mortality is a phenomenon where adult coho salmon, Oncorhynchus kisutch, die before spawning when returning to freshwater streams to spawn. (wikipedia.org)
  • system
  • In early tests in 1978, Schauss observed that color, surprisingly, did affect muscle strength, either invigorating or enervating the subject, and even influenced the cardiovascular system. (wikipedia.org)
  • During systole, when blood volume increases in the finger, the control system increases cuff pressure, too, until the excess blood volume is squeezed out. (wikipedia.org)
  • membrane
  • Taurine crosses the blood-brain barrier and has been implicated in a wide array of physiological phenomena including inhibitory neurotransmission, long-term potentiation in the striatum/hippocampus, membrane stabilization,[unreliable medical source? (wikipedia.org)
  • suggests
  • Exact reasons for this sex-related difference remain unclear although increasing evidence suggests that metabolites of 17β-estradiol (estrogen) may play a role. (ahajournals.org)
  • studies
  • 1 2 In most studies, viscosity was considered a dampening phenomenon and expressed in term of phase delay. (ahajournals.org)
  • Plasma ghrelin level varies with age (decreases with age)(28), some studies demonstrating even gender differences, namely high levels in women during the follicular phase compared to men(29). (medicina-interna.ro)
  • however
  • However, a number of physiological and technical issues can affect the accuracy of the results and appropriate guidelines for the technique have been published. (jove.com)
  • risk factors
  • BA length, diameter and volume, and cerebral lesions were analysed by MRI/TOF-MR angiography or CT/CT angiography in 20 LOPD patients and 40 controls matching in age, sex- and cardiovascular risk factors. (springer.com)
  • activity
  • In hPASMCs, 16αOHE1 increased Nox1 expression, stimulated irreversible oxidation of protein tyrosine phosphatases, decreased nuclear factor erythroid-related factor 2 activity and expression of nuclear factor erythroid-related factor 2-regulated antioxidant genes, and promoted proliferation. (ahajournals.org)
  • In fact, several small molecule ACE2 activators have been identified that selectively increase ACE2 activity without having an effect on ACE activity. (ufl.edu)
  • Increased cortisol usually acts to increase blood glucose, blood pressure, and surpasses lysosomal, and immunological activity. (wikipedia.org)
  • Andreone and Giacoma (1989) speculated that newt migration into the ponds increases after rainy days, since after rainfall, newt activity is not limited by humidity. (wikipedia.org)
  • patients
  • The diameter, length and volume of the BA were significantly increased in LOPD patients compared to controls. (springer.com)
  • During 5 years 2/9 LOPD patients developed an abnormal height of BA bifurcation according to the Smoker's criteria and in all patients the SUCA outlet angle decreased (138 ± 34° vs. 128 ± 32°, p = 0.019). (springer.com)
  • These patients also show a remarkable increase in lateralization towards the right hemisphere of both emotionally and non-emotional prosody rich speech. (wikipedia.org)
  • blood pressure
  • Placebo administration with a blood pressure decrease suggestion. (clinicaltrials.gov)
  • According to this update, an HR deceleration should be a constant observation to identify a TCR episode while a drop in blood pressure should probably not being fixed to a certain percentage of decrease. (frontiersin.org)
  • One of these molecules, Diminazene aceturate (DIZE) has been shown to decrease blood pressure dramatically and dose dependently when administered acutely. (ufl.edu)
  • thus
  • The low pKa of taurine's sulfonic acid group ensures this moiety is negatively charged in the pH ranges normally found in the intestinal tract, thus it improves the surfactant properties of the cholic acid conjugate. (wikipedia.org)
  • effect
  • Higher altitudes, where temperatures begin to decrease, have a direct effect on the size of T. carnifex. (wikipedia.org)
  • This Vaughn-Williams class IC effect increases the risk of conduction disturbance and tachyarrhythmias. (wikipedia.org)
  • Noise can have a detrimental effect on wild animals, increasing the risk of death by changing the delicate balance in predator or prey detection and avoidance, and interfering the use of the sounds in communication, especially in relation to reproduction and in navigation. (wikipedia.org)
  • body
  • 2010) discovered that living in colder temperatures resulted a body size increase in both male and female. (wikipedia.org)
  • stress
  • Selye demonstrated that stress decreases adaptability of an organism and proposed to describe the adaptability as a special resource, adaptation energy. (wikipedia.org)
  • levels
  • Rather it shows that caffeinated coffee induces an increase in blood levels of a growth factor called GCSF (granulocyte colony stimulating factor). (qualitycounts.com)