• greatly decreased
  • The researchers also found that blocking the activity of one of the HP complex proteins in the brain with antibody greatly decreased the hibernation time during which the chipmunks maintained a lowered body temperature, suggesting its critical role in the brain's capacity for dormancy. (redorbit.com)
  • diseases
  • Thus, the elderly are prone to disease, are more likely to suffer a fracture due to progressive osteoporosis, demonstrate a decrease of sensory functions of vision and hearing, more frequently heart attacks and strokes and malignant diseases. (erank.tv)
  • Serious physiological consequences of sleep loss include decreased neurogenesis, cognitive dysfunction (deficits in learning, memory, and decision-making), metabolic alterations, cardiovascular diseases, immune disturbances, and blood-brain barrier disruption [ 1 - 8 ]. (hindawi.com)
  • this polyphenol -- an antibiotic substance produced by plants as a defense against microorganisms -- prevents the growth of some cancers in mice, inhibits enzymes that cause inflammation, shrinks tumors and increases blood flow, thus reducing cardiovascular diseases. (qualitycounts.com)
  • responses
  • We will thus detail how peripheral physiological responses may be analyzed to provide objective evidence that MI is actually performed. (frontiersin.org)
  • This results in a spectrum of hemodynamic responses: On one end of the spectrum is the cardioinhibitory response, characterized by a drop in heart rate (negative chronotropic effect) and in contractility (negative inotropic effect) leading to a decrease in cardiac output that is significant enough to result in a loss of consciousness. (wikipedia.org)
  • One account for these physiological responses is the Bezold-Jarisch reflex. (wikipedia.org)
  • oxygen
  • As hibernation factors endow animals with an incredible ability to cope under otherwise lethal conditions--ratcheting down their metabolic rate to survive on limited energy reserves and withstanding extreme cardiovascular and oxygen stresses--the candidate hormone might also pave the way toward clinical therapies that lend humans the same kind of protection, they added. (redorbit.com)
  • The principal actions of cocaine on the cardiovascular system are from alpha- and beta-1-adrenoceptor stimulation resulting in increased heart rate, systemic arterial pressure, and myocardial contractility, which are major determinants of myocardial oxygen demand. (wikipedia.org)
  • Epicardial coronary arteries are especially vulnerable to these effects, leading to decreased myocardial oxygen supply. (wikipedia.org)
  • This increase in surface area counteracts the decreased oxygen available, by allowing greater oxygen uptake. (wikipedia.org)
  • dysfunction
  • Endothelial cell dysfunction is commonly associated with cardiovascular disease, and altered activity of nitric oxide, prostacyclin, and endothelium-derived hyperpolarizing factor could also contribute to changes in resting K + channel activity, E m , and K + channel-mediated vasodilatation. (ahajournals.org)
  • stimulation
  • Recent progress in cardiovascular therapy suggests that stimulation of Angiotensin Converting Enzyme 2 (ACE2), production of Angiotensin-(1-7) Ang-(1-7), and activation of the Ang-(1-7) receptor, Mas, are viable targets for disease prevention and treatment. (ufl.edu)
  • Cocaine overdose may result in hyperthermia as stimulation and increased muscular activity cause greater heat production. (wikipedia.org)
  • membrane
  • Taurine crosses the blood-brain barrier and has been implicated in a wide array of physiological phenomena including inhibitory neurotransmission, long-term potentiation in the striatum/hippocampus, membrane stabilization,[unreliable medical source? (wikipedia.org)
  • Left: Activation (opening) of a K + channel (gray) in the cell membrane allows K + to flux out of the cell, causing a decrease in E m (ie, hyperpolarization) and consequent inhibition (closure) of voltage-activated Ca 2+ channels (white) and a decrease in cytosolic Ca 2+ levels, resulting in vascular muscle relaxation (vasodilatation). (ahajournals.org)
  • IP 3 contributes to PKC activation by a separate mechanism, through opening of IP 3 -gated Ca 2+ transport channels in the endoplasmic reticulum membrane, thereby increasing [Ca 2+ ] i . (ahajournals.org)
  • effects
  • Estrogen, through estrogen receptor-α, increased Nox-derived ROS and redox-sensitive growth in hPASMCs, with greater effects in PAH-hPASMCs versus control hPASMCs. (ahajournals.org)
  • The ACE2/Ang-(1-7)/Mas axis has been shown to counteract many of the physiological effects of the Angiotensin II (Ang II) Type 1 Receptor (AT1R), including vasoconstrictor and proliferative actions. (ufl.edu)
  • High noise levels can contribute to cardiovascular effects in humans and an increased incidence of coronary artery disease. (wikipedia.org)
  • citation needed] It should be noted though that these sequelae are very transient effects: The total duration of the cardiovascular effects is no more than one to two minutes, while the facial flush may take around 3-4 minutes to dissipate. (wikipedia.org)
  • citation needed] Because these effects are so transient, there is no reason to administer adjunctive therapy to ameliorate either the cutaneous or the cardiovascular effects. (wikipedia.org)
  • Because atracurium undergoes Hofmann elimination as a primary route of chemodegradation, one of the major metabolites from this process is laudanosine, a tertiary amino alkaloid reported to be a modest CNS stimulant with epileptogenic activity and cardiovascular effects such a hypotension and bradycardia. (wikipedia.org)
  • occur
  • These types of stressors tend to have a more negative effect on health because they are sustained and thus require the body's physiological response to occur daily. (wikipedia.org)
  • cytosolic
  • Under normal physiological conditions, RYR2 mutation has no discernable effect on calcium induced-calcium release from the sarcoplasmic reticulum (SR). Ryr2 is normally activated by increased cytosolic calcium, but under stressful conditions such as increased beta adrenergic activation, RYR2 is activated by luminal calcium in association with increased SR calcium loading. (wikipedia.org)
  • hypothesis
  • Based on previous studies indicating the presence of ACE2 and Mas in the brain as well as a protective role for ACE2/Ang-(1-7)/Mas axis during cardiovascular disease, we have developed the general hypothesis that activation of the brain ACE2/Ang-(1-7)/Mas axis will have cerebroprotective action during ischemic stroke. (ufl.edu)
  • sympathetic
  • The application of classical tools for ANS analysis, such as HRV during physiological sleep, showed that the rapid eye movement (REM) stage is characterized by a likely sympathetic predominance associated with a vagal withdrawal, while the opposite trend is observed during non-REM sleep. (frontiersin.org)
  • Emergency treatment of cocaine-associated hyperthermia consists of administering a benzodiazepine sedation agent, such as diazepam (Valium) or lorazepam (Ativan) to enhance muscle relaxation and decrease sympathetic outflow from the central nervous system. (wikipedia.org)
  • gradually
  • In addition, they show a decrease in motor skills, as well as speed, flexibility, coordination and muscle strength decrease gradually. (erank.tv)
  • RSA is pronounced in children, but without sufficient cardiovascular exercise it gradually disappears as a person approaches his/her teenage years. (wikipedia.org)
  • mortality
  • Although overall life expectancy has improved, people with Down syndrome have even greater mortality at any age, compared with age-matched sample from the general population or compared with individuals with intellectual disabilities due to causes other than Down syndrome. (erank.tv)
  • Pre-spawn mortality is a phenomenon where adult coho salmon, Oncorhynchus kisutch, die before spawning when returning to freshwater streams to spawn. (wikipedia.org)
  • calcium
  • A Ryr2 mutation may increase sensitivity to luminal calcium activation, therefore increasing calcium release from the SR under store-overload conditions and thus triggered arrhythmias. (wikipedia.org)
  • system
  • It is essential for cardiovascular function, and development and function of skeletal muscle, the retina, and the central nervous system. (wikipedia.org)
  • In early tests in 1978, Schauss observed that color, surprisingly, did affect muscle strength, either invigorating or enervating the subject, and even influenced the cardiovascular system. (wikipedia.org)
  • muscular
  • With age, the amount of people with Down syndrome is reduced, hypotonia is improving, muscular body mass is reduced and there is increased fat storage. (erank.tv)
  • suggests
  • Exact reasons for this sex-related difference remain unclear although increasing evidence suggests that metabolites of 17β-estradiol (estrogen) may play a role. (ahajournals.org)
  • sensitivity
  • Older males exposed to significant occupational noise demonstrate more significantly reduced hearing sensitivity than their non-exposed peers, though differences in hearing sensitivity decrease with time and the two groups are indistinguishable by age 79. (wikipedia.org)
  • thus
  • Increased vagal tone (and thus vagal action) is associated with a diminished and more variable heart rate. (wikipedia.org)
  • The low pKa of taurine's sulfonic acid group ensures this moiety is negatively charged in the pH ranges normally found in the intestinal tract, thus it improves the surfactant properties of the cholic acid conjugate. (wikipedia.org)
  • axis
  • In addition, activation of the ACE2/Ang-(1-7)/Mas axis also attenuates many of the pathophysiological states that involve increased production of Ang II by Angiotensin Converting Enzyme (ACE), and subsequent activation of the AT1R (ACE/Ang II/AT1R axis). (ufl.edu)
  • Therefore, small molecule ACE2 activators are promising compounds for ACE2/Ang-(1-7)/Mas axis activation and treatment of cardiovascular disease. (ufl.edu)
  • risk
  • BA length, diameter and volume, and cerebral lesions were analysed by MRI/TOF-MR angiography or CT/CT angiography in 20 LOPD patients and 40 controls matching in age, sex- and cardiovascular risk factors. (springer.com)
  • Ablation of the estrogen binding site in the PEMT promoter region may increase risk of hepatic steatosis from choline deficiency. (wikipedia.org)
  • In animals, noise can increase the risk of death by altering predator or prey detection and avoidance, interfere with reproduction and navigation, and contribute to permanent hearing loss. (wikipedia.org)
  • Noise can have a detrimental effect on wild animals, increasing the risk of death by changing the delicate balance in predator or prey detection and avoidance, and interfering the use of the sounds in communication, especially in relation to reproduction and in navigation. (wikipedia.org)
  • This Vaughn-Williams class IC effect increases the risk of conduction disturbance and tachyarrhythmias. (wikipedia.org)
  • activity
  • In hPASMCs, 16αOHE1 increased Nox1 expression, stimulated irreversible oxidation of protein tyrosine phosphatases, decreased nuclear factor erythroid-related factor 2 activity and expression of nuclear factor erythroid-related factor 2-regulated antioxidant genes, and promoted proliferation. (ahajournals.org)
  • In fact, several small molecule ACE2 activators have been identified that selectively increase ACE2 activity without having an effect on ACE activity. (ufl.edu)
  • Increased cortisol usually acts to increase blood glucose, blood pressure, and surpasses lysosomal, and immunological activity. (wikipedia.org)
  • Andreone and Giacoma (1989) speculated that newt migration into the ponds increases after rainy days, since after rainfall, newt activity is not limited by humidity. (wikipedia.org)
  • systemic
  • Compared to the control study, systemic hyperinsulinemia caused an increase in leg blood flow (-0.54 +/- 0.93 vs. 1.97 +/- 1.1 ml. min(-1). (jove.com)
  • role
  • In the present review we discuss the role of inflammatory mediators that increase during sleep loss and their association with general disturbances in peripheral endothelium and epithelium and how those inflammatory mediators may alter the blood-brain barrier. (hindawi.com)
  • patients
  • The diameter, length and volume of the BA were significantly increased in LOPD patients compared to controls. (springer.com)
  • During 5 years 2/9 LOPD patients developed an abnormal height of BA bifurcation according to the Smoker's criteria and in all patients the SUCA outlet angle decreased (138 ± 34° vs. 128 ± 32°, p = 0.019). (springer.com)
  • These patients also show a remarkable increase in lateralization towards the right hemisphere of both emotionally and non-emotional prosody rich speech. (wikipedia.org)
  • brain
  • Here, we will review (1) the inflammatory mediators that increase during periods of sleep loss and their association with general disturbances in peripheral endothelium and epithelium and (2) how those inflammatory mediators might alter the blood-brain barrier during sleep loss. (hindawi.com)
  • state
  • In 20 hibernators examined throughout their lives, concentrations of HPc in the blood started to decrease prior to hibernation and remained low throughout the inactive state. (redorbit.com)
  • body
  • 2010) discovered that living in colder temperatures resulted a body size increase in both male and female. (wikipedia.org)
  • dramatically
  • One of these molecules, Diminazene aceturate (DIZE) has been shown to decrease blood pressure dramatically and dose dependently when administered acutely. (ufl.edu)
  • activation
  • Cocaine-induced platelet activation and thrombus formation is another deleterious effect, caused by alpha-adrenergic- and adenosine diphosphate-mediated increase in platelet aggregation. (wikipedia.org)
  • depression
  • Even humans can maintain seasonal rhythms as exhibited by seasonal affective disorder, a recurrent depression characterized by increased sleep, overeating, and weight gain--behaviors similar to those seen in hibernators, Ohtsu noted. (redorbit.com)
  • mechanism
  • In a recent article, Carter and Nguyen identify several genetic disorders, arguing that far from being a rare phenomenon, antagonistic pleiotropy might be a fundamental mechanism for the survival of these non-optimal alleles. (wikipedia.org)