After initiation of PF-00547659 anti-MAdCAM-1 therapy, there was a small and non-significant increase in the numbers of overall CSF leukocytes, and in lymphocyte subsets (CD3 +, CD4 +, and CD8 + T cells). (elsevierpure.com)
Peripheral blood leucocyte and lymphocyte counts were decreased by approximately 30% in the two highest dose groups. (cdc.gov)
Adhesion16
Of the 8 plasma membrane receptors for complement, only deficiencies of CR3 and CR4 due to CD18 deficiency have been described, known as leukocyte adhesion deficiency (LAD) type 1 . (medscape.com)
Mechanistic studies revealed that this progression was mediated by suppressed TNFα levels, both locally and systemically, resulting in reduced expression of tumor endothelial adhesion molecules, particularly intercellular adhesion molecule-1 (ICAM-1) and a subsequent decrease in the number of activated and effector CD8 + T cells in the tumor. (aacrjournals.org)
Leukocyte adhesion deficiency type 1 is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. (medlineplus.gov)
Starting from birth, people with leukocyte adhesion deficiency type 1 develop serious bacterial and fungal infections. (medlineplus.gov)
One of the first signs of leukocyte adhesion deficiency type 1 is a delay in the detachment of the umbilical cord stump after birth. (medlineplus.gov)
but, in infants with leukocyte adhesion deficiency type 1, this separation usually occurs at three weeks or later. (medlineplus.gov)
In leukocyte adhesion deficiency type 1, bacterial and fungal infections most commonly occur on the skin and mucous membranes such as the moist lining of the nose and mouth. (medlineplus.gov)
A hallmark of leukocyte adhesion deficiency type 1 is the lack of pus formation at the sites of infection. (medlineplus.gov)
Life expectancy in individuals with leukocyte adhesion deficiency type 1 is often severely shortened. (medlineplus.gov)
Leukocyte adhesion deficiency type 1 is estimated to occur in 1 per million people worldwide. (medlineplus.gov)
Mutations in the ITGB2 gene cause leukocyte adhesion deficiency type 1. (medlineplus.gov)
This binding leads to linkage (adhesion) of the leukocyte to the blood vessel wall. (medlineplus.gov)
ITGB2 gene mutations that cause leukocyte adhesion deficiency type 1 lead to the production of a β2 subunit that cannot bind with other subunits to form β2 integrins. (medlineplus.gov)
Cox DP, Weathers DR. Leukocyte adhesion deficiency type 1: an important consideration in the clinical differential diagnosis of prepubertal periodontitis. (medlineplus.gov)
A large body of evidence now implicates increased leukocyte-endothelial cell adhesion as a key early event in the development of diabetic retinopathy. (diabetesjournals.org)
We recently reported that raised activity of the glycosylating enzyme core 2 β 1,6- N -acetylglucosaminyltransferase (GlcNAc-T) through protein kinase C (PKC)β2-dependent phosphorylation plays a fundamental role in increased leukocyte-endothelial cell adhesion and capillary occlusion in retinopathy. (diabetesjournals.org)
Platelets1
Leukocyte-platelet-rich plasma (L-PRP) is a bloodderived portion composed of high concentrations of platelets and white cells, and it has been applied as autogenous biomaterial in bone repair 13 . (bvsalud.org)
Serum4
Significant decreases were also observed in serum adenovirus-specific pan IgG, IgG1, and IgG2a immunoglobulin levels, which was associated with diminished viral neutralization capacity. (nih.gov)
Patients who demonstrate an abnormal genetic variant, a decrease in concentration by seventy-five percent, or who are exposed to chemicals or medications that block or reduce the serum concentration of pseudocholinesterase will potentially experience prolonged duration of action. (ispub.com)
Additionally, CJ decreased the activity of serum hepatic enzymes. (cranberryinstitute.org)
Increasing wet bulb globe temperature, high uric acid, decreased urine pH, urinary leukocyte esterase, and serum hyperosmolality were risk factors for decline in kidney function. (cdc.gov)
Decreased expression of CD200 on peripheral blood leukocytes in alcohol dependence. (qxmd.com)
This study aimed to investigate the expression of CD200 on the surface of peripheral blood leukocytes in patients with alcohol use disorder and compare them with controls. (qxmd.com)
The study indicates that cellular expression of CD200 on the surface of peripheral blood leukocytes is reduced in alcohol-dependent patients. (qxmd.com)
A panel of monoclonal antibodies was used to analyze peripheral blood leukocytes by two-color flow cytometric analysis. (usda.gov)
No significant changes were found in peripheral blood leukocytes of pigs inoculated with attenuated PRRSV or sham inoculum. (usda.gov)
Results indicate that the peripheral blood leukocytes response to PRRSV infection mainly involves CD8+ T cells. (usda.gov)
Fasudil decreased significantly Rho-kinase activity in peripheral blood mononucleated cells (PBMC), myocardium and aortic wall to similar levels as in the sham group. (portlandpress.com)
Enhanced apoptosis in the leukocytes of peripheral blood of PEM patients may be a marker of increased infection and immune disturbances. (who.int)
Metabolism2
To separate hypoxia from systemic effects, we tested whether hypoxia at high altitude affects basal and PMA-stimulated leukocyte metabolism and how this compares to acute (15 min) and 24 h of in vitro hypoxia. (southwales.ac.uk)
These results show that 24 h of high altitude but not 24h in vitro hypoxia decreased basal leukocyte metabolism, whereas PMA-induced JO 2 and ROS formation were not affected, indicating that prolonged high-altitude hypoxia impairs mitochondrial metabolism but does not impair respiratory burst. (southwales.ac.uk)
Retinal1
The exact pathogenic mechanism by which capillary nonperfusion, as demonstrated by fluorescein angiography, occurs is still unclear, but recent experimental animal studies ( 3 - 5 ) demonstrate that increased leukocyte entrapment in retinal capillaries of diabetic rats is an early event associated with areas of capillary nonperfusion and the development of endothelial cell damage. (diabetesjournals.org)
Phosphate1
Chronic hypophosphatemia usually is the result of decreased renal phosphate reabsorption. (msdmanuals.com)
Elevation1
All animals presented leukocyte elevation by increased lymphocytes, however, with no significant difference. (scielo.br)
Significant1
When RBCs in CSF are due to a traumatic tap, a visual comparison between the first and last collection tubes will show a significant decrease in color. (aicompanies.com)
0.051
0.05) alteration of all measured immune function parameters-white blood cells (WBCs), immunoglobulin G glycome, leukocyte transcriptome, and cytokine profile. (jyu.fi)
Exposure3
Acute in vitro hypoxia and high-altitude (4,559m) exposure decreases leukocyte oxygen consumption. (southwales.ac.uk)
Dive into the research topics of 'Acute in vitro hypoxia and high-altitude (4,559m) exposure decreases leukocyte oxygen consumption. (southwales.ac.uk)
The percentage of inhaled benzene that was absorbed and retained during a 6-hour exposure period decreased from 33 to 15% in rats and from 50 to 10% in mice when the exposure concentration was increased from about 10 to 1,000 ppm (Sabourin et al. (cdc.gov)
Responses2
antibody responses to polysaccharide antigens are decreased and antibody responses to protein antigens are slightly reduced. (medscape.com)
These include decreased or absent delayed-type hypersensitivity in some patients with HIES and decreased lymphoproliferative responses to S aureus, Candida species, and tetanus antigens. (medscape.com)
Counts1
Total white blood cell counts decreased shortly after infection then increased with time. (usda.gov)
Infections2
As a result, there is a decreased response to injury and foreign invaders, such as bacteria and fungi, resulting in frequent infections, delayed wound healing, and other signs and symptoms of this condition. (medlineplus.gov)
Infections of the skin, lungs, and gums resemble those seen in the moderate type of LAD-1, but the frequency and severity of infections tend to decrease with age. (lu.se)
Mononuclear1
This study suggests that long-term vitamin C supplementation at high dose, i. e. 500 mg together with vitamin E in moderate dose, 182 mg, decreases the steady-state level of oxidative DNA damage in mononuclear blood cells of smokers. (nih.gov)
Phosphorylation1
Rho-kinase activity is determined in circulating leukocytes measuring phosphorylation of its target myosin phosphatase target subunit 1 (MYPT1), but its relationship with Rho-kinase activity in the myocardium and in vasculature in hypertension has not been evaluated. (portlandpress.com)
Temperature1
Horses with DPJ usually produce larger volumes of reflux (usually greater than 48 liters in the first 24 hours): 322-332 than those with obstruction, and are often pyretic (temperatures of 101.5-102.5) and have alterations in white blood cell levels, while those with obstructions usually have a normal or lower than normal temperature and normal leukocyte levels. (wikipedia.org)
Vitamin4
Antioxidants, in particular vitamin C, have been suggested to decrease oxidative DNA damage. (nih.gov)
Vitamin C intake was assessed by 3-day dietary recall, and plasma and leukocyte vitamin C concentrations were measured colorimetrically. (who.int)
Plasma and leukocyte vitamin C levels were significantly lower in the asthma group. (who.int)
Asthma is a chronic relapsing inflammatory study in Tehran with the hypothesis that disorder of the airways and a major health plasma and leukocyte vitamin C level are problem worldwide [ 1 ]. (who.int)
Significantly lower1
The cellular expression of CD200 on total leukocytes (median ± IQR) [39.94 (28.85, 50.01)] in cases was significantly lower compared to controls [45.07 (37.70, 51.69)] (U = 896, p = 0.015). (qxmd.com)
Diseases1
Purpose: Leukocyte telomere length has gained attention as a marker of oxidative damage and age-related diseases, including cancer. (aacrjournals.org)
Incidence1
Our observations suggest that normal numbers and composition of intrathecal leukocytes do not decrease the incidence of PLPH. (elsevierpure.com)
Patients2
We hypothesize that leukocyte telomere length might be able to predict future risk of cancer and examined this in a cohort of patients with Barrett's esophagus, who are at increased risk of esophageal adenocarcinoma and thus were enrolled in a long-term cancer surveillance program. (aacrjournals.org)
Une corrélation significative positive a été trouvée entre la vitamine C plasmatique et l'apport alimentaire en vitamine C. Le taux de vitamine C plasmatique et leucocytaire était significativement moins élevé dans le groupe des patients asthmatiques. (who.int)
Cells3
Tobacco smoke decreased the number of dendritic cells (DCs) in the lung tissue. (nih.gov)
A decrease in T cells that express CD45RO, the marker for memory T cells, was also reported by other investigators. (medscape.com)
After an initial decrease, the percentage of cells expressing Class II marker increased with time. (usda.gov)
Normal2
Leukocytes may be normal, increased, or decreased. (wikipedia.org)
Horses with proximal enteritis usually have an intestinal diameter that is narrower, but wall thickness is often greater than 6mm, containing a hyperechoic or anechoic fluid, with normal, increased, or decreased peristalsis. (wikipedia.org)
Activity3
Hypoxia impairs metabolic functions by decreasing activity and expression of ATP-consuming processes. (southwales.ac.uk)
Acute hypoxia of lowaltitude samples decreased the activity of complexes I, II, and III. (southwales.ac.uk)
At high altitude, activity of complexes I and III were decreased when measured in normoxia. (southwales.ac.uk)
Immune1
Leukocytes that lack these integrins cannot attach to the blood vessel wall or cross the vessel wall to contribute to the immune response. (medlineplus.gov)
Disorder1
CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness. (nih.gov)
Expression1
The decrease in TLR2 surface expression on the seventh day compared to the preoperative values can be regarded as a mechanism limiting inflammatory response. (hindawi.com)
Risk1
Leukocyte telomere length hazard ratios (HR) for risk of esophageal adenocarcinoma were calculated using multivariate Cox models. (aacrjournals.org)
High2
A metabolic acidosis with a high anion gap is often seen due to loss of bicarbonate in gastric reflux and an increase in lactic acid in the blood, secondary to hypovolemia and decreased tissue perfusion. (wikipedia.org)
Stimulation of leukocytes with PMA increased JO 2,100 at low (twofold) and high altitude (five-fold). (southwales.ac.uk)
Wall1
Signaling through the β2 integrins triggers the transport of the attached leukocyte across the blood vessel wall to the site of infection or injury. (medlineplus.gov)
Body1
Mavik taken at the same time as aluminum- or magnesium-based antacids decreases its absorption into the body. (medicinenet.com)