• absence
  • After 60 minutes of brain death (defined as the absence of electrical activity in the brain), a variety of indicators of cardiac contractile function fell by approximately 50% (thus cardiac index fell from 21 +/- 2 to 11 +/- 1 ml/min per 100 g body weight). (ahajournals.org)
  • Verbal autopsy (VA) is a widely used method for analyzing cause of death in absence of vital registration systems. (diva-portal.org)
  • brain
  • In an era where we are becoming more reliant on vulnerable kidneys for transplantation from older donors, there is an urgent need to understand how brain death leads to kidney dysfunction and, hence, how this can be prevented. (ox.ac.uk)
  • Using a rodent model of hemorrhagic stroke and next-generation proteomic and metabolomic technologies, we aimed to delineate which key cellular processes are perturbed in the kidney after brain death. (ox.ac.uk)
  • Higher amounts of succinate were found in the brain death group, in conjunction with increased markers of oxidative stress. (ox.ac.uk)
  • We characterized the responsiveness of hypoxia inducible factors and found this correlated with post-brain death mean arterial pressures. (ox.ac.uk)
  • Brain death leads to metabolic disturbances in the kidney and alterations in mitochondrial function and reactive oxygen species generation. (ox.ac.uk)
  • Conditioning the brain-dead organ donor by altering metabolism could be a novel approach to ameliorate this brain death-induced kidney injury. (ox.ac.uk)
  • Brain death-induced impairment of cardiac contractile performance can be reversed by explantation and may not preclude the use of hearts for transplantation. (ahajournals.org)
  • The shortage of suitable donor hearts for cardiac transplantation is exacerbated by the exclusion of those that exhibit contractile malfunction during the period after brain death but before excision. (ahajournals.org)
  • We have replicated the phenomenon of brain death-induced hemodynamic deterioration in the rat in vivo. (ahajournals.org)
  • However, once excised and perfused ex vivo, the hearts recovered a level of cardiac function that was identical to that from control animals that had not been subjected to brain death. (ahajournals.org)
  • Similarly, when hearts were excised, stored (6 hours at 4 degrees C), and reperfused ex vivo with blood, they also recovered a functional capability identical to that of normal hearts from animals that had not been subjected to brain death. (ahajournals.org)
  • To increase support for the concept of brain death, changes accommodating requirements of the religious authorities were made to the Brain Death Act in Israel. (declarationofistanbul.org)
  • Reasons included family resistance to brain death testing (27 cases), inability to perform apnea testing (7) and logistic problems related to ancillary testing (26 cases). (declarationofistanbul.org)
  • The number of physicians available to declare brain death also decreased (210 vs. 102). (declarationofistanbul.org)
  • Instead of increasing opportunities, many obstacles were encountered following the changes to the Brain Death Act. (declarationofistanbul.org)
  • Brain death is sudden death following a road traffic accident or a brain haemorrhage, with irreversible brain damage that is not compatible with life. (columbiaasia.com)