• Mucous membrane involvement can result in gastrointestinal hemorrhage, respiratory failure, ocular abnormalities, and genitourinary complications. (medscape.com)
  • Liver biopsy on POD 7 showed no evidence of rejection, biliary complications or drug-induced liver injury. (cdc.gov)
  • But older people are also at higher risk of drug-related heart complications because of the fact that many already have cardiac disease, French said. (medscape.com)
  • If blood sugar levels become ridiculously high severe complications, and potentially death can result. (virtualmedstudent.com)
  • A shorter incubation period is associated with more severe disease, complications, and a higher chance of death. (cdc.gov)
  • Nervous system abnormalities, as well as a variety of complications related to severe spasm and prolonged hospitalization, can accompany generalized tetanus. (cdc.gov)
  • The arrhythmias that lead to faints and sudden death are more likely to occur in specific circumstances, in part determined by which genetic variant is present. (wikipedia.org)
  • Arrhythmias occur more commonly in drug-induced LQTS if the medication in question has been rapidly given intravenously, or if high concentrations of the drug are present in the person's blood. (wikipedia.org)
  • The FDA recommended avoiding the sodium channel blocker's use "in patients who have cardiac conduction disorders (e.g., second- or third-degree heart block), ventricular arrhythmias, or cardiac disease or abnormality (e.g., myocardial ischemia, heart failure, structural heart disease, Brugada syndrome, or other sodium channelopathies). (medscape.com)
  • These factors can lead to coma, heart arrhythmias, and death if left untreated. (virtualmedstudent.com)
  • QTc-prolongation is known as a risk factor for developing ventricular arrhythmias such as Torsade de Pointes (TdP), which may eventually lead to sudden cardiac death. (biomedcentral.com)
  • The transplant donor was a 60-year-old man who had severe cerebral infarction, which progressed to brain death. (cdc.gov)
  • The most serious risks associated with YONDELIS are neutropenic sepsis (severe infections due to decreased white blood cells), rhabdomyolysis (severe muscle problems), cardiomyopathy (heart muscle problems, including heart failure), hepatotoxicity (liver problems, including liver failure), anaphylaxis, and extravasation (leakage of YONDELIS out of the vein during infusion) leading to tissue necrosis (tissue cell damage or death) and embryofetal toxicity. (prnewswire.com)
  • PML is an opportunistic viral infection of the brain caused by the JC virus (JCV) that typically only occurs in patients who are immunocompromised, and that usually leads to death or severe disability. (vumerityhcp.com)
  • Acute hypersensitivity reactions, including anaphylaxis and angioedema, and delayed hypersensitivity reactions, including severe cutaneous adverse drug reactions have been reported postmarketing. (nih.gov)
  • Thalidomide remains one of the world's most notorious drugs due to the severe birth defects it induced in children between 1957 and 1962. (hindawi.com)
  • INDIANAPOLIS, July 16, 2021 /PRNewswire/ - Eli Lilly and Company (NYSE: LLY) and Incyte (NASDAQ:INCY) announced today that the U.S. Food and Drug Administration (FDA) will not meet the Prescription Drug User Fee Act (PDUFA) action date for the supplemental new drug application (sNDA) for baricitinib for the treatment of adults with moderate to severe atopic dermatitis (AD). (nationaleczema.org)
  • Severe direct tissue damage to critical organs (eg, to the heart, brain, spinal cord) is responsible for most immediate trauma deaths. (msdmanuals.com)
  • Pazopanib is susceptible to drug-drug interactions with agents that inhibit or induce hepatic CYP 3A4 activity. (nih.gov)
  • In utero antiepileptic drug exposure: fetal death and malformations. (emmes.com)
  • This initial report focuses on the incidence of serious adverse outcomes including major congenital malformations (which could be attributable to AEDs) or fetal death. (emmes.com)
  • Methotrexate has been reported to cause fetal death and/or congenital anomalies. (nih.gov)
  • The body generally has no reaction to fetal death except for loss of weight. (howstuffworks.com)
  • Fetal death is usually brought to the doctor's attention by the woman's reporting that she has not felt the fetus move for a day or two. (howstuffworks.com)
  • Today, most doctors choose to induce labor and deliver the fetus as soon as possible after the diagnosis of fetal death. (howstuffworks.com)
  • The death of the fetus at some time between the 20th week of pregnancy and birth is called stillbirth -- in medical terms, an intrauterine fetal demise. (howstuffworks.com)
  • The death of the fetus within the uterus usually does not jeopardize the mother's health. (howstuffworks.com)
  • Uncommonly, death of the fetus may cause abnormalities of the mother's blood clotting system, but only after the fetus has been dead for several weeks. (howstuffworks.com)
  • Spontaneous labor may begin any time from a few hours to up to 60 days after the death of the fetus. (howstuffworks.com)
  • Maternal exposure after conception may result in death of the fetus or structural and functional abnormalities in the newborn. (cdc.gov)
  • Methotrexate-induced lung disease, including acute or chronic interstitial pneumonitis, is a potentially dangerous lesion, which may occur acutely at any time during therapy and has been reported at low doses. (nih.gov)
  • Diarrhea and ulcerative stomatitis require interruption of therapy: otherwise, hemorrhagic enteritis and death from intestinal perforation may occur. (nih.gov)
  • Horses don't normally suffer from coronary artery disease, so "heart attacks" rarely occur, although heart disease can cause sudden death. (canadianthoroughbred.com)
  • Generalized spasms occur, frequently induced by sensory stimuli. (cdc.gov)
  • In October 2020, the Food and Drug Administration added a warning to the lamotrigine label that said the drug "could slow ventricular conduction (widen QRS) and induce proarrhythmia, including sudden death, in patients with structural heart disease or myocardial ischemia. (medscape.com)
  • In people, myocardial infarcts are commonly caused by clogged blood vessels that reduce blood flow to the heart and result in damage or death to the heart muscle. (canadianthoroughbred.com)
  • These abnormalities are characterized by delayed myocardial repolarization that leads to varying degrees of QT prolongation and T-wave abnormalities on an EKG. (studybay.net)
  • Ingestion of carbon disulfide in amounts as small as 15 mL may result in the death of an adult. (cdc.gov)
  • Routine donor biopsy did not show any histopathologic abnormality. (cdc.gov)
  • Birth defects can be defined as structural or functional abnormalities, including metabolic disorders, which are present from birth. (who.int)
  • At higher concentrations, ROS induces cell injury and death, which occurs during the aging process, where accelerated generation of ROS and a gradual decline in cellular antioxidant defense mechanisms, especially in the mitochondria. (nih.gov)
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury updated 11 December 2019. (medsafe.govt.nz)
  • Serious drug-induced liver injury, including liver transplantation and death, has been reported with Trilipix. (nih.gov)
  • Injury is the number one cause of death for people aged 1 to 44. (msdmanuals.com)
  • Of intentional injury deaths, more than 65% were due to self-harm. (msdmanuals.com)
  • In addition to deaths, injury results in about 37.9 million emergency department visits and 2.6 million hospital admissions annually. (msdmanuals.com)
  • As the QT prolonging effects of both genetic variants and acquired causes of LQTS are additive, those with inherited LQTS are more likely to experience TdP if given QT prolonging drugs or if they experience electrolyte problems such as low blood levels of low potassium (hypokalaemia). (wikipedia.org)
  • These patients can become very dehydrated and will often have significant electrolyte abnormalities. (virtualmedstudent.com)
  • It is a relatively common cause of sudden death along with Brugada syndrome and arrhythmogenic right ventricular dysplasia. (wikipedia.org)
  • Structural heart disease, such as ventricular hypertrophy, atrial septal defects (a hole between the upper chambers of the heart), arrhythmogenic right ventricular cardiomyopathy, and others refers to physical abnormalities in the heart structure. (ecgedu.com)
  • Several risk factors and genetic predisposition can reduce this repolarization reserve causing abnormalities in the ventricular repolarization [ 9 , 10 ]. (biomedcentral.com)
  • Despite a flurry of publicity about its newfound cardiac risk profile, the antiseizure medication lamotrigine (Lamictal) is "still a good drug" in epilepsy and an excellent treatment for certain groups, New York University neurologist Jacqueline A. French, MD, told colleagues at the annual meeting of the American Epilepsy Society. (medscape.com)
  • Nonspecific EKG abnormalities (e.g., nonspecific ST and T wave abnormalities) are not concerning, and should not preclude these individuals from being prescribed lamotrigine. (medscape.com)
  • Patients with connective tissue disease at the time of the diagnosis of CFPE were excluded from the study, as well as patients with a diagnosis of other interstitial lung diseases, such as drug-induced interstitial lung disease, pneumoconiosis, hypersensitivity pneumonitis, sarcoidosis, pulmonary histiocytosis, lymphangioleiomyomatosis and eosinophilic pneumonia 4 . (ersjournals.com)
  • 2 Some patients may be asymptomatic and VBDS is initially identified based on laboratory abnormalities. (medsafe.govt.nz)
  • These abnormalities are usually asymptomatic and self-limited even if therapy is continued. (nih.gov)
  • We propose that hypometabolism, coupled with oxidative stressors, is responsible for most Alzheimer disease (AD) and cerebrovascular accidents (CVAs) and appears to be a central initiating factor for vascular abnormalities, mitochondrial damage and an imbalance in the activity of vasoactive substances, such as different isoforms of nitric oxide synthase (NOS), endothelin-1 (ET-1), oxidative stress markers, mtDNA and mitochondrial enzymes in the vascular wall and in brain parenchymal cells. (nih.gov)
  • Therefore, mitochondrial DNA abnormalities such as overproliferation and or deletion can be used as a key marker for diseases differentiation and effectiveness of the treatment. (nih.gov)
  • Additional near-term deaths result from infection because of disruption of normal anatomic barriers and immune system dysfunction. (msdmanuals.com)
  • Dr. Kelsey undoubtedly prevented an epidemic of thalidomide-induced birth defects in the USA and for her efforts was subsequently given the President's Award for Distinguished Federal Civilian Service by President John F. Kennedy in 1962 [ 4 ]. (hindawi.com)
  • Other possible adverse outcomes include spontaneous abortions (both early and late), major and minor birth defects, perinatal death, low birth weight, altered sex ratio, developmental or behavioral disabilities, and transplacental exposure to carcinogen (9-11). (cdc.gov)
  • Maternal illnesses like diabetes mellitus, conditions such as iodine and folic acid deficiency, and exposure to medicinal and recreational drugs including alcohol and tobacco, certain environmental chemicals, and high doses of radiation are other factors that cause birth defects. (who.int)
  • In large clinical trials, abnormalities in routine liver tests were common in patients treated with pazopanib, with serum aminotransferase elevations occurring in up to half of patients and total serum bilirubin in approximately one-third. (nih.gov)
  • Horses with heart abnormalities may or may not show clinical signs. (canadianthoroughbred.com)
  • Many of these drugs such as antibiotics and antidepressants are widely used in clinical practice. (biomedcentral.com)
  • Autopsy techniques for fetuses (fragmented or intact), stillbirths, and neonatal deaths with or without congenital anomalies. (case.edu)
  • European Region, where as many as 25% of neonatal deaths are due to congenital anomalies. (who.int)
  • The exact risk of developing QTc-prolongation when using a combination of QTc-prolonging drugs is still unknown, making it difficult to interpret these QT drug-drug interactions (QT-DDIs). (biomedcentral.com)
  • Pulmonary arterial hypertension (PAH) is a haemodynamic consequence of obstructive remodelling of the small pulmonary arteries and patients can progress to right-heart failure and death [ 1 ]. (ersjournals.com)
  • Exposure to trastuzumab products during pregnancy can result in oligohydramnios and oligohydramnios sequence manifesting as pulmonary hypoplasia , skeletal abnormalities, and neonatal death. (rxlist.com)
  • It is an inherited cardiac condition that is characterized by genetically encoded abnormalities in cardiac ion channels, namely through sudden cardiac death, various palpitations, and syncope (temporary loss of consciousness induced by low blood pressure). (studybay.net)
  • The study hypothesizes that abnormalities of the heart, some of which are genetically determined, can be used to identify patients at high risk of SCD. (nih.gov)
  • Antibiotics are most frequently associated with VBDS, although several drug classes and medicines have been implicated. (medsafe.govt.nz)
  • Intravenous drug users accounted for 14% of cases from 2000 through 2019. (cdc.gov)
  • Hepatobiliary tract diseases: infantile cholestasis, autoimmune and drug induced hepatitis, others. (case.edu)
  • The reduced ion transport alters the transmission of electrical signals in the heart, increasing the risk of an irregular heartbeat that can cause fainting (syncope) or sudden death. (medlineplus.gov)
  • This change increases the risk of an abnormal heart rhythm that can cause syncope or sudden death. (medlineplus.gov)
  • The term "heart attack" has incorrectly evolved into common usage to refer to sudden death associated with heart disease. (canadianthoroughbred.com)
  • Racehorses that unexpectedly drop dead due to sudden death syndrome (Swale syndrome) are frequently said to have died of a "heart attack. (canadianthoroughbred.com)
  • Chronic heart disease develops slowly due to the heart's ability to temporarily compensate for abnormalities by increasing its size. (canadianthoroughbred.com)
  • In summary, equine heart disease is multifaceted and can be induced by multiple mechanisms. (canadianthoroughbred.com)
  • Although horses do not routinely suffer from traditional "heart attacks," they do frequently develop heart abnormalities that can negatively impact their health and longevity. (canadianthoroughbred.com)
  • T-wave abnormalities are represented by longer time from Q wave to the T wave, allowing for longer time for the heart to repolarize. (studybay.net)
  • In this population, blood clotting is the most common cause of vascular death after heart attack and stroke. (nih.gov)
  • By analyzing the heart's electrical activity through the P, QRS, and T waves, physicians can detect abnormalities and determine the extent of damage to the heart muscle. (ecgedu.com)
  • Rare cases of acute liver failure and death have been attributed to simvastatin. (nih.gov)
  • These challenges include identifying clinically relevant but nonteratogenic forms of the drug, and the mechanisms underlying phocomelia and species specificity. (hindawi.com)
  • Although the exact mechanisms for the toxicities of the AGEs in diabetic retinopathy have not been definitively determined, the AGE-receptor of the AGE (RAGE) axis, production of reactive oxygen species, inflammatory reactions, and the activation of the cell death pathways are associated with the impairment of the NVUs in diabetic retinopathy. (bvsalud.org)
  • In the bitch, things become even more difficult when we realize that apparent infertility can be due to very different situations which prove difficult to distinguish, such as lack of fertilization (no union between eggs and sperm) and early embryonic death. (vin.com)
  • Even when a death is unequivocally due to a natural disease process, careful attention should be paid to an individual's risk factors for that particular disease. (medscape.com)
  • Diabetes, a history of immunosuppression, and intravenous drug use may be risk factors for tetanus. (cdc.gov)
  • In the US, there were 278,345 trauma deaths in 2020, about 70% of which were accidental. (msdmanuals.com)
  • Generalized EEG abnormalities typically signify dysfunction of the entire brain, although such dysfunction may not be symmetric in distribution. (medscape.com)
  • Shock Shock is a state of organ hypoperfusion with resultant cellular dysfunction and death. (msdmanuals.com)
  • leading to cellular dysfunction, organ failure, and eventually death. (msdmanuals.com)
  • [ 8 ] which is due to Staphylococcus aureus infection rather than to a probable drug hypersensitivity-type reaction. (medscape.com)
  • This review focuses on the basic and pathological findings of AGE-induced neurovascular abnormalities and the potential therapeutic approaches, including the use of anti-glycated drugs to protect the AGE-induced impairments of the NVUs in diabetic retinopathy. (bvsalud.org)
  • Ethoxyquin (EQ), a quinolone-based antioxidant, has demonstrated neuroprotective properties against several neurotoxic drugs in a phenotypic screening and is shown to protect axons in animal models of chemotherapy-induced peripheral neuropathy. (nature.com)
  • We previously identified ethoxyquin (EQ) as a potent neuroprotective compound through a phenotypic screen against three neurotoxic drugs and demonstrated that it prevents development of peripheral neuropathy in paclitaxel and cisplatin models of chemotherapy-induced peripheral neuropathy (CIPN). (nature.com)
  • Current indications for simvastatin are hypercholesterolemia and reduction in risk for death from coronary, cerebrovascular and peripheral artery disease in patients with these diseases. (nih.gov)
  • Peripheral capillary blood smears were pre- necessitates the use of alternative antima- pared, stained with Giemsa and examined larial drugs for the treatment of falciparum under oil immersion for parasites. (who.int)
  • For instance, an abnormality in the inner ear could allow an ear infection to spread to the meninges. (healthline.com)
  • The prevention of diabetes-induced mtDNA deletions may be a potential mechanism of the neuroprotective effects of EQ in diabetic neuropathy. (nature.com)
  • More specifically, neuronal cell death is an irreversible change that is directly associated with vision reduction in diabetic patients. (bvsalud.org)
  • This can happen when someone has an unusual response to certain anti-inflammatory medications, like nonsteroidal anti-inflammatory drugs (NSAIDs). (healthline.com)
  • Our findings confirm that training of drug users constitutes a valuable resource in the management of opiate overdoses and growth of peer interventions that may not otherwise be recognised or addressed. (biomedcentral.com)
  • If the arrhythmia continues, the affected person may experience a cardiac arrest, which if untreated may lead to sudden death. (wikipedia.org)
  • Though it can be acquired, such as from various medications and drugs, it is typically genetic and exists in different forms, with LQTS 1, 2, and 3 being the main forms of the disease. (studybay.net)
  • Like other cytotoxic drugs, methotrexate may induce "tumor lysis syndrome" in patients with rapidly growing tumors. (nih.gov)
  • Pediatric forensic pathology: sudden infant death syndrome, child abuse, child neglect. (case.edu)
  • This is accomplished either by administering the drug oxytocin intravenously or giving drugs called prostaglandins as vaginal suppositories. (howstuffworks.com)
  • Our Herzuma (trastuzumab-pkrb) for Injection, for Intravenous Use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • This observational study will group and follow patients at a higher risk for sudden cardiac death (SCD) who receive an implantable cardioverter defibrillator (ICD) pulse generator replacement as a prevention measure. (nih.gov)
  • The mortality rate among opioid drug users is known to be significantly elevated - approximately 2-3% of heroin users die each year and these rates are between six and twenty times higher than those expected among non-drug using peers of the same age and gender [ 2 ]. (biomedcentral.com)
  • In 1984, the most recent year for which final mortality data are available, 1729 deaths were attributed to TB, representing a mortality rate of 0.7/100,000 population. (cdc.gov)
  • The mild, self-limited ALT elevations are likely due to a toxic intermediate of drug metabolism and the reversal of these elevations due to adaptation. (nih.gov)