• DRUG
  • http://www.iflscience.com/health-and-medicine/researchers-kill-drug-resistant-leukemia-cells-using-dna-trojan-horse-attack Daunorubicin should only be administered in a rapid intravenous infusion. (wikipedia.org)
  • New daunorubicin analog exhibits anticancer activity and overcomes P-gp-mediated drug resistance. (aacrjournals.org)
  • COMPOUND
  • Since a group of French researchers discovered the same compound at about the same time, the two teams named the compound daunorubicin, combining the name Dauni, a pre-Roman tribe that occupied the area of Italy where the compound was isolated, with the French word for ruby, rubis, describing the color. (wikipedia.org)
  • leukemia
  • Small volumes of daunorubicin can be wrapped up in these minuscule pods, which can then be released into a leukemia cell-filled environment. (wikipedia.org)
  • Scheulen M.E., Lennartz K., Heidrich T., Host G., Kramer B. (1987) Determination of the Cellular Uptake of Daunorubicin in Human Leukemia in vivo: Method of Examination and First Results. (springer.com)
  • studies
  • McGown AT, Ward TH, Fox BW (1983) Comparative studies of the uptake of daunorubicin in sensitive and resistant P388 cell lines by flow cytometry and biochemical extraction procedures. (springer.com)
  • Biosynthetic Studies of Daunorubicin and Tetracenomycin C". Chemical Reviews. (wikipedia.org)
  • In vitro studies with recombinant proteins indicate that the CBR1 V88 isoform has a higher Vmax towards the substrates menadione (vitamin K3) and daunorubicin. (wikipedia.org)
  • produce
  • However, by 1967, it was recognized that daunorubicin could produce fatal cardiac toxicity. (wikipedia.org)
  • This was significant because it became clear that all daunorubicin producing strains have the necessary genes to produce DXR, the much more therapeutically important of the two. (wikipedia.org)
  • growth
  • the concentrations of daunorubicin that inhibited the growth of clones by 50% did not differ by more than 2-fold, whereas daunorubicin reductase activities and NADPH diaphorase isozyme activities differed by more than 100-and 15-fold, respectively. (aacrjournals.org)
  • Days
  • We have treated nine adults with erythroleukemia with daunorubicin, 1 mg/kg ยท day, and prednisone, 60 mg/day, for 5 days. (annals.org)
  • complex
  • Daunorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication. (wikipedia.org)
  • combination
  • We conclude that the combination of daunorubicin and prednisone may be especially useful in inducing remissions in erythroleukemia and that erythroleukemia is more responsive to chemotherapy than previously realized. (annals.org)
  • found
  • Daunorubicin has been used intravitreally (inside the eye) for the purposes of preventing proliferative vitreoretinopathy, a common complication following retinal detachment surgery, but has not been found to be effective and is not used for any other ophthalmic purposes at this time. (wikipedia.org)
  • By 1999, they produced recombinant Dox A, a Cytochrome P450 oxidase, and found that it catalyzes multiple steps in DXR biosynthesis, including steps leading to daunorubicin. (wikipedia.org)