Lagunamide A is a cyclic depsipeptide also isolated from marine cyanobacteria, originally identified as Lyngbya majuscula. (sdsu.edu)
The best example, in bioactive natural product discovery from this symbiotic system, is the description of a new cyclic depsipeptide, dentigerumycin, produced by the symbiotic Pseudonocardia strain, isolated from the exoskeleton of the coral fungus agriculture ant, Apterostigma dentigerum. (fapesp.br)
Study1
Much of his study explores Depsipeptide relationship to Stereochemistry. (research.com)
Suberoylanilide hydr2
Notably, the pleiotropic HDAC inhibitors, suberoylanilide hydroxamic acid (SAHA) and depsipeptide, have shown efficacy in a wide range of cancers, in particular for cutaneous T-cell lymphoma (CTCL), and are progressing in phase II clinical studies. (nature.com)
Newly developed compounds, such as suberoylanilide hydroxamic acid and depsipeptide, are more specific inhibitors of HDAC and have shown good clinical outcomes. (medscape.com)
Inhibitors2
Piekarz R, Bates S . A review of depsipeptide and other histone deacetylase inhibitors in clinical trials. (nature.com)
To date, effective inhibitors that do not require incorporation into DNA have not been introduced, but these might be more clinically desirable, because they may have fewer side effects. (medscape.com)
Fungal1
This review surveys the biological activities and the iterative and recursive biosynthetic mechanisms of fungal cyclooligomer depsipeptides, and their structural diversification by various combinatorial biosynthetic methods. (tu-berlin.de)
20181
The suggested launch date is around or beyond 2018. (sirnalibrary.com)
Cancers1
To date, nearly 150 patients with thoracic malignancies (mostly lung cancers) have received deoxyazacytidine (DAC), Depsipeptide (DP), sequential DAC/DP, or sequential DP/Flavopiridol infusions on protocols initiated in the Thoracic Oncology Section. (nih.gov)
Effects1
Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines. (nature.com)
Browser1
To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). (nature.com)
Patients1
To date, over 120 patients with T-cell lymphoma have been treated on a multi-institutional phase II trial of romidepsin. (nih.gov)