• The expressions of retinal GLP-1R, mitochondria-dependent apoptosis-associated genes, reactive gliosis markers, and endoplasmic reticulum stress-related pathway genes were studied by western blotting and immunohistochemistry in vivo and in vitro. (molvis.org)
  • Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
  • They examined the pro-survival mechanisms of GCSF against apoptosis resulting from autophagy, mitochondrial stress and ER stress. (sciencedaily.com)
  • Researchers examined behavior and used immunoblotting to analyze key proteins in ER stress, autophagy and mitochondrial stress-induced apoptosis. (sciencedaily.com)
  • More than 15 million people worldwide suffer from stroke and our study provides new and important insights into GCSF induced protection as it relates to ER stress and mitochondrial stress activated apoptosis, " said Howard Prentice, Ph.D., corresponding author, a professor of biomedical sciences in FAU's Schmidt College of Medicine, and a member of FAU's I-BRAIN. (sciencedaily.com)
  • PM2.5 exposure leads to hepatic insulin resistance (IR) that was accompanied by endoplasmic reticulum (ER) stress-induced apoptosis (Laing et al. (deepdyve.com)
  • Along with lysosomal cathepsin release, mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis, it leads to further inflammation, and stimulation of transforming growth factor (TGF)-beta and activation of hepatic stellate cells with collagen deposition within the hepatic sinusoids become apparent. (medscape.com)
  • The study, published in the Journal of Biomedical Science , is the first to report on the neuroprotective effect of GCSF against autophagy and mitochondrial stress in vivo. (sciencedaily.com)
  • The data support the hypothesis that GCSF is one of the few growth factors that can reduce infarction by decreasing endoplasmic reticulum (ER) and mitochondrial stress while improving behavioral performance. (sciencedaily.com)
  • Researchers used a mechanism-based therapeutic approach for stroke first to examine the connection of mitochondrial, autophagy and ER stress inhibition in the protective action of GCSF and then to analyze relevant ER stress pathways in the bilateral common carotid artery occlusion (BCAO) model of stroke. (sciencedaily.com)
  • They confirmed the neuroprotection of GCSF gene therapy in the BCAO mouse stroke model by a decrease of dynamin-related protein (DRP1), a marker of mitochondrial stress, in the frontal and middle brain of the GCSF treated group. (sciencedaily.com)
  • multiple systems, including alteration of calcium mineral homeostasis4, mitochondrial perturbation, induction of NADPH oxidase appearance5, and activation of endoplasmic reticulum oxidoreductases6. (mingsheng88.org)
  • Autophagy could be activated by inhibiting the transfer of Ca 2+ from the endoplasmic reticulum to the mitochondrial matrix. (open.ac.uk)
  • Microsomal glutathione transferase 1 (MGST1) is an antioxidant enzyme located predominantly in the mitochondrial outer membrane and endoplasmic reticulum and has been shown to protect cells from lipid peroxidation induced by a variety of cytostatic drugs and pro-oxidant stimuli. (cdc.gov)
  • Data show that hepatic mitochondrial dysfunction is crucial to the pathogenesis of NAFLD. (medscape.com)
  • Endoplasmic reticulum stress (ERS) is a self-protective mechanism resulting from an imbalance in quality control of unfolded proteins when cells are stressed, which plays an active role in lung cancer development, but the relationship between ERS and the pathological characteristics and clinical prognosis of LUAD patients remains unclear. (biomedcentral.com)
  • Endoplasmic reticulum stress (ERS) is a state induced by increased synthesis of intracellular proteins, accumulation of mal-folded proteins, changes in cytosolic calcium levels, or imbalances in endoplasmic reticulum (ER) redox homeostasis [ 8 ]. (biomedcentral.com)
  • Endoplasmic reticulum stress (ERS) might be stimulated by a dysfunctional activity of ER dealing with the misfolded or unfold proteins [ 1 ]. (hindawi.com)
  • Lacking proteosomal function on aggregates of unfolded proteins, ER stress may induce autophagic machinery. (spandidos-publications.com)
  • Endoplasmic reticulum (ER) is an essential organelle responsible for protein synthesis, folding, post-translational modification of proteins and protein trafficking in eukaryotes ( 8 ). (spandidos-publications.com)
  • The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum can cause an endoplasmic reticulum stress (ERS) response. (biomedcentral.com)
  • We identified increased expression in 38 proteins not previously linked to the UPR, of which 15 likely remediate ER stress, and the remainder may contribute to pathological outcomes. (torvergata.it)
  • Unexpectedly, there are few strongly downregulated proteins, despite expression of the pro-apoptotic transcription factor CHOP, suggesting that IRE1-dependent mRNA decay (RIDD) has a limited contribution to ER stress-mediated cell death in our system. (torvergata.it)
  • It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). (cancerindex.org)
  • HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. (origene.com)
  • ER stress occurs due to accumulation of unfolded proteins. (helsinki.fi)
  • ER stress triggers Unfolded protein response (UPR) that protects against ER stress by decreasing unfolding of proteins. (helsinki.fi)
  • Our data also showed that SiO2 nanoparticle -induced cytotoxicity is mitigated in the presence of serum, potentially through masking of reactive surface groups by serum proteins, whereas ZnO nanoparticle s were cytotoxic both in the presence and in the absence of serum. (cdc.gov)
  • When an accumulation of unfolded or misfolded proteins occurs in the lumen of the endoplasmic reticulum, the UPR works to protect the cell against the damage caused by these improperly folded proteins. (medscape.com)
  • The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE 101 partner repository with the dataset identifier PXD031522 . (nature.com)
  • In comparison, HCV or HCV protein were discovered by another research13,14 to induce ROS creation and activate Nrf2/ARE pathway, which protected hepatic cells from oxidative stress subsequently. (mingsheng88.org)
  • Conclusions: The cell-permeable PSELT is able to induce pharmacological preconditioning cardioprotection by mitigating ERS and oxidative stress, and by regulating endogenous SELENOT. (unical.it)
  • Angiotensin II (AngII) stimulates oxidative stress in VSMC, inducing VSMC proliferation and migration, which is a critical factor in both developments of hypertension and angioplasty-induced arterial restenosis. (hindawi.com)
  • These results indicate that fisetin increases the expression of antioxidant PON2 via activation of PPAR γ , reducing oxidative stress, inhibiting VSMC proliferation and migration, and alleviates neointimal hyperplasia after intimal injury. (hindawi.com)
  • Via AT1a receptor, AngII increased oxidative stress, which is a critical regulator of VSMC proliferation and migration in hypertension and vascular remodeling [ 6 - 8 ]. (hindawi.com)
  • Fisetin, a flavonoid phytonutrient present in almost all kinds of fruits and vegetables, has recently emerged as a powerful antioxidant for health promotion [ 9 , 10 ] and exerts multiple protective effects in different oxidative stress-related conditions in human, such as degenerative diseases (e.g., vascular dementia), cancer, diabetes, and cardiovascular diseases [ 11 - 14 ]. (hindawi.com)
  • Unlike its allozymes PON1 and PON3 are bound with HDL in circulatory vessels protecting LDL against oxidation, PON2 is ubiquitously located in subcellular structures, such as perinuclear region, endoplasmic reticulum (ER), and mitochondria, compartments that are crucial for balancing intracellular oxidative stress. (hindawi.com)
  • PON2 is mainly involved in prevention of intracellular oxidative stress [ 17 - 19 ] and is an important endogenous defense mechanism against vascular oxidative stress in atherogenesis [ 16 , 20 - 22 ]. (hindawi.com)
  • Moreover, elevated sensitivity to oxidative stress, as induced by amyloid oligomers or peroxide, was detected in both fAD- and sAD-derived neurons. (biomedcentral.com)
  • We evaluated the induction of cytotoxicity and oxidative stress by TiO2, CeO2, SiO2, and ZnO in the human MCF-7 cell line with or without overexpression of MGST1. (cdc.gov)
  • Oxidative stress is thought to be obligatory. (medscape.com)
  • ER alerts a self-protective mechanism that is called ER stress during nutrient deprivation, pathogen infection, alterations in redox status, intraluminal Ca 2+ levels and folding defective protein conditions ( 9 ). (spandidos-publications.com)
  • The data suggest that inhibitors of the Fd/FNR redox system should be avoided as ART partner drugs in ART combination therapy for treating malaria. (biorxiv.org)
  • Endoplasmic reticulum (ER), commonly known as a significant component of endomembrane system, is responsible for the regulation of lipid, glucose, Ca 2+ homeostasis and protein synthesis [ 7 ]. (biomedcentral.com)
  • The ER-resident protein fat-inducing transcript 2 (FIT2) catalyzes acyl-CoA cleavage in vitro and is required for endoplasmic reticulum (ER) homeostasis and normal lipid storage in cells. (sdsc.edu)
  • HCT 116 colon cancer cells were exposed to purvalanol, which activated ER stress via upregulation of PERK, IRE1α gene expression, eIF-2α phosphorylation and ATF-6 cleavage at early time-points in the HCT 116 colon cancer cells. (spandidos-publications.com)
  • For the first time to our knowledge, we demonstrate that CRELD2 can serve as a sensitive urinary biomarker for detecting ER stress in podocytes or renal tubular cells in murine models of podocyte ER stress-induced nephrotic syndrome and tunicamycin- or ischemia-reperfusion-induced acute kidney injury (AKI), respectively. (jci.org)
  • Therefore, since several studies have shown that peroxisome proliferator-activated receptor (PPAR)β/δ inhibits ER stress, the main goal of this study consisted in investigating whether activation of this nuclear receptor was able to prevent lipid-induced ER stress in cardiac cells. (nih.gov)
  • Our results demonstrate that palmitate induced ER stress in AC16 cells, a fact which was prevented after PPARβ/δ activation with GW501516. (nih.gov)
  • In contrast, tunicamycin-induced ER stress resulted in increased IL8, CXCL1, and CXCL2 production in cells with knockdown of VCP, while enhanced expression of these proinflammatory molecules was abolished upon knockout of NOD2. (ox.ac.uk)
  • Our results demonstrate that tumor growth, peritoneal dissemination and peritoneum or organ metastasis implanted MKN45 cells were significantly decreased in shAhR and Biseugenol-treated mice and that endoplasmic reticulum (ER) stress was caused. (oncotarget.com)
  • Our data suggested that exosomal ERp44 derived from ER-stressed NPC cells took an inevitable role in NPC chemoresistance and might act as a treatment target. (biomedcentral.com)
  • Challenging FIT2-LKO mice with a high-fat diet worsened hepatic ER stress and liver injury, but unexpectedly reversed the steatosis phenotype, similar to what is observed in FIT2-deficient cells loaded with fatty acids. (sdsc.edu)
  • This pathway, known as 'store-operated Ca 2+ entry' (SOCE), was activated by depleting endoplasmic reticulum Ca 2+ stores using inhibitors of sarco/endoplasmic reticulum ATPases (SERCA). (open.ac.uk)
  • However, if the stress on the ER is chronic or severe and quality control of protein folding cannot be met, ER activates its stress receptor, the unfolded protein response, which triggers programmed cell death [ 9 ]. (biomedcentral.com)
  • These data are discussed in terms of three exposure periods-acute (14 days or less), intermediate (15-364 days), and chronic (365 days or more). (cdc.gov)
  • Here, we demonstrate that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1) drive NK cell responses against viral infection and tumors in vivo. (cancerindex.org)
  • The Core performs assays and data interpretation for in vivo metabolic function tests, including IV, IP and oral glucose tolerance tests and insulin tolerance tests for parameters of insulin sensitivity, insulin secretion and glucose disposal. (mmpc.org)
  • ER stress has been reported to be induced after high-fat diet feeding in mice and also after saturated fatty acid treatment in vitro. (nih.gov)
  • In accordance with this, feeding on a high-fat diet or suppression of PPARβ/δ in knockout mice induced ER stress in the heart. (nih.gov)
  • Here, we report that hepatocyte-specific Fitm2 knockout (FIT2-LKO) mice fed a chow diet exhibited elevated acyl-CoA levels, ER stress, and signs of liver injury. (sdsc.edu)
  • This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). (nih.gov)
  • The data point toward a role of lipid peroxidation in SiO2 nanoparticle -induced cell death. (cdc.gov)
  • Expression of angiogenic factors such as VEGF under conditions of hypoxia or other kinds of cell stress contributes to neovascularization during wound healing. (jci.org)
  • METHODS: Population-based clinical data analysis was conducted to assess a possible therapeutic effect of combined dipyridamole and aspirin treatment in inhibiting CRC compared with either monotherapy. (lu.se)
  • As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)
  • Our data demonstrate that POH is an effective anti-glioma agent for recurrent temozolomide resistant gliomas which can be administered intranasally. (cns.org)
  • We found the increased expression of ERp44 and GRP78 in NPC and ERp44 was highly expressed in ER-stressed tissues. (biomedcentral.com)
  • Estimates of exposure levels posing minimal risk to humans (MRLs) have been made, where data were believed reliable, for the most sensitive noncancer effect for each exposure duration. (cdc.gov)
  • MRLs include adjustments to reflect human variability and extrapolation of data from laboratory animals and humans. (cdc.gov)
  • The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. (cancerindex.org)
  • In cultured human macrophages, inhibition of ORP150 expression caused retention of VEGF antigen within the endoplasmic reticulum (ER), while overexpression of ORP150 promoted the secretion of VEGF into hypoxic culture supernatants. (jci.org)
  • Perceived Hospital Stress, Severe Acute Respiratory Syndrome Coronavirus 2 Activity, and Care Process Temporal Variance During the COVID-19 Pandemic. (cdc.gov)
  • A county increase in 10 severe acute respiratory syndrome coronavirus 2 cases per 100,000 residents was associated with an increase in the odds of overall hospital, ICU, and ED stress by 9% (95% CI, 5-12%), 7% (3-10%), and 4% (2-6%), respectively. (cdc.gov)
  • Graph generated 29 August 2019 using data from PubMed using criteria . (cancerindex.org)
  • Part of the problem lies in the difficulty of extracting high-quality, three-dimensional, quantitative measures of actin network features from microscopy data. (biorxiv.org)
  • Endoplasmic reticulum stress (ERS) has been demonstrated to exhibit a critical role in osteoarthritic chondrocytes. (hindawi.com)
  • This systematic quantification of the proteome-wide expression changes that follow proteostatic stress is a resource for the scientific community, enabling the discovery of novel players involved in the pathophysiology of the broad range of disorders linked to proteostasis. (torvergata.it)
  • Unlike the globular units of microtubules and actin filaments, intermediate filaments are themselves constructed from filamentous sub-units, and confer strength as well as stress resistance to the cell[ 10 ]. (biorxiv.org)
  • Characterisation of ER stress in PD models may be important for the current and future drug development of PD. (helsinki.fi)
  • If ER stress is a significant factor that affects the disease development, it would be important to find a drug that alters these mechanisms and UPR. (helsinki.fi)
  • Most importantly, urinary CRELD2 elevation occurs in patients with autosomal dominant tubulointerstitial kidney disease caused by UMOD mutations, a prototypical tubular ER stress disease. (jci.org)
  • Thus, there is an urgent need to develop ER stress biomarkers in the incipient stages of ER stress-mediated kidney disease, when a kidney biopsy is not yet clinically indicated, for early therapeutic intervention. (jci.org)
  • Based on our preliminary data, the focus of this proposal is to apply developed high throughput technology (comparative epigenomics and metabolomics) to decipher the primate epigenome and metabolome in the obese maternal environment and then measure the impact of supplementation on the differentially altered epigenome and resultant disease. (nih.gov)
  • In conclusion, our study has identified CRELD2 as a potentially novel urinary ER stress biomarker with potential utility in early diagnosis, risk stratification, treatment response monitoring, and directing of ER-targeted therapies in selected patient subgroups in the emerging era of precision nephrology. (jci.org)
  • A mix of pumkin Seed, horsetail and flax is highly effective on stress urinary incontinence. (greenmedinfo.com)