Data apoptosis. Medical search. Frequent questions

Palcitoclax [APG-1252] is a novel and potent inhibitor of the Bcl-2 family of proteins and induces apoptosis in tumor cells. (pharmiweb.com)
The short-chain fatty acid butyrate induces apoptosis in col. (lww.com)
This inhibition of AMPK ultimately leads to inhibition of mTOR and thus induces apoptosis in the HepG2 cells. (biomedcentral.com)

Ray P, Guha D, Chakraborty J, Banerjee S, Adhikary A, Chakraborty S, Sa G (2016) Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer. (springer.com)
The present findings suggest that local IFN production may interact with a genetic factor ( PTPN2 ) to induce aberrant proapoptotic activity of the BH3-only protein Bim, resulting in increased β-cell apoptosis via JNK activation and the intrinsic apoptotic pathway. (diabetesjournals.org)
Infection of epithelial cells and lymphocytes has been shown to induce apoptosis in vitro ( 4 - 8 ). (cdc.gov)
Infection with virulent influenza (H5N1) virus was also shown to induce lymphopenia and lymphocyte apoptosis in vivo ( 14 ). (cdc.gov)
Further work is now needed to reveal the signalling complexes that TNFR2 uses to induce apoptosis. (biologists.com)
AT7519 was able to override this phenotype to induce apoptosis in ARDS neutrophils with reduced expression of the pro-survival protein Mcl-1. (bmj.com)
We demonstrate the first pharmacological compound to induce neutrophil apoptosis in sepsis-related ARDS, highlighting cyclin-dependent kinase inhibitors as potential novel therapeutic agents. (bmj.com)

Flow cytometry was used to examine apoptosis, cell cycle distribution, and accumulation of reactive oxygen species (ROS). (jcancer.org)
Further, AMP-17 treatment resulted in an increase in reactive oxygen species (ROS) levels, depolarization of the mitochondrial membrane potential (MMP), and changes in the cell cycle, leading to the apoptosis and necrosis, which ultimately contributed to the death of C. albicans cells. (researchsquare.com)

As these studies also revealed impaired cytochrome c release and a block in apoptosis upon small interfering RNA-mediated n-cofilin knockdown, n-cofilin was postulated to be essential for apoptosis induction. (nature.com)
Thus, we conclude that ADF/cofilin activity is not generally required for induction or progression of apoptosis in mammalian cells. (nature.com)
We found that, upon induction of apoptosis in control MEFs, n-cofilin, and its homolog ADF translocated to mitochondria together with actin. (nature.com)
In summary, our work demonstrates that in mammalian cells ADF/cofilin activity is not generally required for efficient induction of apoptosis. (nature.com)
Therefore, based on clinical experience as well as cytotoxic activity against multiple human cancer cells, we hypothesized that induction of apoptosis is the underlying mechanism for the treatment of psoriasis. (hindawi.com)
Several modes of apoptosis induction and responsible viral genes have been proposed ( 8 - 13 ). (cdc.gov)
These results demonstrate that conversion of mesenchyme to epithelial requires at least two steps, rescue of the mesenchyme from apoptosis and induction of differentiation. (rupress.org)
Upon induction of apoptosis, BAX becomes organelle membrane-associated, and in particular, mitochondrial membrane associated. (wikipedia.org)
Solanum nigrum (SN) is a herb with anticancer effects such as destruction of tumor cell membrane, induction of apoptosis by NF-kappaB, caspase activation, nitric oxide production and inhibition of angiogenesis [ 3 ]. (ijpsonline.com)
Induction of apoptosis leads to characteristic cellular changes leading to death. (ijpsonline.com)

Overall, the findings suggested that S/V could downregulate the expression of MALAT1, inhibit inflammation and apoptosis and improve endothelial function in ox‑LDL‑induced HUVECs via inactivating the TLR4/NF‑κB signaling pathway. (spandidos-publications.com)
Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)

The mechanisms of the cytotoxicity, apoptosis, and oxidative stress induced by the 5-15 nm SiNPs still remain unclear. (mdpi.com)
It is thus concluded that AVM inhibits the activity of BCR/ABL and their subsequent molecular signals, including AKT and MAPK, resulting in cytotoxicity via apoptosis. (spandidos-publications.com)
In this investigation, the role of autophagy and apoptosis in Solanum nigrum fruit extract-induced cytotoxicity in MDA-MB-468, a triple negative breast cancer cell line was studied. (ijpsonline.com)

This study suggests that dihydrotanshinone I inhibits MV4-11 proliferation by apoptosis via antagonizing FLT3-ITD/STAT5/Mcl-1 path-way, which might provide a novel therapy for acute myeloid leukemia. (banglajol.info)

Real-time cell analyzer and flow cytometry data reveal that tumor cell proliferation and apoptosis were impacted by FO. (hindawi.com)
Furthermore, Tan IIA-induced apoptosis and mitochondrial membrane potential changes were also further demonstrated by DNA fragmentation, single-cell gel electrophoresis assay (SCGE), and flow cytometry methods. (hindawi.com)
Cell apoptosis was analyzed by flow cytometry. (degruyter.com)

DAVID bioinformatic data showed that most of the biological process GO terms are related to proliferation and apoptosis. (hindawi.com)
We hypothesized that FO might regulate related genes in apoptosis and PI3K-AKT pathways to mediate the proliferation and apoptosis of liver cancer cells. (hindawi.com)

Apoptosis occurred 48 hours after EBF3 expression with caspase-3 activation. (aacrjournals.org)
Eldadah and Faden, 2000 ), we hypothesized that suppression of apoptotic capability during maturation of mammalian brain results from repression of genes involved in the caspase-3 activation pathway, and that injury-induced neuronal apoptosis in the mature brain results from reactivation of these genes. (jneurosci.org)

In this study, we investigate the influence of AST against glutamate- and hypoxia-induced apoptosis, as well as oxidative stress-induced necrosis, in primary rat RGC cultures. (molvis.org)

C1QBP significantly increased ROS level, apoptosis, and the expression of apoptotic proteins such as cleaved caspase-3 and bax/bcl2 via regulating XDH. (medsci.org)
Although they cannot encode proteins, they are involved in many biological processes as regulators, such as proliferation, apoptosis, migration and invasion ( 9 ). (spandidos-publications.com)
Importantly, the mitochondrial association of n-cofilin and ADF had no impact on apoptosis signaling because ablation of either n-cofilin, ADF, or both proteins together did not change cell death progression. (nature.com)
Western blotting and reverse transcriptase PCR were used to determine the expression levels of apoptosis-related proteins and genes, including bcl-2 , bax , cytochrome c , and capase-3 . (biomedcentral.com)

The expression levels of apoptosis-related genes Bcl2 and Bax were determined by real-time PCR. (ijpsonline.com)
Excessive oxidative stress alters the expression levels of apoptosis-related genes and triggers sperm apoptosis through bcl-2, bax, cytochrome c and caspase-3 signaling pathways. (biomedcentral.com)
miRNA target genes were predicted, and the mechanism of miRNA regulation of apoptosis was verified. (bvsalud.org)

Hepatic cells apoptosis was measured using TUNEL assay method. (springer.com)
Cd exposure is strongly associated with oxidative stress, inflammation, antioxidant depletion, and liver cells apoptosis. (springer.com)

We presently evaluated the mechanisms by which PTPN2 , a candidate gene for T1D, modulates β-cell apoptosis after exposure to type I and II interferons (IFNs), cytokines that contribute to β-cell loss in early T1D. (diabetesjournals.org)
and TNFR2, which signals cell proliferation, gene activation and apoptosis mainly in T cells. (biologists.com)
Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. (wikipedia.org)
The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. (wikipedia.org)
Orthologs of the BAX gene have been identified in most mammals for which complete genome data are available. (wikipedia.org)

To test the relevance of ADF/cofilin activity for apoptotic processes, we here employed a genetically well-defined system of mouse embryonic fibroblasts (MEFs) devoid of any ADF/cofilin activity and challenged these cells with well-characterized apoptosis inducers. (nature.com)
There was also no translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus in apoptotic keratinocytes, indicating Tan IIA-induced apoptosis occurs mainly through the caspase pathway. (hindawi.com)

However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)

Mitochondrial regulation of apoptosis further downstream was investigated, showing changes in the mitochondrial membrane potential, cytochrome c release into the cytoplasm, and enhanced activation of cleaved caspase-3 and Poly ADP-ribose polymerase (PARP). (hindawi.com)

Our data suggest that apoptosis may play a major role in the pathogenesis of influenza (H5N1) virus in humans by destroying alveolar epithelial cells. (cdc.gov)
Apoptosis has been implicated in the pathogenesis of influenza. (cdc.gov)
Further study on the mechanisms of p38MAPK in human TM cell apoptosis may help to illuminate the pathogenesis of POAG. (molvis.org)

The present study aimed to investigate the effects of S/V on the expression of metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), inflammation and apoptosis in human umbilical vein endothelial cells (HUVECs) induced by oxidized low‑density lipoprotein (ox‑LDL) and to elucidate its possible mechanism. (spandidos-publications.com)
While the cyclin-dependent kinase inhibitor AT7519 induces neutrophil apoptosis to promote inflammation resolution in preclinical models of lung inflammation, its potential efficacy in ARDS has not been examined. (bmj.com)
Overexpression of miR-128-3p or knockdown of TGFBR2 ameliorated LPS-induced inflammation and apoptosis. (degruyter.com)
Moreover, TGFBR2 was a direct target of miR-128-3p, and its overexpression reversed the inhibitory effects of miR-128-3p overexpression on inflammation and apoptosis in LPS-induced HK2 cells. (degruyter.com)
miR-128-3p could inhibit apoptosis and inflammation by targeting TGFBR2 in LPS-induced HK2 cells, which might provide therapeutic strategy for the treatment of sepsis. (degruyter.com)

The apoptosis was transduced by multiple signaling pathways mediated by FasL and TNFR2 and mainly activated the mitochondrial control of apoptosis via Bid and Bim, which was rescued by silencing Bid or/and Bim . (biomedcentral.com)

In addition, cell apoptosis was measured by double staining, DNA fragmentation and annexin V-fluorescein isothiocyanate binding assays. (ijpsonline.com)

Aresenic trioxide (ATO) is proven to be active against leukaemia cells by inducing apoptosis and differentiation. (lu.se)

Interestingly, mitochondrial association of ADF and n-cofilin during apoptosis was preceded by, and dependent on, actin that translocated by a yet unknown mechanism to mitochondria during cell death. (nature.com)
8 Recently, it was shown that n-cofilin translocates to mitochondria during the early phase of apoptosis, but the mechanism for this translocation remained obscure. (nature.com)
To investigate the mechanism by which inducers prevented apoptosis we tested the effects of protein kinase C modulators on this process. (rupress.org)
A colorectal cancer model was used to decipher the molecular mechanism of BF-rTK + GCV (bifidobacterial recombination thymidine kinase/ganciclovir) using a human apoptosis antibody array kit in a murine cancer model in vivo . (biomedcentral.com)
Another major part of the research work performed in my laboratory has to do with cancer and the understanding of the mechanism of apoptosis. (csuohio.edu)
A potential mechanism for the role of calcium in prostate cancer development and progression is that intracellular calcium controls the growth of prostate cancer cells and the process of apoptosis (9). (cdc.gov)

C1QBP knockdown and overexpression cells were established via lentiviral infection and subjected to apoptosis and ROS assay in vitro . (medsci.org)
The aim of the present investigation was to elucidate the cellular mechanisms whereby Tanshinone IIA (Tan IIA) leads to cell cycle arrest and apoptosis in vitro in keratinocytes, the target cells in psoriasis. (hindawi.com)
We found that when embryonic mesenchyme was induced in vitro and in vivo, many of the cells surrounding the new epithelium showed morphological evidence of programmed cell death (apoptosis) such as condensed nuclei, fragmented cytoplasm, and cell shrinking. (rupress.org)
Therefore, the current study used integrated in vitro and in silico approaches to figure out Amy and Sor's possible synergistic activity in targeting AMPK/mTOR and BCL-2 for anti-angiogenesis and apoptosis cell death in HepG2 cells. (biomedcentral.com)
However, one pitfall observed throughout the years in in vitro and in in a multitude of human trials in vivo , is the resistance of cancer cell lines to hTRAIL-induced apoptosis. (csuohio.edu)

KEGG enrichment analysis showed that FO mainly regulates PI3K-AKT- and apoptosis-related signals, in which BBC3, DDIT3, NOXA, and CDKN1A on the surface serve as the novel targets of FO inducing HCC cell apoptosis. (hindawi.com)
miR-127-5p regulates FAIM2-mediated cell apoptosis and participates in cerebral ischemia-reperfusion injury. (bvsalud.org)

PTPN2 knockdown exacerbated type I IFN-induced apoptosis in INS-1E, primary rat, and human β-cells. (diabetesjournals.org)
Of note, both Bim and JNK1 knockdown protected β-cells against IFN-induced apoptosis in PTPN2-silenced cells. (diabetesjournals.org)
Cell apoptosis was weakened after miR-127-5p knockdown, and tissue infarction in animal models was also reduced. (bvsalud.org)
silencing FAIM2 enhanced apoptosis after miR-127-5p knockdown. (bvsalud.org)

4 Although the mechanisms of caspase activation in the cytosol are well characterized, the steps that control cytochrome c release from mitochondria and thereby activate the apoptosis program have remained largely elusive. (nature.com)

To elucidate the general importance of ADF/cofilin activity for apoptosis, we exposed mouse embryonic fibroblasts deficient for n-cofilin, ADF (actin depolymerizing factor), or all ADF/cofilin isoforms to well-characterized apoptosis inducers. (nature.com)

N- trans -Feruloyloctopamine (FO) is the extract of garlic skin, which possesses high antioxidant activity and selectively induces cell apoptosis in leukemia tumors [ 6 ]. (hindawi.com)

The tumor tissues were analyzed using apoptosis antibody arrays, real time PCR and western blot. (biomedcentral.com)

However, oxidative stress could play salient role in the observed cellular and genetic toxicity and apoptosis-like effects which could be abrogated by antioxidant vitamins and flavonoids, including vitamin E, quercetin, kolaviron, myricetin and bioactive extractives with antioxidant effects. (frontiersin.org)

Neuronal apoptosis plays an essential role in early brain development and contributes to secondary neuronal loss after acute brain injury. (jneurosci.org)

In the present study, we evaluated the role of the intrinsic pathway in neuronal apoptosis at different stages of rat brain development and during maturation of primary cortical neurons in vivo as well as in response to brain injury. (jneurosci.org)

ASCO2020) Ascentage Pharma Presents Latest Clinical Data. (pharmiweb.com)
Through the showcase at ASCO, Ascentage Pharma is demonstrating its capabilities of global clinical development in apoptosis. (pharmiweb.com)
The apoptosis in health and disease clinical and therapeutic aspects, Even, which shows of already local a l in reputable request, were driven for moving those new projections of Girgenti and Syracuse, of which the strata 'm us upward to a geological present in solid wine. (singlewheel.com)
Clinical scores, histopathologic severity, macrophage apoptosis and depletion, and T cell subset development were evaluated. (nih.gov)
The clinical data were compared respectively, and univariate and multivariate Logistic regression analysis was performed. (bvsalud.org)
This report summarizes the epidemiology of human papillomavirus (HPV) and associated diseases, describes the licensed HPV vaccines, provides updated data from clinical trials and postlicensure safety studies, and compiles recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) for use of HPV vaccines. (cdc.gov)

Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. (hindawi.com)
Among other results, they show that TNFR2-mediated apoptosis is blocked by caspase-8 inhibitors and depends on Fas-associated protein with death domain (FADD) but does not require simultaneous activation of TNFR1. (biologists.com)
This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert -butyl hydroperoxide ( t BHP)-induced apoptosis of human trabecular meshwork (iHTM) cells. (molvis.org)

This study provides results of early diminished platelet function in IBS-treated PCs as compared to conventional PCs, i.e., reduced aggregation response to collagen or thrombin and adhesion to collagen or vWF under flow, increased platelet apoptosis, MAPK p38 activation, and glycoprotein Ibα (GPIbα) shedding and enhanced clearance from the circulation of mice. (haematologica.org)
We report that necroptosis, autophagy, NF-ƘB and MAPK signalling pathway are not involved in ATO-induced apoptosis. (lu.se)

Following cecal ligation and puncture (CLP) in rats, thymocytes underwent apoptosis in a time-dependent manner. (jci.org)

These findings indicated that Solanum nigrum extract induced cell death in MDA-MB-468 cells by two distinct mechanisms, apoptosis and autophagy, and these findings further suggest a possibility that this extract could be used to treat triple negative breast cancer. (ijpsonline.com)

Data for: Berberis hispanica alkaloids extract induced cell death and apoptosis in human laryngeal cancer cells Hep-2. (mendeley.com)

APG-115 is a highly potent MDM2-p53 inhibitor, and our data on liposarcoma presented in last year's ASCO report were promising," said Prof. Xing Zhang, Chief Physician of Melanoma and Sarcoma Medical Oncology Unit of Sun Yat-sen University Cancer Center. (pharmiweb.com)
Drugs that activate BAX, such as ABT-737, a BH3 mimetic, hold promise as anticancer treatments by inducing apoptosis in cancer cells. (wikipedia.org)
Silibinin considerably reduced the development of oral cancer cells by inducing apoptosis, G 0 /G 1 arrest, ROS generation, and activation of the JNK/c-Jun pathway. (jcancer.org)
We have recently demonstrated convincingly in melanoma and triple negative breast cancer cell lines that recombinant (r) hTRAIL together with several natural compounds (Quercetin, Silibinin, Ursolic Acid) are efficient in inducing apoptosis in previously described TRAIL-resistant cancer cell lines. (csuohio.edu)
Thus, by using natural non-harmful substances and rhTRAIL, under the conditions established, only cancer cells will undergo apoptosis while normal cells will not be affected. (csuohio.edu)
These data demonstrate that cancer cells can acquire the ATO-resistance ability by increasing the Bcl-2 expression. (lu.se)
Data on the effects of calcium intake on prostate cancer are inconsistent. (cdc.gov)
We used data from an ongoing case-control study of veterans screened for prostate cancer at the Durham Veterans Affairs Medical Center (DVAMC) in Durham, North Carolina. (cdc.gov)
In addition to oral lesions, smokeless tobacco users are at increased risk for stomach and pancreatic cancers, although the data regarding the risks for pancreatic cancer are mixed, with some studies showing a statistical association. (medscape.com)

Meanwhile, excessive apoptosis in such conditions as ischemia reperfusion injury and amyotrophic lateral sclerosis may benefit from drug inhibitors of BAX. (wikipedia.org)
Now we have strong data with GLP-1 receptor agonists, SGLT2 inhibitors, and pioglitazone that they are cardioprotective. (medscape.com)
From the standpoint of renal disease, we also now have very strong data with the SGLT2 inhibitors, emerging data from the GLP-1 receptor agonists, and a new class of drugs that don't lower glucose, but finerenone, which is effective in providing protection against cardiovascular disease and renal disease. (medscape.com)

BF-rTK + GCV induced tumor apoptosis mediated by FasL and TNFR2 through the mitochondrial control of apoptosis via Bid and Bim without inducing necroptosis and autophagy. (biomedcentral.com)

A previous study reported that the extract of the whole plant of SN activated cell death in hepatoma cells through autophagy and apoptosis [ 7 ]. (ijpsonline.com)
Autophagy and apoptosis are two forms of programmed cell death, which are essential for cellular homeostasis. (ijpsonline.com)
The results suggested that BF-rTK + GCV induced tumor apoptosis without autophagy and necroptosis occurrence. (biomedcentral.com)

A substantial synergistic interaction between Amy and Sor was observed (CI 50 = 0.56), which was connected to cell cycle arrest at the S and G2/M stages and increased apoptosis and potential necroptosis. (biomedcentral.com)

Recent studies reported a mitochondrial translocation of n-cofilin during apoptosis. (nature.com)

Cell apoptosis was analyzed by Hoechst 33258 staining and annexin V-PI labeling. (molvis.org)
C5a blockade dramatically reduced thymocyte apoptosis as measured by thymic weight, binding of annexin V to thymocytes, and laddering of thymocyte DNA. (jci.org)

Therefore, The present study investigates whether RF-EMR at a frequency of 900 MHz can trigger sperm cell apoptosis and affect semen morphology, concentration, and microstructure. (biomedcentral.com)

The initial data with our drug candidates, including MDM2-p53 inhibitor APG-115, novel Bcl-2/Bcl-xL dual inhibitor palcitoclax or APG-1252, and IAP inhibitor APG-1387, support further study with great potential in combination therapies," said Dr. Dajun Yang, Chairman & CEO of Ascentage Pharma. (pharmiweb.com)
Apoptosis was partially blocked by the caspase-3 inhibitor Ac-DEVD-CHO. (hindawi.com)

When C5a was generated in vivo by infusion of purified cobra venom factor (CVF), thymocyte apoptosis was significantly increased. (jci.org)

Both in vivo near-infrared imaging of caspase activity and TUNEL staining demonstrated that TRA-8 rapidly induced apoptosis of macrophages in inflamed synovium. (nih.gov)

These data suggest that CLL may derive from normal B cells whose function is to remove cellular debris, and also to provide a first line of defense against pathogens. (nih.gov)

C1QBP promotes the catabolism of hypoxanthine and elevates the apoptosis of RCC cells by modulating XDH-mediated ROS generation. (medsci.org)

ATZ also induces morphological changes similar to apoptosis and initiates mitochondria-dependent cell death in several experimental models. (frontiersin.org)
Apoptosis is a genetically controlled cell death that was initially recognized for its role in development. (jneurosci.org)

The result implied that FO might exacerbate HCC cell apoptosis by regulating BBC3, DDIT3, CDKN1A, and NOXA signals. (hindawi.com)

Multiorgan apoptosis occurs during sepsis. (jci.org)
These data suggest that systemic activation of complement induces C5a-dependent apoptosis of thymocytes and that the blockade of C5a during sepsis rescues thymocytes from apoptosis. (jci.org)

Anatomy31

Organisms9

Diseases12

Chemicals and Drugs134

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes51

Disciplines and Occupations1

Information Science3

Induces apoptosis3

Induce7

Reactive oxygen2

Induction10

Signaling pathway2

Cytotoxicity3

Inhibits1

Flow cytometry3

Proliferation and apoptosis2

Caspase-3 activation2

Oxidative stress induced1

Proteins4

Genes3

Cells apoptosis2

Gene5

Apoptotic2

Tumor cell1

Mitochondrial membrane potential1

Pathogenesis3

Inflammation5

Pathways1

Assays1

Differentiation1

Mechanism6

Vitro5

Regulates2

Knockdown4

Cytochrome1

Inducers1

Tumors1

Western blot1

Antioxidant1

Acute1

Intrinsic1

Clinical6

Protein3

MAPK2

Time-dependent manner1

Mechanisms1

Extract induced1

Cancer9

Inhibitors3

TNFR21

Autophagy3

Necroptosis1

Translocation1

Annexin2

Morphology1

Inhibitor2

Significantly increased1

Vivo1

Cellular1

Promotes1

Cell death2

NOXA1

Sepsis2