• gluten-free
  • Because dapsone can cause some serious side effects, your physician may start you on a small dose and ramp that dosage up over time if needed as your symptoms begin to subside and as you get the hang of the gluten-free diet. (verywell.com)
  • If you can't tolerate dapsone or if it doesn't work for you, there are very few effective drug alternatives that might offer some relief while you're waiting for your gluten-free diet to take effect. (verywell.com)
  • sulfone
  • in cooperation with J. Wittmann, Emil Fromm synthesised various sulfone compounds in 1908, including both dapsone and some of its derivatives, such as promin. (wikipedia.org)
  • Rifampin
  • In bacteriologically negative tuberculoid and indeterminate disease, the recommendation is the coadministration of Dapsone 100 mg daily with six months of Rifampin 600 mg daily. (rxlist.com)
  • In lepromatous and borderline lepromatous patients, the recommendation is the co-administration of Dapsone 100 mg daily with two years of Rifampin 600 mg daily. (rxlist.com)
  • Rifampin is additionally recommended to reduce the incidence of dapsone resistance. (drugs.com)
  • hemolysis
  • A case of hemolysis in a neonate from dapsone in breast milk has been reported. (wikipedia.org)
  • Some subjects with G6PD deficiency using Dapsone Gel developed laboratory changes suggestive of hemolysis. (drugs.com)
  • There was no evidence of clinically relevant hemolysis or anemia in patients treated with Dapsone Gel, 5%, including patients who were G6PD deficient. (drugs.com)
  • relapses
  • Secondary Dapsone resistance should be suspected whenever a lepromatous or borderline lepromatous patient receiving Dapsone treatment relapses clinically and bacteriologically, solid staining bacilli being found in the smears taken from the new active lesions. (rxlist.com)
  • dosage
  • In the multidrug program Dapsone should be maintained at the full dosage of 100 mg daily without interruption (with corresponding smaller doses for children) and provided to all patients who have sensitive organisms with new or recrudescent disease or who have not yet completed a two year course of Dapsone monotherapy. (rxlist.com)
  • erythema
  • Dapsone is the recommended treatment for erythema elevatum diutinum, as a review found that using oral dapsone alone was effective in 80% of early cases of the disease. (wikipedia.org)
  • Combined contact sensitization/irritation studies with Dapsone Gel, 5%, in 253 healthy subjects resulted in at least 3 subjects with moderate erythema. (drugs.com)
  • dose
  • Therefore, separate your dose of dapsone from your doses of any of these products by at least 2 hours. (medicinenet.com)
  • Ask your doctor or pharmacist for more details.If you are taking dapsone for a skin disorder, your doctor may start you on a low dose of dapsone and gradually adjust your dose to control your disease. (medicinenet.com)
  • Male Wistar rats were treated with L-arginine at 5, 15, 30, 60 and 180 mg/kg doses (p.o., gavage) in single or multiple dose regimens 2 hours prior to dapsone administration (40 mg/kg, i.p. (scielo.br)
  • rash
  • Contact your doctor immediately if you develop a rash while taking dapsone. (rxlist.com)
  • Seek immediate medical attention if you develop signs of an infection (e.g., fever , chills , persistent sore throat ), easy bruising/bleeding, unusual tiredness , pale skin , yellowing eyes/skin, dark urine , stomach/ abdominal pain .Dapsone can commonly cause a rash that is usually not serious. (medicinenet.com)
  • If you develop any unusual rash while taking dapsone, talk to your doctor immediately. (verywell.com)
  • If there are signs of this rash being infected then you may well need the Dapsone. (drugs.com)
  • dermal
  • Dapsone Gel, 5%, did not induce phototoxicity or photoallergy in human dermal safety studies. (drugs.com)
  • Prophylaxis
  • The addition of pyrimethamine appears to significantly increase the activity of dapsone for PCP prophylaxis. (drugs.com)
  • If unfamiliar with prescribing dapsone for prophylaxis, the oncologist was not alone. (ahrq.gov)
  • treatment
  • If there is no improvement after 12 weeks, treatment with Dapsone Gel, 5%, should be reassessed. (drugs.com)
  • Peripheral neuropathy (motor loss and muscle weakness) has been reported with oral dapsone treatment. (drugs.com)
  • The effect of the nitric oxide synthase inhibitor L-NAME was investigated by treatment with multiple doses of 30 mg/kg (p.o., gavage) 2 hours before dapsone administration. (scielo.br)
  • Initially, Promin appeared to be safer than dapsone, so it was further investigated at the Mayo Clinic as a treatment for tuberculosis in a guinea pig model. (wikipedia.org)
  • resistance
  • If such cases show no response to regular and supervised Dapsone therapy within three to six months or good compliance for the past 3-6 months can be assured, Dapsone resistance should be considered confirmed clinically. (rxlist.com)
  • acne
  • After the skin is gently washed and patted dry, apply approximately a pea-sized amount of Dapsone Gel, 5%, in a thin layer to the acne affected areas twice daily. (drugs.com)
  • therapy
  • Abnormalities in white blood cell formation, including aplastic anemia, are rare, yet are the cause of the majority of deaths attributable to dapsone therapy. (wikipedia.org)
  • Therapy with dapsone alone is now strongly contraindicated. (wikipedia.org)
  • side
  • However, dapsone can potentially cause severe side effects, meaning that sometimes steroids or other antibiotics should be used instead, although these alternative treatments are much less effective. (wikipedia.org)
  • See the full dapsone side effects document. (drugs.com)
  • When prescribing dapsone , add cimetidine "to help avoid some of the side effects of dapsone ," Dr. (thefreedictionary.com)
  • compound
  • Beyond its solubility, however, promin was later found to have no real advantages over the simpler compound dapsone (which is administered in tablet form). (wikipedia.org)
  • reactions
  • In addition, rare cases have been reported in which dapsone was associated with serious and potentially fatal skin reactions. (verywell.com)
  • patients
  • Then Dapsone should be continued for an additional three years for tuberculoid and indeterminate patients and for five years for borderline tuberculoid patients. (rxlist.com)
  • Dapsone should then be continued for an additional 10 years for borderline patients and for life for lepromatous patients. (rxlist.com)
  • Advise patients to discontinue Dapsone Gel, 5% and seek immediate medical attention in the event of cyanosis. (drugs.com)
  • Psychosis was reported in 2 of 2372 patients treated with Dapsone Gel, 5%, and in 0 of 1660 patients treated with vehicle. (drugs.com)
  • Dapsone Gel, 5%, was evaluated for 12 weeks in four controlled studies for local cutaneous events in 1819 patients. (drugs.com)
  • All patients on dapsone see some reduction in their hemoglobin, the part of red blood cells that carries oxygen. (verywell.com)
  • A very few patients also develop liver problems while taking dapsone. (verywell.com)
  • The patients were randomized to receive either Dapsone or placebo. (clinicaltrials.gov)
  • liver
  • In rare cases, dapsone has been associated with serious, and sometimes fatal blood and/or liver problems. (rxlist.com)
  • While taking the Dapsone, you will want to have regular blood work done to check for liver function. (drugs.com)
  • clinical
  • The Dapsone is continued until all signs of clinical activity are controlled - usually after an additional six months. (rxlist.com)
  • Dapsone 100 mg daily is continued 3-10 years until all signs of clinical activity are controlled with skin scrapings and biopsies negative for one year. (rxlist.com)