• Several radioactive substances are considered carcinogens, but their carcinogenic activity is attributed to the radiation, for example gamma rays and alpha particles, which they emit. (wikipedia.org)
  • In many of these cases, we don't know what's caused but we hope now, that if we can experimentally reproduce these patterns by taking some of the chemical carcinogens that we know or suspect of being carcinogenic, and seeing what type of patterns they produce across the whole genome in a test system, we may be able to identify the actual causative agent in more cases of human cancer. (thenakedscientists.com)
  • Chemical carcinogens that reach contribute to carcinogenic effects in when organogenesis starts. (who.int)
  • Low-level ionizing radiation may induce irreparable DNA damage (leading to replicational and transcriptional errors needed for neoplasia or may trigger viral interactions) leading to pre-mature aging and cancer. (wikipedia.org)
  • We identified targeted metabolites (probable carcinogens) such as 3-monochloropropane-1,2-diol (3-MCPD) and glycidyl ester (GE), indicating the conversion of 3-MCPD to GE in repeatedly heated oils based on PCA and OPLSDA models. (imperial.ac.uk)
  • That segment of the population exposed to physical and/or chemical agents or other workplace hazards that may damage the human body in any way. (cdc.gov)
  • ATSDR comparison values represent chemical concentrations many times lower than levels at which no effects were observed in experimental animal or human epidemiologic studies. (cdc.gov)
  • Kat - So, you're going to take human cells, you take the chemical, you chuck it on it, then you look in the DNA and say, "Oh! (thenakedscientists.com)
  • The chemical compound that has saved more human lives than any other in history, DDT, was banned by order of one man, the head of the U.S. Environmental Protection Agency (EPA). (akdart.com)
  • At least in experimental animals, genetical y modified strains, because on the differential effects of a wide greater susceptibility to chemical in these species the interval between variety of carcinogens in humans at carcinogens in utero and during birth and sexual maturity is only a different stages of life, including var early postnatal life is usual y man few weeks. (who.int)
  • Therefore, the types of ious forms of radiation, carcinogen ifested as a higher incidence of the tumours that occur during childhood ic infectious agents, and chemicals same kinds of tumours that occur in in humans, including various embry and chemical mixtures. (who.int)
  • Thus, chemical carcinogen. (who.int)
  • CERCLA identifies all radionuclides as carcinogens, although the nature of the emitted radiation (alpha, beta, gamma, or neutron and the radioactive strength), its consequent capacity to cause ionization in tissues, and the magnitude of radiation exposure, determine the potential hazard. (wikipedia.org)
  • So we conducted a meta-analysis, and to explore the influence of low concentration benzene exposure on workers' genetic damage indicators using 3.25 mg/m 3 as the boundary value, in order to provide a basis for improved prevention and control of the harm from benzene exposure to the occupational population. (biomedcentral.com)
  • Occupational benzene exposure can affect multiple genetic damage indicators. (biomedcentral.com)
  • This chapter exposed adults, with a shorter laten onal solid tumours, are observed as summarizes the literature that docu cy period from the time of exposure tumours of adult life in conventional ments this high susceptibility of the to the carcinogen until the appear rodents. (who.int)
  • Studies in experimental incidence and multiplicity of tumours to Wilms tumour in humans - in the animals increase and the latency period de adult rat after perinatal exposure to a creases with increasing dose. (who.int)
  • Most experimental studies of the predominant results of earlylife do not develop in rats exposed to the carcinogenesis during prenatal life exposure are what would be expect same carcinogen during adult life and infancy have been conducted ed from a higher effective dose to the (Diwan and Rice, 1995 ). (who.int)
  • NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
  • Repeated low exposures can cause permanent kidney damage that may go unnoticed. (dcceew.gov.au)
  • High exposures can cause rapid lung damage, shortness of breath, chest pain, and a build up of fluid in the lungs. (dcceew.gov.au)
  • Water pollution is any contamination of water with chemicals or other hazardous substances that are detrimental to human, animal, or plant health. (nih.gov)
  • Kat - "Carcinogen" is a word you might hear in the media, but it basically means "something that causes cancer", and usually refers to things such as chemicals in our environment or food, or even things like UV radiation from the sun and sunbeds or ionising radiation such as X-rays. (thenakedscientists.com)
  • In the meantime, we've identified a lot of other environmental carcinogens, i.e. chemicals to which we're exposed environmentally which at least have the potential to cause cancer. (thenakedscientists.com)
  • In the last year or so, work at the Sanger Institute in Cambridge has sequenced more around 7,000 different human tumours. (thenakedscientists.com)
  • which may render the genetic mate doses of NDMA is the kidney, but a Transplacental carcinogenesis rial of fetal cells highly accessible to much lower incidence of tumours is stu dies with ENU in nonhuman pri carcinogens. (who.int)
  • There is evidence of it causing prostate and kidney cancer in humans, it has been shown to cause lung and testicle cancer in animals. (dcceew.gov.au)
  • In severe cases death or permanent lung damage occurs. (dcceew.gov.au)
  • Common examples of non-radioactive carcinogens are inhaled asbestos, certain dioxins, and tobacco smoke. (wikipedia.org)
  • Examples of activation-dependent carcinogens[verification needed] range from certain viruses, such as HPV, to consumed alcohol, to excessive amounts of red and processed meats, impacting a person's health in ways they may not immediately associate with cancer. (wikipedia.org)
  • As far back as the 1930s, industrial smoke and tobacco smoke were identified as sources of dozens of carcinogens, including benzo[a]pyrene, tobacco-specific nitrosamines such as nitrosonornicotine, and reactive aldehydes such as formaldehyde, which is also a hazard in embalming and making plastics. (wikipedia.org)
  • A carcinogen (/kɑːrˈsɪnədʒən/) is any substance, radionuclide, or radiation that promotes carcinogenesis (the formation of cancer). (wikipedia.org)
  • Carcinogens are agents in the environment capable of contributing to cancer growth. (wikipedia.org)
  • Carcinogens can be categorized into two different types: activation-dependent and activation-independent, and each nature impacts their level and type of influence when it comes to promoting cancer growth. (wikipedia.org)
  • Activation-dependent carcinogens require metabolic activation or modification to induce cancer, while activation-independents ones do not. (wikipedia.org)
  • Certain viruses such as hepatitis B and human papilloma virus have been found to cause cancer in humans. (wikipedia.org)
  • Other infectious organisms which cause cancer in humans include some bacteria (e.g. (wikipedia.org)
  • The International Agency of Research on Cancer has classified benzene as a Group I carcinogen. (biomedcentral.com)
  • To find out more about these damaging agents, and how researchers are figuring out exactly how they cause cancer, I spoke to one of the UK's leading experts - David Phillips, professor of environmental carcinogenesis at Kings College London. (thenakedscientists.com)
  • These increases are correlated with the decay in residual environmental DDT concentrations and growing human populations, but not with temperature. (akdart.com)
  • The National Institute of Environmental Health Sciences (NIEHS) is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere. (nih.gov)
  • These changes can be inherited or can accrue from damage caused by environmental factors. (healthandenvironment.org)
  • Aspergillus -derived mycotoxins, including aflatoxins and ochratoxin A, and fumonisins (members of the fusariotoxin group) can cause pathological damage to vital organs, including the kidney or liver. (frontiersin.org)
  • It is also a teratogen, and may cause reproductive damage. (dcceew.gov.au)
  • To improve the reliability and valid- that may contribute to addiction and respiratory damage (5,6). (cdc.gov)
  • The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • David - Well, there are signatures because when the DNA is damaged, that can lead to errors of replication, when the cell divides and replicates its DNA. (thenakedscientists.com)
  • The National Institutes of Health has classified 54 compounds as known human carcinogens based on studies indicating they cause at least one type of cancer in people, according to the nation's 11th Report on Carcinogens. (scientificamerican.com)
  • The U.S. Department of Health and Human Services today added eight substances to its Report on Carcinogens, a science-based document that identifies chemicals and biological agents that may put people at increased risk for cancer. (nih.gov)
  • With these additions, the 12th Report on Carcinogens now includes 240 listings. (nih.gov)
  • Reducing exposure to cancer-causing agents is something we all want, and the Report on Carcinogens provides important information on substances that pose a cancer risk," said Linda Birnbaum, Ph.D., director of both the National Institute of Environmental Health Sciences (NIEHS) and the National Toxicology Program (NTP). (nih.gov)
  • The Report on Carcinogens is a congressionally mandated document that is prepared for the HHS Secretary by the NTP. (nih.gov)
  • A listing in the Report on Carcinogens does not by itself mean that a substance will cause cancer. (nih.gov)
  • The strength of this report lies in the rigorous scientific review process," said Ruth Lunn, Dr.P.H., director of the NTP Office of the Report on Carcinogens. (nih.gov)
  • A detailed description of each substance listed in the Report on Carcinogens is included in the new report. (nih.gov)
  • Formaldehyde was first listed in the 2nd Report on Carcinogens as a substance that was reasonably anticipated to be a human carcinogen, after laboratory studies showed it caused nasal cancer in rats. (nih.gov)
  • CERCLA identifies all radionuclides as carcinogens, although the nature of the emitted radiation (alpha, beta, gamma, or neutron and the radioactive strength), its consequent capacity to cause ionization in tissues, and the magnitude of radiation exposure, determine the potential hazard. (wikipedia.org)
  • It has been known for several years that exposure to some xenohormones increases the production of reactive oxygen species, which in turn could inflict structural damage to cell DNA of target organs, as well as to DNA from other systemic cells [4, 5]. (researchgate.net)
  • On the other hand, it has been reported that exposure to some xenoestrogens and to estrogenic metabolites promotes the production of free radicals through the hydrogen peroxide (H 2 O 2 ) reduction cycle, by means of the P 450 oxidase and reductase enzymes, giving origin to the production of oxygen reactive species which might damage the genetic material [33]. (researchgate.net)
  • [ 34 ] Inherited genomic biomarkers measure genetic propensity to carcinogen exposure (e.g. predisposition to tobacco addiction) or to a cancer-predisposing state (e.g. obesity). (medscape.com)
  • Inherited genotypes influence physiological states, which, in turn, can modify the cancer risk itself or the propensity to exposure to specific carcinogens. (medscape.com)
  • The probability of an exposure leading to somatic DNA damage, [ 44 ] early tissue changes or preneoplastic lesions might vary according to genotype. (medscape.com)
  • SUMMARY AND CONCLUSIONS 1.1 Identity, physical and chemical properties, analytical methods 1.2 Sources of human exposure 1.3 Environmental transport, distribution and transformation 1.4 Environmental levels and human exposure 1.5 Kinetics and metabolism 1.6 Effects on laboratory mammals and in vitro test systems 1.6.1 Systemic toxicity 1.6.2 Genotoxicity and carcinogenicity 1.6.3 Reproductive toxicity, embryotoxicity and teratogenicity 1.6.4 Immunotoxicity 1.7 Effects on humans 1.8 Conclusions 2. (inchem.org)
  • SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE 3.1 Natural occurrence 3.2 Anthropogenic sources 3.2.1 Production levels and processes 3.2.2 Uses 4. (inchem.org)
  • ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 5.1 Environmental levels 5.1.1 Air 5.1.2 Water 5.1.3 Soil and sediments 5.1.4 Food 5.2 General population exposure 5.3 Occupational exposure during manufacture, formulation or use 6. (inchem.org)
  • KINETICS AND METABOLISM IN LABORATORY ANIMALS AND HUMANS 6.1 Absorption 6.1.1 Air 6.1.2 Oral 6.1.3 Dermal 6.2 Distribution 6.2.1 Inhalation exposure 6.2.2 Oral and dermal exposures 6.3 Metabolic transformation 6.4 Elimination and excretion 6.4.1 Inhalation exposure 6.4.2 Oral exposure 6.4.3 Dermal exposure 6.5 Retention and turnover 6.6 Reaction with body components 6.7 Modelling of pharmacokinetic data for benzene 7. (inchem.org)
  • Once you have exposure to UV rays the damage starts. (uwrfvoice.com)
  • Measures can then be taken to prevent or effectively reduce the exposure of human beings to these agents. (ubc.ca)
  • Previously, the extent of DNA repair (autoradiographic detection of unscheduled ³HTdR incorporation) in hamster and human cells following exposure to strongly, weakly and non-oncogenic isomers and derivatives of 4-nitroquinoline 1-oxide (4NQO) was examined. (ubc.ca)
  • As a probe into possible variations in sensitivity within the human population towards chemical carcinogens, cells from Xeroderma pigmentosum patients (known to be deficient in correcting UV-induced DNA damage) and normal persons were examined for their DNA repair capacity, frequency of chromosome aberrations and clone forming efficiency following exposure to chemical carcinogens. (ubc.ca)
  • The human health assessment for Benzidine-based Dyes and Related Substances focuses on substances that are in commerce (based on information received in response to the section 71 survey) and/or for which available information indicates potential exposure to the general population of Canada: 3,3'-DMB and Acid Red 97. (gc.ca)
  • Some human acute intoxications related to selenium exposure involve accidental or suicidal ingestion of products containing selenium, such as metal gun bluing agent (metal polisher). (canada.ca)
  • Whether chronic arsenic exposure in humans causes oxidative stress is less certain. (biomedcentral.com)
  • There is now sufficient evidence from studies in humans to show that individuals with higher measures of exposure to formaldehyde are at increased risk for certain types of rare cancers, including nasopharyngeal (the nasopharnyx is the upper part of the throat behind the nose), sinonasal, as well as a specific cancer of the white blood cells known as myeloid leukemia. (nih.gov)
  • The results of the current study provide further insights into differences in carcinogen metabolism among individuals possessing the NAT1*14B haplotype. (nih.gov)
  • Genetic factors can modify the efficiency of metabolism of specific carcinogens and the likelihood of biologically effective doses, or influence the rate of preneoplastic tissue change. (medscape.com)
  • Genetic variation influences both of these stages in the metabolism of carcinogens. (medscape.com)
  • Evidence already exists that nutrients may alter prostate cancer risk and tumor cell behavior by influencing hormonal regulation, cell signaling, cell cycle control, apoptosis, differentiation, and carcinogen metabolism. (nih.gov)
  • Activation-dependent carcinogens require metabolic activation or modification to induce cancer, while activation-independents ones do not. (wikipedia.org)
  • This includes 29 directly active proximate or ultimate carcinogens, 15 precarcinogens, that require metabolic activation, 16 non-oncogenic compounds and 4 chemicals of unknown carcinogenicity. (ubc.ca)
  • Dr. Nelson's laboratory has discovered the most common known somatic genome alteration in human prostatic carcinoma cells. (hopkinsmedicine.org)
  • The DNA lesion-hypermethylation of deoxycytidine nucleotides in the promoter of a carcinogen-defense enzyme gene-appears to inactivate the gene, making prostatic cells more vulnerable to carcinogens. (hopkinsmedicine.org)
  • This phytochemical has been shown to inhibit the growth of LNCaP human prostatic cancer cells in culture (IC50 = 50 ?M). It also has been shown to reduce one of the most fundamental biomarkers for prostate cancer, PSA, as well as modulate other proliferation and cell cycle related factors including PCNA, p21 (WAF1) and p27 (Kip1). (nih.gov)
  • PCBs are reasonably anticipated to be human carcinogen (NTP 2002). (ewg.org)
  • Six other substances - captafol, cobalt-tungsten carbide (in powder or hard metal form), certain inhalable glass wool fibers, o-nitrotoluene, riddelliine, and styrene - are added as substances that are reasonably anticipated to be human carcinogens. (nih.gov)
  • Several radioactive substances are considered carcinogens, but their carcinogenic activity is attributed to the radiation, for example gamma rays and alpha particles, which they emit. (wikipedia.org)
  • Carcinogens are substances capable of causing cancer. (uwrfvoice.com)
  • The report identifies agents, substances, mixtures, or exposures in two categories: known to be a human carcinogen and reasonably anticipated to be a human carcinogen. (nih.gov)
  • DNA-damaging agents activate several signal-transduction pathways in damaged cells, which trigger cell-fate decisions such as proliferation, genomic repair, differentiation and death. (hopkinsmedicine.org)
  • Current studies are directed at further characterizing the genomic abnormality and developing methods to restore expression of epigenetically silenced genes and/or to augment expression of other carcinogen-defense enzymes in prostate cells as prostate cancer prevention strategies. (hopkinsmedicine.org)
  • The pesticide DDT and the food colorant Red No. 3 were found to increase the growth of HTB 133 but not estrogen receptor (ER) negative human breast cells (HTB 125) or rat liver epithelial cells (RLE). (researchgate.net)
  • Site-specific DNA binding by p53 in RLE, HTB 125, HTB 133, and MCF-7 cells was increased when they were treated with Red No. 3, which suggests that cellular DNA was damaged by this colorant. (researchgate.net)
  • In the current study, we used Chinese hamster ovary (CHO) cells stably transfected with human NAT1*4 (reference allele) or NAT1*14B (variant allele) to measure AcCoA kinetic parameters for N -acetyltransferase activity measurements towards p -aminobenzoic acid (PABA), 4-aminobiphenyl (4-ABP), β-naphthylamine (BNA), benzidine and 3,4-dimethylaniline (3,4-DMA). (nih.gov)
  • In normal cells, failure of a DNA-damaging agent (i.e., a carcinogen) to activate processes culminating in DNA repair or cell death might promote neoplastic transformation. (hopkinsmedicine.org)
  • In cancer cells, failure of a DNA-damaging agent (i.e., an antineoplastic drug) to promote differentiation or cell death might undermine cancer treatment. (hopkinsmedicine.org)
  • In this project, we will test a conceptually novel hypothesis that Ni(II) disrupts a unique biochemical process and the resulting metabolic dysfunction causes gross genetic alterations and cancerous transformation of human lung cells. (nih.gov)
  • The results suggest the suitability of using DNA repair synthesis as endpoint, and cultured human cells as subjects in a prescreening programme for chemical carcinogens. (ubc.ca)
  • The XP cells show a considerably reduced DNA repair synthesis when exposed to some but not all chemical carcinogens. (ubc.ca)
  • Penicillin ranks pretty darn low on the drug toxicity scale for humans, but it kills off guinea pigs like you wouldn't believe. (drugsandpoisons.com)
  • Non-protein sulfhydrl groups such as glutathione in serum, which act as nucleophilic scavengers and protect against oxidative damage, were also inversely correlated with mean serum arsenic levels. (biomedcentral.com)
  • The genotoxic action of contaminating agents affects human health directly, damaging the genetic material, which is considered to play an important role in oncogenesis [6,7]. (researchgate.net)
  • The genotoxicity of some environmental contaminants may affect human health directly by damaging genetic material and thus plays an important role in cancer development. (researchgate.net)
  • Despite this dependence of cancer development on multiple genetic events, many human lung carcinogens are tested as nonmutagenic in standard assays. (nih.gov)
  • Carcinogens are metabolized to activated intermediates, which might form DNA adducts or be further metabolized to hydrophilic compounds and excreted. (medscape.com)
  • In the present study, 64 compounds representing key groups of carcinogens of different molecular structures were examined for the capacity to evoke an unscheduled DNA synthesis in cultured human fibroblasts. (ubc.ca)
  • All directly acting carcinogens triggered a DNA repair synthesis, whereas no unscheduled ³HTdR incorporation was observed following the application of the 16 non-oncogenic compounds. (ubc.ca)
  • This disarrangement is also responsible for the formation of DNA adducts, segments of DNA which bind to carcinogens, which furthers harm. (wikipedia.org)
  • Most, if not all, chemical carcinogens bind to DNA, Furthermore, almost all DNA-damaging agents, whether physical or chemical, that have been investigated in the proper test system show evidence of a repair effect. (ubc.ca)
  • Carcinogens can be categorized into two different types: activation-dependent and activation-independent, and each nature impacts their level and type of influence when it comes to promoting cancer growth. (wikipedia.org)
  • In 1976, the manufacture of PCBs was banned in the United States because of concern for human health impacts, but are still widely found in the general population of the U.S. (ewg.org)
  • The American Cancer Society recommends: slip on a shirt, slop on some sunscreen, slap on a hat, and wrap on sunglasses to protect the eyes and delicate skin around them All sources agreed light skinned, fair people are at higher risk for sun damage and skin cancers. (uwrfvoice.com)
  • Project Summary Mutations in various oncogenes and tumor-suppressor genes as well as other genome rearrangements are a principal cause of human cancers. (nih.gov)
  • In laboratory animals, PCBs are known to cause cancer and damage to the reproductive, endocrine, immune, and nervous systems. (ewg.org)
  • This nomination is strongly supported by the National Renewable Energy Laboratory (NREL) and First Solar Inc. The material has the potential for widespread applications in photovoltaic energy generation that will involve extensive human interfaces. (nih.gov)
  • 2006). This amount is based on two human intervention studies (Chinese male population deficient in selenium supplemented with 10-90 µg selenomethionine for 8 months, and a New Zealand population with low selenium intake given selenomethionine for 20 weeks), which demonstrated the amount needed to maximize glutathione peroxidase activity (Institute of Medicine, 2000). (canada.ca)
  • Radio frequencies have been associated with brain and breast cancer and impaired sperm health in human studies. (theepochtimes.com)
  • Carcinogens are agents in the environment capable of contributing to cancer growth. (wikipedia.org)
  • That segment of the population exposed to physical and/or chemical agents or other workplace hazards that may damage the human body in any way. (cdc.gov)
  • This type of smoke has higher concentrations of nicotine and cancer-causing agents (carcinogens) than mainstream smoke. (cancer.org)
  • A carcinogen (/kɑːrˈsɪnədʒən/) is any substance, radionuclide, or radiation that promotes carcinogenesis (the formation of cancer). (wikipedia.org)
  • Metals is one important group of widespread carcinogens that are largely nonmutagenic, including lung cancer-causing nickel (Ni). (nih.gov)
  • Since 1981, agencies and institutes have cited the same estimate when regulating carcinogens in the workplace, air, water and consumer products. (scientificamerican.com)
  • Although the human body emits its own EMFs , it's also vulnerable and susceptible to certain external EMFs. (theepochtimes.com)
  • Sun damage can occur from natural sun or UV rays at the tanning salon. (uwrfvoice.com)
  • The absorption of tricresyl phosphates caused peripheral nervous system damage, leading to neuromuscular problems (Hewstone 1994a). (cdc.gov)
  • For example, Thorotrast, a (incidentally radioactive) suspension previously used as a contrast medium in x-ray diagnostics, is a potent human carcinogen known because of its retention within various organs and persistent emission of alpha particles. (wikipedia.org)
  • As far back as the 1930s, industrial smoke and tobacco smoke were identified as sources of dozens of carcinogens, including benzo[a]pyrene, tobacco-specific nitrosamines such as nitrosonornicotine, and reactive aldehydes such as formaldehyde, which is also a hazard in embalming and making plastics. (wikipedia.org)
  • Those nonsmokers who are exposed to tobacco smoke are exposed to the same toxic constituents of tobacco smoke as smokers (U.S. DHHS, 1986), although active smokers and those exposed to ETS may differ in the relative amounts of carcinogens to which they are exposed. (druglibrary.net)
  • It is important while you are young to protect your skin every day because damaged skin will become loose, saggy, and wrinkly as you age. (uwrfvoice.com)
  • Other infectious organisms which cause cancer in humans include some bacteria (e.g. (wikipedia.org)
  • The Indoor Tanning Association states they do not agree with the current science about the serious nature of UV skin damage and will wait until there is more study. (uwrfvoice.com)
  • The Skin Cancer Foundation and The American Cancer Society agree, sun damage will age skin without skin cancer being present. (uwrfvoice.com)
  • UV radiation from the sun is a proven carcinogen, doing damage to the skin. (uwrfvoice.com)
  • This study found 40 to 70 percent of them had detectable skin damage. (uwrfvoice.com)
  • Vinyl chloride, from which PVC is manufactured, is a carcinogen and thus a hazard in PVC production. (wikipedia.org)
  • DNA repair synthesis in cultured human fibroblasts. (ubc.ca)
  • The effects of PCBs have been studied in humans who were exposed through diet, work, and industrial accidents. (ewg.org)