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  • protein
  • Hispolon inhibited the expression of MMP-9 protein, indicating that MMP-9 played an important role in the development of CCl 4 -induced rat liver damage. (hindawi.com)
  • Quercetin
  • The effects of quercetin on brain damage after subarachnoid hemorrhage (SAH), however, have not been investigated. (medsci.org)
  • The findings suggest that the early administration of optimal dose of quercetin may ameliorate brain damage and provide neuroprotection in the SAH model, potentially by enhancing the activity of endogenous antioxidant enzymes and inhibiting free radical generation. (medsci.org)
  • protects
  • Therefore, we speculate that hispolon protects rats from liver damage through their prophylactic redox balancing ability and anti-inflammation capacity. (hindawi.com)
  • Detection
  • In recent years, development of immunochemical detection of HNE-histidine adducts opened more advanced methodological possibilities for qualitative and quantitative detection of lipid peroxidation in various human and animal tissues[full citation needed] as well as in body fluids, including human serum and plasma samples. (wikipedia.org)
  • Detection and quantification of M1dG adducts in the body as measured by free M1G is a tool for detecting DNA damage that may lead to cancer. (wikipedia.org)
  • fatty
  • This radical is also an unstable species that reacts with another free fatty acid, producing a different fatty acid radical and a lipid peroxide, or a cyclic peroxide if it had reacted with itself. (wikipedia.org)
  • liver
  • The hepatoprotective potential of hispolon against carbon tetrachloride (CCl 4 )-induced liver damage was evaluated in preventive models in rats. (hindawi.com)
  • We also examined the involvement of matrix metalloproteinase (MMP)-9 in the development of CCl 4 -induced liver damage in rats. (hindawi.com)
  • Liver damage occurs more frequently in this form of hemochromatosis than in type 4A, and some individuals develop cirrhosis of the liver. (wikipedia.org)
  • Increase
  • Conclusions: Maximal and supra-maximal races induce a significant increase in lipid peroxidation and cause non-negligible inflammation and muscle damage. (iranepf.ir)
  • We examined the potential for watercress extracts and PEITC to increase the DNA damage caused by ionising radiation (IR) in breast cancer cells and to be protective against radiation-induced collateral damage in healthy breast cells. (springer.com)
  • causes
  • Radiotherapy also causes damage in healthy cells and can potentially trigger new cancer-initiating DNA mutations in local tissue. (springer.com)
  • tissues
  • As the disease progresses, iron may accumulate in the tissues of affected individuals over time, potentially resulting in organ damage. (wikipedia.org)
  • acid
  • Furthermore, when phosgene hydrolyzes it forms hydrochloric acid, which can damage the cell surface and cause cell death in the alveoli and bronchioles. (wikipedia.org)
  • biological
  • for example, some posit it is programmed by gene expression changes, others that it is the cumulative damage caused by biological processes. (wikipedia.org)
  • organic
  • The larger members are also poorly soluble in organic solvents as well as lipids. (wikipedia.org)
  • Past animal studies have shown good correlations between organic peroxide damage in human case reports and test animals. (wikipedia.org)
  • primary
  • Radiation-induced damage activates several signal transduction pathways whose primary role is to detect genomic injury leading to cell cycle arrest and DNA repair. (springer.com)
  • DNA damage is considered to be the primary cause of carcinogenesis. (wikipedia.org)
  • result
  • Replicative senescence is the result of telomere shortening that ultimately triggers a DNA damage response. (wikipedia.org)
  • Research
  • DNA Damage, DNA Repair and Cancer, New Research Directions in DNA Repair, Prof. Clark Chen (Ed.), ISBN 978-953-51-1114-6, InTech, http://www.intechopen.com/books/new-research-directions-in-dna-repair/dna-damage-dna-repair-and-cancer Kastan MB (April 2008). (wikipedia.org)
  • cells
  • The percentage of damaged cells were determined by single-cell gel electrophoresis. (brillonline.com)
  • 1 H nuclear magnetic resonance spectroscopy-based metabolic profiling was coupled with DNA damage-related assays (cell cycle, Comet assay, viability assays) to profile the comparative effects of watercress and PEITC in MCF-7 breast cancer cells and MCF-10A non-tumorigenic breast cells with and without exposure to IR. (springer.com)
  • In contrast, watercress-protected non-tumorigenic breast cells from radiation-induced damage. (springer.com)
  • contributes
  • Transforming growth factor-beta (TGF-beta) signalling is induced in liver as a consequence of damage and contributes to wound healing with transient activation, whereas it mediates fibrogenesis with long-term up-regulation in chronic disease. (diva-portal.org)
  • In biology, hypochlorous acid is generated in activated neutrophils by myeloperoxidase-mediated peroxidation of chloride ions, and contributes to the destruction of bacteria. (wikipedia.org)
  • In response to infection, the human immune system will produce a strong oxidizer, hypochlorous acid, which is generated in activated neutrophils by myeloperoxidase-mediated peroxidation of chloride ions, and contributes to the destruction of bacteria. (wikipedia.org)
  • ozone
  • However, the ozone layer (a portion of the stratosphere with a higher concentration of ozone, from two to eight ppm) is beneficial, preventing damaging ultraviolet light from reaching the Earth's surface, to the benefit of both plants and animals. (wikipedia.org)
  • activity
  • The raw material under study possessed free-radical scavenging activity and the formulation with it protected hairless mouse skin barrier function against UV damage. (lifeextension.com)
  • process
  • These and other considerations from the extensive literature on MDA, TBA reactivity, and oxidative lipid degradation support the conclusion that MDA determination and the TBA test can offer, at best, a narrow and somewhat empirical window on the complex process of lipid peroxidation. (wikipedia.org)