Damage aminoglycosides. Medical search. Frequent questions

Taking certain antibiotics with tenofovir can increase your risk of kidney damage. (healthline.com)
Vestibular injury is also a notable adverse effect of aminoglycoside antibiotics and may appear early on with positional nystagmus. (medscape.com)
The aminoglycosides are bactericidal antibiotics that bind to the 30S ribosome and inhibit bacterial protein synthesis. (medscape.com)
Aminoglycoside antibiotics display bactericidal activity against Gram-negative aerobes and some anaerobic bacilli where resistance has not yet arisen but generally not against Gram-positive and anaerobic Gram-negative bacteria. (wikipedia.org)
It has been proposed that aminoglycoside antibiotics cause oxidation of guanine nucleotides in the bacterial nucleotide pool, and that this contributes to the cytotoxicity of these antibiotics. (wikipedia.org)
There are some gram-positive Staphyloccus that are sensitive to amikacin although generally the aminoglycosides are combined with other antibiotics when both gram-negative and gram-positive bacteria are present. (wedgewoodpharmacy.com)
Aminoglycoside antibiotics have poor activity in the presence of pus and cellular debris. (wedgewoodpharmacy.com)
If renal function or hydration status is questionable, other antibiotics outside the aminoglycoside family may be preferable. (wedgewoodpharmacy.com)
Systemic use of amikacin and other aminoglycoside antibiotics are usually reserved for serious illnesses because of the risk of nephrotoxicity and ototoxicity. (wedgewoodpharmacy.com)
When using amikacin or other aminoglycoside antibiotics, monitoring of renal function and peak trough drug concentrations can be very useful to decrease the risks of nephrotoxicity. (wedgewoodpharmacy.com)
Kanamycin belongs to the class of medicines known as aminoglycoside antibiotics. (drugs.com)
University of Michigan scientists have found that iron chelators can prevent deafness in guinea pigs exposed to antibiotics that damage delicate hair cells in the inner ear. (sciencedaily.com)
ANN ARBOR---University of Michigan scientists have found that ironchelators---medications used to "soak up" excess iron in the bloodstream---canprevent deafness in guinea pigs exposed to antibiotics that damage delicate haircells in the inner ear. (sciencedaily.com)
If clinical trials show that iron chelators work as well in humans as they do inguinea pigs, the U-M research could lead to a safe and inexpensive way toeliminate the threat of deafness to individuals treated with a common class ofbroad-spectrum antibiotics called aminoglycosides. (sciencedaily.com)
In the United States, aminoglycosides are most often used for emergencytreatment of people with serious infections who have not responded to othertypes of antibiotics," said Jochen Schacht, a professor of biological chemistryand otolaryngology in the U-M Medical School. (sciencedaily.com)
Toxic medications or contrast - eg aminoglycoside antibiotics, non-steroidal anti-inflammatory drugs, tetracyclines, iodine contrast. (healthengine.com.au)
One class of ototoxic drugs included those producing temporary threshold shift, and another, including aminoglycoside antibiotics, caused permanent impairment. (cdc.gov)
Common drugs that might contribute to tinnitus include ototoxics, psychotropic drugs, aminoglycosides, certain antibiotics and vancomycin. (banishtinnitus.net)
For aquatic use Sulfas are often maligned by many aquarists as not effective or out of date, yet in reality Sulfathiazole often will work where other antibiotics fail and sometimes with less side effects as well (this is not to say Sulfas do not have side effects as they are somewhat toxic, producing blood abnormalities and kidney damage when indiscriminately used). (americanaquariumproducts.com)
Tobramycin belongs to a group of drugs called aminoglycoside antibiotics. (rxwiki.com)
It is even possible that absent CFTR function in the kidney may protect people with CF from renal insults, and certainly it has been recognised for many years that people with CF have increased renal clearance of many drugs including aminoglycoside antibiotics. (bmj.com)
It is also very important to avoid nonsteroidal anti-inflammatory drugs (NSAIDs), iodinated IV contrast and aminoglycoside antibiotics. (lls.org)
In emergency life-threatening conditions, mainly infectious, the doctor might have to start a medication that is known to be ototoxic (e.g. one of the aminoglycoside group of antibiotics) without having a baseline hearing test. (humelan.com)
Gentamicin belongs to a class of drugs known as aminoglycoside antibiotics . (webmd.com)
Some medications have a temporary or permanent harmful effect on the ear, for example the aminoglycoside class of antibiotics including streptomycin and quinine. (clinicbarcelona.org)
A history of hypersensitivity to bacitracin and / or neomycin, or to other aminoglycoside antibiotics. (pillbuys.com)
If systemic absorption occurs, the concomitant administration of cephalosporins or other aminoglycoside antibiotics may increase the likelihood of a nephrotoxic reaction. (pillbuys.com)

Other examples of aminoglycosides include the deoxystreptamine-containing agents kanamycin, tobramycin, gentamicin, and neomycin (see below). (wikipedia.org)
Kanamycin A Amikacin Tobramycin Dibekacin Gentamicin Sisomicin Netilmicin Neomycins B, C Neomycin E (paromomycin) Streptomycin Plazomicin Aminoglycosides display concentration-dependent bactericidal activity against "most gram-negative aerobic and facultative anaerobic bacilli" but not against gram-negative anaerobes and most gram-positive bacteria. (wikipedia.org)
As with other aminoglycosides, gentamicin injection is potentially nephrotoxic. (nih.gov)
Neurotoxicity manifested by ototoxicity, both vestibular and auditory, can occur in patients treated with gentamicin, primarily in those with pre-existing renal damage and in patients with normal renal function treated with higher doses and/or for longer periods than recommended. (nih.gov)
Gentamicin sulfate, a water-soluble antibiotic of the aminoglycoside group, is derived by the growth of Micromonospora purpurea , an actinomycete. (nih.gov)
It is less nephrotoxic than gentamicin although all aminoglycosides have the potential for both renal and otic toxicity. (wedgewoodpharmacy.com)
Asthese gentamicin-iron molecules form, they trigger production of freeradicals---unstable molecules that rip apart and damage cells. (sciencedaily.com)
Gentamicin (GM) is an aminoglycoside that has harmful effects on the male germ cells and sperm quality. (academicjournals.org)
Gentamicin, Tobramycin are some of the most nephrotoxic aminoglycosides. (brainscape.com)
Garamycin* Injection is a brand of gentamicin sulfate, an aminoglycoside antibiotic that is used for intramuscular and intravenous administration. (pharmacily.com)
Precautions should be taken in patients with renal impairment, neuromuscular disorders, or a history of allergic reactions to gentamicin or other aminoglycosides. (pharmacily.com)

Neomycin is available only for topical and oral use (oral aminoglycosides can be used to decontaminate the digestive tract because they are not absorbed). (msdmanuals.com)
Neomycin is an aminoglycoside antibiotic used in treating bacterial and fungal infections of the skin. (apollopharmacy.in)
Neomycin is an antibiotic aminoglycoside that inhibits bacterial protein synthesis. (pillbuys.com)
Like all other aminoglycosides, neomycin penetrates the placental barrier. (pillbuys.com)
Neomycin is known to cause damage to the ear. (alldaygeneric.com)

An aminoglycoside is often added to a beta-lactam antibiotic when serious Pseudomonas aeruginosa infections are treated. (medscape.com)
Streptomycin is the first-in-class aminoglycoside antibiotic. (wikipedia.org)
In addition, when administered intravenously, diuretics may enhance aminoglycoside toxicity by altering the antibiotic concentration in serum and tissue. (nih.gov)
Amikacin is an aminoglycoside antibiotic that is used to treat serious gram-negative bacterial infections. (wedgewoodpharmacy.com)
In the 1940s, permanent damage to the cochlea was reported in several patients treated with the newly discovered drug for treatment of tuberculosis, the aminoglycoside antibiotic streptomycin (Hinshaw and Feldman 1945). (cdc.gov)
An aminoglycoside, Antibiotic, Ammonium Detoxicant. (medicineindia.org)

Amikacin and other aminoglycosides are eliminated via the kidney and can be nephrotoxic. (wedgewoodpharmacy.com)
Amikacin and other aminoglycosides are commonly used in ophthalmic preparations to treat corneal ulcers. (wedgewoodpharmacy.com)

Nephrotoxicity (kidney damage). (rxwiki.com)
The use of aminoglycosides, especially when used in combination with cephalosporins, can cause nephrotoxicity. (picmonic.com)
Some of the common side effects include nephrotoxicity (kidney damage) and neurotoxicity (affecting the vestibular and auditory nerves). (pharmacily.com)

Tobramycin can cause kidney damage and hearing loss. (rxwiki.com)
6, 7 Finally, as a cohort, these patients are exposed to industrial quantities of potentially nephrotoxic chemotherapeutic agents (in our CF centre some children have received a cumulative intravenous dose of over 300 g of the aminoglycoside tobramycin). (bmj.com)

Etimicin (ETM), a fourth-generation aminoglycosides (AGs), is now widely clinically used in China due to its high efficacy and low toxicity. (chinaphar.com)
Patients treated with aminoglycosides should be under close clinical observation because of the potential toxicity associated with their use. (nih.gov)
Excessive peak and/or trough serum concentrations of aminoglycosides may increase the risk of renal and eighth cranial nerve toxicity. (nih.gov)

Aminoglycosides that are derived from bacteria of the Streptomyces genus are named with the suffix -mycin, whereas those that are derived from Micromonospora are named with the suffix -micin. (wikipedia.org)
Aminoglycosides first cross bacterial cell walls-lipopolysaccharide in gram-negative bacteria-and cell membranes, where they are actively transported. (wikipedia.org)
Aminoglycosides work by preventing bacteria from producing proteins they need to grow and multiply. (msdmanuals.com)
It is important to note that bacteria resistant to one aminoglycoside may also show resistance to others. (pharmacily.com)

Aminoglycoside-induced ototoxicity is usually irreversible. (nih.gov)

All aminoglycosides are nephrotoxic, most likely if taken more than 5 days. (brainscape.com)

In the following gallery, kanamycin A to netilmicin are examples of the 4,6-disubstituted deoxystreptamine sub-class of aminoglycosides, the neomycins are examples of the 4,5-disubstituted sub-class, and streptomycin is an example of a non-deoxystreptamine aminoglycoside. (wikipedia.org)

The inhibition of protein synthesis is mediated through aminoglycosides' energy-dependent, sometimes irreversible binding, to the cytosolic, membrane-associated bacterial ribosome (image at right). (wikipedia.org)
Aminoglycosides can cause irreversible injury to sensory cells of the inner ear, resulting in hearing loss and disturbed balance. (picmonic.com)

The main drugs are the aminoglycosides like (streptomycin), salicylates (like aspirin), chemotherapy drugs, and loop diuretics like Lasix. (autoaccident.com)

With systemic use of aminoglycosides in a high dose, the development of damage to the cochlear apparatus of the fetus is noted. (pillbuys.com)

Spectinomycin, a related but distinct chemical structure class often discussed with aminoglycosides, does not induce mRNA misreading and is generally not bactericidal. (wikipedia.org)

Spectinomycin is chemically related to aminoglycosides and works in a similar way. (msdmanuals.com)

Aminoglycosides can also be effective in the treatment of tuberculosis. (medscape.com)

The side effect of ototoxicity increases when aminoglycosides are used concurrently with loop diuretics. (picmonic.com)

For very serious bacterial infections, an injection of aminoglycosides may be used. (adam.com)
Aminoglycosides are medications used against a variety of gram negative infections. (picmonic.com)

Certain chemotherapy drugs, such as cisplatin, can effectively cause cochlea damage that leads to hearing loss. (adrohearingaid.com)
AMINOGLYCOSIDES and CISPLATIN) that cause functional impairments of the INNER EAR characterized by transient or permanent dysequilibrium, HEARING LOSS, and/or TINNITUS. (bvsalud.org)

medications that can damage the kidneys such as aminoglycosides. (rxwiki.com)
However, it may also cause some serious side effects, including damage to your hearing, sense of balance, and kidneys. (drugs.com)
As the kidneys are one of the primary means that the body excretes drugs and drug by-products, they are susceptible to damage induced by medications such as those listed above. (healthengine.com.au)
All aminoglycosides can damage the ears and kidneys. (msdmanuals.com)

Kidney damage and reduced kidney function. (healthline.com)
Taking alpha-lipoic acid by mouth with or without standard hydration therapy during a coronary angiography doesn't seem to prevent kidney damage caused by contrast agents. (medlineplus.gov)
Because they are so effective and rarely produce allergic reactions,physicians continue to prescribe them, even though they are known to causehearing loss and kidney damage in a significant percentage of individuals whotake them. (sciencedaily.com)
In rare cases, a procedure known as "plasmapheresis and exchange" may be helpful in limiting kidney damage. (lls.org)

Drug-induced damage to these structures of the auditory and balance system can result in hearing loss, tinnitus , and dysequilibrium or dizziness . (medscape.com)
Health care professionals who incline to offer patients an option or strategy to deal with tinnitus are confronted with the variability inherent to this disorder.5 The cause of tinnitus can vary, although people who experience tinnitus have usually first developed hearing loss due to ageing or from exposure to loud noise that caused peripheral auditory damage. (banishtinnitus.net)
Ototoxicity is the property that certain chemicals and medications exhibit that can lead to severe damage to the auditory nerve or inner ear, causing hearing loss issues such as tinnitus. (adrohearingaid.com)

Garamycin Injection, like other aminoglycosides, may cause adverse reactions. (pharmacily.com)

Although the ototoxic effects of aminoglycosides are well documented, this class of drugs is still widely used today. (medscape.com)
Of all ototoxic drugs, the aminoglycosides are the most vestibulotoxic, although they vary greatly in their differential effects on the vestibular and cochlear systems. (medscape.com)
If a perforation is present, instillation of preparations with ototoxic potential could lead to inner ear damage. (medscape.com)
Ototoxic medications damage hearing over time. (humelan.com)
Which medications can be ototoxic and cause hearing damage? (humelan.com)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside (sugar). (wikipedia.org)
While specific steps in protein synthesis affected may vary somewhat between specific aminoglycoside agents, as can their affinity and degree of binding, aminoglycoside presence in the cytosol generally disturbs peptide elongation at the 30S ribosomal subunit, giving rise to inaccurate mRNA translation and therefore biosynthesis of proteins that are truncated, or bear altered amino acid compositions at particular points. (wikipedia.org)
Recent single-molecule tracking experiments in live E. coli showed an ongoing but slower protein synthesis upon treatment with different aminoglycoside drugs. (wikipedia.org)
This aminoglycoside cause protein synthesis inhibition by 'irreversibly' bind to specific 30S-subunit proteins and 16S rRNA. (medicineindia.org)

Clotrimazole is an antifungal medication that stops the growth of fungi by causing damage and leakage to the fungal cell membrane. (apollopharmacy.in)
The ear can also be damaged by illness, toxins and medication that destroy the ability of the ear to hear. (autoaccident.com)
It's important to have a baseline hearing test before starting to take medication that can damage your hearing. (humelan.com)
To reduce the risk for hearing damage, the level of the medication in your body is closely monitored and as soon as the medical condition allows, a hearing test is performed. (humelan.com)
This medication can cause serious kidney problems and nerve damage , resulting in permanent hearing loss (including deafness or decreased hearing) and balance problems. (webmd.com)

Garamycin Injection may still be effective against bacterial strains that are resistant to other aminoglycosides. (pharmacily.com)

Inappropriate use of certain medications, such as aminoglycosides, cytotoxic agents, antimalarial drugs and diuretics. (clinicbarcelona.org)

In patients treated with aminoglycosides and/or glycopeptides, an elevation of N-acetylglutamine in urine suggests renal tubular injury. (hmdb.ca)

Vertigo is typical of one sided damage to the peripheral vestibular system in the acute stage (within days of disruption), but can be evident in central lesions as well. (vestibular.org)
In the acute stage of damage to one side of the peripheral vestibular system, this sensation is often accompanied by eye movements called nystagmus (i.e. a rhythmic moving of the eyes left to right or up-down). (vestibular.org)
Baneocin should not be used in patients with pronounced disorders of the excretory function, including renal etiology, and already having damage to the vestibular and cochlear systems, in cases where uncontrolled absorption of the drug is possible. (pillbuys.com)

This inhibits the formation of the membrane attack complex (C5b-C9), which prevents membrane damage and bacterial cell death. (medscape.com)

Most multidrug-resistant (MDR) K. pneumoniae isolates, which produce extended-spectrum β-lactamases (ESBLs) and/or carbapenemases in combination with quinolone and aminoglycoside resistance, belong to particular clones ( 4 - 6 ). (cdc.gov)

They can be damaged by continual exposure (e.g., working in a noisy atmosphere without adequate protection or continually listening to loud music) or due to a short-lived but very loud sound (e.g., a shotgun being fired or fireworks exploding). (clinicbarcelona.org)

Serum concentrations of aminoglycosides should be monitored when feasible to assure adequate levels and to avoid potentially toxic levels. (nih.gov)

The nature of the potentiation of noise damage by aminoglycosides appeared to be a general cochlear process that predisposed the cochlea to damage from low and high frequency and from impulse noise. (cdc.gov)
Cochlear damage may also manifest as tinnitus. (medscape.com)

It involves damaging the hair cells in the inner ear from over-stimulation. (autoaccident.com)
Very loud sounds can damage cells in the inner ear. (clinicbarcelona.org)

The fact that aminoglycosides have toxic side-effects has been well-known sincethe 1940s, but only recently---thanks to 20 years of research by Schacht andcolleagues at the U-M and other universities---have scientists figured out howthese drugs do their damage. (sciencedaily.com)

Aminoglycosides are poorly absorbed from the gastrointestinal (GI) tract and must be given parenterally. (wedgewoodpharmacy.com)

Below we answer some of the most common questions related to medications that can damage your hearing. (humelan.com)

However, even for the largest group of tinnitus sufferers (those who may develop tinnitus due to hearing damage), effective treatments have been hard to come by. (banishtinnitus.net)
Tinnitus is often the first sign of damage, as these drugs damage the 8th cranial nerve. (picmonic.com)
One of the symptoms of damage to ear is tinnitus. (alldaygeneric.com)

It belongs to a group of drugs called aminoglycosides. (alldaygeneric.com)

Allergic reactions such as contact eczema were less common than usual (associated with cross-allergy to other aminoglycosides in about 50% of cases). (pillbuys.com)

A certain genetic makeup may make some people more susceptible to damage caused by loud noises or greater deterioration as they get older. (clinicbarcelona.org)

Anatomy5

Organisms23

Diseases14

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes21

Information Science1

Antibiotics27

Gentamicin11

Neomycin5

Antibiotic6

Amikacin2

Nephrotoxicity3

Tobramycin2

Toxicity3

Bacteria4

Ototoxicity is usually irreversible1

Nephrotoxic1

Kanamycin1

Irreversible2

Streptomycin1

Systemic1

Bactericidal1

Spectinomycin1

Treatment of tuberculosis1

Loop diuretics1

Infections2

Cisplatin2

Kidneys4

Kidney damage4

Auditory3

Adverse1

Ototoxic5

Protein synthesis4

Medication5

Injection1

Diuretics1

Glycopeptides1

Vestibular3

Bacterial cell1

Resistance1

Exposure1

Concentrations1

Cochlear2

Inner ear2

1940s1

Poorly1

Medications that can damage1

Tinnitus3

Drugs1

Reactions1

Susceptible to damage1