that immunologic reactivity to anthrax antigens, if any, and Germaine Hanquet would very likely demonstrate exposure to B. anthracis . (cdc.gov)
To determine immunologic reactivity to Bacillus anthrax antigens, we conducted serologic testing of workers in a The Study factory that performed scouring of wool and goat hair. (cdc.gov)
Antibody-dependent ce2
Contrast with antibody-dependent cellular cytotoxicity (ADCC) Schroeder, Harry W. (wikipedia.org)
some cells require the presence of humoral antibodies directed against the tumor cells (antibody-dependent cellular cytotoxicity) to initiate the interactions that lead to the death of tumor cells. (msdmanuals.com)
Lymphocytes3
To determine the immunologic characteristics of tumor infiltrating lymphocytes (TILs) in comparison with the corresponding peripheral blood lymphocytes (PBLs) of patients with ovarian cancer in order to detect specific antitumor-reactive-immunocompetent cells. (nih.gov)
Peripheral blood lymphocytes had a higher proliferative activity and cytotoxicity against natural killer-sensitive tumor cells than the corresponding TILs. (nih.gov)
Their Fab fragments blocked the cytotoxicity of the allogeneic antisera for B lymphocytes and were potent inhibitors of the mixed lymphocyte reaction. (ox.ac.uk)
Vitro cytotoxicity2
In vitro cytotoxicity to oral keratinocyte targets is greater in patients with active recurrent aphthous ulcers (canker sores) than in control subjects or in patients with traumatic ulcers. (medscape.com)
We assessed the construct's enzymatic activity, as well as in vitro cytotoxicity and internalization into target cells. (bmj.com)
Granules1
In addition, transport of granules to the immunologic synapse is required for intact CD8 T cell and NK cell cytotoxicity. (immunodeficiencysearch.com)
Chronic1
Chediak-Higashi syndrome - Patients are characterized by partial oculocutaneous albinism, bleeding disorder from platelet dysfunction, chronic neutropenia, and defective cell cytotoxicity. (immunodeficiencysearch.com)
Adjuvants1
It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants. (rush.edu)
Complement4
Complement-dependent cytotoxicity (CDC) is an effector function of IgG and IgM antibodies. (wikipedia.org)
Zhou 2008 Complement dependent cytotoxicity activity of therapeutic antibody fragments is acquired by immunogenic glycan coupling. (wikipedia.org)
In the presence of human serum the antibody initiated a strong lysis of melanoma tumour cells in complement-dependent cellular cytotoxicity (CDCC) assays. (duke.edu)
Effect of rabbit strain on activity level and cytotoxicity of serum complement. (jax.org)
Cells2
T cells carry out immunologic surveillance, then proliferate and destroy newly transformed tumor cells after recognizing TAAs. (msdmanuals.com)
define NK cell differentiation states based on their education via NKG2a and expression of CD16 (FcγRIII), an activating Fc receptor that mediates antibody-dependent cell-mediated cytotoxicity (ADCC) 8 , and demonstrate that nonpathogenic SIVagm infection in African green monkeys (AGMs) imprints the maturation of NK cells inducing terminally differentiated NKG2a low CD16 + NK cells, which express high levels of interleukin (IL)−21R. (nature.com)
Vivo2
Conclusion GrB(C210A)-Fc-IT4 demonstrated excellent, specific cytotoxicity in vitro and impressive in vivo efficacy with no significant toxicity in normal murine models. (bmj.com)
furthermore, in vivo IFNα-induced NK cell cytotoxicity correlates with reductions in HIV-DNA during antiretroviral therapy (ART) 16 . (nature.com)
Diseases2
2010 Primer on Allergic and Immunologic Diseases. (wikipedia.org)
Farm er's lung is one of the most important environmental agricultur al diseases in the U.S. However, the immunologic process and its relationship to the pathophysiology of the class of diseases characterized by hypersensitivity pneumonitis are not clear. (cdc.gov)
Activity2
As expected with this abnormal immunologic activity, corticosteroids are effective therapy. (medscape.com)
Effect of rabbit strain on activity level and cytotoxicity of serum c" by R R. Fox, M Cherry et al. (jax.org)
Infection1
In SIVagm infection, systemic IL-15 was associated with NK cell proliferation in lymph node (LN), while systemic IFNα correlated with NK cell cytotoxicity in LN 17 . (nature.com)
Findings1
METHODS/PRINCIPLE FINDINGS: Resting hepatocytes cell lines expressed low levels of MHC Class I, but remained susceptible to CTL cytotoxicity. (ox.ac.uk)
Function1
Anti-inflammatory, antivirotic, central nervous system inhibit function and immunologic suppression. (kingherbs.com.cn)
Evidence1
No histologic or immunologic evidence of vasculitis could be found. (cdc.gov)
Human1
Results GrB(C210A)-Fc-IT4 protein exhibited high affinity and selective cytotoxicity within the nanomolar range when tested against a panel of Fn14-positive human cancer cell lines. (bmj.com)
Antigen2
Conversely, providing Langerin/OVA exclusively to LCs failed to prime cytotoxicity, despite initial antigen cross-presentation to CD8(+) T cells. (cnrs.fr)
The assay of INTERFERON-GAMMA released from lymphocytes after their exposure to a specific test antigen, to check for IMMUNOLOGIC MEMORY resulting from a previous exposure to the antigen. (nih.gov)
Lymphoma3
14. Targeting of natural killer-like T immunologic effector cells against leukemia and lymphoma cells by reverse antibody-dependent cellular cytotoxicity. (nih.gov)
Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma. (umassmed.edu)
IL‐12/18 preactivated NK cells mediated stronger GVL (Graft vs. Lymphoma) effect than control NK cells mainly due to their elevated activation/cytotoxicity and sustained proliferative potential. (jeffreydachmd.com)
Adjuvants1
It is initiated by lymphokines , such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants. (lookformedical.com)
ADCC3
Contrast with antibody-dependent cellular cytotoxicity (ADCC) Schroeder, Harry W. (wikipedia.org)
Recent studies have revealed that fucose removal from the oligosaccharides of human IgG1 antibodies results in a significant enhancement of antibody-dependent cellular cytotoxicity (ADCC) via improved IgG1 binding to FcγRIIIa. (aacrjournals.org)
Antibodies of the human IgG1 isotype are commonly used for therapeutic applications as they can mediate multiple effector functions including antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and direct apoptosis induction (1-3) . (aacrjournals.org)
Cells13
In normal NK cells, WASp was expressed and localized to the activating immunologic synapse (IS) with filamentous actin (F-actin). (nih.gov)
This study aims to investigate the role of NK cells in CRF by comparing NK cell-induced cytotoxicity in fatigued patients and healthy individuals. (nih.gov)
Natural killer cells and spontaneous cell-mediated cytotoxicity in the human intestine. (ox.ac.uk)
Spontaneous cell-mediated cytotoxicity (SCMC) has been investigated in mononuclear cells (MNC) isolated from intestinal mucosa and autologous peripheral blood from human subjects. (ox.ac.uk)
However, at high E:T, ratios, significant cytotoxicity was demonstrated for most intestines examined probably reflecting a low proportion of effector cells within the intestinal MNC population. (ox.ac.uk)
T-cell bispecific antibodies (TCB) are novel antibody constructs capable of binding simultaneously to T cells and tumor cells, allowing cross-linking and the formation of immunologic synapses. (aacrjournals.org)
Therefore, the aim of the study was to examine the effect of amalgam on cytotoxicity and production of pro-inflammatory cytokine by cells isolated from PL. Methods. (rs.ba)
T cells carry out immunologic surveillance, then proliferate and destroy newly transformed tumor cells after recognizing TAAs. (msdmanuals.com)
some cells require the presence of humoral antibodies directed against the tumor cells (antibody-dependent cellular cytotoxicity) to initiate the interactions that lead to the death of tumor cells. (msdmanuals.com)
Splenocytes, isolated from nude mice transplanted with fully allogeneic or syngeneic thymic fragments and stimulated in vitro with trinitrophenyl-modified cells, displayed H-2-restricted, hapten-specific cytotoxicity. (aai.org)
Langerin/OVA combined with imiquimod could not prime CD8(+) T cells and resulted in poor cytotoxicity in subsequent responses. (cnrs.fr)
EMT-exo suppressed the proliferation, cytotoxicity, IFN-γ production, and perforin-1 and granzyme B secretion of NK cells. (biomedcentral.com)
Overexpression of SNHG10 in exosomes (oe-lnc-SNHG10 exo) significantly suppressed the viability and cytotoxicity of NK cells. (biomedcentral.com)
Effector1
Complement-dependent cytotoxicity (CDC) is an effector function of IgG and IgM antibodies. (wikipedia.org)
Cellular1
Future studies are warranted to investigate differences in the biological availability, cellular toxicity, and immunologic sensitization mechanisms for HDI monomer and HDI isocyanurate. (cdc.gov)
Synapse1
â Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation,â Blood, vol. (panoramavillapark.hu)
Antibody1
Zhou 2008 Complement dependent cytotoxicity activity of therapeutic antibody fragments is acquired by immunogenic glycan coupling. (wikipedia.org)
MeSH1
Cytotoxicity Tests, Immunologic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
Lymphocyte1
Lymphocyte proliferation and cytotoxicity in vitro were measured to assess immunologic reconstitution. (aai.org)
Protein2
Here we show that pp65, the main tegument protein of human cytomegalovirus, inhibited natural killer cell cytotoxicity by an interaction with the activating receptor NKp30. (ox.ac.uk)
Thus, pp65 is a ligand for the NKp30 receptor and demonstrates a unique mechanism by which an intracellular viral protein causes general suppression of natural killer cell cytotoxicity by specific interaction with an activating receptor. (ox.ac.uk)
Assay2
SCMC in both intestinal and autologous peripheral blood MNC were similarly related to the Leu 7+:T ratios used in the assay indirectly suggesting that the Leu 7+ cell may be responsible for the observed cytotoxicity. (ox.ac.uk)
Cytotoxicity was determined by MTT assay (n = 7 cultures) and apoptosis/necrosis assays (n = 8 cultures), whereas cytokine production was measured by a Flow Cytomix Microbeads Assay (n = 8 cultures). (rs.ba)
Tests2
This graph shows the total number of publications written about "Cytotoxicity Tests, Immunologic" by people in this website by year, and whether "Cytotoxicity Tests, Immunologic" was a major or minor topic of these publications. (childrensmercy.org)
Below are the most recent publications written about "Cytotoxicity Tests, Immunologic" by people in Profiles. (childrensmercy.org)
Natural1
Immunologic (T-cell, B cell, and natural killer cell cytotoxicity) studies revealed no underlying immunodeficiency. (cdc.gov)
Monitoring1
Through this limited competition Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) invites applications to continue support for the Cancer Immune Monitoring and Analysis Centers Cancer Immunologic Data Center (CIMAC-CIDC) Network. (nih.gov)
Immune1
Immune impairment data shown poor NK cell cytotoxicity (NK cell function, not number) that correlates with illness severity in ME/CFS (SEID) patients and could serve as a biomarker for the severity of the disease. (rezilirhealth.com)
Effects2
Perversely, many of the immunologic effects of NSAIAs may very well be detrimental to patients with rheumatoid arthritis, particularly as regards the stimulation of cytotoxicity. (utmb.edu)
Goodwin, JS 1985, ' Immunologic effects of nonsteroidal anti-inflammatory agents ', Medical Clinics of North America , vol. 69, no. 4, pp. 793-804. (utmb.edu)
Patients1
Kidney transplant patients at high immunologic risk. (nih.gov)
Direct1
Groupings of these reactions include direct cytotoxicity and/or drug accumulation, immunologic hypersensitivity, and aberrant molecular signaling. (elsevierpure.com)