• chemicals
  • P450 expression in tumor cells may lead to the localized production of intracellular drug metabolites, and may thereby either increase or decrease the cytotoxicity of test chemicals being evaluated. (aspetjournals.org)
  • Introduction The evaluation of chemical toxicity by traditional animal testing protocols has proven prohibitively costly and time consuming for screening large numbers of chemicals. (docplayer.net)
  • Applications discussed range from measurement of slow oxidative degradation of polymers and instability of hazardous industrial chemicals to detection of bacteria in urine and evaluation of the effects of drugs on parasitic worms. (wikipedia.org)
  • clinical
  • Smyth JF, Robins AB, Leese CL: The metabolism of cytosine arabinoside as a predictive test for clinical response to the drug in acute myeloid leukemia. (springer.com)
  • large
  • The cytochrome P450s are a superfamily of hemeprotein monooxygenases that catalyze the oxidative metabolism of a large number of drugs, environmental carcinogens, as well as steroids and other endobiotics. (aspetjournals.org)
  • cells
  • An attempt to estabilish the relationship between anti-cell adhesive action of phenylacetylshikonin anallogues and their cytotoxicity against A549 cells was done. (springer.com)
  • Based on these observations, it is proposed that the anti-cell adhesive action of phenylacetylshikonins might be responsible for their cytotoxicity in A549 cells. (springer.com)
  • Taxus
  • Higher plants have yielded many effective, clinically useful anticancer drugs, including those derived from Catharanthus alkaloids, Taxus diterpenes, Camptotheca alkaloids, and Podophyllum lignans. (schoolbag.info)
  • Paclitaxel drug eluting coated stents for coronary artery placement are sold under the trade name Taxus by Boston Scientific in the United States. (wikipedia.org)
  • Paclitaxel
  • Fortunately, Paclitaxel (Taxol) is proved to be a successful drug extracted from natural product to answer the call to fill the need. (biomedcentral.com)
  • Paclitaxel drug eluting coated stents for femoropopliteal artery placement are sold under the trade name Zilver PTX by Cook Medical, Inc. Common side effects include nausea and vomiting, loss of appetite, change in taste, thinned or brittle hair, pain in the joints of the arms or legs lasting two to three days, changes in the color of the nails, and tingling in the hands or toes. (wikipedia.org)
  • citation needed] A number of these side effects are associated with the excipient used, Cremophor EL, a polyoxyethylated castor oil, and allergies to cyclosporine, teniposide, and other drugs containing polyoxyethylated castor oil may indicate increased risk of adverse reactions to paclitaxel. (wikipedia.org)
  • inhibitors
  • Negative correlations between 7-ethoxycoumarin O -deethylation and cell line chemosensitivity to a group of topoisomerase inhibitors were also seen, again suggesting P450-dependent drug inactivation. (aspetjournals.org)
  • further
  • Among four fractions, the IC50s of n-BuOH fraction of EAC (EAC-B) against the five cell lines and time-dependent inhibition to gastric cancer cell line (MGC-803) were further investigated (MTT assay). (biomedcentral.com)
  • Therefore
  • Therefore, in order to be sure what process or processes are producing the measured heat flow, great care must be taken in both experimental design and in the initial use of related chemical, physical and biologic assays. (wikipedia.org)
  • treatment
  • This was approved by the U.S. Food and Drug Administration in January 2005 for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within six months of adjuvant chemotherapy. (wikipedia.org)
  • therapy
  • These findings provide a new drug candidate from purified components of ACM as an alternative therapy for head and neck cancer in the future. (hindawi.com)
  • treat
  • Catharanthus alkaloids, particularly vinblastine (A1) and vincristine (A2), are well known anticancer drugs, which are used clinically to treat Hodgkin's lymphoma and acute childhood lymphoblastic leukemia, respectively. (schoolbag.info)