• Advanced head and neck squamous cell carcinoma (HNSCC) is treated with radiotherapy, chemotherapy, targeted therapy or a combination of these treatments. (researchsquare.com)
  • Findings were categorized by type of treatment (radiotherapy, chemotherapy, targeted therapy, or combination therapy). (researchsquare.com)
  • Treatment of HNSCCs includes one of the surgery, radiotherapy or chemotherapy treatments or a combination of these treatments. (researchsquare.com)
  • Some cases have been associated with resistance to radiotherapy or chemotherapy and local recurrence. (researchsquare.com)
  • The current treatments for melanoma are surgery, which is performed in the early stages of the disease, and neoadjuvant treatments for advanced patients, including chemotherapy, radiotherapy, targeted therapy, immunotherapy and combination therapy [ 2 , 3 ]. (medsci.org)
  • High-grade glioma (HGG) are optimally treated with maximum safe surgery, followed by radiotherapy (RT) and/or systemic chemotherapy (CT). (surgicalneurologyint.com)
  • Autophagy also protects tumor cells attacked by chemotherapy drugs or radiotherapy radiation to prevent apoptosis [ 9 ]. (biomedcentral.com)
  • All patients were treated with conventionally fractionated radiotherapy combined with induction (platinum- and 5-fluorouracil-based) or concurrent platinum chemotherapy. (ox.ac.uk)
  • It is concluded that thymidine phosphorylase is associated with angiogenesis, with resistance to radiotherapy and cytotoxic therapy, and with poorer survival in squamous cell head and neck cancer. (ox.ac.uk)
  • A strong rationale is provided for subsequent clinical trials of concurrent radiotherapy and chemotherapy with antiangiogenic agents or with specific TP inhibitors. (ox.ac.uk)
  • Although the NWTSG/COG and SIOP guidelines concur that combined surgery, chemotherapy and radiotherapy is the initial treatment for Wilms tumor in children, they differ on the preferred strategy for delivery of therapy. (medscape.com)
  • following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable) (see section 5.1) - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)
  • For those who are ineligible for cisplatin-based regimens or experience progression of disease, in 2016-2017 the United States Food and Drug Administration approved five monoclonal antibodies that achieve immune checkpoint blockade by targeting the programmed cell death protein-1/programmed death-ligand 1 (PD-1/PD-L1) pathway. (iospress.com)
  • Recent phase 1-2 trials reported manageable safety profiles and promising antitumor activities of anti-PD-1 drugs (pembrolizumab, nivolumab, camrelizumab and JS001) with/without chemotherapy in recurrent/metastatic nasopharyngeal carcinoma (RM-NPC), however head-to-head comparison among these regimens is lacking. (bmj.com)
  • According to tumour histotype, patients received chemotherapeutic regimens containing the main emetic cytotoxic agents, including cisplatin and athracyclines. (unimib.it)
  • 1 The development of novel targeted anticancer agents, such as the tyrosine kinase inhibitors (TKIs)-whether these are used as monotherapy or in combination regimens with chemotherapy-has contributed to improved quality of life and longer survival for cancer patients. (oncologynurseadvisor.com)
  • as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)
  • In December 1992 paclitaxel was approved to use in chemotherapy. (wikipedia.org)
  • In most cases, modern treatment of ovarian cancer includes radical cytoreductive surgery, followed by platinum- and paclitaxel-based systemic chemotherapy ( 5 - 7 ). (spandidos-publications.com)
  • In this study, we clarified that Fangjihuangqi Decoction (FJHQ, traditional Chinese medicine) is an autophagy inhibitor, which can synergistically enhance the effect of cisplatin and paclitaxel on non-small cell lung cancer (NSCLC) cells. (biomedcentral.com)
  • Apoptosis was detected after the combination of FJHQ with cisplatin or paclitaxel, and NAC (ROS scavenger) was further used to verify the activation of ROS-MAPK pathway by FJHQ. (biomedcentral.com)
  • Finally, we found that the combination of FJHQ with cisplatin or paclitaxel increased the apoptosis rate of NSCLC cells, due to increased ROS accumulation and further activation of the ROS-MAPK pathway. (biomedcentral.com)
  • Collectively, these results demonstrate that FJHQ is a novel late-stage autophagy inhibitor that can amplify the anti-tumor effect of cisplatin and paclitaxel against NSCLC cells. (biomedcentral.com)
  • Cisplatin and paclitaxel are commonly used as first-line chemotherapeutic agents in clinical practice, and their activity induces increased levels of autophagy in NSCLC cells. (biomedcentral.com)
  • 11 ] demonstrated a substantial overall survival (OS) benefit in patients with PD-L1-positive (PD-L1 + ) metastatic or inoperable locally advanced TNBC through the addition of the anti-PD-L1 agent atezolizumab to first-line chemotherapy with nab-paclitaxel. (biomedcentral.com)
  • Cell lines utilized in our tests had been resistant to cytotoxic medicines from the 1st range chemotherapy routine of ovarian tumor - paclitaxel (PAC) and cisplatin (CIS) [20] - as well as to two medicines frequently utilized in the second range of chemotherapy - doxorubicin (DOX) and topotecan (Best) [21, 22]. (scienceexhibitions.org)
  • Collectively, our results indicate that JIB extract showed anti-tumor effects and synergized with cisplatin against B16/F10 cells, indicating the possibility of JIB extract to be developed as adjuvant therapy for melanoma. (medsci.org)
  • Introduction In patients with non-small cell lung cancer, surgical treatment with postoperative adjuvant chemotherapy is performed. (bmj.com)
  • However, the improvement of overall survival achieved by postoperative adjuvant chemotherapy may be insufficient in consideration of the deterioration of quality of life (QOL). (bmj.com)
  • Standard treatment includes cytoreductive surgery and adjuvant chemotherapy with platinum and taxane-based cytostatics. (biomedcentral.com)
  • Surgery (radiation if the patient is not a surgical candidate), with or without adjuvant chemotherapy based on risk factors, for stages IB and II is generally appropriate. (medscape.com)
  • the benefit of adding adjuvant chemotherapy increases as disease stage increases. (medscape.com)
  • 1. Patient has received neoadjuvant/adjuvant systemic chemotherapy for primary Stage IIIc2 or IV disease and has had a recurrence or PD within 6 months of completing chemotherapy treatment prior to entering the study. (who.int)
  • 2 cm in diameter, as adjuvant therapy following neoadjuvant chemotherapy and surgery (see sections 4.4 and 5.1). (who.int)
  • In order to achieve a more effec- were recommended postoperative radiation and adjuvant tive and individualised chemotherapeutic treatment of breast chemotherapy. (lu.se)
  • The aims of this study are to clarify the antitumor effects of TCEE on human hepatocellular carcinoma cells and also evaluate the combination drug effects with conventional chemotherapy agents, cisplatin and doxorubicin. (hindawi.com)
  • In combination with the chemotherapy agents, TCEE treatment further enhanced the tumor suppression efficiency of cisplatin and doxorubicin. (hindawi.com)
  • Chemotherapy agents such as doxorubicin, cisplatin, and 5-fluorouracil are the primary choices for treating liver cancer cases but the response rate and overall survival remained poor [ 3 , 4 ]. (hindawi.com)
  • Furthermore, the combined drug effects of TCEE with conventional chemotherapy agents, cisplatin and doxorubicin, were also analyzed to clarify whether TCEE enhances or antagonizes the cytotoxicity of the selected chemotherapy agents in hepatocellular carcinoma cells. (hindawi.com)
  • L01DB01 - doxorubicin : Belongs to the class of cytotoxic antibiotics, anthracyclines and related substances. (azurewebsites.net)
  • Unresectable or widely disseminated tumors may be palliated by adrenolytic therapy with mitotane, antihormonal drugs (i.e., ketoconazole and metyrapone), systemic chemotherapy, and/or radiation therapy. (cancer.gov)
  • The purpose of this study is to assess the antitumor effectiveness and safety of perioperative enfortumab vedotin (EV) plus pembrolizumab and radical cystectomy (RC) + pelvic lymph node dissection (PLND) compared with the current standard of care (neoadjuvant chemotherapy [gemcitabine plus cisplatin] and RC + PLND) for participants with MIBC who are cisplatin-eligible. (mayo.edu)
  • The dual primary hypotheses are preoperative EV + pembrolizumab and RC + PLND (Arm A) will achieve superior pathologic complete response (pCR) rate and perioperative EV and pembrolizumab and RC + PLND (Arm A) will achieve superior event free survival (EFS) compared with neoadjuvant gemcitabine + cisplatin and RC + PLND (Arm B). (mayo.edu)
  • In addition, a deeper characterization of immune infiltrates, including the presence of a high number of cytotoxic (CD8 + ) TILs or a high CD8 + /FOXP3 + ratio, is able to define TNBC patients with a better prognosis following neoadjuvant chemotherapy [ 6 ]. (biomedcentral.com)
  • This randomized phase III trial studies how well standard-dose combination chemotherapy works compared to high-dose combination chemotherapy and stem cell transplant in treating patients with germ cell tumors that have returned after a period of improvement or did not respond to treatment. (cincinnatichildrens.org)
  • It is not yet known whether high-dose combination chemotherapy and stem cell transplant are more effective than standard-dose combination chemotherapy in treating patients with refractory or relapsed germ cell tumors. (cincinnatichildrens.org)
  • Febrile Neutropenia (FN) is a common complication of chemotherapy and a main cause of morbidity and mortality in cancer patients[ 1 ]. (ijpsonline.com)
  • The European Society for Medical Oncology (ESMO, 2016) reported an incidence of approximately 8 cases of FN per 1000 patients who received chemotherapy[ 1 ]. (ijpsonline.com)
  • A multicenter study in Argentina reported 515 episodes of FN in 346 patients, of which 77 % were secondary to chemotherapy. (ijpsonline.com)
  • In contrast, the novel INT230-6 formulation enables cytotoxic drugs to disperse and stay within the tumor, which has resulted in prolonged disease control in several patients with different tumor types," said Dr Thomas. (ahdbonline.com)
  • Cisplatin-based chemotherapy has been the best option for decades, but only 50% of patients benefit in the form of objective responses, and just 13-25% experience a complete response [ 1 ]. (iospress.com)
  • Risk of interference with cytotoxic action through antioxidant effects contentious, but evidence inconclusive and likely not uniform for all agents, conditions, or patients. (interactionsguide.com)
  • ARM II: Patients receive bleomycin sulfate IV on day 1 and etoposide phosphate* IV over 1 hour and cisplatin IV over 30 minutes on days 1-5. (clinicaltrialsgps.com)
  • Most patients are no longer able to undergo surgical resection when diagnosed, and chemotherapy remains the most common treatment for NSCLC [ 2 ]. (biomedcentral.com)
  • Although first-line clinical chemotherapy drugs can prolong the survival of NSCLC Patients to a certain extent, long-term drug use is prone to drug resistance with a greatly reduced chemotherapy effect. (biomedcentral.com)
  • METHODS: The study included 40 consecutive advanced cancer patients with untreatable chemotherapy-induced vomiting. (unimib.it)
  • In early disease, treatment with chemotherapy can be curative but in advanced ovarian cancer, most patients will have a recurrent disease within 18 months [ 3 ]. (biomedcentral.com)
  • these patients may receive chemotherapy alone or chemotherapy with radiation before surgical resection. (medscape.com)
  • Note: Low-dose cisplatin given as a radiation sensitizer or hormonal therapies do not exclude patients from study participation. (who.int)
  • Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. (who.int)
  • Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)
  • Delivery of siRNA-peptide nanoplexes co-targeting MK2 and XPA to pre-existing p53-deficient tumors in a highly aggressive, immunocompetent mouse model of lung adenocarcinoma improves long-term survival and cisplatin response beyond those of the synthetic lethal p53 mutant/MK2 combination alone. (nature.com)
  • The results demonstrated that JIB extract combined with cisplatin enhanced the inhibition of cell growth, proliferation, and survival through the obstruction of cell cycle progression and AKT/mTOR and MAPK signaling as well as the induction of cell apoptosis. (medsci.org)
  • Drug activity was compared with respect to EOC subtype, preoperative chemotherapy, cross‑resistance and association with progression‑free survival (PFS). (spandidos-publications.com)
  • In contrast, the antitumor effects and related biological mechanism of TCEE as well as the combination drug effects with conventional chemotherapy agents remain unclear particularly in human hepatocellular carcinoma cells. (hindawi.com)
  • In this paper, we hypothesized that in order to improve the outcome of conventional chemotherapy, it will be more effective to utilize CSC stimulating factors in combination with conventional chemotherapeutics. (ommegaonline.org)
  • Taken together, our study provided evidence to support the hypothesis that the addition of PRL to conventional chemotherapy (cisplatin) may be an effective alternative to target BCSC. (ommegaonline.org)
  • Furthermore, failure of targeting CSC soften results in treatment resistance and cancer recurrence, which remain to be one of the major obstacles in conventional chemotherapy [2,3] . (ommegaonline.org)
  • We show that loss of the DNA repair protein XPA markedly augments the synthetic lethality between MK2 and p53, enhancing anti-tumor responses alone and in combination with cisplatin chemotherapy. (nature.com)
  • The Meals and Drug Administration lately granted accelerated approval to erdafitinib for sufferers with superior UC with alterations of FGFR2 or FGFR3 after development on platinum-based chemotherapy. (aetox.com)
  • Urothelial bladder cancer (BC) represents a highly heterogeneous disease with regard to natural history, ranging from non-muscle invasive BC (NMIBC), which represents 75% of primary diagnoses and is characterized by frequent recurrence but a low risk of mortality, to muscle invasive BC (MIBC), which requires platinum-based chemotherapy followed by radical surgery, to metastatic disease [ 1 ]. (e-crt.org)
  • It is not yet known which chemotherapy regimen is more effective in treating sex cord-ovarian stromal tumors. (clinicaltrialsgps.com)
  • INT230-6 is composed of cisplatin, vinblastine, and an amphiphilic cell-penetration excipient small molecule that improves intracellular transport and tissue dispersion by passive diffusion," said Dr Thomas. (ahdbonline.com)
  • The quest for hostile to cancerous growth compounds from plant sources began vigorously during the 1950s with the disclosure and advancement of the different regular mixtures like vinca alkaloids, vinblastine, vincristine and cytotoxic podophyllotoxins. (researchsquare.com)
  • nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy. (nih.gov)
  • initial and repeat courses of moderately emetogenic cancer chemotherapy. (nih.gov)
  • Moderately emetogenic chemotherapy: 8mg every 8hrs for 2 doses beginning 30 mins before chemotherapy, then 8mg every 12hrs for 1-2 days after chemotherapy completed. (empr.com)
  • Giving colony-stimulating factors, such as filgrastim or pegfilgrastim, and certain chemotherapy drugs, helps stem cells move from the bone marrow to the blood so they can be collected and stored. (cincinnatichildrens.org)
  • Tubulin inhibitors are chemotherapy drugs that interfere directly with the tubulin system, which is in contrast to those chemotherapy drugs acting on DNA. (wikipedia.org)
  • A novel intratumoral chemotherapy agent delivered by direct injection permits the dispersion of cytotoxic drugs into cancer cells to eradicate tumors. (ahdbonline.com)
  • Sphingolipid-targeting drugs have been tested alone or in combination with chemotherapy, exhibiting antitumor activity alone and in synergism with chemotherapy in vitro and in vivo . (frontiersin.org)
  • In a study published in the Journal of Thoracic Oncology, researchers found that deleting a gene from adenoviruses made the drugs pemetrexed and cisplatin more cytotoxic to mesothelioma cells in the lab. (survivingmesothelioma.com)
  • The present study investigated the pattern of drug activity in type I and type II EOC for standard cytotoxic drugs and recently introduced tyrosine kinase inhibitors (TKIs), and assessed the association with treatment history and clinical outcome. (spandidos-publications.com)
  • Isolated EOC tumor cells obtained at surgery were investigated for their sensitivity to seven standard cytotoxic drugs and nine TKIs using a short‑term fluorescent microculture cytotoxicity assay (FMCA). (spandidos-publications.com)
  • In line with clinical experience, EOC type I samples were generally more resistant than type II samples to both standard cytotoxic drugs and the TKIs, reaching statistical significance for cisplatin (P=0.03) and dasatinib (P=0.002). (spandidos-publications.com)
  • We aimed to comprehensively compare the efficacy and safety of different anti-PD-1 drugs, standard chemotherapy, and their combination therapy in RM-NPC. (bmj.com)
  • Clinically, although chemotherapy is one of the most commonly used methods of treating tumors, chemotherapeutic drugs can induce autophagic flux and increase tumor cell resistance, leading to drug tolerance. (biomedcentral.com)
  • AIM: Corticosteroids, antidopaminergig agents and 5-HT3 antagonists are the most commonly used drugs in the treatment of chemotherapy-induced vomiting. (unimib.it)
  • Because of its bifunctional role, TP may have interactions with cytotoxic drugs or radiation via pathways requiring thymidine or prodrug activation. (ox.ac.uk)
  • For unilateral Wilms tumor, the NWTSG/COG guidelines, primarily followed in North America, recommend surgery prior to chemotherapy, whereas the SIOP guidelines, followed in Europe, recommend both preoperative and postoperative chemotherapy. (medscape.com)
  • While platinum-based combination chemotherapy still is the mainstay of treatment, advances in the understanding of the underlying biology have fundamentally changed how to treat BC, and therapeutic options have been expanded to include immune checkpoint inhibitors (ICIs) and molecularly-targeted agents [ 2 ]. (e-crt.org)
  • Giving more than one drug (combination chemotherapy) may kill more tumor cells. (clinicaltrialsgps.com)
  • Most advanced and recurrent cases therefore will receive systemic chemotherapies as the alternative approach. (hindawi.com)
  • DBL Cisplatin Injection has been chosen as your therapy, as the benefits of treatment are expected to be greater than the unwanted or side effects. (news-medical.net)
  • Your doctor should discuss this issue with you before you begin therapy with cisplatin. (news-medical.net)
  • As a class, NSCLCs are relatively insensitive to chemotherapy and radiation therapy compared with SCLC. (medpagetoday.com)
  • Prior treatment for NMIBC with intravesical BCG/chemotherapy is permitted) or prior therapy with an anti- programmed cell death 1 (PD-1), anti-programmed cell death ligand 1/ ligand 2 (PD-L1/L2), or anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). (mayo.edu)
  • 3 Although there have been no randomised controlled trials to compare surgery with radiation therapy or chemotherapy, observational studies have suggested that surgery is the most curative treatment for lung cancer. (bmj.com)
  • Angiogenesis, thymidine phosphorylase, and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy. (ox.ac.uk)
  • HFSR from TKIs can appear within the first 2 to 4 weeks of therapy, 2,10 and this occurrence constitutes a variation of HFS distinct from that seen in traditional cytotoxic agents. (oncologynurseadvisor.com)
  • Among many MRP2 substrates the most essential can be cisplatin (CIS) and it can be the most regularly utilized antitumor agent in tumor therapy [6, 12]. (scienceexhibitions.org)
  • With chemotherapy for stage I or II NSCLC, the goal is to complete four cycles. (medscape.com)
  • As differentiated cells are more susceptible to chemotherapy [10] , differentiation of BCSCs may increase susceptibility to chemotherapeutic agents. (ommegaonline.org)
  • Giving chemotherapy before a stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. (cincinnatichildrens.org)
  • DBL Cisplatin Injection is a platinum-containing medicine and is used as an anticancer drug to interfere with the growth of cancer cells and eventually destroy them. (news-medical.net)
  • These findings establish a mechanism for co-targeting DNA damage-induced cell cycle checkpoints in combination with repair of cisplatin-DNA lesions in vivo using RNAi nanocarriers, and motivate further exploration of ASL as a generalized strategy to improve cancer treatment. (nature.com)
  • Febrile neutropenia is a common and serious complication of cancer chemotherapy. (ijpsonline.com)
  • These results together suggested that TCEE is a potential ingredient for developing an integrated chemotherapy for human liver cancer. (hindawi.com)
  • Moreover, treatment with TCEE is found to enhance the cytotoxic effects of amphotericin B in human colon cancer cell both in vitro and in vivo [ 17 ]. (hindawi.com)
  • Conventional cancer chemotherapy mainly targets proliferating cancer cells in a non-specific manner. (ommegaonline.org)
  • A systematic review of the therapeutic approaches for various cancer-related liver metastases would provide a better understanding of the latest progression and controversies regarding the surgical options, systematic chemotherapy, and palliative treatment. (cancertreatmentjournal.com)
  • A low percentage of cancer cells with nuclear TP expression in pretreatment biopsies was associated with a high rate of CR after combined chemoradiotherapy (P = 0.006) and induction chemotherapy (0.01). (ox.ac.uk)
  • Most of these cancers required treatment with radiation and/or chemotherapy, interventions that help 65% of persons with cancer to survive at least 5 years after their initial diagnosis. (oncologynurseadvisor.com)
  • The phase III IMpassion130 trial comparing chemotherapy plus atezolizumab versus chemotherapy plus placebo brought breast cancer into the immunotherapy era. (biomedcentral.com)
  • Background Multiple medication resistance (MDR) of cancer cells is the main reason of intrinsic or acquired insensitivity to chemotherapy in many cancers. (scienceexhibitions.org)
  • Conclusions Effectiveness of TOP and DOX in second line of chemotherapy in ovarian cancer can be limited because of their cross-resistance to PAC. (scienceexhibitions.org)
  • Toxicity from radiation must have recovered to grade 1 or less prior to initiating chemotherapy. (stanfordhealthcare.org)
  • Here, we represent preliminary evidence for the comparative safety and efficacy of existing anti-PD-1 agents with/without chemotherapy in RM-NPC, which indicated that camrelizumab has the least toxicity profile and merits future investigation. (bmj.com)
  • The concept has now been extended to embrace synthetic lethal drug sensitivity, such as that observed with PARP inhibitors in combination with DNA-damaging chemotherapy in a variety of BRCA defective tumors 10 . (nature.com)
  • Cisplatin showed concentration-dependent antitumor effects due to loss of cell adhesion and spheroid disruption in each cell line, while cetuximab exhibited antitumor effects that correlated with EGFR expression in each cell line. (medsci.org)
  • DBL Cisplatin Injection belongs to a group of medicines known as antineoplastic or cytotoxic agents. (news-medical.net)
  • When cytotoxic agents alone are administered, the majority of the drug leaks out of the tumor. (ahdbonline.com)
  • L01XA01 - cisplatin : Belongs to the class of platinum-containing antineoplastic agents. (azurewebsites.net)
  • For example, agents such as bleomycins oxidatively degrade DNA, whereas cisplatin forms interstrand cross-links within DNA. (aacrjournals.org)
  • Reactive and transient QMs and related electrophiles are formed during the metabolic activation of cytotoxic and genotoxic agents and may lead to DNA alkylation. (aacrjournals.org)
  • Aprepitant has been shown in animal models to inhibit emesis induced by cytotoxic chemotherapeutic agents, such as cisplatin, via central actions. (mdtodate.com)
  • HFSR is a distinct variant of the more widely known HFS, which occurs with more traditional chemotherapy agents such as capecitabine. (oncologynurseadvisor.com)
  • Bullous forms of HFS are more severe and tend to be associated with specific chemotherapy agents such as cisplatin (Platinol-AQ), methotrexate (Trexall), and the TKIs. (oncologynurseadvisor.com)
  • Therefore, it is reasonable to hypothesize that increased chemotherapy sensitivity of tumor cells may be achieved by inhibiting autophagy. (biomedcentral.com)
  • Because most tumors are deficient in one or more aspects of the function of the p53 tumor suppressor, either as a consequence of mutations within p53, or impairment of upstream and downstream modulators of p53 activity 19 , targeting MK2 has the potential to selectively enhance tumor cell killing without increasing the genotoxic effects of chemotherapy on normal p53-wild type tissues. (nature.com)
  • Radiation must be completed prior to starting chemotherapy with the exception of brain metastases where chemotherapy and radiation can be given concurrently. (stanfordhealthcare.org)
  • Treatment recommendations include the use of concurrent chemotherapy and radiation, or chemotherapy and radiation can be given sequentially if necessary. (medscape.com)
  • Aprepitant has little or no affinity for serotonin (5-HT 3 ), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CINV). (mdtodate.com)
  • the decision to treat the patient with concurrent chemoradiation rather than surgery, radiation, or chemotherapy individually should be made by a multidisciplinary tumor board (including a medical oncologist, radiation therapist, and thoracic surgeon). (medscape.com)
  • DBL Cisplatin Injection may be used alone or with other anticancer therapies. (news-medical.net)
  • The aim of this study was to evaluate the efficacy of acupressure in the treatment of chemotherapy-induced vomiting resistant to the standard antiemetic therapies. (unimib.it)
  • In animals, the emetic response to cisplatin can be prevented by pretreatment with an inhibitor of serotonin synthesis, bilateral abdominal vagotomy and greater splanchnic nerve section, or pretreatment with a serotonin 5-HT 3 receptor antagonist. (nih.gov)
  • In humans, urinary 5-HIAA (5-hydroxyindoleacetic acid) excretion increases after cisplatin administration in parallel with the onset of emesis. (nih.gov)
  • Animal and human studies have shown that aprepitant augments the antiemetic activity of the 5-HT 3 -receptor antagonist ondansetron and the corticosteroid dexamethasone and inhibits both the acute and delayed phases of cisplatin-induced emesis. (mdtodate.com)
  • Treatment varies with stage and generally includes surgery with or without chemotherapy and radiation. (msdmanuals.com)
  • Data about sociodemographic characteristics, the type of neoplasm and the chemotherapy scheme proposed were collected. (bvsalud.org)
  • The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. (cincinnatichildrens.org)
  • PD-1 is a transmembrane receptor expressed on dendritic, NK, CD4, CD8, and T-cells and involved in downregulation of the immune system by promotion of activated T-cell apoptosis and diminution of regulatory T-cell apoptosis to stop unrestrained cytotoxic functions ( 3 , 4 ). (cdc.gov)
  • Therefore, theoretically, inhibiting autophagy may improve the efficacy of chemotherapy. (biomedcentral.com)