SeV's ability to fuse eukaryotic cells and to form syncytium was used to produce hybridoma cells capable of manufacturing monoclonal antibodies in large quantities. (wikipedia.org)
Data from the recent conferences of the American Society of Clinical Oncology ( ASCO ) clearly show that in solid tumours monoclonal antibodies allow an average increase in survival of around two months, and only in rare cases, with or without associated chemotherapy, does this figure rise to or exceed four months. (beatingcancercenter.com)
Dendritic2
Crucial cells in CLE pathogenesis comprise plasmacytoid dendritic cells (pDCs) as major producers of type I IFN, T cells exerting cytotoxic effects, and B cells, previously believed to contribute via secretion of autoantibodies. (frontiersin.org)
Myasthenia gravis (MG) is a relatively rare acquired, autoimmune disorder caused by an antibody-mediated blockade of neuromuscular transmission resulting in skeletal muscle weakness and rapid muscle fatigue. (medscape.com)
Through these mechanisms B cells are involved both in autoimmune diseases that are traditionally viewed as antibody mediated and also in autoimmune diseases that are commonly classified as T cell mediated. (hindawi.com)
Mechanisms1
His research is focused on the mechanisms that regulate the immunological response of T lymphocytes, especially strategies to manipulate those responses in clinically relevant areas, including autoimmunity, allergies, vaccinations, and tumor therapy. (euroacadti.eu)
Cells6
B cells have antibody-dependent and antibody-independent pathogenic functions. (hindawi.com)
Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)
Binding of the Fc portion of the antibodies to FcR leads to activation of effector cells and further release of proinflammatory cytokines and proteolytic enzymes, mediators of antibody-dependent cell-mediated cytotoxicity (ADCC). (hindawi.com)
c) Effect of antibodies and antigen-specific B cells on antigen uptake. (hindawi.com)
Although these studies warrant independent confirmation, they support the notion that apoptotic cells could harbor the immunogens responsible for antinuclear antibody formation. (biomedcentral.com)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
Specific3
As a result of vaccination against HPIV1 a significant boost in virus-specific neutralizing antibodies was observed. (wikipedia.org)
It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs. (lookformedical.com)
Action1
2017-2021 COST Action (The European Cooperation in Science and Technology ) CA16223: LEukaemia GENe Discovery by data sharing, mining and collaboration (LEGEND) M.Antica is representative and Management Committee member for Croatia, Funded by the Horizon 2020 Framework Programme of the European Union. (irb.hr)
Immune2
Throughout this first era of my career, 1956-1980/1981, we were trying to understand the immune system. (nih.gov)
Transfer factor is an extract obtained from immune lymphocytes capable of transferring antigen-specific information for cell-mediated immunity (CMI) from an immunized donor to a na ve recipient. (50webs.com)
Capable2
SeV's ability to fuse eukaryotic cells and to form syncytium was used to produce hybridoma cells capable of manufacturing monoclonal antibodies in large quantities. (wikipedia.org)
Transfer factor (TF) is a low-molecular weight lymphocyte extract capable of transferring antigen-specific cell-mediated immunity (CMI) to T lymphocytes. (50webs.com)
Studies1
In vitro and in vivo studies in mammalian systems showed that crystalline silica was cytotoxic and genotoxic. (nih.gov)
Study1
A study in France reported antibodies to SeV in 17% of mouse colonies examined. (wikipedia.org)